Patents by Inventor Charon Robin Ganellin

Charon Robin Ganellin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridyl alkylguanidine compounds, composition therewith, and methods of inhibiting H-2 histamine receptors
    Patent number: 3971786
    Abstract: The compounds are pyridyl alkylguanidines, for example N-benzenesulphonyl-N'-methyl-N"-[2-((3-hydroxy-2-pyridyl)methylthio)ethyl] guanidine, which are inhibitors of histamine activity.
    Type: Grant
    Filed: March 14, 1975
    Date of Patent: July 27, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Guanidino, thioureido and isothioureido derivatives containing imidazole groups
    Patent number: 3968227
    Abstract: The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N" -disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido) groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
    Type: Grant
    Filed: January 22, 1975
    Date of Patent: July 6, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin
  • Method of inhibiting histamine activity with guanidine compounds
    Patent number: 3968216
    Abstract: A method of inhibiting histamine activity in particular inhibiting H-2 histamine receptors, by administering heterocyclicalkylguanidines.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: July 6, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: James Whyte Black, Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Ethylene derivatives
    Patent number: 3953460
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[2-((4-methyl-5-imidazolyl) methylthio)ethylamino]-ethylene.
    Type: Grant
    Filed: May 9, 1974
    Date of Patent: April 27, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
  • Pharmacologically active thiourea and urea compounds
    Patent number: 3950353
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.
    Type: Grant
    Filed: March 14, 1974
    Date of Patent: April 13, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pharmacologically active guanidine compounds
    Patent number: 3950333
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.
    Type: Grant
    Filed: March 14, 1974
    Date of Patent: April 13, 1976
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • H2 histamine receptor inhibitors
    Patent number: 3932644
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: April 24, 1974
    Date of Patent: January 13, 1976
    Assignee: Smith Kline & French Laboratories, Inc.
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pyridyl substituted aminoalkyl-thioureas and ureas
    Patent number: 3932427
    Abstract: The compounds are pyridyl substituted aminoalkylthioureas and ureas which are inhibitors of H-2 histamine receptors. A compound of this invention is N-methyl-N'-[2-(2-pyridylmethylamino)ethyl]thiourea.
    Type: Grant
    Filed: March 13, 1974
    Date of Patent: January 13, 1976
    Assignee: Smith Kline & French Laboratories, Inc.
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin