Patents by Inventor Chengalrayan Kudithipudi

Chengalrayan Kudithipudi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200239899
    Abstract: The present disclosure provides approaches for reducing nicotine. Also provided are tobacco plants with decreased tobacco-specific nitrosamines (TSNAs). The present disclosure further provides modified tobacco plants with low nicotine and increased antioxidant capacity. Further provided are tobacco plants or material with low nicotine and low TSNAs. Also provided is cured tobacco material of the tobacco plants provided herein and tobacco products comprising this cured tobacco material.
    Type: Application
    Filed: January 23, 2020
    Publication date: July 30, 2020
    Applicant: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Dongmei Xu, James A. Strickland, Marcos Fernando de Godoy Lusso
  • Patent number: 10647989
    Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radical absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: May 12, 2020
    Assignee: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Dongmei Xu, James Strickland
  • Patent number: 10626409
    Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: April 21, 2020
    Assignee: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan Kudithipudi, Alec J. Hayes, Robert Frank Hart, III, Yanxin Shen, Jesse Frederick, Dongmei Xu
  • Publication number: 20200071717
    Abstract: This disclosure provides tobacco plants containing a PMT RNAi and tobacco plants having a mutation in PMT, and methods of making and using such plants.
    Type: Application
    Filed: November 5, 2019
    Publication date: March 5, 2020
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan KUDITHIPUDI, Alec J. HAYES, Marcos Fernando de GODOY LUSSO, Jerry Whit MORRIS
  • Publication number: 20200060136
    Abstract: A process for producing a reduced tobacco-specific nitrosamine (TSNA) tobacco plant comprising reducing and/or eliminating anatabine biosynthesis in wild-type tobacco plant. In addition, use of such plants for discovery of molecular markers that are closely linked with genes required for anatabine biosynthesis and for discovery of genes required for anatabine biosynthesis. In addition, a smoking composition, a smoking article and a smokeless tobacco oral delivery product contain the tobacco material.
    Type: Application
    Filed: August 1, 2019
    Publication date: February 27, 2020
    Applicant: Altria Client Services LLC
    Inventors: Chengalrayan KUDITHIPUDI, Rutger VAN DER HOEVEN, Ndjido KANE
  • Publication number: 20200040350
    Abstract: The present disclosure provides the identification of promoters that are preferentially active in tobacco axillary buds. Also provided are tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing tobacco plants comprising reduced or no sucker growth.
    Type: Application
    Filed: August 1, 2019
    Publication date: February 6, 2020
    Applicant: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Jaemo Yang, Yanxin Shen, Dongmei Xu, Ujwala Warek, James Strickland, Jesse Frederick
  • Publication number: 20200029522
    Abstract: The present disclosure provides compositions and methods related to tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
    Type: Application
    Filed: July 26, 2019
    Publication date: January 30, 2020
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan KUDITHIPUDI, Dong QI, Yanxin SHEN, Ujwala WAREK, James A. STRICKLAND, Dongmei XU
  • Publication number: 20200032283
    Abstract: This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.
    Type: Application
    Filed: October 1, 2019
    Publication date: January 30, 2020
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan KUDITHIPUDI, Yanxin SHEN, Dongmei XU, Jesse FREDERICK, Jaemo YANG
  • Patent number: 10435700
    Abstract: This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: October 8, 2019
    Assignee: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan Kudithipudi, Yanxin Shen, Dongmei Xu, Jesse Frederick, Jaemo Yang
  • Publication number: 20190300893
    Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radical absorbance capacity (ORAC), increase phenylalanine, or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.
    Type: Application
    Filed: April 2, 2019
    Publication date: October 3, 2019
    Applicant: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Dongmei Xu, James Strickland, Yanxin Shen
  • Publication number: 20190271000
    Abstract: The present disclosure includes methods and compositions for improving leaf quality in low-alkaloid tobacco plants, e.g., by combining inducible promoters and non-coding RNAs for suppression of an ornithine decarboxylase (ODC) gene. Also provided are low alkaloid tobacco plants with normal, suppressed, or otherwise altered polyamine levels. Further provided are tobacco plants with altered total alkaloid, nicotine levels, commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
    Type: Application
    Filed: March 4, 2019
    Publication date: September 5, 2019
    Applicant: Altria Client Services LLC
    Inventors: Marcos Fernando de GODOY LUSSO, James A STRICKLAND, Jesse FREDERICK, Dongmei XU, Chengalrayan KUDITHIPUDI
  • Patent number: 10375910
    Abstract: A process for producing a reduced tobacco-specific nitrosamine (TSNA) tobacco plant comprising reducing and/or eliminating anatabine biosynthesis in wild-type tobacco plant. In addition, use of such plants for discovery of molecular markers that are closely linked with genes required for anatabine biosynthesis and for discovery of genes required for anatabine biosynthesis. In addition, a smoking composition, a smoking article and a smokeless tobacco oral delivery product contain the tobacco material.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: August 13, 2019
    Assignee: ALTRIA CLIENT SERVICES LLC
    Inventors: Chengalrayan Kudithipudi, Rutger Van der Hoeven, Ndjido Kane
  • Publication number: 20190241900
    Abstract: The present specification provides for, and includes recombinant polynucleotides that encode plant-native, callus-preferred promoters operably linked to a coding region for a visual marker gene. The present specification also provides for, and includes plants comprising the recombinant nucleotides, methods to select callus comprising the disclosed recombinant nucleotides, and methods to create plants comprising the recombinant nucleotides.
    Type: Application
    Filed: December 20, 2018
    Publication date: August 8, 2019
    Applicant: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Raja Payyavula, Dong Qi, Yanxin Shen
  • Patent number: 10287598
    Abstract: Various embodiments are directed to transgenic plants, including transgenic tobacco plants and derivative seeds, genetically modified to impede the transport of Cadmium (Cd) from the root system to aerial portions of transgenic plants by reducing the expression levels of HMA-related transporters. Various embodiments are directed to transgenic tobacco plants genetically modified to stably express a RNAi construct encoding RNAi polynucleotides that enable the degradation of endogenous NtHMA RNA variants. Reduced expression of NtHMA transporters in transgenic plants results in substantially reduced content of Cadmium (Cd) in the leaf lamina. Various consumable products that are substantially free or substantially reduced in Cd content can be produced by incorporating leaves derived from transgenic tobacco plants modified to reduce the expression of NtHMA transporters.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: May 14, 2019
    Assignee: Philip Morris USA Inc.
    Inventors: Chengalrayan Kudithipudi, Alec J. Hayes, Rutger S. van der Hoeven
  • Publication number: 20190078112
    Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.
    Type: Application
    Filed: September 7, 2018
    Publication date: March 14, 2019
    Inventors: Dongmei XU, Jesse FREDERICK, Chengalrayan KUDITHIPUDI, Yanxin SHEN, James STRICKLAND, Jaemo YANG
  • Publication number: 20190069506
    Abstract: The present disclosure provides metabolic signatures and genetic markers for tracking enhanced nitrogen utilization efficiency phenotypes in tobacco plants and for introgressing enhanced nitrogen utilization efficiency phenotypes into tobacco plants. The disclosure also provides tobacco plants comprising enhanced nitrogen utilization efficiency and methods to the creation of tobacco plants comprising enhanced nitrogen utilization efficiency. The disclosure also provides recombinant polynucleotides and polypeptides for enhancing nitrogen utilization efficiency in modified tobacco plants and tobacco plants comprising the provided recombinant polynucleotides and polypeptides.
    Type: Application
    Filed: August 31, 2018
    Publication date: March 7, 2019
    Applicant: Altria Client Services LLC
    Inventors: Jesse Frederick, Chengalrayan Kudithipudi, Dongmei Xu
  • Publication number: 20190055574
    Abstract: This disclosure provides tobacco plants having a mutation in PR50 and transgenic tobacco plants containing a PR50 RNAi, and methods of making and using such plants.
    Type: Application
    Filed: October 2, 2018
    Publication date: February 21, 2019
    Inventors: Chengalrayan Kudithipudi, Alec J. Hayes
  • Patent number: 10113174
    Abstract: This disclosure provides tobacco plants having a mutation in PR50 and transgenic tobacco plants containing a PR50 RNAi, and methods of making and using such plants.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: October 30, 2018
    Assignee: Altria Client Services LLC
    Inventors: Chengalrayan Kudithipudi, Alec J. Hayes
  • Publication number: 20180119163
    Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.
    Type: Application
    Filed: October 6, 2017
    Publication date: May 3, 2018
    Inventors: Chengalrayan Kudithipudi, Dongmei Xu, James Strickland
  • Publication number: 20180098564
    Abstract: This disclosure provides a number of sequences involved in nitrogen utilization, methods of using such sequences, tobacco plants carrying modifications to such sequences, tobacco plants transgenic for such sequences, and tobacco products made from such plants.
    Type: Application
    Filed: October 6, 2017
    Publication date: April 12, 2018
    Inventors: Jesse Frederick, Chengalrayan Kudithipudi, Dongmei Xu