Abstract: The present invention relates to a metaallylsilane-based linker compound, a method for preparing same, and the like. The present invention makes it possible to prepare a nanoprobe in which two or more functional molecules are incorporated in a silica nanoparticle that is modified with the linker compound by means of a one-pot process through a continuous bioorthogonal reaction. The nanoprobe of the present invention can be incorporated in a targeting ligand capable of delivering a drug to a specific location, a fluorescent dye for molecular imaging, a radioactive isotope, a magnetic substance, a drug for treatment, and the like, and thus can be used for in vivo molecular imaging, theranostics, and the like.

Abstract: Disclosed is a cloud DID agent including a memory and at least one processor, in which the at least one processor is configured to receive an upload action request for a file from a mobile agent, generate an encryption key corresponding to the file in response to the upload action request and encrypt the file based on the encryption key, generate a plurality of chunks by dividing the encrypted file into a predetermined size, generate a plurality of data blocks corresponding to each of the plurality of chunks, and distribute and transmit the plurality of data blocks to a plurality of external cloud servers so that the plurality of data blocks are distributed and stored in the plurality of external cloud servers. In addition to this, various embodiments grasped through the specification are possible.

Abstract: The present invention relates to a composite formulation for oral dosage that comprises an API selected from 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazol-4-carboxylic acid or a pharmaceutically acceptable salt thereof and does not comprise a pH modifier as an excipient. Since the composite formulation for oral dosage according to the present invention does not comprise a pH modifier, it has the advantage of having a high level of dissolution rate as well as enhanced dosing convenience and productivity, in spite of comprising a high content of API.

Abstract: The present invention relates to a composite formulation for oral administration comprising an active pharmaceutical ingredient (API) selected from 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazol-4-carboxylic acid or a pharmaceutically acceptable salt thereof, wherein the API has a particle size of granules corresponding to 90% of the maximum particle size in the cumulative particle size distribution (D(0.9)) of 80 ?m or more and 300 ?m or less. The composite formulation for oral administration according to the present invention has a low friability and an increased dissolution rate even if a high content of API is included, by regulating the particle size of the API to a certain range.

Abstract: A particle with a yolk-shell structure including a shell including carbon; and a care including silicon (Si) provided inside the shell, wherein at least a part of the shell is spaced apart from the core, and the particle with the yolk-shell structure has a micropore volume of 0.15 cm3/g or less, and a method for preparing the same.

Abstract: The present invention relates to an oral formulation comprising an API selected from 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazol-4-carboxylic acid or a pharmaceutically acceptable salt thereof in high content. Since the oral formulation according to the present invention has a high content and excellent physical properties by comprising a glidant in excipients, economic efficiency and the convenience of administration can be increased.

Abstract: A refrigerator includes a main body having a storage compartment formed therein, and a cooling module forming a machine compartment in which a compressor is disposed and detachably mounted to the main body. The cooling module includes a module body forming the machine compartment, a condenser of an L shape disposed on one side of the compressor and including a first part corresponding to a portion of a rear surface of the machine compartment and a second part corresponding to one side of the machine compartment. The condenser is vertically mounted on a base plate disposed below the module body. A module cover is provided to cover the rear of the machine compartment, and a suction flow path includes first and second suction flow paths.

Abstract: The present invention relates to a stable oral formulation comprising 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazol-4-carboxylic acid or a pharmaceutically acceptable salt thereof as an API. The stable oral formulation according to the present invention has the characteristics of maintaining stability even if it does not comprise a stabilizer as an excipient, and does not comprise a stabilizer but has increased API content, and thus the convenience of administration can be increased.

Abstract: A single-atom catalyst structure comprises: a three-dimensional ordered mesoporous carbon structure; and a single-atom catalyst doped inside the three-dimensional ordered mesoporous carbon structure, wherein the single-atom catalyst may comprise transition metal, nitrogen, and carbon. In an alternative implementation, a single-atom catalyst structure comprises: a three-dimensional ordered mesoporous carbon structure; and a single-atom catalyst doped inside the three-dimensional ordered mesoporous carbon structure, wherein the single-atom catalyst includes transition metal, nitrogen, and carbon.

Abstract: The present invention relates to an injectable pharmaceutical composition containing a caspase inhibitor, and a preparation method therefor, and, more specifically, to an injectable pharmaceutical composition, and a preparation method therefor, the composition comprising: as an active ingredient, (R)-N-((2S,3S)-2-(fluoromethyl)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-5-isopropyl-3-(isoquinolin-1-yl)-4,5-dihydroisoxazole-5-carboxamide, which is a caspase inhibitor, or a pharmaceutically acceptable salt or isomer thereof; and, as a biocompatible polymer, microspheres containing poly(lactide-co-glycolide).

Abstract: A refrigerator and a method for controlling the same. The refrigerator includes a main body; a first storage chamber and a second storage chamber provided in the main body; a first evaporator provided in the first storage chamber, configured to generate cool air; a second evaporator provided in the second storage chamber, configured to generate the cool air; a switching valve configured to supply a refrigerant to at least one of the first evaporator or the second evaporator; and a controller configured to generate a control signal for controlling the switching valve so that the refrigerant supplied to at least one of the first evaporator or the second evaporator is distributed according to a predetermined reference, and lower the temperature of the first storage chamber and the second storage chamber to a predetermined temperature based on the generated control signal.

Abstract: Provided is a functional fabric including a base fabric layer; and an insulation flexible sheet attached to at least one surface of the base fabric layer. The insulation flexible sheet includes a first flexible base; and an insulation coating layer attached to at least one surface of the base. The insulation flexible sheet may additionally include a second flexible base on the insulation coating layer. Accordingly, the functional fabric may have effective insulation properties by using silica particles having pores in a small amount used, and may have excellent strength due to the strength of the silica particles. In addition, Manufacturing methods of an insulation flexible sheet and a functional fabric are provided.

Abstract: A refrigerator includes a main body having a storage compartment formed therein, and a cooling module forming a machine compartment in which a compressor is disposed and detachably mounted to the main body. The cooling module includes a module body forming the machine compartment, a condenser of an L shape disposed on one side of the compressor and including a first part corresponding to a portion of a rear surface of the machine compartment and a second part corresponding to one side of the machine compartment. The condenser is vertically mounted on a base plate disposed below the module body. A module cover is provided to cover the rear of the machine compartment, and a suction flow path includes first and second suction flow paths.

Abstract: An aspect of the present disclosure is to provide a refrigerator that enables a refrigerating chamber evaporator to replace an existing accumulator and defrost heater by improving a structure of the refrigerating chamber evaporator and a control method. The refrigerator in which a compressor, a condenser, a throttle, a freezing chamber evaporator, and a refrigerating chamber evaporator are connected through a refrigerant passage to form a refrigeration cycle. The refrigerating chamber evaporator may be provided between the freezing chamber evaporator and the compressor. A straight passage of a certain length may be formed at a refrigerant inlet side of the refrigerating chamber evaporator. A curved passage having a plurality of curved sections may be formed at a refrigerant outlet side of the refrigerating chamber evaporator.

Abstract: An electronic device according to various exemplary embodiments may include a housing; a first antenna module configured to be disposed in a first end portion in the housing and to include a first antenna and a first amplifier circuitry to output a signal corresponding to the first antenna, a second antenna module configured to be disposed in a second end portion in the housing and to include a second antenna and a second amplifier circuitry to output a signal corresponding to the second antenna, and a transceiver configured to include a first port connected to the first antenna through the first amplifier circuitry and a second port connected to the second antenna through the second amplifier circuitry.

Abstract: A particle with a yolk-shell structure including a shell including carbon; and a care including silicon (Si) provided inside the shell, wherein at least a part of the shell is spaced apart from the core, and the particle with the yolk-shell structure has a micropore volume of 0.15 cm3/g or less, and a method for preparing the same.

Abstract: A refrigerator and a method for controlling the same. The refrigerator includes a main body; a first storage chamber and a second storage chamber provided in the main body; a first evaporator provided in the first storage chamber, configured to generate cool air; a second evaporator provided in the second storage chamber, configured to generate the cool air; a switching valve configured to supply a refrigerant to at least one of the first evaporator or the second evaporator; and a controller configured to generate a control signal for controlling the switching valve so that the refrigerant supplied to at least one of the first evaporator or the second evaporator is distributed according to a predetermined reference, and lower the temperature of the first storage chamber and the second storage chamber to a predetermined temperature based on the generated control signal.

Abstract: A light emitting device can include a light emitting structure including a p-GaN based semiconductor layer, an active layer having multiple quantum wells, and an n-GaN based semiconductor layer; a p-electrode and an n-electrode electrically connecting with the light emitting structure, respectively, wherein the n-electrode has a plurality of layers; a first passivation layer including a first portion contacting a portion of the n-electrode, a second portion vertically overlapped with the p-electrode, and a third portion that extends outside of outermost side surfaces of the light emitting structure; a phosphor layer disposed on a top surface of the light emitting structure; and a second passivation layer including a first portion disposed between the phosphor layer and the top surface of the light emitting structure, and a second portion disposed on the outermost side surfaces of the light emitting structure, in which the phosphor layer includes a pattern to bond a wire with a p-pad on a portion of the p-elec

Abstract: Provided is a piston for an internal combustion engine. The piston includes a body including, at an upper part of the body, a crown including a combustion chamber where fuel is burnt and including, at a lower part of the body, a piston pin boss into which a piston pin is inserted and a skirt corresponding to a cylinder wall, and a cooling channel including a refrigerant channel, a refrigerant inlet provided at a side of the refrigerant channel, and a refrigerant outlet provided at the other side of the refrigerant channel, wherein a cross section of the cooling channel has an overall elliptic shape to reduce stress occurring at an upper side of the cooling channel when the fuel is burnt in the internal combustion engine, and at least one of arcs of the ellipse is configured as a first elliptical arc of a quadratic curve.

Abstract: A system and method, including determining, by a processor, distinction bit positions for index keys of a database index; determining, by the processor, concatenation of the bits of the index keys; and generating a record of the concatenation. Other systems and methods include collecting, by a processor, index keys of a database index in parallel, wherein data pages of a target table are evenly distributed to a plurality of processor cores; scanning, by each of the cores the data pages to extract compressed keys and corresponding record identifiers; sorting, by a plurality of the processor cores, pairs of the compressed key and corresponding record identifier in accordance with a parallel sorting algorithm; generating an index tree in a bottom-up fashion; and storing a record of the generated index tree.