Abstract: A gene editing system of Candida viswanathii includes a Candida viswanathii, a first gene editing fragment and a second gene editing fragment. The first gene editing fragment successively includes a first homology arm and a screening gene. The second gene editing fragment is connected to a C-terminus of the first gene editing fragment and includes a second homology arm, a Cas9 expression cassette and a sgRNA cassette. The Cas9 expression cassette successively includes a Cas9 promoter, a Cas9 gene and three nuclear localization sequences. The sgRNA cassette successively includes a sgRNA promoter, a first ribozyme, a targeting sequence, a scaffold and a second ribozyme. The first gene editing fragment and the second gene editing fragment are constructed as a linear fragment for gene editing of a chromosome of the Candida viswanathii.

Abstract: A tire and a tire wear indicating structure thereof are disclosed. The tire wear indicating structure includes an indicator, at least three inclined portions of different heights, and at least two indicating grooves. The indicator has an indicator depth. The inclined portions are adjacently arranged to each other and located in the indicator. The heights of the inclined portions decrease progressively. The indicating grooves are disposed between the adjacent inclined portions. The indicating grooves each have an indicating groove depth that is the main groove depth minus 1.8 to 2.2 mm and is greater than the indicator depth. The current wear condition of the tire can be seen more intuitively, without too much information interfering with the judgment.

Abstract: A communication method and apparatus are provided. The method includes: A terminal device receives a first downlink reference signal from a first network device, and the terminal device receives a second downlink reference signal from a second network device. The terminal device determines channel state information. The channel state information is determined based on a ratio of a first channel estimation value to a second channel estimation value. The first channel estimation value is determined based on the first downlink reference signal, and the second channel estimation value is determined based on the second downlink reference signal. The terminal device sends the channel state information.

Abstract: The present invention provides a novel pan-RAF kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a use or method of the compound of formula (I) in the treatment or prevention of a disorder related to the activity of RAF and/or RAS kinase.

Abstract: A tire and a tire wear indicating structure thereof are disclosed. The tire wear indicating structure includes an indicator, at least three inclined portions of different heights, and at least two indicating grooves. The indicator has an indicator depth. The inclined portions are adjacently arranged to each other and located in the indicator. The heights of the inclined portions decrease progressively. The indicating grooves are disposed between the adjacent inclined portions. The indicating grooves each have an indicating groove depth that is the main groove depth minus 1.8 to 2.2 mm and is greater than the indicator depth. The current wear condition of the tire can be seen more intuitively, without too much information interfering with the judgment.

Abstract: A two-stage stochastic programming based V2G scheduling for operator revenue maximization is provided. Said method aims for the charge/discharge scheduling of electric vehicles, and establishes, based on a distributed renewable energy-storage-EVs charge/discharge power system, a V2G two-stage nonlinear stochastic programming model combining the V2G scheduling randomness with the renewable energy power generation randomness. Said model is converted into a mixed integer linear programming model (MILP) by means of constraint linearization. Furthermore, in order to enable random scenarios to cover uncertainty factors comprehensively, a scenario generation and combination method is designed to combine the V2G scheduling resources with the randomness of the renewable energy level.

Abstract: A system includes a hardware processor, and a system memory storing a software code. The hardware processor executes the software code to receive, from a user, a request related to a digital asset, obtain, from the user, verification data for use in creating a record of ownership of the digital asset, create, using the verification data, the record of ownership of the digital asset in an ownership database, embed a digital watermark into the digital asset to generate a digitally watermarked digital asset, and provide, to the user, the digitally watermarked digital asset. The digital watermark embedded in the digitally watermarked digital asset and the record of ownership of the digital asset in the ownership database enable ownership verification of the digital asset.

Abstract: A gene editing system of Candida viswanathii includes a Candida viswanathii, a first gene editing fragment and a second gene editing fragment. The first gene editing fragment successively includes a first homology arm and a screening gene. The second gene editing fragment is connected to a C-terminus of the first gene editing fragment and includes a second homology arm, a Cas9 expression cassette and a sgRNA cassette. The Cas9 expression cassette successively includes a Cas9 promoter, a Cas9 gene and three nuclear localization sequences. The sgRNA cassette successively includes a sgRNA promoter, a first ribozyme, a targeting sequence, a scaffold and a second ribozyme. The first gene editing fragment and the second gene editing fragment are constructed as a linear fragment for gene editing of a chromosome of the Candida viswanathii.

Abstract: Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-? receptor II (dnTGF?RII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Abstract: Disclosed herein relates to biopharmaceuticals, and more particularly to a continuous flow method for preparing (R)-3-hydroxy-5-hexenoate. Carbonyl reductase and isopropanol dehydrogenase are co-immobilized onto an inert solid medium simultaneously to prepare a carbonyl reductase/isopropanol dehydrogenase co-immobilized catalyst, which is then filled into a microchannel reactor of the micro reaction system. A solution containing substrate 3-carbonyl-5-hexenoate is subsequently pumped into the microchannel reactor to perform an asymmetric carbonyl reduction reaction to obtain (R)-3-hydroxy-5-hexenoate.

Abstract: A kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. A method and a use for using the inhibitor for treatment of diseases related to CDK9 and/or mutagenic activity thereof.

Abstract: A mobile power supply system includes a mobile power supply management device and one or more cascaded mobile power supplies. The mobile power supply includes a battery and a battery control circuit. The mobile power supply management device includes at least one of a direct-current discharge circuit and an alternating-current discharge circuit. The mobile power supply management device is used for managing charging and discharging of a battery of the mobile power supply. The mobile power supply management device and the one or more cascaded mobile power supplies are detachably and mechanically connected. The number and power of the mobile power supplies of the mobile power supply system can be adjusted according to requirements, and different battery capacities and discharging capacities are achieved.

Abstract: A gene editing system of Escherichia coli includes an Escherichia coli, a helper plasmid and a donor plasmid. The helper plasmid successively includes a transposase complex expression cassette, a Cas12k expression cassette, a first sgRNA cassette, a first antibiotic resistance gene and a first replication origin. The donor plasmid successively includes a left end sequence of a ShCAST transposon, an exogenous gene expression cassette, a right end sequence of the ShCAST transposon, a second sgRNA cassette, a second antibiotic resistance gene and a second replication origin.

Abstract: A system includes a computing platform having processing hardware and a memory storing software code. The processing hardware executes the software code to receive content data identifying new content and a future release date for the new content, provide a prediction identifying a subset of the users likely to request the new content upon its release, and prioritize, based on the prediction, a schedule for pre-provisioning authentication data for accessing the new content to the subset of users. The processing hardware further executes the software code to pre-provision, using the prioritized schedule, the authentication data to the subset of users prior to the release of the new content.

Abstract: The present invention relates to a kinase inhibitor, comprising a compound of Formula I or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also relates to a pharmaceutical composition comprising the kinase inhibitor, and to uses and methods for using these compounds and compositions to inhibit the activity of wild-type FLT3, mutant FLT3-ITD, PDGFR? and/or PDGFR? kinase in a cell or a subject, as well as uses and methods of these compounds and compositions to preventing or treating kinase-associated conditions in a subject.

Abstract: The present disclosure provides a temperature measurement method, a temperature measurement device, an electronic apparatus and a computer-readable storage medium. The method includes obtaining an image frame pair including a target object by a visible light camera and a thermal imaging camera, and a blackbody being also set in an image acquisition region of the thermal imaging camera; determining a measured temperature of the target object based on the image frame pair; performing a blackbody detection on the infrared image to obtain a detection result of the blackbody; determining a measured temperature of the blackbody based on the detection result of the blackbody and the infrared image; and correcting the measured temperature of the target object according to the measured temperature of the blackbody and a preset temperature of the blackbody, a corrected temperature being used as a temperature measurement result of the target object.

Abstract: The present disclosure relates to a transformant for producing 2,5-furandicarboxylic acid. The transformant for producing 2,5-furandicarboxylic acid includes a Pseudomonas putida and at least one exogenous gene. The exogenous gene is an HmfH gene or an HMFO gene, and the exogenous gene is integrated into the chromosome of the Pseudomonas putida.