Patents by Inventor Chiajen Lai

Chiajen Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID FORMS OF A NUCLEOSIDE ANALOGUE AND USES THEREOF
    Publication number: 20240051962
    Abstract: The disclosure provides solid forms, e.g. salts and polymorphs, of the compound of Formula (I) and uses thereof. Also provided are the methods of making the solid forms and pharmaceutical formulations comprising the solid forms.
    Type: Application
    Filed: June 28, 2023
    Publication date: February 15, 2024
    Inventors: Kassibla E. Dempah, Stefani Kocevska, Chiajen Lai
  • SOLID FORMS OF A NUCLEOSIDE ANALOGUE AND USES THEREOF
    Publication number: 20240043466
    Abstract: The present disclosure relates to solid forms (e.g. crystalline forms, solvates, and crystalline forms thereof) of a compound which is ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl neopentyl carbonate, which is useful in the treatment of treating viral infections, for example paramyxoviridae, pneumoviridae, picornaviridae, flaviviridae, filoviridae, arenaviridae, orthomyxovirus, and coronaviridae infections.
    Type: Application
    Filed: June 29, 2023
    Publication date: February 8, 2024
    Inventors: Kassibla E. Dempah, Chiajen Lai
  • METHODS OF PREPARING 1`-CYANO NUCLEOSIDES
    Publication number: 20230295214
    Abstract: The present disclosure generally describes methods of preparing 1?-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
    Type: Application
    Filed: February 10, 2023
    Publication date: September 21, 2023
    Inventors: Pavel R. Badalov, Stacy Bremner, Matthew R. Chin, Detian Gao, Nolan Griggs, Lars V. Heumann, Chiajen Lai, Robert R. Milburn, Sankar Mohan, Sean T. Neville, Bing Shi, Andrew C. Stevens, Nicholas A.J. Uhlig, Tiago Vieira, Todd A. Wenderski
  • CRYSTALLINE FORMS OF 6-(6-AMINOPYRAZIN-2-YL)-N-(4-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)PHENYL)IMIDAZO[l,2-a]PYRAZIN-8-AMINE AS SYK INHIBITORS
    Publication number: 20230098309
    Abstract: Solid forms of the compound, 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine, and solid forms of salts or co-crystals of Compound I, were prepared and characterized: Also provided are processes of making the solid forms and methods of use thereof.
    Type: Application
    Filed: May 19, 2022
    Publication date: March 30, 2023
    Inventors: Patricia Andres, Peter C. Fung, Pierre Giguere, Chiajen Lai, Craig Stewart, Jing Teng, Duong D. Tran, Iva Trantcheva, Yarmuch
  • Methods of preparing 1?-cyano nucleosides
    Patent number: 11613553
    Abstract: The present disclosure generally describes methods of preparing 1?-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: March 28, 2023
    Assignee: Gilead Sciences, Inc.
    Inventors: Pavel R. Badalov, Stacy Bremner, Matthew R. Chin, Detian Gao, Nolan Griggs, Lars V. Heumann, Chiajen Lai, Robert R. Milburn, Sankar Mohan, Sean T. Neville, Bing Shi, Andrew C. Stevens, Nicholas A. J. Uhlig, Tiago Vieira, Todd A. Wenderski
  • CRYSTALLINE FORMS OF TENOFOVIR ALAFENAMIDE
    Publication number: 20230091736
    Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Application
    Filed: August 11, 2022
    Publication date: March 23, 2023
    Inventors: Chiajen Lai, Bing Shi, Robert G. Strickley
  • Crystalline forms of tenofovir alafenamide
    Patent number: 11440928
    Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: September 13, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Chiajen Lai, Bing Shi, Robert G. Strickley
  • Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors
    Patent number: 11339168
    Abstract: Solid forms of the compound, 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine, and solid forms of salts or co-crystals of Compound I, were prepared and characterized: Also provided are processes of making the solid forms and methods of use thereof.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: May 24, 2022
    Assignee: Kronos Bio, Inc.
    Inventors: Patricia Andres, Peter C. Fung, Pierre Giguere, Chiajen Lai, Craig Stewart, Jing Teng, Duong D. Tran, Iva Trantcheva, Brian Yarmuch
  • METHODS OF PREPARING 1'-CYANO NUCLEOSIDES
    Publication number: 20210309689
    Abstract: The present disclosure generally describes methods of preparing 1?-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
    Type: Application
    Filed: March 11, 2021
    Publication date: October 7, 2021
    Inventors: Pavel R. Badalov, Stacy Bremner, Matthew R. Chin, Detian Gao, Nolan Griggs, Lars V. Heumann, Chiajen Lai, Robert R. Milburn, Sankar Mohan, Sean T. Neville, Bing Shi, Andrew C. Stevens, Nicholas A.J. Uhlig, Tiago Vieira, Todd A. Wenderski
  • SOLID FORMS OF A SYK INHIBITOR
    Publication number: 20200291035
    Abstract: Solid forms of the compound, 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine, and solid forms of salts or co-crystals of Compound I, were prepared and characterized: Also provided are processes of making the solid forms and methods of use thereof.
    Type: Application
    Filed: February 20, 2020
    Publication date: September 17, 2020
    Inventors: Patricia Andres, Peter C. Fung, Pierre Giguere, Chiajen Lai, Craig Stewart, Jing Teng, Duong D. Tran, Iva Trantcheva, Brian Yarmuch
  • Crystalline forms of darunavir
    Patent number: 10407438
    Abstract: The present invention relates to novel crystalline forms of darunavir, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: September 10, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Chiajen Lai, Bing Shi
  • CRYSTALLINE FORMS OF TENOFOVIR ALAFENAMIDE
    Publication number: 20190233448
    Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Application
    Filed: March 21, 2019
    Publication date: August 1, 2019
    Inventors: Chiajen Lai, Bing Shi, Robert G. Strickley
  • Crystalline forms of tenofovir alafenamide
    Patent number: 10287307
    Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: May 14, 2019
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Chiajen Lai, Bing Shi, Robert G. Strickley
  • CRYSTALLINE FORMS OF TENOFOVIR ALAFENAMIDE
    Publication number: 20180265530
    Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Application
    Filed: January 29, 2018
    Publication date: September 20, 2018
    Inventors: Chiajen Lai, Bing Shi, Robert G. Strickley
  • CRYSTALLINE FORMS OF DARUNAVIR
    Publication number: 20180170945
    Abstract: The present invention relates to novel crystalline forms of darunavir, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Application
    Filed: October 25, 2017
    Publication date: June 21, 2018
    Inventors: Chiajen Lai, Bing Shi
  • CRYSTALLINE FORM
    Publication number: 20170217952
    Abstract: The invention provides a crystalline form of the compound of formula (Ia), methods for making the crystalline form of the compound of formula (Ia), and therapeutic methods for the use of the crystalline form of the compound of formula (Ia).
    Type: Application
    Filed: January 24, 2017
    Publication date: August 3, 2017
    Inventors: Chiajen Lai, Lok Him Lawrence Yu, Richard Hung Chiu Yu
  • Crystal structures of SGLT2 inhibitors and processes for preparing same
    Patent number: 9453039
    Abstract: The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: September 27, 2016
    Assignee: AstraZeneca AB
    Inventors: Jack Z. Gougoutas, Hildegard Lobinger, Srividya Ramakrishnan, Prashant P. Deshpande, Jeffrey T. Bien, Chiajen Lai, Chenchi Wang, Peter Riebel, John Anthony Grosso, Alexandra A. Nirschl, Janak Singh, John D. DiMarco
  • METHODS OF PRODUCING C-ARYL GLUCOSIDE SGLT2 INHIBITORS
    Publication number: 20140243517
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 28, 2014
    Applicant: AstraZeneca AB
    Inventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas
  • CRYSTAL STRUCTURES OF SGLT2 INHIBITORS AND PROCESSES FOR PREPARING SAME
    Publication number: 20130303467
    Abstract: The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
    Type: Application
    Filed: July 10, 2013
    Publication date: November 14, 2013
    Inventors: Jack Z. Gougoutas, Hildegard Lobinger, Srividya Ramakrishnan, Prashant P. Deshpande, Jeffrey T. Bien, Chiajen Lai, Chenchi Wang, Peter Riebel, John Anthony Grosso, Alexandra A. Nirschl, Janak Singh, John D. DiMarco
  • Crystal structures of SGLT2 inhibitors and processes for preparing same
    Patent number: 8501698
    Abstract: The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: August 6, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jack Z. Gougoutas, Hildegard Lobinger, Srividya Ramakrishnan, Prashant P. Deshpande, Jeffrey T. Bien, Chiajen Lai, Chenchi Wang, Peter Riebel, John Anthony Grosso, Alexandra A. Nirschl, Janak Singh, John D. DiMarco