Patents by Inventor Chengalrayan Kudithipudi

Chengalrayan Kudithipudi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12077765
    Abstract: The present disclosure provides approaches for reducing nicotine. Also provided are tobacco plants with decreased tobacco-specific nitrosamines (TSNAs). The present disclosure further provides modified tobacco plants with low nicotine and increased antioxidant capacity. Further provided are tobacco plants or material with low nicotine and low TSNAs. Also provided is cured tobacco material of the tobacco plants provided herein and tobacco products comprising this cured tobacco material.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: September 3, 2024
    Assignee: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Dongmei Xu, James A. Strickland, Marcos Fernando de Godoy Lusso
  • Publication number: 20240247277
    Abstract: This disclosure provides tobacco plants having a mutation in PR50 and transgenic tobacco plants containing a PR50 RNAi, and methods of making and using such plants.
    Type: Application
    Filed: April 9, 2024
    Publication date: July 25, 2024
    Applicant: Altria Client Services LLC
    Inventors: Chengalrayan KUDITHIPUDI, Alec J. HAYES
  • Publication number: 20240229054
    Abstract: The present disclosure relates to tobacco plants, plant parts, seeds, compositions, and methods related to modulating the expression of novel genes in tobacco to regulate alkaloid levels.
    Type: Application
    Filed: August 4, 2023
    Publication date: July 11, 2024
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan KUDITHIPUDI, Rajanikanth GOVINDARAJULU, Raja S. PAYYAVULA
  • Publication number: 20240218386
    Abstract: The present disclosure provides composition and methods for manipulating alkaloid or nicotine levels in tobacco plants. Also provided are the identification and genetic engineering of target genes (e.g., arginine decarboxylase (ADC), aspartate oxidase (AO), or ornithine decarboxylase (ODC)) for producing tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
    Type: Application
    Filed: December 2, 2020
    Publication date: July 4, 2024
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan KUDITHIPUDI, Chengalrayan KUDITHIPUDI, Yanxin SHEN, Dongmei XU
  • Patent number: 11999961
    Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), increase phenylalanine, or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.
    Type: Grant
    Filed: June 1, 2022
    Date of Patent: June 4, 2024
    Assignee: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Dongmei Xu, James Strickland, Yanxin Shen
  • Patent number: 11981903
    Abstract: This disclosure provides tobacco plants having a mutation in PR50 and transgenic tobacco plants containing a PR50 RNAi, and methods of making and using such plants.
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: May 14, 2024
    Assignee: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Alec J. Hayes
  • Publication number: 20240132901
    Abstract: The present disclosure relates to tobacco plants, plant parts, seeds, compositions, and methods related to modulating the expression of novel genes in tobacco to regulate alkaloid levels.
    Type: Application
    Filed: August 3, 2023
    Publication date: April 25, 2024
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan KUDITHIPUDI, Rajanikanth GOVINDARAJULU, Raja S. PAYYAVULA
  • Publication number: 20240117370
    Abstract: The present disclosure includes methods and compositions for improving leaf quality in low-alkaloid tobacco plants, e.g., by combining inducible promoters and non-coding RNAs for suppression of an ornithine decarboxylase (ODC) gene. Also provided are low alkaloid tobacco plants with normal, suppressed, or otherwise altered polyamine levels. Further provided are tobacco plants with altered total alkaloid, nicotine levels, commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
    Type: Application
    Filed: November 22, 2023
    Publication date: April 11, 2024
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Marcos Fernando de GODOY LUSSO, James A. STRICKLAND, Jesse FREDERICK, Dongmei XU, Chengalrayan KUDITHIPUDI
  • Publication number: 20240117371
    Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.
    Type: Application
    Filed: December 4, 2023
    Publication date: April 11, 2024
    Applicant: ALTRIA CLIENT SERVICES INC.
    Inventors: Chengalrayan KUDITHIPUDI, Alec J. HAYES, Robert Frank HART, III, Yanxin SHEN, Jesse FREDERICK, Dongmei XU
  • Publication number: 20240102038
    Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.
    Type: Application
    Filed: December 12, 2023
    Publication date: March 28, 2024
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Dongmei XU, Jesse FREDERICK, Chengalrayan KUDITHIPUDI, Yanxin SHEN, James STRICKLAND, Jaemo YANG
  • Publication number: 20240099257
    Abstract: The present disclosure provides metabolic signatures and genetic markers for tracking enhanced nitrogen utilization efficiency phenotypes in tobacco plants and for introgressing enhanced nitrogen utilization efficiency phenotypes into tobacco plants. The disclosure also provides tobacco plants comprising enhanced nitrogen utilization efficiency and methods to the creation of tobacco plants comprising enhanced nitrogen utilization efficiency. The disclosure also provides recombinant polynucleotides and polypeptides for enhancing nitrogen utilization efficiency in modified tobacco plants and tobacco plants comprising the provided recombinant polynucleotides and polypeptides.
    Type: Application
    Filed: February 2, 2023
    Publication date: March 28, 2024
    Applicant: Altria Client Services LLC
    Inventors: Jesse Frederick, Chengalrayan Kudithipudi, Dongmei Xu
  • Publication number: 20240067977
    Abstract: The present disclosure provides composition and methods for improving leaf quality of low-alkaloid tobacco plants. Also provided are the identification and genetic engineering of target genes (Leaf Quality Genes) for producing tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
    Type: Application
    Filed: October 9, 2020
    Publication date: February 29, 2024
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan KUDITHIPUDI, Rajanikanth GOVINDARAJULU, Nazmul BHUIYAN, Raija PAYYAVULA, Yanxin SHEN, Dongmei XU
  • Publication number: 20240035042
    Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.
    Type: Application
    Filed: September 28, 2023
    Publication date: February 1, 2024
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Dongmei XU, Chengalrayan KUDITHIPUDI, Yanxin SHEN, Jaemo YANG, Jesse FREDERICK, James STRICKLAND
  • Patent number: 11879130
    Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: January 23, 2024
    Assignee: ALTRIA CLIENT SERVICES LLC
    Inventors: Dongmei Xu, Jesse Frederick, Chengalrayan Kudithipudi, Yanxin Shen, James Strickland, Jaemo Yang
  • Publication number: 20240018536
    Abstract: The present disclosure relates to compositions and methods related to tissue-specific promoters and their uses in plants, including tobacco and Cannabis. The provided trichome-specific promoters enable the expression of heterologous polynucleotides in trichome tissues.
    Type: Application
    Filed: August 15, 2023
    Publication date: January 18, 2024
    Inventors: Chengalrayan KUDITHIPUDI, Yanxin SHEN, Dongmei XU, Michael Paul TIMKO, Roel RABARA
  • Publication number: 20240018534
    Abstract: The present disclosure provides the identification of promoters that are preferentially active in tobacco axillary buds. Also provided are tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing tobacco plants comprising reduced or no sucker growth.
    Type: Application
    Filed: August 16, 2023
    Publication date: January 18, 2024
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan KUDITHIPUDI, Jaemo YANG, Yanxin SHEN, Dongmei XU, Ujwala WAREK, James Strickland, Jesse FREDERICK
  • Patent number: 11873500
    Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.
    Type: Grant
    Filed: February 28, 2022
    Date of Patent: January 16, 2024
    Assignee: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan Kudithipudi, Alec J. Hayes, Robert Frank Hart, Yanxin Shen, Jesse Frederick, Dongmei Xu
  • Patent number: 11859192
    Abstract: The present disclosure includes methods and compositions for improving leaf quality in low-alkaloid tobacco plants, e.g., by combining inducible promoters and non-coding RNAs for suppression of an ornithine decarboxylase (ODC) gene. Also provided are low alkaloid tobacco plants with normal, suppressed, or otherwise altered polyamine levels. Further provided are tobacco plants with altered total alkaloid, nicotine levels, commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: January 2, 2024
    Assignee: Altria Client Services LLC
    Inventors: Marcos Fernando de Godoy Lusso, James A. Strickland, Jesse Frederick, Dongmei Xu, Chengalrayan Kudithipudi
  • Patent number: 11849695
    Abstract: A process for producing a reduced tobacco-specific nitrosamine (TSNA) tobacco plant comprising reducing and/or eliminating anatabine biosynthesis in wild-type tobacco plant. In addition, use of such plants for discovery of molecular markers that are closely linked with genes required for anatabine biosynthesis and for discovery of genes required for anatabine biosynthesis. In addition, a smoking composition, a smoking article and a smokeless tobacco oral delivery product contain the tobacco material.
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: December 26, 2023
    Assignee: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Rutger Van Der Hoeven, Ndjido Ardo Kane
  • Publication number: 20230399651
    Abstract: The present disclosure provides compositions and methods related to tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
    Type: Application
    Filed: October 9, 2020
    Publication date: December 14, 2023
    Applicant: Altria Client Services LLC
    Inventors: Dong QI, Chengalrayan KUDITHIPUDI, Yanxin SHEN