Abstract: The present invention relates to the technical field of medicine, and disclosed a maleate of a nicotinyl alcohol ether derivative, a crystal form thereof, and an application thereof, i.e., (S)-N-(2-(pyridin-3-yl-methoxy)-4-(2-bromo-3-phenylbenzyloxy)-5-chlorobenzyl) serine isopropyl ester maleate and a stereoisomer and a crystal form thereof, a preparation method therefor, a pharmaceutical composition, and a use thereof. Specifically, the present invention relates to the (S)-N-(2-(pyridin-3-yl-methoxy)-4-(2-bromo-3-phenylbenzyloxy)-5-chlorobenzyl) serine isopropyl ester maleate represented by formula I, and a crystal form thereof, a stereoisomer thereof, a preparation method therefor, a composition containing said compound or the crystal form thereof, and a use of said compound or the crystal form thereof in the preparation of a medicine for treating diseases related to a PD-1/PD-L1 signaling pathway, such as cancer, infectious diseases and autoimmune diseases.

Abstract: The present invention relates to the technical field of medicine, and disclosed a maleate of a nicotinyl alcohol ether derivative, a crystal form thereof, and an application thereof, i.e., (S)-N-(2-(pyridin-3-yl-methoxy)-4-(2-bromo-3-phenylbenzyloxy)-5-chlorobenzyl) serine isopropyl ester maleate and a stereoisomer and a crystal form thereof, a preparation method therefor, a pharmaceutical composition, and a use thereof. Specifically, the present invention relates to the (S)-N-(2-(pyridin-3-yl-methoxy)-4-(2-bromo-3-phenylbenzyloxy)-5-chlorobenzyl) serine isopropyl ester maleate represented by formula I, and a crystal form thereof, a stereoisomer thereof, a preparation method therefor, a composition containing said compound or the crystal form thereof, and a use of said compound or the crystal form thereof in the preparation of a medicine for treating diseases related to a PD-1/PD-L1 signaling pathway, such as cancer, infectious diseases and autoimmune diseases.

Abstract: Disclosed herein are membranes comprising: porous substrate; and two or more graphene oxide (GO) sheets disposed on the porous substrate, each GO layer comprising a plurality of GO flakes, each GO flake comprising a planar graphene structure with oxygen moieties extending therefrom, wherein the membrane, when a pressure from 10 bar to 50 bar of transmembrane pressure is applied from 1 hour to 48 hours, has an aqueous flux wherein the aqueous flux changes by 5% or less while the pressure is applied. The membranes can also include an intercalating agent disposed between the two or more GO sheets, the intercalating agent interacting with each GO sheet, wherein the intercalating agent provides a non-covalent stabilization of the two or more GO sheets. Also disclosed herein are methods of making and using the same and systems for implementing the same.

Abstract: A method of forming a molecular separation device is provided. The method comprises growing or depositing a silica MFI zeolite coating on a ceramic support. The method further comprises growing a ZIF-8 coating on the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite comprises applying a first reactant fluid including a metal salt and a second reactant fluid including an imidazole reactant to the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite further comprises reacting the first and second reactant fluid with the silica MFI zeolite coating to produce the ZIF-8 coating. In certain implementations, at least a portion of the ZIF-8 coating is interspersed with a portion of the silica MFI coating. A molecular separation device including the ZIF-8 coating and the silica MFI zeolite is also disclosed.

Abstract: A method of forming a molecular separation device is provided. The method comprises growing or depositing a silica MFI zeolite coating on a ceramic support. The method further comprises growing a ZIF-8 coating on the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite comprises applying a first reactant fluid including a metal salt and a second reactant fluid including an imidazole reactant to the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite further comprises reacting the first and second reactant fluid with the silica MFI zeolite coating to produce the ZIF-8 coating. In certain implementations, at least a portion of the ZIF-8 coating is interspersed with a portion of the silica MFI coating. A molecular separation device including the ZIF-8 coating and the silica MFI zeolite is also disclosed.

Abstract: An automatic test method and apparatus, an electronic device, and a storage medium are provided, which relate to the fields of the automatic test, the voice testing, the voice effect acceptance check, etc. The method includes: receiving a test task initiated by a visualization front-end; issuing the test task to a plurality of clients deployed; and scheduling execution of the test task for the plurality of clients, and feeding back obtained task execution results to the visualization front-end.

Abstract: An automatic test method and apparatus, an electronic device, and a storage medium are provided, which relate to the fields of the automatic test, the voice testing, the voice effect acceptance check, etc. The method includes: receiving a test task initiated by a visualization front-end; issuing the test task to a plurality of clients deployed; and scheduling execution of the test task for the plurality of clients, and feeding back obtained task execution results to the visualization front-end.

Abstract: Disclosed herein are membranes comprising: porous substrate; and two or more graphene oxide (GO) sheets disposed on the porous substrate, each GO layer comprising a plurality of GO flakes, each GO flake comprising a planar graphene structure with oxygen moieties extending therefrom, wherein the membrane, when a pressure from 10 bar to 50 bar of transmembrane pressure is applied from 1 hour to 48 hours, has an aqueous flux wherein the aqueous flux changes by 5% or less while the pressure is applied. The membranes can also include an intercalating agent disposed between the two or more GO sheets, the intercalating agent interacting with each GO sheet, wherein the intercalating agent provides a non-covalent stabilization of the two or more GO sheets. Also disclosed herein are methods of making and using the same and systems for implementing the same.

Abstract: Recommendation system for processing an input dataset that identifies a set of users, a set of items, and user-item interaction data. A plurality of unique triplets are identified based on the input dataset, wherein each triplet includes: a positive user-item pair; and a negative user-item pair. Over a plurality of training iterations system parameters are learned, including (i) a set of model embeddings for generating respective user-item relevance scores for the positive user-item pairs and the negative user-item pairs; and (ii) weight parameters for each of the triplets. The learning is configured to jointly optimize the model embeddings and the weight parameters to reach a learning objective that is based on weighted difference values determined for the triplets.

Abstract: A recommendation system (RS) for processing an input dataset that identifies a set of users, a set of items, and user-item interaction data about historic interactions between users in the set of users and items in the set of items. The RS is configured to: generate, based on a user-item interaction dataset, a user-user similarity dataset and an item-item similarity dataset, filter the user-user similarity dataset based on a user similarity threshold vector that includes a respective user similarity threshold value for each user, filter the item-item similarity dataset based on an item similarity threshold vector including a respective item similarity threshold value for each item generate a set of user neighbour embeddings based on the filtered user-user similarity dataset, and generating a set of item neighbour embeddings based on the filtered item-item similarity dataset.

Abstract: Provided is use of IL-15 protein complex joint PD-L1 antibody for treating tumor diseases.

Abstract: Disclosed is a method for calculating combustion in the bed of a waste incinerator. The method is based on a model of combustion in a waste incinerator bed and comprises a water evaporation model, a volatile matter analysis model, a volatile matter combustion model, and a fixed carbon combustion model. The volatile matter of the volatile matter combustion model comprises CO, H2, CH4, NH3, and H2S. The volatile matter combustion model comprises a combustion reaction equation for said volatile matter and O2, and respective equations for CO and CH4 reacting with water vapor. Equations governing the model of combustion in the bed of a waste incinerator comprise a continuity equation, an energy equation, a momentum equation, and a component equation. Boundary conditions of said governing equations comprise: equations of heat transfer and mass transfer from an upper boundary layer of the bed to the exterior; and equations of heat transfer and mass transfer from lower boundary layer of the bed to the exterior.

Abstract: An underwater camera system for monitoring fish in a fish pen is described. A stereoscopic camera may be used to determine dimensions of fish, and the underwater camera system may use the fish dimensions to estimate a biomass value of fish within the fish pen. The biomass value and rates of change of the biomass value may be used to adjust feeding of the fish in the fish pen. Images captured by the stereoscopic camera may be used to focus a variable focal lens camera on a fish to obtain high-resolution images that can be used for diagnosing fish conditions. Images captured by the stereoscopic camera may be used to predict motion of the fish, and the predicted motion may be used to generate various fish monitoring analytic values. The fish monitoring analytic values may be used to automatically control operation of the fish pen.

Abstract: In some embodiments, an underwater camera system for monitoring fish in a fish pen is provided. In some embodiments, a stereoscopic camera may be used to determine dimensions of fish, and the underwater camera system may use the fish dimensions to estimate biomass of fish within the fish pen. The biomass value and rates of change of the biomass value may be used to adjust feeding of the fish in the fish pen. In some embodiments, images captured by the stereoscopic camera may be used to focus a variable focal lens camera on a fish to obtain high-resolution images that can be used for diagnosing fish conditions. In some embodiments, images captured by a camera may be used to predict motion of the fish, and the predicted motion may be used to generate various fish monitoring analytic values. The fish monitoring analytic values may be used to automatically control operation of the fish pen.

Abstract: Provided are a composite probiotic lactic acid bacteria powder and a preparation method and use thereof, the composite probiotic lactic acid bacteria powder can be composited from Lactobacillus casei Zhang bacteria powder, Bifidobacterium animalis V9 bacteria powder, Lactobacillus plantarum P8 bacteria powder, Lactobacillus plantarum C2 bacteria powder, with prebiotics and fruit-vegetable powder. The composite probiotic lactic acid bacteria powder has a significantly protective effect against irritable bowel syndrome, oral infection and nasal cavity infection, and can prevent the occurrence of upper respiratory tract infection, at the same time, it can improve gastrointestinal symptoms, regulate gut microbiota and improve the body's immunity.

Abstract: A method of forming a molecular separation device is provided. The method comprises growing or depositing a silica MFI zeolite coating on a ceramic support. The method further comprises growing a ZIF-8 coating on the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite comprises applying a first reactant fluid including a metal salt and a second reactant fluid including an imidazole reactant to the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite further comprises reacting the first and second reactant fluid with the silica MFI zeolite coating to produce the ZIF-8 coating. In certain implementations, at least a portion of the ZIF-8 coating is interspersed with a portion of the silica MFI coating. A molecular separation device including the ZIF-8 coating and the silica MFI zeolite is also disclosed.

Abstract: Disclosed is a method for calculating combustion in the bed of a waste incinerator. The method is based on a model of combustion in a waste incinerator bed and comprises a water evaporation model, a volatile matter analysis model, a volatile matter combustion model, and a fixed carbon combustion model. The volatile matter of the volatile matter combustion model comprises CO, H2, CH4, NH3, and H2S. The volatile matter combustion model comprises a combustion reaction equation for said volatile matter and O2, and respective equations for CO and CH4 reacting with water vapor. Equations governing the model of combustion in the bed of a waste incinerator comprise a continuity equation, an energy equation, a momentum equation, and a component equation. Boundary conditions of said governing equations comprise: equations of heat transfer and mass transfer from an upper boundary layer of the bed to the exterior; and equations of heat transfer and mass transfer from lower boundary layer of the bed to the exterior.

Abstract: Embodiments of the present disclosure disclose a method, apparatus and system for testing an intelligent voice device. A specific implementation of the method includes: acquiring test data, the test data comprising: to-be-executed field control data and to-be-played voice data; sending, based on the to-be-executed field control data, a first motion instruction to the omnidirectional mobile mechanism connected to the intelligent voice device and/or the voice playing device; sending a playing instruction, in response to determining that a relative pose of the intelligent voice device and the voice playing device is the target relative pose; receiving predefined device information, associated with the voice recognition, of the intelligent voice device; and generating a test result based on the device information.

Abstract: Embodiments of the present disclosure disclose a method, apparatus and system for testing an intelligent voice device. A specific implementation of the method includes: acquiring test data, the test data comprising: to-be-executed field control data and to-be-played voice data; sending, based on the to-be-executed field control data, a first motion instruction to the omnidirectional mobile mechanism connected to the intelligent voice device and/or the voice playing device; sending a playing instruction, in response to determining that a relative pose of the intelligent voice device and the voice playing device is the target relative pose; receiving predefined device information, associated with the voice recognition, of the intelligent voice device; and generating a test result based on the device information.

Abstract: Provided are a composite probiotic lactic acid bacteria powder and a preparation method and use thereof, the composite probiotic lactic acid bacteria powder can be composited from Lactobacillus casei Zhang bacteria powder, Bifidobacterium animalis V9 bacteria powder, Lactobacillus plantarum P8 bacteria powder, Lactobacillus plantarum C2 bacteria powder, with prebiotics and fruit-vegetable powder. The composite probiotic lactic acid bacteria powder has a significantly protective effect against irritable bowel syndrome, oral infection and nasal cavity infection, and can prevent the occurrence of upper respiratory tract infection, at the same time, it can improve gastrointestinal symptoms, regulate gut microbiota and improve the body's immunity.