Abstract: The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.

Abstract: A reactor system configured to use valve pulsing to control precursor pressure as part of substrate or other processing. A controller in the reactor system runs a pressure control module to process pressure signals from a pressure sensor sensing pressure within an accumulator disposed between a reaction chamber and a precursor source vessel. Based on a pressure set point for the accumulator and the sensed pressure feedback, the controller generates valve control or valve pulsing signals to operate one or more fill valves used to control fill of the accumulator with gas (e.g., precursor) from the precursor source vessel. The fill valves may be high-speed diaphragm valves configured for operation in high temperature applications to be fully opened or fully closed, and the control signals cause the valves to rapidly pulse open and closed to adjust the pressure within the accumulator.

Abstract: An automatic real-time basketball box score recording and analysis system with videos captured from arbitrary angles is applied to a basketball game. A shot analyzing step is performed to analyze the videos to determine whether one of the videos is a real shot event to generate a shot analysis result. A data calculating step is performed to analyze the videos to determine that the real shot event is a three-point shot, a two-point shot or a free throw to generate a scoring result, and then calculate a game data according to the shot analysis result and the scoring result. A player analyzing step is performed to analyze the videos to obtain a posture analysis data of a shooter. The posture analysis data is configured to evaluate a performance of the shooter when shooting. An interface device is configured to modify and display the game data.

Abstract: Methods and apparatuses for measuring a flow conductance of a showerhead assembly are described. For example, a showerhead assembly may be seated in a housing. A gas source may be coupled to an intake port of the showerhead assembly and supply gas to the showerhead assembly via the intake port. A pressure controller may be coupled between the gas source and the showerhead assembly. The pressure controller may measure a flow throughput of the gas that passes through the pressure controller. The pressure controller may maintain the gas being supplied to the showerhead assembly at a first pressure value. A pressure transducer coupled to an exhaust port of the showerhead assembly may measure a second pressure value. A controller may determine a flow conductance of the showerhead assembly based on the flow throughput and the first and second pressure values.

Abstract: The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.

Abstract: A method for preparing a high viscosity index poly-?-olefin subjects ?-olefin to a polymerization reaction in the presence of a metallocene catalyst to obtain a poly-?-olefin. The polymerization reaction is carried out in the absence of a solvent, and the metallocene catalyst is formed of, or is formed by interaction between, a metallocene compound and an activator.

Abstract: A metallocene compound having a structure shown by formula (I). A functional group connected to a bridging atom of the metallocene compound is an amine-substituted group and/or a metallocene-substituted group and/or a substituted metallocene group. A metallocene catalyst containing the metallocene compound has high catalytic activity, and can synthesize metallocene polypropylene having high isotacticity.

Abstract: The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.

Abstract: BCMA-specific fibronectin type III (FN3) domains, BCMA-targeting chimeric antigen receptors (CARs) comprising the FN3 domains, and engineered BCMA-targeting immune cells expressing the CARs are described. Also described are nucleic acids and expression vectors encoding the FN3 domains and the CARs, recombinant cells containing the vectors, and compositions comprising the engineered immune cells. Methods of making the FN3 domains, CARs, and engineered immune cells, and methods of using the engineered immune cells to treat diseases including cancer are also described.

Abstract: BCMA-specific fibronectin type III (FN3) domains, BCMA-targeting chimeric antigen receptors (CARs) comprising the FN3 domains, and engineered BCMA-targeting immune cells expressing the CARs are described. Also described are nucleic acids and expression vectors encoding the FN3 domains and the CARs, recombinant cells containing the vectors, and compositions comprising the engineered immune cells. Methods of making the FN3 domains, CARs, and engineered immune cells, and methods of using the engineered immune cells to treat diseases including cancer are also described.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for grouping a plurality of resources into a plurality of cohorts, wherein each of the plurality of resources is associated with a risk level and a benefit level, and resources in each cohort share the same risk level and the same benefit level; obtaining a plurality of provider-level adjustments; constructing an optimization model for determining a resource flow solution; and according to the plurality of cohort-provider-level adjustments, identifying one or more resources in each of the plurality of cohorts that are provided by a first provider to be transferred to a second provider; and automatically sending one or more requests to the first provider and the second provider to transfer the determined one or more first resources from the first provider to the second provider.

Abstract: The present disclosure provides a system and method for dynamically defining a specific input pin of a management controller (e.g., a baseboard management controller (BMC)) of a server system in response to a new device being plugged into the server system. The new device comprises one of a power supply unit (PSU), an automatic transfer switch (ATS), or a battery backup unit (BBU) of the server system. In some implementations, the PSU, the ATS, and the BBU are modularized into a plurality of ATS modules, a plurality of PSU modules, and a plurality of BBU modules, respectively. Each of the plurality of ATS modules, the plurality of PSU modules, and the plurality of BBU modules has substantially the same physical size.

Abstract: A system and method is directed to charging and discharging an energy-tank capacitor of a power supply unit (PSU) in a computing system. The PSU has a forward converter, a buck converter, a switch box, and an option box. The forward converter has a transformer. A primary winding of the transformer is coupled to an input of the PSU, while a secondary winding of the transformer is coupled to an output of the PSU. Two or more components of the forward converter are shared with the buck converter to support the functionality of the buck converter when it is enabled. The switch box has a power switch and a controller switch connected to the forward converter. The energy stored on the energy-tank capacitor is capable of supporting power consumption of the server system during a hold-up time, when an input power to the PSU is interrupted.

Abstract: A system and method is directed to charging and discharging an energy-tank capacitor of a power supply unit (PSU) in a computing system. The PSU has a forward converter, a buck converter, a switch box, and an option box. The forward converter has a transformer. A primary winding of the transformer is coupled to an input of the PSU, while a secondary winding of the transformer is coupled to an output of the PSU. Two or more components of the forward converter are shared with the buck converter to support the functionality of the buck converter when it is enabled. The switch box has a power switch and a controller switch connected to the forward converter. The energy stored on the energy-tank capacitor is capable of supporting power consumption of the server system during a hold-up time, when an input power to the PSU is interrupted.

Abstract: The present disclosure provides a system and method for dynamically defining a specific input pin of a management controller (e.g., a baseboard management controller (BMC)) of a server system in response to a new device being plugged into the server system. The new device comprises one of a power supply unit (PSU), an automatic transfer switch (ATS), or a battery backup unit (BBU) of the server system. In some implementations, the PSU, the ATS, and the BBU are modularized into a plurality of ATS modules, a plurality of PSU modules, and a plurality of BBU modules, respectively. Each of the plurality of ATS modules, the plurality of PSU modules, and the plurality of BBU modules has substantially the same physical size.

Abstract: BCMA-specific fibronectin type III (FN3) domains, BCMA-targeting chimeric antigen receptors (CARs) comprising the FN3 domains, and engineered BCMA-targeting immune cells expressing the CARs are described. Also described are nucleic acids and expression vectors encoding the FN3 domains and the CARs, recombinant cells containing the vectors, and compositions comprising the engineered immune cells. Methods of making the FN3 domains, CARs, and engineered immune cells, and methods of using the engineered immune cells to treat diseases including cancer are also described.

Abstract: A novel receptor for GDF15 was identified (GFRAL), as well as the use of this receptor in the identification or screening of GDF15 agonists or antagonists. These agonist or antagonist compounds may be used to either potentiate or suppress GDF15-like effects, respectively, at the cellular and organism levels, and may be used in treatment of metabolic diseases, including obesity, type 2 diabetes, hyperglycemia, hyperinsulinemia, dyslipidemia, diabetic nephropathy, or anorexia.

Abstract: The present invention relates to a polyimide precursor and a lithography pattern formed by the same. The polyimide precursor has a repeating unit having a structure of formula (I): in the formula (I), Ar represents a tetravalent group derivated from a tetracarboxylic dianhydride compound; R1 represents a divalent group derivated from a diamine compound; and R2 independently represent a thermal-crosslinking group, a photosensitive-crosslinking group, or a hydrogen atom. The polyimide precursor has an excellent pattern-forming ability.

Abstract: In some implementations, power provided to a computing system, such as a rack system, may be interrupted. This interruption is detected, and in response, power from a battery backup system is directed to the computing system to replace the interrupted power source, which in some implementations may be a main AC power grid source. A signal is received indicating that a backup power source, for example a backup generator system, is online and prepared to deliver power to the computing system. For an initial period of time, this backup power source is prevented from providing power to the computing system. For example, the backup generator system may be providing power to a power supply unit of the computing system, but the power is not allowed to flow to the computing system.

Abstract: The present invention relates to an n-heterocyclic carbene (NHC) type palladium catalyst and its preparation method as well as applications. Its preparation process is as below: select glyoxal as the raw material to synthesize glyoxaldiimine in the presence of Lewis acid or Bronsted acid, and then react with paraformaldehyde to get the NHC type ligand. Use palladium(II) to react with the compound containing carbon-nitrogen double bonds to get palladium(II) cyclic dimer; make the palladium cyclic dimer and the NHC type ligand coordinated to get the NHC type palladium catalyst. The palladium catalyst with a brand new structure according to the present invention, boasts high activity and multi-purpose.