Patents by Inventor Charon Robin Ganellin

Charon Robin Ganellin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inhibiting histamine activity with quanidine compounds
    Patent number: 4048319
    Abstract: A method of inhibiting histamine activity, in particular inhibiting H-2 histamine receptors, by administering heterocyclicalkylguanidines.
    Type: Grant
    Filed: March 19, 1976
    Date of Patent: September 13, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: James Whyte Black, Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Imidazole alkylaminoethylene compounds
    Patent number: 4046907
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[2-((4-methyl-5-imidazolyl)methylthio)-ethylamino] ethylene.
    Type: Grant
    Filed: November 5, 1975
    Date of Patent: September 6, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
  • Certain thiazolyl and isothiazolyl compounds and compositions and methods which employ them
    Patent number: 4038408
    Abstract: The compounds are heterocyclomethylsulphinylethyl derivatives of N-cyanoguanidines, thioureas and 2-amino-1-nitroethylene which are histamine H.sub.2 -antagonists or are converted into histamine H.sub.2 -antagonists in the animal body. Two specific compounds of the present invention are 1-nitro-2-[2-((2-thiazolyl)methylsulphinyl)ethylamino]-2-[2-((2-thiazolyl) methylthio)ethylamino]ethylene and 1-nitro-2,2-bis-[2-((2-thiazolyl)methylsulphinyl)ethylamino]ethylene.
    Type: Grant
    Filed: July 13, 1976
    Date of Patent: July 26, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Torben Hesselbo, George Raymond White
  • Amidino compounds
    Patent number: 4036971
    Abstract: The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkyl-isothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: February 19, 1975
    Date of Patent: July 19, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Rodney Christopher Young
  • Imidazolyl alkylaminopyridone and pyridinethione compounds
    Patent number: 4035374
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: October 6, 1975
    Date of Patent: July 12, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • N-Oxy and N-amino guanidines
    Patent number: 4034101
    Abstract: The compounds are N-oxy and N-amino guanidines which are histamine H.sub.2 -antagonists. A compound of this invention is N-hydroxy-N'methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)-ethyl]guanidi ne.
    Type: Grant
    Filed: June 11, 1975
    Date of Patent: July 5, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Geoffrey Robert Owen
  • Pharmaceutical compositions and methods of inhibiting H-2 histamine receptors with pyridyl substituted thioalkyl- and oxyalkyl-thioureas and ureas
    Patent number: 4027026
    Abstract: Pharmaceutical compositions and methods of inhibiting H-2 histamine receptors with pyridyl substituted thioalkyl- and oxyalkyl-thioureas and ureas.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: May 31, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Certain thiazoles and oxazoles
    Patent number: 4025527
    Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. Two compounds of this invention are N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea and N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-cyanoguanidine.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: May 24, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin
  • Ethylene derivatives
    Patent number: 4024260
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[2-((4-methyl-5-imidazolyl)methylthio)-ethylamino[ ethylene.
    Type: Grant
    Filed: November 11, 1975
    Date of Patent: May 17, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
  • Pharmacologically active guanidine compounds
    Patent number: 4024271
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: May 17, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Certain thiazole, isothiazole, oxazole, and isoxazole compounds
    Patent number: 4022797
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: May 10, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pharmacologically active thiourea and urea compounds
    Patent number: 4018931
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: April 19, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pyridyl substituted aminoalkyl-thioureas and ureas
    Patent number: 4018928
    Abstract: The compounds are pyridyl substituted aminoalkylthioureas and ureas which are inhibitors of H-2 histamine receptors. A compound of this invention is N-methyl-N'-[2-(2-pyridylmethylamino)ethyl]thiourea.
    Type: Grant
    Filed: October 29, 1975
    Date of Patent: April 19, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines
    Patent number: 4013678
    Abstract: Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas by treating a heterocyclicalkyl derivative with a mercaptoalkyl-N-cyanoguanidine or thiourea. Two specific products are N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine and N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea, both useful as histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: August 20, 1975
    Date of Patent: March 22, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas Henry Brown, Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pyridyl-alkylaminoethylene compounds
    Patent number: 4013769
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]-2-[2-((3-chlor o-2-pyridyl)methylthio)ethylamino]ethylene.
    Type: Grant
    Filed: November 5, 1975
    Date of Patent: March 22, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
  • Certain N,N'-disubstituted guanidine compounds and their use
    Patent number: 4013659
    Abstract: N-(4-Imidazolyl)propyl-N'-heterocyclomethylthioethyl guanidines which are selective histamine H.sub.2 -receptor agonists.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: March 22, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Michael Edward Parsons
  • Compositions and methods for inhibiting H.sub.2 histamine receptors
    Patent number: 4005205
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: October 6, 1975
    Date of Patent: January 25, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pyridylbutylamino ethylene compounds
    Patent number: 4002759
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[4-(3-chloro-pyridyl)butylamino]ethylene.
    Type: Grant
    Filed: November 5, 1975
    Date of Patent: January 11, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
  • Imidazole alkylguanidine compounds
    Patent number: 4000296
    Abstract: The compounds are guanidines, for example N-benzenesulphonyl-N'-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidi ne, which are inhibitors of histamine activity.
    Type: Grant
    Filed: March 21, 1975
    Date of Patent: December 28, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • N-cyano-N'-heterocyclic-alkyl quanidine inhibitors of H.sub.2 histamine receptors
    Patent number: 3975530
    Abstract: N-Cyano-N'-heterocyclic-alkylguanidinos which are inhibitors of histamine activity.
    Type: Grant
    Filed: April 18, 1975
    Date of Patent: August 17, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin