Patents by Inventor Cheryl Grice

Cheryl Grice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20200270223
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
    Type: Application
    Filed: December 17, 2019
    Publication date: August 27, 2020
    Inventors: Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Micah J. NIPHAKIS, Jae Won CHANG, Kenneth M. LUM, Benjamin F. CRAVATT
  • SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20200255427
    Abstract: Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: August 28, 2018
    Publication date: August 13, 2020
    Inventors: Cheryl A. GRICE, Olivia D. WEBER, Daniel J. BUZARD, Michael B. SHAGHAFI, Todd K. JONES
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20200190063
    Abstract: Described herein is the MAGL inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts and solvates thereof.
    Type: Application
    Filed: November 15, 2017
    Publication date: June 18, 2020
    Inventors: Cheryl A. GRICE, Todd K. JONES, Kurt G. GRIMM, Jaqueline Lorayne BLANKMAN, Channing Rodney BEALS
  • PHARMACEUTICAL FORMLATIONS
    Publication number: 20200188393
    Abstract: Provided herein are pharmaceutical formulations comprising a monoacylglycerol lipase (MAGL) inhibitor, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.
    Type: Application
    Filed: November 15, 2017
    Publication date: June 18, 2020
    Inventors: Cheryl A. GRICE, Nicole S. WHITE, Joel P. ZINGERMAN, Hibreniguss TEREFE, Isaac GHEBRE-SELLASSIE
  • MAGL INHIBITORS
    Publication number: 20200148653
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: January 10, 2020
    Publication date: May 14, 2020
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI
  • PYRAZOLE MAGL INHIBITORS
    Publication number: 20200087304
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 22, 2018
    Publication date: March 19, 2020
    Inventors: Cheryl A. GRICE, Olivia D. WEBER, Daniel J. BUZARD, Michael B. SHAGHAFI, John J.M. WIENER, Justin S. CISAR, Katharine K. DUNCAN
  • MAGL inhibitors
    Patent number: 10570106
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: February 25, 2020
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
  • METHODS OF TREATING INFLAMMATION OR NEUROPATHIC PAIN
    Publication number: 20200055841
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Application
    Filed: September 6, 2019
    Publication date: February 20, 2020
    Inventors: Jacqueline Lorayne BLANKMAN, Jason Robert CLAPPER, R. Alan B. EZEKOWITZ, Iain Peter FRASER, Cheryl A. GRICE, Todd K. JONES, Gary Paul O'NEILL, Archie Wayne THURSTON, JR., Channing Rodney BEALS
  • SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20200022977
    Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 11, 2017
    Publication date: January 23, 2020
    Applicant: Abide Therapeutics, Inc.
    Inventors: Daniel J. BUZARD, Michael B. SHAGHAFI, Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Olivia D. WEBER
  • Pyrazole compounds and methods of making and using same
    Patent number: 10519134
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: December 31, 2019
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Olivia D. Weber, Michael B. Shaghafi, Cheryl A. Grice, Todd K. Jones
  • MAGL INHIBITORS
    Publication number: 20190352273
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 14, 2019
    Publication date: November 21, 2019
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI
  • Radiolabeled monoacylglycerol lipase occupancy probe
    Patent number: 10463753
    Abstract: Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: November 5, 2019
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, Todd K. Jones, Justin S. Cisar, Iain Peter Fraser
  • Methods of treating inflammation or neuropathic pain
    Patent number: 10450302
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: October 22, 2019
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Jacqueline Lorayne Blankman, Jason Robert Clapper, R. Alan B. Ezekowitz, Iain Peter Fraser, Cheryl A. Grice, Todd K. Jones, Gary Paul O'Neill, Archie Wayne Thurston, Jr., Channing Rodney Beals
  • DUAL MAGL AND FAAH INHIBITORS
    Publication number: 20190282568
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Application
    Filed: June 4, 2019
    Publication date: September 19, 2019
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J.M. Wiener, Olivia D. Weber
  • PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20190256494
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Application
    Filed: November 18, 2016
    Publication date: August 22, 2019
    Inventors: Olivia D. WEBER, Michael B. SHAGHAFI, Cheryl A. GRICE, Todd K. JONES
  • Pyrazole compounds and methods of making and using same
    Patent number: 10385057
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: August 20, 2019
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, Todd K. Jones, Katharine K. Duncan, Olivia D. Weber, Justin S. Cisar, Jeffrey E. Merit
  • Dual MAGL and FAAH inhibitors
    Patent number: 10350205
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: July 16, 2019
    Assignee: Abide Therapeutics, Inc.
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J. M. Wiener, Olivia D. Weber
  • PIPERAZINE CARBAMATES AND METHODS OF MAKING AND USING SAME
    Publication number: 20190202801
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: September 18, 2017
    Publication date: July 4, 2019
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI, Olivia D. WEBER
  • Lp-PLA2 inhibitors
    Patent number: 10336709
    Abstract: Provided herein are lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors, pharmaceutical compositions thereof, and methods of their use for the treatment of disease.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: July 2, 2019
    Assignee: ABIDE THERAPEUTICS, INC
    Inventors: Cheryl A. Grice, Micah Niphakis, Todd K. Jones
  • Pyrazole compounds and methods of making and using same
    Patent number: 10323038
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 18, 2019
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Cheryl A. Grice, Todd K. Jones, Katharine K. Duncan, Justin S. Cisar, Jeffrey E. Merit, Olivia D. Weber