Patents by Inventor Chiajen Lai

Chiajen Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PRODUCING C-ARYL GLUCOSIDE SGLT2 INHIBITORS
    Publication number: 20140243517
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 28, 2014
    Applicant: AstraZeneca AB
    Inventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas
  • CRYSTAL STRUCTURES OF SGLT2 INHIBITORS AND PROCESSES FOR PREPARING SAME
    Publication number: 20130303467
    Abstract: The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
    Type: Application
    Filed: July 10, 2013
    Publication date: November 14, 2013
    Inventors: Jack Z. Gougoutas, Hildegard Lobinger, Srividya Ramakrishnan, Prashant P. Deshpande, Jeffrey T. Bien, Chiajen Lai, Chenchi Wang, Peter Riebel, John Anthony Grosso, Alexandra A. Nirschl, Janak Singh, John D. DiMarco
  • Crystal structures of SGLT2 inhibitors and processes for preparing same
    Patent number: 8501698
    Abstract: The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: August 6, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jack Z. Gougoutas, Hildegard Lobinger, Srividya Ramakrishnan, Prashant P. Deshpande, Jeffrey T. Bien, Chiajen Lai, Chenchi Wang, Peter Riebel, John Anthony Grosso, Alexandra A. Nirschl, Janak Singh, John D. DiMarco
  • Methods of Producing C-Aryl Glucoside SGLT2 Inhibitors
    Publication number: 20110201795
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Application
    Filed: April 25, 2011
    Publication date: August 18, 2011
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas
  • CRYSTAL STRUCTURES OF SGLT2 INHIBITORS AND PROCESSES FOR PREPARING SAME
    Publication number: 20110172176
    Abstract: The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 14, 2011
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Jack Z. Gougoutas, Hildegard Lobinger, Srividya Ramakrishnan, Prashant P. Deshpande, Jeffrey T. Bien, Chiajen Lai, Chenchi Wang, Peter Riebel, John Anthony Grosso, Alexandra A. Nirschl, Janak Singh, John D. DiMarco
  • Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
    Patent number: 7968718
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: June 28, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nachimuthu Soundararajan, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Methods of producing C-aryl glucoside SGLT2 inhibitors
    Patent number: 7932379
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: April 26, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas
  • Crystal structures of SGLT2 inhibitors and processes for preparing same
    Patent number: 7919598
    Abstract: The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: April 5, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jack Z. Gougoutas, Hildegard Lobinger, Srividya Ramakrishnan, Prashant P. Deshpande, Jeffrey T. Bien, Chiajen Lai, Chenchi Wang, Peter Riebel, John Anthony Grosso, Alexandra A. Nirschl, Janak Singh, John D. DiMarco
  • FORMULATIONS OF 1-(4-BENZOYL-PIPERAZIN-1-YL)-2-[4-METHOXY-7-(3-METHYL-[1,2,4]TRIAZOL-1-YL)-1H-PYRROLO[2,3-C]PYRIDIN-3-YL]-ETHANE-1,2-DIONE
    Publication number: 20100292246
    Abstract: The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations.
    Type: Application
    Filed: July 30, 2010
    Publication date: November 18, 2010
    Inventors: Chong-Hui Gu, Qi Gao, Shan-Ming Kuang, Chiajen Lai, Jaquan Kalani Levons, Feng Qian
  • Method of preparation of azaindole derivatives
    Patent number: 7820820
    Abstract: A method of preparing azaindole compounds for antiviral use having the formula
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: October 26, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wansheng Liu, Sunil S. Patel, Nicolas Cuniere, Yvonne Lear, Prashant P. Deshpande, Jeffrey N. Simon, Chiajen Lai, Annie J. Pullockaran, Nachimuthu Soundararajan, Jeffrey T. Bien
  • PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN
    Publication number: 20100076191
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Application
    Filed: August 27, 2009
    Publication date: March 25, 2010
    Inventors: NACHIMUTHU SOUNDARARAJAN, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2, 1-F][1,2,4]triazin-6-yloxy]-1-methylethyl ester
    Patent number: 7671199
    Abstract: The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: March 2, 2010
    Assignee: Britsol-Myers Squibb Company
    Inventors: Gerard A. Crispino, Mourad Hamedi, Thomas L. LaPorte, John E. Thornton, Jaan A. Pesti, Zhongmin Xu, Paul C. Lobben, David K. Leahy, Jale Muslehiddinoglu, Chiajen Lai, Lori Ann Spangler, Robert P. Discordia, Francis S. Gibson
  • METHOD OF PREPARATION OF AZAINDOLE DERIVATIVES
    Publication number: 20090312549
    Abstract: A method of preparing azaindole compounds for antiviral use having the formula
    Type: Application
    Filed: August 24, 2009
    Publication date: December 17, 2009
    Inventors: WANSHENG LIU, Sunil S. Patel, Nicolas Cuniere, Yvonne Lear, Prashant P. Deshpande, Jeffrey N. Simon, Chiajen Lai, Annie J. Pullockaran, Nachimuthu Soundararajan, Jeffrey T. Bien
  • Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
    Patent number: 7601715
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: October 13, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nachimuthu Soundararajan, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Method of preparation of azaindole derivatives
    Patent number: 7598380
    Abstract: A method of preparing azaindole compounds for antiviral use having the formula
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: October 6, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wansheng Liu, Sunil S. Patel, Nicolas Cuniere, Yvonne Lear, Prashant P. Deshpande, Jeffrey N. Simon, Chiajen Lai, Annie J. Pullockaran, Nachimuthu Soundararajan, Jeffrey T. Bien
  • Methods of producing C-aryl glucoside SGLT2 inhibitors
    Patent number: 7375213
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: May 20, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas
  • CRYSTAL STRUCTURES OF SGLT2 INHIBITORS AND PROCESSES FOR PREPARING SAME
    Publication number: 20080004336
    Abstract: The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 3, 2008
    Inventors: Jack Gougoutas, Hildegard Lobinger, Srividya Ramakrishnan, Prashant Deshpande, Jeffrey Bien, Chiajen Lai, Chenchi Wang, Peter Riebel, John Grosso, Alexandra Nirschl, Janak Singh, John DiMarco
  • PROCESS FOR THE PREPARATION OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER
    Publication number: 20070249610
    Abstract: The invention relates to an improved process for preparing [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.
    Type: Application
    Filed: April 20, 2007
    Publication date: October 25, 2007
    Inventors: Gerard Crispino, Mourad Hamedi, Thomas LaPorte, John Thornton, Jaan Pesti, Zhongmin Xu, Paul Lobben, David Leahy, Jale Muslehiddinoglu, Chiajen Lai, Lori Spangler, Robert Discordia
  • METHODS OF PRODUCING C-ARYL GLUCOSIDE SGLT2 INHIBITORS
    Publication number: 20070238866
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 11, 2007
    Inventors: Prashant Deshpande, Bruce Ellsworth, Janak Singh, Theodor Denzel, Chiajen Lai, Gerard Crispino, Michael Randazzo, Jack Gougoutas
  • Method of preparation of azaindole derivatives
    Publication number: 20070032503
    Abstract: A method of preparing azaindole compounds for antiviral use having the formula
    Type: Application
    Filed: July 25, 2006
    Publication date: February 8, 2007
    Inventors: Wansheng Liu, Sunil Patel, Nicolas Cuniere, Yvonne Lear, Prashant Deshpande, Jeffrey Simon, Chiajen Lai, Annie Pullockaran, Nachimuthu Soundararajan, Jeffrey Bien