Patents by Inventor Cheryl Grice

Cheryl Grice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DUAL MAGL AND FAAH INHIBITORS
    Publication number: 20210386734
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 16, 2021
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J.M. Wiener, Olivia D. Weber
  • Spirocycle compounds and methods of making and using same
    Patent number: 11161856
    Abstract: Provided herein are compounds of the formula: and compositions comprising the same, which are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: November 2, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Olivia D. Weber, Daniel J. Buzard, Michael B. Shaghafi
  • Synthesis of a Monoacylglycerol Lipase Inhibitor
    Publication number: 20210323938
    Abstract: Described herein is the manufacture of MAGL inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate including salts thereof.
    Type: Application
    Filed: April 19, 2021
    Publication date: October 21, 2021
    Inventors: Cheryl A. GRICE, Kurt G. GRIMM, Todd K. JONES, Giuseppe GUERCIO
  • Pyrazole MAGL inhibitors
    Patent number: 11149037
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: October 19, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Olivia D. Weber, Daniel J. Buzard, Michael B. Shaghafi, John J. M. Wiener, Justin S. Cisar, Katharine K. Duncan
  • Spirocycle compounds and methods of making and using same
    Patent number: 11142526
    Abstract: Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 12, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Olivia D. Weber, Daniel J. Buzard, Michael B. Shaghafi, Todd K. Jones
  • Crystalline forms of a MAGL inhibitor
    Patent number: 11142517
    Abstract: Described herein is the MAGL inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts and solvates thereof.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: October 12, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Todd K. Jones, Kurt G. Grimm, Jacqueline Lorayne Blankman, Channing Rodney Beals
  • Dual MAGL and FAAH inhibitors
    Patent number: 11129827
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: September 28, 2021
    Assignee: Abide Therapeutics, Inc.
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J. M. Wiener, Olivia D. Weber
  • METHODS OF TREATING INFLAMMATION OR NEUROPATHIC PAIN
    Publication number: 20210230145
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 29, 2021
    Inventors: Jacqueline Lorayne BLANKMAN, Jason Robert CLAPPER, R. Alan B. EZEKOWITZ, Iain Peter FRASER, Cheryl A. GRICE, Todd K. JONES, Gary Paul O'NEILL, Archie Wayne THURSTON, JR., Channing Rodney BEALS
  • SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20210214375
    Abstract: Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: August 28, 2018
    Publication date: July 15, 2021
    Inventors: Cheryl A. GRICE, Olivia D. WEBER, Daniel J. BUZARD, Michael B. SHAGHAFI
  • MAGL inhibitors
    Patent number: 11059822
    Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: July 13, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
  • MAGL INHIBITORS
    Publication number: 20210206735
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 14, 2019
    Publication date: July 8, 2021
    Applicant: Lundbeck La Jolla Research Center, Inc.
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI
  • CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20210188793
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
    Type: Application
    Filed: March 8, 2021
    Publication date: June 24, 2021
    Inventors: Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Micah J. NIPHAKIS, Jae Won CHANG, Kenneth M. LUM, Benjamin F. CRAVATT
  • Methods of treating inflammation or neuropathic pain
    Patent number: 11034674
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: June 15, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Jacqueline Lorayne Blankman, Jason Robert Clapper, R. Alan B. Ezekowitz, Iain Peter Fraser, Cheryl A. Grice, Todd K. Jones, Gary Paul O'Neill, Archie Wayne Thurston, Jr., Channing Rodney Beals
  • Carbamate compounds and methods of making and using same
    Patent number: 11021453
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for a method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: June 1, 2021
    Assignees: LUNDBECK LA JOLLA RESEARCH CENTER, INC., THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Micah J. Niphakis, Jae Won Chang, Kenneth M. Lum, Benjamin F. Cravatt
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20210147367
    Abstract: Described herein is new crystalline forms of the MAGL inhibitor 2-(2-((4-(((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)carbonyl)piperazin-1-yl)methyl)-5-(trifluoromethyl)phenoxy)-2-methylpropanoic acid, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 12, 2020
    Publication date: May 20, 2021
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI, Nicole S. WHITE, Heidi LOPEZ DE DIEGO, Frans Dennis THERKELSEN, Ida Marie Brødsgaard KNUDSEN
  • PYRAZOLE MAGL INHIBITORS
    Publication number: 20210053960
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 22, 2018
    Publication date: February 25, 2021
    Inventors: Cheryl A. GRICE, John J.M. WIENER, Olivia D. WEBER, Katharine K. DUNCAN
  • Pyrazole MAGL inhibitors
    Patent number: 10927105
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: February 23, 2021
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, John J. M. Wiener, Olivia D. Weber, Katharine K. Duncan
  • Piperazine carbamates and methods of making and using same
    Patent number: 10899737
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: January 26, 2021
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi, Olivia D. Weber
  • Spirocycle compounds and methods of making and using same
    Patent number: 10781211
    Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 22, 2020
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Daniel J. Buzard, Michael B. Shaghafi, Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Olivia D. Weber
  • MAGL INHIBITORS
    Publication number: 20200291023
    Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: November 15, 2017
    Publication date: September 17, 2020
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI