Abstract: The present invention provides an isolated or engineered polypeptide, a microorganism comprising a nucleic acid sequence encoded by the polypeptide, and a method for synthesizing a polyphenolic phytochemicals phosphate derivative using the polypeptide or the microorganism. The polypeptide having a homologous protein sequence that is more than 70% identical to the polyphenol phosphorylation synthetase (SEQ ID NO: 13) comprises a conserved domain which sequentially comprises: an ATP-binding domain, which includes active catalytic sites of Lys27, Arg102, and Glu282; a substrate-binding domain, which includes a conserved motif of DDHHFYIDAMLDAKAR (SEQ ID NO: 14), and includes active catalytic sites of Asp627, His629, and His630; and a phosphorylated histidine catalytic domain, which includes His795 based on SEQ ID NO: 13.

Abstract: The present invention provides an application of genistein and its phosphate ester derivative for treating or preventing diseases mediated by the cannabinoid receptor type 1 (CB1 receptor) in an individual. The present invention also provides a pharmaceutical composition for treating or preventing CB1 receptor-mediated diseases, comprising an effective amount of genistein and its phosphate ester derivative.

Abstract: The present invention provides a coupled enzyme system, comprises: a first enzyme, comprising a polyphenol phosphorylation synthetase; a second enzyme, which is ATP regeneration enzyme; and a substrate, being phosphorylated by the first enzyme. The coupled enzyme system of the present invention integrates polyphenol phosphorylation synthetase with ATP regeneration enzyme so that the polyphenol phosphorylation synthetase is used to phosphorylate polyphenol and the ATP regeneration enzyme regenerate ATP from AMP. Therefore, the present invention not only improves the water-solubility and bioavailability of the phenolic phytochemicals but also significantly reduces ATP consumption, presenting the potential of enzymatic systems in the production of polyphenol monophosphates.

Abstract: A signal receiver and a signal transceiver are provided, which may avoid unnecessary leakage current. The signal receiver includes a termination switch pair, a first resistor, a second resistor, and a pull-down circuit. The termination switch pair receives an operation power supply. The termination switch pair has a common control end. The first resistor is coupled between a first signal input end and the common control end. The second resistor is coupled between a second signal input end and the common control end. The pull-down circuit is coupled between the common control end and a reference voltage end. The pull-down circuit determines whether to pull down a first control voltage on the common control end to a reference voltage according to a power-on state or a power-off state of the signal receiver.

Abstract: An isolated or engineered polypeptide, a microorganism comprising a nucleic acid sequence encoded by the polypeptide, and a method for synthesizing a polyphenolic phytochemicals phosphate derivative using the polypeptide or the microorganism are provided. The polypeptide having a homologous protein sequence that is more than 70% identical to the polyphenol phosphorylation synthetase (SEQ ID NO: 13) comprises a conserved domain which sequentially comprises: an ATP-binding domain, which includes active catalytic sites of Lys27, Arg102, and Glu282; a substrate-binding domain, which includes a conserved motif of DDHHFYIDAMLDAKAR (SEQ ID NO: 14), and includes active catalytic sites ofAsp627, His629, and His630; and a phosphorylated histidine catalytic domain, which includes His795 based on SEQ ID NO: 13.

Abstract: A signal receiver and a signal transceiver are provided, which may avoid unnecessary leakage current. The signal receiver includes a termination switch pair, a first resistor, a second resistor, and a pull-down circuit. The termination switch pair receives an operation power supply. The termination switch pair has a common control end. The first resistor is coupled between a first signal input end and the common control end. The second resistor is coupled between a second signal input end and the common control end. The pull-down circuit is coupled between the common control end and a reference voltage end. The pull-down circuit determines whether to pull down a first control voltage on the common control end to a reference voltage according to a power-on state or a power-off state of the signal receiver.

Abstract: The present invention provides a method for treatment or prevention of a disease associated with a decrease in bone mass comprising administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate. The present invention also provides a method of improving bone architecture and bio-mechanical strength of bone comprising administering to a subject in need of such treatment of a composition comprising an effective amount of genistein phosphate conjugate. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.

Abstract: The present invention is related to a biotransformation process, effected by means of an isolated polypeptide possessing benzopyrone phosphate synthetase activity, and also a microorganism comprising a nucleic acid sequence that encodes the polypeptide, for the preparation of phosphate-conjugated derivatives of benzopyrone compounds. The hydrophilic property of the benzopyrone compounds is enhanced after catalyzed by the benzopyrone phosphate synthetase of the present invention.

Abstract: The present invention provides a method for treatment or prevention of a disease associated with a decrease in bone mass comprising administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate. The present invention also provides a method of improving bone architecture and bio-mechanical strength of bone comprising administering to a subject in need of such treatment of a composition comprising an effective amount of genistein phosphate conjugate. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.

Abstract: An assembled record player includes: a box having a cover and a base, and the cover being covered onto the base, and a accommodating space being included between the cover and the base; a record player contained in the accommodating space; at least one loudspeaker and contained in the accommodating space; and a circuit board contained in the accommodating space. The cover and the base are separated, and an accommodating hole is formed on the cover, and the record player is installed and fixed to the accommodating hole, and the loudspeaker and the circuit board are fixed to the base, and the circuit board is electrically connected to the record player and the loudspeaker, and the cover of the record player is covered onto the base to form the record player. Therefore, users can experience the fun of assembling the record player.

Abstract: An assembled record player includes: a box having a cover and a base, and the cover being covered onto the base, and a accommodating space being included between the cover and the base; a record player contained in the accommodating space; at least one loudspeaker and contained in the accommodating space; and a circuit board contained in the accommodating space. The cover and the base are separated, and an accommodating hole is formed on the cover, and the record player is installed and fixed to the accommodating hole, and the loudspeaker and the circuit board are fixed to the base, and the circuit board is electrically connected to the record player and the loudspeaker, and the cover of the record player is covered onto the base to form the record player. Therefore, users can experience the fun of assembling the record player.

Abstract: The present invention is related to a biotransformation process, effected by means of an isolated polypeptide possessing benzopyrone phosphate synthetase activity, and also a microorganism comprising a nucleic acid sequence that encodes the polypeptide, for the preparation of phosphate-conjugated derivatives of benzopyrone compounds. The hydrophilic property of the benzopyrone compounds is enhanced after catalyzed by the benzopyrone phosphate synthetase of the present invention.

Abstract: The present invention relates to a non-invasive blood glucose sensor, comprising: a substrate, a first metal layer, a second metal layer, and a blood glucose sensing unit, wherein the first metal layer is formed on the one surface of the substrate and has a microstrip antenna in the internal thereof, the second metal layer is formed on the other surface of the substrate, and the blood glucose sensing unit is electrically connected to the first metal layer and the second metal layer. In the present invention, the non-invasive blood glucose sensor can be used to measure a numerical value of the blood glucose in a human body by way of disposing the non-invasive blood glucose sensor near the human body, without using any body-invading ways, for example, the acupuncture treatment; therefore the inconveniences and incorrect measurements resulting from the body-invading ways can be avoided.

Abstract: An electrode structure adapted for high applied voltage is provided, which comprises a conductive plate substrate and a covering layer disposed thereon such that a covering percentage of the covering layer over the conductive plate substrate is more than 50%. Since area of the conductive plate substrate covered by the covering layer is larger than the area exposed, the possibility of arcing is reduced and the breakdown voltage applied to the electrode structure may be increased.

Abstract: A semiconductor light-emitting device with light-modulating function and a method of fabrication the same are provided. The semiconductor light-emitting device as provided includes a light-emitting layer and a super-paramagnetic layer. The light-emitting layer functions for emitting a first light. In particular, a portion or most of the first light is modulated by the super-paramagnetic layer into a second light when the first light passes through the super-paramagnetic layer. In some embodiments, the semiconductor light-emitting device is designed in such a way that a portion of the first light, which is not modulated into the second light, blends with the second light into a third light, e.g., a white light.

Abstract: An electrode structure adapted for high applied voltage is provided, which comprises a conductive plate substrate and a covering layer disposed thereon such that a covering percentage of the covering layer over the conductive plate substrate is more than 50%. Since area of the conductive plate substrate covered by the covering layer is larger than the area exposed, the possibility of arcing is reduced and the voltage applied to the electrode structure may be increased.

Abstract: A camera tripod includes a mounting platform assembly and a tripod adjusting means. The mounting platform assembly includes a base and a platform. A handle is provided beneath the base. When the handle is loosened, the inclination of the platform can be controlled, but when the handle is locked, the inclination is fixed. The tripod adjusting means is mounted on the periphery of the base. The adjusting means includes supporting legs and tabs with stepped portions provided on the periphery of the base. Further, positioning elements and elastic elements are provided between the supporting legs and the tabs. The elastic element applies a resistant force to hold the positioning element between the tab and the supporting leg. The positioning element can escapes from the stepped portions of the tab to adjust the inclination of the supporting leg.