Patents by Inventor Che-Hung Robert Lee

Che-Hung Robert Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing complex multivalent immunogenic conjugates
    Patent number: 8173135
    Abstract: Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: May 8, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventor: Che-Hung Robert Lee
  • POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES
    Publication number: 20120076817
    Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
    Type: Application
    Filed: September 23, 2011
    Publication date: March 29, 2012
    Inventors: Che-Hung Robert Lee, Carl E. Frasch
  • Meningococcal And Pneumococcal Conjugate Vaccine And Method Of Using Same
    Publication number: 20120009213
    Abstract: This disclosure relates to vaccine formulations comprising an immunogenic composition for inducing antibodies to both S. pneumoniae and N. meningitides in a subject. In a preferred aspect, the immunogenic composition comprises covalently conjugated recombinant PsaA (“rPsaA”) from S. pneumoniae and capsular polysaccharide from N. meningitidis serogroup C. This disclosure further relates to methods for producing the immunogenic composition as well as methods for their use.
    Type: Application
    Filed: July 14, 2011
    Publication date: January 12, 2012
    Inventors: Stanley Shih-Peng Tai, Che-Hung Robert Lee
  • Polysaccharide-protein conjugate vaccines
    Patent number: 8048432
    Abstract: Abstract of the Disclosure Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: November 1, 2011
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Che-Hung Robert Lee, Carl E. Frasch
  • Meningococcal and pneumococcal conjugate vaccine and method of using same
    Patent number: 8003112
    Abstract: This disclosure relates to vaccine formulations comprising an immunogenic composition for inducing antibodies to both S. pneumoniae and N. meningitides in a subject. In a preferred aspect, the immunogenic composition comprises covalently conjugated recombinant PsaA (“rPsaA”) from S. pneumoniae and capsular polysaccharide from N. meningitidis serogroup C. This disclosure further relates to methods for producing the immunogenic composition as well as methods for their use.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: August 23, 2011
    Assignees: Howard University, The United States of America as represented by the Secretary, Department of Health and Human Services; National Institutes of Health, Office of Technology Transfer
    Inventors: Stanley Shih-Peng Tai, Che-Hung Robert Lee
  • Meningococcal and Pneumococcal Conjugate Vaccine and Method of Using Same
    Publication number: 20100266625
    Abstract: This disclosure relates to vaccine formulations comprising an immunogenic composition for inducing antibodies to both S. pneumoniae and N. meningitides in a subject. In a preferred aspect, the immunogenic composition comprises covalently conjugated recombinant PsaA (“rPsaA”) from S. pneumoniae and capsular polysaccharide from N. meningitidis serogroup C. This disclosure further relates to methods for producing the immunogenic composition as well as methods for their use.
    Type: Application
    Filed: April 16, 2009
    Publication date: October 21, 2010
    Inventors: Stanley Shih-Peng Tai, Che-Hung Robert Lee
  • Methods for preparing complex multivalent immunogenic conjugates
    Publication number: 20090092632
    Abstract: Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant.
    Type: Application
    Filed: September 15, 2008
    Publication date: April 9, 2009
    Inventor: Che-Hung Robert Lee