Abstract: The present invention relates to a tetracyclic derivative, a method for preparing same and the use thereof in medicine. In particular, the present invention relates to a tetracyclic derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, especially as a K-Ras GTPase inhibitor, with definitions of each substituent in general formula (I) being the same as of which are defined in the description.

Abstract: The present invention relates to a substituted quinazoline derivative, a preparation method therefor, a pharmaceutical composition comprising the derivative, and use of the quinazoline derivative or a composition thereof in medicine. Specifically, the present invention relates to substituted quinazoline derivative represented by general formula (I), a preparation method therefor, a pharmaceutically acceptable salt thereof, and use thereof as therapeutic agents, in particular as SOS1 inhibitors. The definition of each substituent in general formula (I) is the same as the definition in the description.

Abstract: The present invention relates to a fused polycyclic Myc regulator and a preparation method therefor, a pharmaceutical composition containing the regulator, and a use of the regulator in medicine. Disclosed in the present invention are a fused polycyclic derivative represented by general formula (I), or a stereoisomer thereof, a tautomer thereof, a pharmaceutically acceptable salt thereof and a preparation method therefor, and a use thereof as a Myc regulator.

Abstract: The present invention relates to an aromatic amide derivative, a preparation method therefor, and use of a pharmaceutical composition containing the derivative in medicine.

Abstract: An aromatic amide derivative, a preparation method therefor, and use of a pharmaceutical composition containing the derivative in medicine. Specifically, the present invention relates to an aromatic amide derivative as shown by general formula (I), a preparation method therefor, a pharmaceutically acceptable salt thereof, and use thereof as a therapeutic agent, particularly as a KIF18A inhibitor, wherein the definition of each substituent in general formula (I) is the same as the definition in the description.

Abstract: The present application relates to a striker assembly and a seat assembly. A striker assembly includes a motor, a worm screw operably coupled with the motor, a gear segment engaged with the worm screw, and a striker connected to the gear segment and configured for engagement with a latch of a seat back of the seat to adjustably couple the seat back with a mounting surface.

Abstract: A portable fan include: a handheld portion; a housing, connected to the handheld portion; a display screen, arranged on the fan housing or the handheld portion and configured to display a currently airflow speed level and an adjustable airflow speed interval formed by the adjustable airflow speed interval; and an airflow speed regulator, configured to receive a control instruction that is in a continuous state or has a changing trend and configured to perform, through the control instruction, a continuous adjustment or an adjustment in a skip-level manner on the current airflow speed level within the adjustable airflow speed interval. For the continuous adjustment, an adjustment magnitude in which the current airflow speed level is adjusted is one level; and for the adjustment in the skip-level manner, the adjustment magnitude in which the current airflow speed level is adjusted is greater than or equal to two levels.

Abstract: A portable fan, including: a housing, a mixed-flow fan, and a booster. An air inlet portion is arranged at a rear side of the housing, an air outlet portion is arranged at a front side of the housing, the air inlet portion and the air outlet portion are fluidly communicated to each other through an interior of the housing. The mixed-flow fan is arranged inside the housing; the mixed-flow fan is configured to rotate around a rotation shaft to generate an airflow. The booster is disposed inside the housing and surrounds an outer periphery of the mixed-flow fan. The booster includes a booster surface facing the mixed-flow fan; a radial size of at least part of the booster surface gradually increases in a direction from the rear side to the front side; a gap is formed between the booster and the housing.

Abstract: A portable fan includes: a housing, a mixed-flow fan, and a pressurizing member. An air inlet portion is arranged at a rear side of the housing, an air outlet portion is arranged at a front side of the housing. The mixed-flow fan is arranged inside the housing and can rotate around a rotation shaft to generate an airflow. The pressurizing member is disposed at a front of the mixed-flow fan and includes a pressurizing seat having a pressurizing surface, and a radial size of at least part of the pressurizing surface gradually increases from the rear side to the front side. A cross-sectional area, in a radial direction of the housing, of a front end of the pressurizing seat is defined to enable the air inlet portion to be invisible by being shielded by the pressurizing seat, when viewing from the front side to the rear side.

Abstract: A portable fan includes: a housing, a mixed-flow fan, and a pressurizing member. The mixed-flow fan includes a rotation seat, an extension wall, a motor, and a plurality of first blades; the plurality of first blades are mounted on the rotation seat; the extension wall and the rotation seat cooperatively define a first cavity; a pressurizing seat of the pressurizing member has a second cavity; the extension wall is inserted into the second cavity. An orthographic projection of the first cavity along a radial direction onto a side wall of the housing is at least partially overlapped with an orthographic projection of the second cavity along the radial direction onto the side wall of the housing; the motor is received in the first cavity and the second cavity.

Abstract: A nuclear reactor includes a reactor vessel containing an alkali metal thermoelectric converter. The bottom part of the vessel contains liquid alkali metal. A reactor core is arranged in the vessel and includes fuel rods. The surface of each fuel rod is provided with a first liquid absorption core. The bottom part of the reactor core is provided with second liquid absorption cores which are connected to the first liquid absorption cores. The cores are together configured to use capillary action to pump liquid alkali metal to an upper portion of an outer surface of the fuel rods, where the liquid alkali metal is vaporized into alkali metal vapor. The converter divides the inside of the reactor vessel into a high-pressure vapor chamber and a low-pressure vapor chamber. The converter is configured to receive alkali metal vapor from the high-pressure vapor chamber for use in electric power generation.

Abstract: The present invention relates to an aromatic acetylene derivative, a preparation method therefor, and pharmaceutical use of a pharmaceutical composition comprising the derivative. Specifically, the present invention relates to an aromatic acetylene derivative represented by general formula (I), a preparation method therefor, a pharmaceutically acceptable salt thereof, and use thereof as a therapeutic agent, particularly as an LPXC inhibitor, wherein the definitions of the substituents in general formula (I) are the same as those in the specification.

Abstract: A portable fan includes a fan and a power supply drive assembly electrically connected to the fan. The power supply drive assembly includes a battery and a fan drive circuit electrically connected to the battery; the fan drive circuit includes: a master control circuit; and a three-phase drive circuit, including at least three signal input ends and three drive signal output ends. Each of the at least three signal input ends is electrically connected to the master control circuit to receive control signals; each of the three drive signal output ends is electrically connect to a respective one of three signal ends of a fan motor to respectively output the three-phase drive signal to drive the fan motor to rotate. The battery is configured to supply power to the fan drive circuit.

Abstract: A portable fan includes: a fan and a power supply drive assembly electrically connected to the fan. The power supply drive assembly comprises a battery and a fan drive circuit electrically connected to the battery. The fan drive circuit includes a master control circuit; a three-phase drive circuit; and an inverted-phase electric potential detection circuit. The battery is configured to supply power to the fan drive circuit.

Abstract: Provided are a macrolide derivative represented by formula (I), a preparation method thereof, and an application of the macrolide derivative as an inhibitor of one or more protein kinases of TRK, ALK and ROS1,

Abstract: Systems and methods for pharyngeal phenotyping in obstructive sleep apnea are described herein. An example method includes receiving manometry data for a subject; extracting a plurality of features from the manometry data, where the extracted features include one or more of a high-level breath feature, a frequency feature, or a largest negative connected component (LNCC) feature; inputting the extracted features into a trained machine learning model; and predicting, using the trained machine learning model, at least one of a location of pharyngeal collapse for the subject or a degree of pharyngeal collapse for the subject.

Abstract: The present application relates to a striker assembly and a seat assembly. A striker assembly includes a motor, a worm screw operably coupled with the motor, a gear segment engaged with the worm screw, and a striker connected to the gear segment and configured for engagement with a latch of a seat back of the seat to adjustably couple the seat back with a mounting surface.

Abstract: The present invention relates to a piperazine amide derivative as represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof, and use of same as a therapeutic agent, especially as a selective Rearranged During Transfection (RET) kinase inhibitor. Ring a, ring e, X1, X2, X3, X4, R1, R2, R3, R4, R4?, R5, R5?, R6, R6?, R7, R7?, R8, m and n have the same definitions as those in the specification.

Abstract: A portable fan includes: a fan and a power supply drive assembly electrically connected to the fan. The power supply drive assembly comprises a battery and a fan drive circuit electrically connected to the battery. The fan drive circuit includes a master control circuit; a three-phase drive circuit; and an inverted-phase electric potential detection circuit. The battery is configured to supply power to the fan drive circuit.

Abstract: A portable fan includes a shell, a mix-flow fan, arranged inside the shell and configured to rotate around a rotation shaft to generate wind, and a booster, arranged inside the shell. The booster surrounds a circumference of the mix-flow fan. A first air channel is defined between the mix-flow fan and the booster.