Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: Certain embodiments of the invention provide a composition comprising at least two compounds selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the composition is substantially free of flavokawain B. Certain embodiments of the invention also provide a method for treating or preventing cancer in a mammal (e.g., a human) in need of such treatment comprising, administering to the mammal a carrier and a compound selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the compound is substantially free of other kava extract components.

Abstract: Systems, methods, and computer-readable media for providing cross-domain assurance for networks in different network domains. In some embodiments, a method can include collecting first fabric data for a first network in a first network domain and second fabric data for a second network in a second network domain. The second fabric data for the second network can be normalized based on the first network domain to create normalized second fabric data. The first fabric data can then be correlated with the normalized second fabric data to create correlated fabric data. Subsequently, assurance can be provided across the first network in the first network domain and the second network in the second network domain using the correlated fabric data.

Abstract: Embodiments of the present application relate to the technical field of semiconductors, and provide a manufacturing method for an N-polar GaN transistor structure and a semiconductor structure. A Ga-polar epitaxial functional layer is formed by depositing, a supporting substrate is formed on the epitaxial functional layer by bonding, after the epitaxial structure is inverted, a structural substrate and a buffer layer are removed, and a source, a drain, and a gate are manufactured on the side of the exposed epitaxial functional layer away from the supporting substrate, to form an N-polar GaN transistor structure.

Abstract: A dynamic load shearing test device and method based on a hopkinson bar system are provided in this disclosure, which relates to the technical field of rock detection tests. The device according to the disclosure includes a bearing frame, a carriage, a sample holding unit, a pressure environment generating unit, a sample switching unit, an incident bar and a transmission bar, and the test method includes following steps: test device assembly, device leveling, pre-test preparation, test conducting, sample angle switching and test device resetting. The disclosure has advantages that the cylindrical sample can be quickly fixed, a required temperature environment can be well maintained, the cylindrical sample can be better fixed in a high-pressure environment, rotation of the cylindrical sample is not hindered in a low-pressure environment, switching of test positions is facilitated, and test efficiency can be accelerated.

Abstract: The present disclosure provides a display panel and a display device. The display panel includes an array substrate, a first electrode layer, a pixel definition layer, and a luminescent material layer laminated one on another. The pixel definition layer includes a first portion and a second portion, the first portion corresponds to and is arranged in an active area of the display panel, the second portion surrounds the first portion. A depression structure is arranged in the second portion, and an aperture of the depression structure is oriented to a side of the pixel definition layer away from the array substrate.

Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The present invention relates to a board assembly used for a base station antenna and a base station antenna including such a board assembly. The board assembly includes a first circuit board (3) and a second circuit board (4), and the first circuit board and the second circuit board are spaced apart from each other. The first circuit board has a plurality of first electrical connectors, the second circuit board has a plurality of second electrical connectors, and the first electrical connectors and the second electrical connectors are electrically connected by a plurality of coaxial cable assemblies (5). Each coaxial cable assembly extends between the first circuit board and the second circuit board, and includes a coaxial cable, a first corresponding electrical connector matching the first electrical connector on a first end of the coaxial cable, and a second corresponding electrical connector matching the second electrical connector on a second end opposite to the first end on the coaxial cable.

Abstract: Compounds which are oxadiazaborole derivatives are disclosed, including compounds of the following genus: The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.

Abstract: The invention relates to methods of therapy using compounds of formula (I) and formula (II): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (II) and pharmaceutical compositions thereof are integrin inhibitors that are useful in therapy for a condition, for example, caused by or associated with an infectious agent, shock, pancreatitis, or trauma. The condition can include one or more of pulmonary fibrosis associated with rheumatoid arthritis or progressive familial intrahepatic cholestasis (PFIC).

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A method for counting suckling piglets based on self-attention spatiotemporal feature fusion is disclosed, which includes: detecting a side-lying sow in a video frame by using CenterNet to acquire a key frame of suckling piglets and a region of interest of the video frame, and overcome the interference of the movement of non-suckling piglets on the spatiotemporal feature extraction for the region of interest; transforming spatiotemporal features extracted by a spatiotemporal two-stream convolutional network from a key frame video clip into a spatiotemporal feature vector, inputting the obtained spatiotemporal feature vector into a temporal, a spatial and a fusion transformer to obtain a self-attention matrix; performing element-wise product for the self-attention matrix and the fused spatiotemporal features to obtain a self-attention spatiotemporal feature map; and inputting the self-attention spatiotemporal feature map into a regression branch of the number of suckling piglets to complete the counting of the

Abstract: Disclosed is a children's vehicle, which comprises a main vehicle frame extending in a front-rear direction, two front wheels disposed respectively on the left and right sides of the bottom-front portion of the main vehicle frame, a joystick extending upwardly inclined from front to rear, a sliding member slidingly disposed on the main vehicle frame, and a connecting bar rotatably connected between the joystick and the sliding member, wherein a lower portion of the joystick is connected to rotatably a front portion of the main vehicle frame. The children's vehicle further comprises first connecting rods, one end of each of which is rotatably connected on the main vehicle frame, and second connecting rods rotatably connected between the first connecting rods and the sliding member, the front wheels are mounted on the other ends of the first connecting rods.

Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by ROR?. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.