Abstract: A substrate includes a device region and at least one bonding region close to any edge of the substrate relative to the device region. The substrate includes a base, device groups arranged in a first direction and a second direction, signal line groups and bridging portions. A device group includes at least one electronic element. A signal line group includes signal lines extending in the second direction and arranged at intervals in the first direction. At least one bridging portion includes a conductive portion. At least two signal lines in at least one signal line group and electrically connected by a conductive portion, and/or at least one signal line in at least one signal line group includes at least two sub-portions spaced apart in the second direction, and two adjacent sub-portions in the same signal line are electrically connected by a conductive portion.

Abstract: A brake system includes a bicycle frame and a housing which is mounted to the bicycle frame. The housing includes an oil chamber for brake fluid storage, and one of two ends of the housing is hinged to a brake lever via a hinge. The brake lever includes an arm for compressing the brake fluid within the oil chamber to initiate braking. The housing has a connector connected to another one of the two ends thereof. The connector communicates with the oil chamber and is located close to the bicycle frame. An output end of the connector is connected to a hose that runs along the bicycle frame.

Abstract: A driving backplane includes a substrate, pad groups and line groups. A line of each line group is connected to a pad of a pad group. At least one pad of a pad group and a line connected thereto define line hollowed-out regions. The line hollowed-out regions include a first line hollowed-out region and a second line hollowed-out region that are disposed on two sides of the pad(s) in a second direction. The driving backplane further includes a reflective layer covering a first surface of the substrate and the line groups. Each window region in the reflective layer includes a first region, a second region and a third region that are arranged in the second direction. The second region exposes a pad group and a pad spacer region corresponding to the pad group, and the first region and the third region expose portions of the first surface of the substrate.

Abstract: A drilling device for coal mining is provided, including a placement board. The placement board is fixedly connected to a first support pillar and a second support pillar, and the first support pillar and the second support pillar are together fixedly connected to a transmission rod; the transmission rod is connected to support rods symmetrically distributed in a limited sliding manner, and the support rods symmetrically distributed are connected to a connecting rod in a sliding manner; the connecting rod is provided with grooves evenly distributed in a circumferential direction, the grooves are fixedly connected to pneumatic telescopic blocks, and the telescopic end of each pneumatic telescopic block is fixedly connected to an arc-shaped plate. The arc-shaped plate is extended in a circumferential direction to support the drilled hole close to the drill bit, preventing the collapse of the drilling wall close to the drill bit.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: Certain embodiments of the invention provide a composition comprising at least two compounds selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the composition is substantially free of flavokawain B. Certain embodiments of the invention also provide a method for treating or preventing cancer in a mammal (e.g., a human) in need of such treatment comprising, administering to the mammal a carrier and a compound selected from the group consisting of dihydromethysticin, methysticin, dihydrokavain, kavain, desmethoxyyangonin and 11-methoxyyangonin, wherein the compound is substantially free of other kava extract components.

Abstract: Systems, methods, and computer-readable media for providing cross-domain assurance for networks in different network domains. In some embodiments, a method can include collecting first fabric data for a first network in a first network domain and second fabric data for a second network in a second network domain. The second fabric data for the second network can be normalized based on the first network domain to create normalized second fabric data. The first fabric data can then be correlated with the normalized second fabric data to create correlated fabric data. Subsequently, assurance can be provided across the first network in the first network domain and the second network in the second network domain using the correlated fabric data.

Abstract: Embodiments of the present application relate to the technical field of semiconductors, and provide a manufacturing method for an N-polar GaN transistor structure and a semiconductor structure. A Ga-polar epitaxial functional layer is formed by depositing, a supporting substrate is formed on the epitaxial functional layer by bonding, after the epitaxial structure is inverted, a structural substrate and a buffer layer are removed, and a source, a drain, and a gate are manufactured on the side of the exposed epitaxial functional layer away from the supporting substrate, to form an N-polar GaN transistor structure.

Abstract: A dynamic load shearing test device and method based on a hopkinson bar system are provided in this disclosure, which relates to the technical field of rock detection tests. The device according to the disclosure includes a bearing frame, a carriage, a sample holding unit, a pressure environment generating unit, a sample switching unit, an incident bar and a transmission bar, and the test method includes following steps: test device assembly, device leveling, pre-test preparation, test conducting, sample angle switching and test device resetting. The disclosure has advantages that the cylindrical sample can be quickly fixed, a required temperature environment can be well maintained, the cylindrical sample can be better fixed in a high-pressure environment, rotation of the cylindrical sample is not hindered in a low-pressure environment, switching of test positions is facilitated, and test efficiency can be accelerated.

Abstract: The present disclosure provides a display panel and a display device. The display panel includes an array substrate, a first electrode layer, a pixel definition layer, and a luminescent material layer laminated one on another. The pixel definition layer includes a first portion and a second portion, the first portion corresponds to and is arranged in an active area of the display panel, the second portion surrounds the first portion. A depression structure is arranged in the second portion, and an aperture of the depression structure is oriented to a side of the pixel definition layer away from the array substrate.

Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The present invention relates to a board assembly used for a base station antenna and a base station antenna including such a board assembly. The board assembly includes a first circuit board (3) and a second circuit board (4), and the first circuit board and the second circuit board are spaced apart from each other. The first circuit board has a plurality of first electrical connectors, the second circuit board has a plurality of second electrical connectors, and the first electrical connectors and the second electrical connectors are electrically connected by a plurality of coaxial cable assemblies (5). Each coaxial cable assembly extends between the first circuit board and the second circuit board, and includes a coaxial cable, a first corresponding electrical connector matching the first electrical connector on a first end of the coaxial cable, and a second corresponding electrical connector matching the second electrical connector on a second end opposite to the first end on the coaxial cable.

Abstract: Compounds which are oxadiazaborole derivatives are disclosed, including compounds of the following genus: The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.

Abstract: The invention relates to methods of therapy using compounds of formula (I) and formula (II): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (II) and pharmaceutical compositions thereof are integrin inhibitors that are useful in therapy for a condition, for example, caused by or associated with an infectious agent, shock, pancreatitis, or trauma. The condition can include one or more of pulmonary fibrosis associated with rheumatoid arthritis or progressive familial intrahepatic cholestasis (PFIC).

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.