Abstract: The temperature sensitivity of a reflective electro-absorption modulator can be reduced through the use, e.g., in the optical cavity thereof, of optical materials having positive and negative thermo-optic coefficients (TOCs). In some embodiments, a multiple-quantum-well structure of the modulator comprises positive-TOC materials, and a Bragg reflector bounding the optical cavity comprises one or more negative-TOC materials. In some embodiments, the thicknesses of the layers of positive- and negative-TOC materials are selected such that the average refractive index along the optical path through the modulator is approximately temperature independent. In some embodiments, the optical length of the optical cavity is an integer multiple of a nominal operating wavelength.

Abstract: Techniques are described for utilizing drawing guides in an electronic canvas. The techniques may include detecting a first input at an edge of an artboard associated with the electronic canvas, triggering, responsive to the detected first input, a plurality of selectable indicators to enable configuration of a drawing guide for providing an interactive reference for placing content in the artboard, detecting a second input pertaining to at least one of the plurality of selectable indicators, determining a location in the artboard corresponding to the distance from the edge of the artboard, and triggering the at least one drawing guide for display in the artboard at the determined location.

Abstract: The present disclosure provides an image processing system and method. The system includes an image capturing unit and an image processing unit. The image capturing unit includes a camera, a light source, and a wafer transfer stage. The camera captures an image of a wafer mark. The light source is capable of projecting through a plurality of chemical residues on the wafer mark. The image processing unit includes an image processor and an object matching subsystem. The image processor is configured to perform calculations of the image processing unit to generate an output result. The object matching subsystem includes an object matching unit and a memory unit. The object matching unit includes an artificial intelligence (AI) statistical model for identifying each character of the wafer mark. The memory unit stores a set of probabilities of the object matching unit detecting each character of the wafer mark in each image.

Abstract: The present disclosure relates to a gene editing system of Pseudomonas putida. The gene editing system of Pseudomonas putida includes a Pseudomonas putida, a RedCas expression plasmid and an exogenous gene expression plasmid. The RedCas expression plasmid includes a first replication origin, a first antibiotic resistance gene, a ?-Red expression cassette and a Cas expression cassette. The exogenous gene expression plasmid includes a second replication origin, a left homology arm, a second antibiotic resistance gene, an exogenous gene expression cassette, a right homology arm and a gRNA cassette.

Abstract: The present disclosure relates to a transformant for producing 2,5-furandicarboxylic acid. The transformant for producing 2,5-furandicarboxylic acid includes a Pseudomonas putida and at least one exogenous gene. The exogenous gene is an HmfH gene or an HMFO gene, and the exogenous gene is integrated into the chromosome of the Pseudomonas putida.

Abstract: The present invention provides a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound of formula (I), as well as the use and method for preventing or treating FLT3-related conditions, especially conditions related to mutant FLT3 kinase (particularly, FLT3/ITD mutant kinase).

Abstract: An anode active material for a lithium-ion battery with greatly reduced recharging time includes SiO particles, graphite particles, and a carbon coating layer. The graphite particles and SiO particles are processed to form spherical SiO/graphite composite particles. A layer of carbon coating is applied to the surface of the SiO/graphite composite particle and the resulting anode active material resembles a pomegranate structure.

Abstract: Techniques are described for utilizing drawing guides in an electronic canvas. The techniques may include detecting a first input at an edge of an artboard associated with the electronic canvas, triggering, responsive to the detected first input, a plurality of selectable indicators to enable configuration of a drawing guide for providing an interactive reference for placing content in the artboard, detecting a second input pertaining to at least one of the plurality of selectable indicators, determining a location in the artboard corresponding to the distance from the edge of the artboard, and triggering the at least one drawing guide for display in the artboard at the determined location.

Abstract: The present invention relates to a kinase inhibitor, comprising a compound of Formula I or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also relates to a pharmaceutical composition comprising the kinase inhibitor, and to uses and methods for using these compounds and compositions to inhibit the activity of wild-type FLT3, mutant FLT3-ITD, PDGFR? and/or PDGFR? kinase in a cell or a subject, as well as uses and methods of these compounds and compositions to preventing or treating kinase-associated conditions in a subject.

Abstract: The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof. The compound itself in the present invention or in combination with at least one therapeutic agent can be used for preventing or treating diseases, disorders or symptoms caused by the adjustment of the activity of tyrosine kinase C-KIT, or affected by the activity of the tyrosine kinase C-KIT or involving in the activity of the tyrosine kinase C-KIT, especially cancers or other cell proliferation diseases.

Abstract: Embodiments of the present disclosure provide signal encoding and decoding methods and devices. The method includes: determining, a quantity k of subbands to be encoded, where i is a positive number, and k is a positive integer; selecting, according to quantized envelopes of all subbands, k subbands from all the subbands, or selecting k subbands from all subbands according to a psychoacoustic model; and performing a first-time encoding operation on spectral coefficients of the k subbands. In some embodiments of the present disclosure, the quantity k of subbands to be encoded is determined according to the quantity of available bits and the first saturation threshold, and encoding is performed on the k subbands that are selected from all the subbands, instead of on an entire frequency band.

Abstract: The present application provides a compound of Formula (I) as an inhibitor against wild-type EGFR and/or mutant EGFR, which may be used for treating human non-small cell lung cancer individually or in combination with other therapeutic agent(s). The compound of Formula (I) of the present application may be used for treating patients of drug-resistant human non-small cell lung cancer harboring wild-type EGFR and/or EGFR T790M mutation and/or EGFR L858R mutation and/or EGFR delE746_A750 mutation.

Abstract: Optical transmitters, receivers, and transceivers implemented using a plurality of surface-coupled optical devices that can be manufactured on the same planar substrate and then post-processed to provide some of the devices with different respective partially transparent front mirrors compatible with and/or customized for different respective optical functions. When appropriately electrically biased and driven, different subsets of such devices can operate as lasers, optical modulators, optical amplifiers, and photodetectors, respectively. In this manner, an integrated array of such devices can be customized to provide the optical functions needed for the intended product. For example, an optical transmitter can be constructed using an integrated array that comprises three surface-coupled optical devices configured to operate as a laser, an optical modulator, and an optical amplifier, respectively.

Abstract: A memory management system and a method thereof are introduced. The memory management system can be configured to do memory management for a device system with a plurality of host devices. A memory block is coupled to a central processing unit. The system is configured to determine a number of the host devices configured in the device system; provide a corresponding device code to each host device; determine the memory capacity of the memory block; and allocate memory to each host device and accordingly build an allocation table. When the host device requests the central processing unit for accessing data, the central processing unit responds to the host device according to the allocation table, such that the host device uses the memory block to access data.

Abstract: The present invention provides an inhibitor of Bruton's tyrosine kinase, which is a compound of formula (I), or its pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method for inhibiting the activity of tyrosine kinase activity or for treating a disease, disorder, or condition, which would benefit from the inhibition of Bruton's tyrosine kinase(s), by using the Bruton's tyrosine kinase inhibitor, as well application of the Bruton's tyrosine kinase inhibitor for the same.

Abstract: An inhibitor of a wild type and Y641F mutant of human histone methyltransferase EZH2 is provided herein. Particularly, the inhibitor is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The inhibitor can be used to treat a cancer or precancerous condition related to EZH2 activity.

Abstract: One aspect of this disclosure relates to presenting a user with a stimulus to elicit user interaction with a task on a computing platform associated with the user. The stimulus may be presented on the computing platform when a set of triggering criteria is satisfied. The stimulus includes a task for the user to complete. The stimulus prompts the user to complete the task. The task includes a set of task criteria for completion. Responsive to the user satisfying the set of task criteria, the user is presented with one or more options to modify the stimulus. The user may be continuously prompted by the stimulus until the set of task criteria is satisfied.

Abstract: The present invention provides a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound of formula (I), as well as the use and method for preventing or treating FLT3-related conditions, especially conditions related to mutant FLT3 kinase (particularly, FLT3/ITD mutant kinase).

Abstract: An inhibitor of a wild type and Y641 F mutant of human histone methyltransferase EZH2 is provided herein. Particularly, the inhibitor is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The inhibitor can be used to treat a cancer or precancerous condition related to EZH2 activity.

Abstract: One aspect of this disclosure relates to presenting a user with a stimulus to elicit user interaction with a task on a computing platform associated with the user. The stimulus may be presented on the computing platform when a set of triggering criteria is satisfied. The stimulus includes a task for the user to complete. The stimulus prompts the user to complete the task. The task includes a set of task criteria for completion. Responsive to the user satisfying the set of task criteria, the user is presented with one or more options to modify the stimulus. The user may be continuously prompted by the stimulus until the set of task criteria is satisfied.