Abstract: The present invention relates to a pharmaceutical composition comprising a weak acid drug, with the use of a bicarbonate salt to achieve a high incorporation of the drug into the liposome and a better therapeutic efficacy. Also disclosed is a method for treating a respiratory disease using the pharmaceutical composition disclosed herein.

Abstract: In an embodiment, a method includes forming active devices over a semiconductor substrate; forming an interconnect structure over the semiconductor substrate, the interconnect structure comprising a contact pad embedded in a dielectric layer; forming a first passivation layer over the interconnect structure; forming a first opening through the first passivation layer to expose the contact pad; depositing a seed layer over the first passivation layer and in the first opening; forming a sacrificial material over the seed layer; patterning the sacrificial material to reform the first opening and to form a second opening; depositing conductive material to form a first redistribution line in the first opening and a second redistribution line in the second opening; removing the sacrificial material; and attaching an integrated circuit die to the first redistribution line and the second redistribution line.

Abstract: Systems and methods are provided for initiating a media content item group watch session with an identified contact. A user profile is identified, and a media content item is generated for output at a first computing device. A contact is identified based on the user profile and the media content item, and an invitation to join a media content item group session is generated based on the media content item and the identified contact. The invitation is transmitted to a second computing device associated with the contact, and an indication that the invitation has been accepted is received. The media content item group session is initiated between the first and second computing devices, and the media content item is received at the first and second computing devices.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may transmit an indication of a set of frequency bands supported for uplink transmission switching between frequency bands, the frequency bands including one or more bandwidth parts. The UE may transmit an indication of a subset of the set of frequency bands, the subset supported for dynamic uplink transmission switching between the frequency bands. The UE may transmit one or more uplink communications via one or more frequency bands of the subset of the set of frequency bands. Numerous other aspects are described.

Abstract: The present disclosure discloses a multi-sensor-based hot forming production system for an aluminum alloy sheet metal part and a control method thereof, and belongs to the field of aluminum alloy sheet metal forming manufacturing technology. A plurality of sensors are disposed in the hot forming production system, and closed-loop control of a whole process and adaptive production can be realized based on deformation properties, a microstructure evolution law, and a mechanical property change law of the aluminum alloy sheet metal part. The hot forming production system comprises a control system based on a multi-physical quantity model, an environmental heating furnace, an automated transfer and positioning device, a hot stamping and forming device, and an in-die aging device.

Abstract: The invention provides a method of producing a cold compactible metallic powder, the method comprising: providing (i) a first metallic powder comprising large metal particles and (ii) a second metallic powder comprising small metal particles, wherein the d50 particle size of the second metallic powder is less than the d50 particle size of the first metallic powder; combining at least the first metallic powder and the second metallic powder to provide a precursor powder comprising the large metal particles and the small metal particles; and subjecting the precursor powder to an impact blending process to adhere the small metal particles to the large particles, thereby producing a cold compactible metallic powder comprising non-spherical particles, wherein the non-spherical particles comprise one of the large metal particles as a core and a plurality of the small metal particles as protrusions from the core.

Abstract: Methods are generally provided for forming a multi-metallic component. The method can include: positioning a nickel-based layer between an iron-based alloy and a nickel-based alloy and applying heat and pressure to the iron-based alloy and a nickel-based alloy such that the nickel-based layer forms a diffusion bond region. The nickel-based layer comprises greater than 50% by weight nickel, and the iron-based alloy, the nickel-based alloy, or both is in a powder form. The diffusion bond region is between a first region comprising the iron-based alloy and a second region comprising the nickel-based alloy to form the multi-metallic component.

Abstract: A method of forming a plurality of lipid bilayers over an array of cells in a nanopore based sequencing chip is disclosed. Each of the cells comprises a well. A salt buffer solution is flowed over the array of cells in the nanopore based sequencing chip to substantially fill the wells in the cells with the salt buffer solution. A lipid and solvent mixture is flowed over the array of cells to deposit the lipid and solvent mixture over at least some of the wells in the cells. A first portion of the cells, each having a lipid bilayer over its well, is detected. A second portion of the cells, each having a lipid membrane but not a lipid bilayer over its well, is detected. An electrical lipid-thinning stimulus is selectively applied to the second portion of the cells but not to the first portion of the cells.

Abstract: A microscopic confocal fluorescence spectrometer is provided. The microscopic confocal fluorescence spectrometer includes an optical system and an instrument body. By adopting an open microscopic fluorescence light path, a lens body part of an existing spectrometer microscope is omitted, so that the space behind an objective lens is significantly increased. By reasonably arranging a laser, a spectrum detection device and other components, the space on the side of the objective lens is further increased, and the occupied space of the optical system is reduced, so that the overall volume of the instrument is reduced, and the adaptability of the instrument is further improved. In addition, the spectrum detection device is arranged outside the second shell to facilitate the heat dissipation of the spectrum detection device, so that the heat stability and working reliability of the instrument are further improved.

Abstract: The present application relates to the field of power equipment detection devices, and in particular to a power transformer fault detection device, which includes a detection component for detecting the oil composition of the transformer, and also includes a rotating part comprising multiple groups of oil pools that are evenly spaced around the rotating axis of the rotating part. The multiple groups of oil pools are connected to oil outlets at different heights on the transformer, and a light-transmitting window is provided on the oil pool. A detection component is installed on the rotating part, and can detect the composition of the liquid in the oil pool through the light-transmitting window. The present application has the effect of allowing staff to monitor the working status of the transformer in a timely manner and reducing the labor burden of the staff.

Abstract: An analysis method for optimizing number and position of screws used in long bone (fracture fixation) surgery, including the following steps. Perform a CT scan on a surgical patient to obtain a medical image to build a long bone 3D model. Analyze an X-ray image to obtain a long bone fracture condition and a bone quality condition. Select a bone plate 3D model from the model database. Import the bone plate 3D model into the long bone 3D model and set an initial fixation position of the bone plate 3D model. Instruct the first artificial intelligence to comprehensively analyze the conditions to automatically select alternative solutions in the model database. Then, use a computer-aided analysis system to analyze the stress distribution of the alternative solutions, and a first preferred solution is obtained through simulating analysis, thereby excluding incorrect or ineffective surgical plans to reduce the analysis time and patient wait time and increasing the surgery success rate.

Abstract: A manufacturing method of a package structure includes: forming a first package component, where the first package component includes a first insulating encapsulation laterally covering semiconductor dies and a redistribution structure formed on the first insulating encapsulation and the semiconductor dies; coupling the first package component to a second package component; forming an underfill layer between the first and second package component, where the underfill layer extends to cover a sidewall of the first package component; forming a metallic layer on opposing surfaces of the semiconductor dies and the first insulating encapsulation by using a jig, where a window of the jig accessibly exposes the opposing surfaces of the semiconductor dies and the first insulating encapsulation, and a peripheral region of the opposing surface of the first insulating encapsulation is shielded by the jig.

Abstract: A semiconductor structure includes a first semiconductor stack having a first conductivity type, a second semiconductor stack having a second conductivity type, an active structure disposed between the first semiconductor stack and the second semiconductor stack, and an aluminum-containing cap layer in the active structure. The active structure includes a plurality of group III nitride barrier layers and a plurality of group III-nitride quantum well layers which are alternately stacked. The thickness of the group III-nitride barrier layers is ranged between 200 angstroms to 550 angstroms, and the aluminum-containing cap layer is disposed between the group III nitride quantum well layers and the group III nitride barrier layers, and the active structure has a wavelength of at least 600 nm.

Abstract: The present invention relates to a compound represented by general formula (I) or a stereoisomer, a tautomer, a deuterated substance, a solvate, a prodrug, a metabolite and a pharmaceutically acceptable salt or eutectic crystal thereof, an intermediate thereof, and a use of the compound in METTL3-related diseases such as cancer.

Abstract: The utility model discloses a dishwasher with grouped storage basket, which relates to the field of dishwashers, including a dishwasher body and a power cord. The power cord is connected to the power supply after being inserted into the socket of the dishwasher body. The utility model is characterized in that a washing chamber is provided on the dishwasher body, and one or more baskets are provided in the washing chamber. The baskets are arranged in layers and are rotatably connected to the top of the washing chamber. The utility model has a simple structure and is easy to use. The washing operation can keep the daily use combination of the washing objects as much as possible, reducing unnecessary transfer and sorting.

Abstract: Provided are an amide compound as a potassium channel regulator, and the preparation therefor and the use thereof. The compound has a structure as represented by formula I, wherein the definition of each group and substituent is as described in the description.

Abstract: Provided is a sensing and adaptation method for exercise. The method is applied to a sensing and adaptation device for exercise and includes the following steps: generating an exercise game and a first resistance setting to an exercise equipment according to a first exercise target data; receiving an exercise interactive data of a user operating the exercise game from the exercise equipment; generating a reaction-time data according to a stage data of the exercise game and the exercise interactive data and generating an operation trajectory data according to the first resistance setting, the stage data and the exercise interactive data; calculating a deviation degree of the operation trajectory data; calculating a second exercise target data according to the deviation degree; generating a second resistance setting and updating the exercise game according to the second exercise target, and transmitting the second resistance setting to the exercise equipment.

Abstract: A screw tightening device includes a fixing mechanism extend in a first direction and including first and second ends arranged opposite to each other in the first direction, a regulating mechanism arranged at the first end and including a regulating port, a screw feeding mechanism arranged at the regulating mechanism and configured to convey a screw to the regulating port, a tightening mechanism arranged at the fixing mechanism and configured to drive the screw to rotate, a first driving mechanism arranged at the second end and configured to be drivingly connected to the tightening mechanism and to drive the tightening mechanism to move in the first direction to the regulating port, and a second driving mechanism arranged at the second end and configured to be drivingly connected to the tightening mechanism and to drive the tightening mechanism to move in the first direction to extend out of the regulating port.

Abstract: Embodiments of the present disclosure disclose a method and apparatus for verifying a vehicle function, an electronic device, and a storage medium, wherein the method includes: acquiring operation scenario data respectively corresponding to each of one or operation scenarios; determining, based on the operation scenario data respectively corresponding to each of the operation scenarios, first perception result information corresponding to a preset vehicle function of an ego vehicle in each of the operation scenarios; performing perception failure simulation processing on the first perception result information based on a perception failure simulation rule to obtain second perception result information corresponding to each of the operation scenarios; and verifying the preset vehicle function based on the second perception result information to obtain a verification result.

Abstract: A rotatable paste container is provided in the disclosure, which includes a paste box, a screw assembly and a rotating assembly. A first protrusion is formed at an outer side of a bottom of the paste box, and a sliding track is provided on the first protrusion, and a pit is provided on the sliding track. The rotating assembly includes a screw sleeve member and a rotating body. The screw sleeve member includes at least one support arm, and a sliding projection which is repeatedly engaged with the sliding track and the pit respectively is provided at a top of the at least one support arm, so that when the rotating assembly rotates relative to the paste box, the sliding projection is repeatedly engaged with the pit along the sliding track, thereby constantly controlling a rotation angle of the rotating body with a predetermined angle.