Abstract: Provided herein are compositions and methods for driving high expression of a transgene. Compositions and methods for driving high expression of a transgene comprising one or more human-derived regulatory elements, which, when operably linked to a transgene, can result in high expression of the transgene in one or more cell types or tissues.

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

Abstract: The present invention discloses a high-threshold power semiconductor device and a manufacturing method thereof. The high-threshold power semiconductor device includes, in sequence from bottom to top: a metal drain electrode, a substrate, a buffer layer, and a drift region; further including: a composite column body which is jointly formed by a drift region protrusion, a columnar p-region and a columnar n-region on the drift region, a channel layer, a passivation layer, a dielectric layer, a heavily doped semiconductor layer, a metal gate electrode and a source metal electrode. The composite column body is formed by sequentially depositing a p-type semiconductor layer and an n-type semiconductor layer on the drift region and then etching same. The channel layer and the passivation layer are formed in sequence by deposition. Thus, the above devices are divided into a cell region and a terminal region.

Abstract: The present disclosure refers to a method and a system of sudden water pollutant source detection by forward-inverse coupling, including: building an one-dimensional forward water quality simulation model of a river way according to acquired mechanical parameters and water quality parameters; according to the one-dimensional forward water quality simulation model of the river way, measuring and calculating each monitoring index by using an inverse optimization source-detection model; by constructing the one-dimensional forward water quality simulation model of the river way, using the inverse optimization source-detection model for measurement and calculation; and performing the Bayesian updating, in order to realize multi-information fusion.

Abstract: Provided are a soft-start method, a power converter system, and a household energy storage system, which are applied to the field of household energy storage technology and are used to improve the soft-start effect of a full-bridge resonant converter. The method includes the following manners: A soft-start process is configured as multiple operating periods, and a duty cycle is adjusted in periods and gradually increases; and in the soft-start process, according to the conversion of the duty cycle, a voltage is slowly output, and the value of the output voltage is gradually increased, so that the operating current in the soft-start process can be effectively controlled, thereby reducing the voltage stress of a power switch transistor when the power switch transistor is hard turned off.

Abstract: The present disclosure provides a power conversion circuit and an energy storage system. The circuit includes at least one first active bridge and at least one second active bridge, where the at least one second active bridge includes a first bidirectional control switch, a second bidirectional control switch, a third bidirectional control switch and a fourth bidirectional control switch, and the at least one first active bridge includes a first switch, a second switch, an third switch and a fourth switch; at least one transformer, configured to couple the first active bridge with the second active bridge; a common port and a DC port; at least one first inductor; and a controller. The power conversion circuit includes a DC-AC power conversion mode, a first DC-DC power conversion mode, an AC-DC power conversion mode, and a second DC-DC power conversion mode.

Abstract: A vehicle localization method and device, an electronic device and a storage medium. The vehicle localization method includes: acquiring an image of a scene where a vehicle is located, the image comprising a semantic element; determining an element category corresponding to the semantic element; matching the semantic element with a map element to acquire a matching result by a matching method corresponding to the element category; and determining localization information of the vehicle according to the matching result.

Abstract: An experimental device and method for co-existence of overflow and lost circulation in a fractured formation during drilling of a deviated well are provided. An inner cavity of an outer pipe is provided with an inner pipe to form a deviated casing. An upper side of the outer pipe is provided with a mixture outlet. A middle-lower side of the outer pipe is provided with a leakage port and two overflow ports. The gap width can be changed by adjusting a bolt and a support block to be compatible with different types of fracture models. A gas injection system includes an air compressor and a gas flowmeter. An upper port of a liquid injection system is connected to a joint arranged at upper ends of the inner pipe and outer pipe through a water pump, a liquid flowmeter and a liquid regulating valve.

Abstract: A structured tissue belt assembly including a supporting layer and a nonwoven web contacting layer. The supporting layer has a top surface and a bottom surface and is formed of monofilaments including one or more layers of warp yarns interwoven with weft yarns in a repeating pattern. At least one of: a) at least some of the warp yarns; or b) at least some of the weft yarns, include laser energy absorbent material, and at least one of: a) at least some of the warp yarns; or b) at least some of the weft yarns include laser energy scattering material. Laser welds attach the bottom surface of the web contacting layer to the top surface of the supporting layer at points where the web contacting layer contacts the at least one of: a) the at least some of the warp yarns; or b) the at least some of the weft yarns that include laser energy absorbent material.

Abstract: A three-phase AC-DC converter is provided that can offer a low total harmonic distortion (THD) of input current and good power factor with the capability of soft-switching of the active switches. In one aspect, a phase shift is introduced to the gate signal of one of the primary side active switches of the three-phase AC-DC converter and the gate signal of a corresponding one of the secondary side active switches of the three-phase AC-DC converter.

Abstract: A shaft wall pressure corrosion test system includes a pressure bearing device, a confining pressure application device, and a seepage pressure application device. The confining pressure application device and the seepage pressure application device provide confining pressure and seepage pressure for the pressure bearing device, respectively, and keep the confining pressure and the seepage pressure constant on the pressure bearing device. In the system, axial pressure is applied to a piston by means of a hydraulic jack and is then transferred to a sample to complete axial pressure application. The confining pressure is applied to hydraulic oil by a manual pump in combination with an energy accumulator and then transferred to the sample to complete confining pressure application. The seepage pressure is applied to a corrosion solution by a water pump group in combination with an energy accumulator and then transferred to the sample to complete seepage pressure application.

Abstract: The present disclosure provides a defect detection method and apparatus for a cushion layer of a cable, a device, and a storage medium. The method includes: obtaining specification parameters of a corrugated sheath of a to-be-detected cable, calculating a first volume of a cushion layer without deformation and a second volume of a deformed portion of the cushion layer when the cushion layer is deformed under stress, and calculating a stressed-state deformation ratio of the cushion layer based on the first volume and the second volume; obtaining a voltage, a current, an electrode area, an electrode distance, and an initial electrode distance of the cushion layer when the stressed-state deformation ratio is reached, and calculating volume resistivity of the cushion layer; and comparing the volume resistivity with a preset evaluation parameter to obtain a defect detection result of the cushion layer.

Abstract: A photovoltaic module and a method for manufacturing the photovoltaic module are provided. A respective solar cell has a front surface and a rear surface opposite to the front surface, each of which has a plurality of electrodes formed thereon. Each connection member of the plurality of connection members is configured to connect two adjacent solar cells of the plurality of solar cells and has a first end portion disposed over the front surface of a first solar cell of the two adjacent solar cells and a second end portion disposed over the rear surface of a second solar cell of the two adjacent solar cells. Each encapsulation layer includes a first encapsulation sub-layer and a second encapsulation sub-layer, where flowability of the first encapsulation sub-layer is smaller than flowability of the second encapsulation sub-layer.

Abstract: Disclosed are a cross-flow air duct and an air outlet device. The cross-flow air duct includes a volute and a volute tongue. The volute includes a first body, a first side of the first body is an air inlet side, and a second side of the first body is an air outlet side. The volute tongue includes a second body, a first side of the second body is an air inlet side, and a second side of the second body is an air outlet side. An air inlet port is formed between the first sides, and an air outlet port is formed between the second sides. According to the cross-flow air duct, multiple groups of air outlet areas in different directions are formed, the air outlet width is enlarged as a whole, and the air supply range is increased.

Abstract: The present disclosure relates to the technical field of oil and gas field exploitation, in particular to an early strength material suitable for a cement slurry system, a cement slurry composition, a cement slurry system, a preparation method therefor and the use thereof. The early strength material contains an aluminum salt, a sodium salt, crystal whiskers, an inorganic mineral and dispersing agent I, wherein the weight ratio of the aluminum salt, the sodium salt, the crystal whiskers, the inorganic mineral and dispersing agent I is (1-3):(1-3):(1-4):(1-8):1.

Abstract: Described herein are systems, methods, and instrumentalities associated with using a multi-layer perceptron (MLP) neural network to process medical images of an anatomical structure. The processing may include padding an input image in accordance with the training of the MLP neural network, splitting the input image (e.g., the padded input image) into patches of a same size, and processing the patches through the MLP neural network over one or more iterations. During an iteration of the processing, the patches may be processed separately and re-combined into an intermediate image before the intermediate image is shifted to concatenate portions of the image that are derived from different patches. This way, global features of the anatomical structure may be learned and used to improve the quality of the image generated by the MLP neural network, without incurring significant computation or memory costs.

Abstract: A flexible mechanism-based anti-backlash device for a planetary gear train, a gearbox, and a robot joint are provided. The anti-backlash device includes an integrated flexible planet carrier, an adjusting screw and a spring, the integrated flexible planet carrier is provided with a moving platform, the moving platform is provided with a spring hole, and the spring is sleeved outside the screw and is installed in the spring hole; when the threaded connection depth of the adjusting screw and the integrated flexible planet carrier reaches or exceeds a set depth, the adjusting screw can extrude the spring to make the moving platform generate elastic movement along a radial direction of the integrated flexible planet carrier, and the radial elastic movement is transformed into circumferential elastic rotation of a planet carrier bearing hole around the center of the planet carrier through an elastic connector.

Abstract: A source-network-load-storage coordination dispatching method in a background of a coupling of renewable energy sources, including: taking an expectation of a minimum grid operating cost in a dispatching cycle as an objective function; generating an approximate value function of an output of a set for generating electricity from renewable energy sources and a user load, and constructing a source-network-load-storage coordination dispatching model with combination of the objective function; obtaining forecast data of the output of a set for generating electricity from renewable energy sources and the user load, and inputting the forecast data into the dispatching model for solving; performing iterative updating on the approximate value function, importing the approximate value function after the iterative updating into the dispatching model for iterative solving, and terminating an iterative process until a solving result satisfies a preset convergence condition; and using a solving result of a last iteration

Abstract: A GaN power semiconductor device integrated with a self-feedback gate control structure comprises a substrate, a buffer layer, a channel layer and a barrier layer. A gate control area is formed by a first metal source electrode, a first P-type GaN cap layer, a first metal gate electrode, a first metal drain electrode, a second P-type GaN cap layer and a second metal gate electrode. An active working area is formed by the first metal source electrode, a third P-type GaN cap layer, a third metal gate electrode, a second metal drain electrode, the second P-type GaN cap layer and a second metal source electrode. The overall gate leaking current of the device is regulated by the gate control area, the integration level is high, the parasitic effect is small, and the charge-storage effect can be effectively relieved, thus improving the threshold stability of the device.

Abstract: An experimental device and method for co-existence of overflow and lost circulation in a fractured formation during drilling of a deviated well are provided. An inner cavity of an outer pipe is provided with an inner pipe to form a deviated casing. An upper side of the outer pipe is provided with a mixture outlet. A middle-lower side of the outer pipe is provided with a leakage port and two overflow ports. The gap width can be changed by adjusting a bolt and a support block to be compatible with different types of fracture models. A gas injection system includes an air compressor and a gas flowmeter. An upper port of a liquid injection system is connected to a joint arranged at upper ends of the inner pipe and outer pipe through a water pump, a liquid flowmeter and a liquid regulating valve.