Abstract: A method for assembling a physiological signal monitoring apparatus on a body surface of a living body is provided, wherein the physiological signal monitoring apparatus is used to measure a physiological signal and includes a sensor module and a transmitter. The method comprises steps of: (a) detaching the bottom cover from the housing to expose the sticker from the bottom opening; (b) while holding the housing, causing the adhesive pad to be attached to the body surface; (c) applying a pressing force on the housing to cause the sensor module to be detached from the implantation module and the signal sensing end to be implanted under the body surface; (d) removing the implanting device while leaving the sensor module on the body surface; and (e) placing the transmitter on the base so that the signal output end is electrically connected to the port.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a fixing indentation containing the sensor, a filler disposed in the fixing indentation to retain the sensor in the holder, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor in the holder and restrict the filler in the fixing indentation.

Abstract: A charging device for a physiological signal transmitter is disclosed, wherein the physiological signal transmitter is to receive and externally transmit a physiological signal from a subcutaneous tissue of a living body, and has a first electrical connecting port. The charging device comprises a transmitter placing seat, a charging module and a locking module. The transmitter placing seat includes a bearing surface, and a first opening. The bearing surface disposes thereon the physiological signal transmitter; and the first opening aligns therewith the first electrical connecting port of the physiological signal transmitter. The charging module includes a second electrical connecting port, a third electrical connecting port and a circuit assembly. The second electrical connecting port is disposed in the first opening and moveable between a first position and a second position. The third electrical connecting port is for connecting thereto a power source.

Abstract: A biosensing device includes a sensor module and an electric signal transducer. The sensor module includes a biosensor adapted for measuring a biosignal of a host, and a fixed seat including a conducting member that is electrically connected to the biosensor. The electric signal transducer is for receiving and sending the biosignal measured by the biosensor, is coupled to the sensor module, and includes an electric signal unit electrically connected to the conducting member, and a battery connected to the electric signal unit. The electric signal unit has two electrical contacts that cooperatively define a switch. The battery provides power supply to the biosensor when the electric signal transducer is coupled to the sensor module.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a fixing indentation containing the sensor, a filler disposed in the fixing indentation to retain the sensor in the holder, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor in the holder and restrict the filler in the fixing indentation.

Abstract: A method for prolonging a usage lifetime of a micro biosensor to measure a physiological signal associated with an analyte is provided. The micro biosensor includes a working electrode, a counter electrode including silver and a silver halide having an initial amount, and an auxiliary electrode. The method includes cyclic steps of: applying a measurement voltage to drive the working electrode to measure the physiological signal; stopping applying the measurement voltage; and whenever the physiological parameter is obtained, applying a replenishment voltage between the counter electrode and the auxiliary electrode to drive the counter electrode, thereby the silver halide of a replenishment amount being replenished to the counter electrode, wherein a guarding value of a sum of the replenishment amount and the initial amount subtracting a consumption amount is controlled within a range of the initial amount plus or minus a specific value.

Abstract: The present invention provides a sensing structure of a micro biosensor for performing a measurement of a physiological parameter of a target analyte of a biofluid and reducing an interference of an interferant of the biofluid on the measurement by an electrochemical reaction. The sensing structure includes: a substrate having a surface; a first working electrode configured on the surface, and including an active surface; at least one second working electrode configured on the surface and adjacent to the first working electrode, for consuming the interferant by the electrochemical reaction; and an isolated layer configured with respect to the active surface to program a diffusive distribution of the interferant when the biofluid flows through the second working electrode, wherein at least the interferant of the biofluid passes through the second working electrode over a time period and is consumed by the second working electrode by the electrochemical reaction.

Abstract: A biosensing device includes a sensor module and an electric signal transducer. The sensor module includes a biosensor adapted for measuring a biosignal of a host, and a fixed seat including a conducting member that is electrically connected to the biosensor. The electric signal transducer is for receiving and sending the biosignal measured by the biosensor, is coupled to the sensor module, and includes an electric signal unit electrically connected to the conducting member, and a battery connected to the electric signal unit. The electric signal unit has two electrical contacts that cooperatively define a switch. The battery provides power supply to the biosensor when the electric signal transducer is coupled to the sensor module.

Abstract: A physiological signal monitoring device includes a base, a biosensor and a transmitter. The biosensor includes a sensing section. The transmitter includes a connection part. The connection part and the signal output section cooperatively form a connection portion after the transmitter moving from an initial position to an assembled position. A safety gap is formed between the transmitter and the biosensor. When the transmitter moves from the initial position toward the assembled position, the safety gap serves to prevent at least one of the connection part of the transmitter and the signal output section of the biosensor from collision.

Abstract: An elastic physiological patch includes a patch assembly and an implant assembly. The patch assembly includes an electronic device, and a soft patch body defining a chamber for receiving the electronic device. The implant assembly is mountable to the electronic device and includes an implant which is capable of being driven to partially pass through the patch body and which is adapted to be implanted in the skin of a subject. The implant and the patch body cooperatively seal the chamber.

Abstract: A physiological signal monitoring device includes a base, a biosensor mounted to the base and adapted to measure an analytical substance, and a transmitter. The base includes a flexible base body and a first coupling structure. The first coupling structure is disposed on the bottom plate. The transmitter is removably mounted to the base body, and includes a bottom casing and a second coupling structure. The first and second coupling structures are coupled to each other when the transmitter is mounted to the base body, and are uncoupled from each other by the flexibility of the base body when an external force is applied on a periphery of the base body. The first and second coupling structures are disposed to be distal from a periphery cooperatively defined by the base and the transmitter when the first and second coupling structures are coupled to each other.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting therethrough the sensor and containing a part of the sensor, and a containing indentation containing the signal output end, wherein the containing indentation has a surrounding wall kept apart from the signal output end to define a space.

Abstract: A charging device for a physiological signal transmitter is disclosed. The charging device includes a transmitter placing seat, and a controlling module controlling an operation between the charging device and the physiological signal transmitter in a safe state. When the physiological signal transmitter is at the predetermined position, the locking portion unlocks the operating portion to perform one of driving the second electrical connecting port to move from the first position to the second position to electrically connect to the first electrical connecting port and driving the second electrical connecting port to move from the second position to the first position to electrically disconnect to the first electrical connecting port.

Abstract: An elastic physiological patch includes a patch assembly and an implant assembly. The patch assembly includes an electronic device, and a soft patch body defining a chamber for receiving the electronic device. The implant assembly is mountable to the electronic device and includes an implant which is capable of being driven to partially pass through the patch body and which is adapted to be implanted in the skin of a subject. The implant and the patch body cooperatively seal the chamber.

Abstract: The present invention provides a measuring method for prolonging a usage lifetime of a micro biosensor implanted subcutaneously to measure a physiological signal associated with an analyte. The micro biosensor includes a working electrode and a counter electrode, wherein the counter electrode includes silver and a silver halide having an initial amount. The method includes cyclic steps of: applying a measurement voltage to drive the working electrode to measure the physiological signal, where the silver halide is consumed by a specific amount; stopping applying the measurement voltage; and whenever the physiological parameter is obtained, applying a replenishment voltage to drive the counter electrode, thereby the silver halide of a replenishment amount being replenished to the counter electrode, wherein a guarding value of a sum of the replenishment amount and the initial amount subtracting the consumption amount is controlled within a range of the initial amount plus or minus a specific value.

Abstract: A charging device for a physiological signal transmitter used to receive a physiological signal from the subcutaneous tissue of a living body and having a first electrical connecting port is disclosed. The charging device includes a transmitter placing seat and a charging module. The transmitter placing seat includes a bearing surface for placing the physiological signal transmitter and an opening configured to align with the first electrical connection port of the physiological signal transmitter. The charging module includes a second electrical connecting port, a third electrical connecting port, a circuit assembly and a control module. The second electrical connecting port is disposed in the opening, and driven to move between a first position and a second position. The third electrical connecting port connects to a power source.

Abstract: A charging device for a physiological signal transmitter is disclosed, wherein the physiological signal transmitter is to receive and transmit a physiological signal from a subcutaneous tissue of a living body, and has a first electrical connecting port. The charging device comprises a body including a placing portion, a charging module and an operating module. The placing portion disposes thereon the physiological signal transmitter, and includes a bearing surface and a first opening. The bearing surface disposes thereon the physiological signal transmitter, and the first opening aligns therewith the first electrical connecting port of the physiological signal transmitter. The charging module is accommodated in the body and includes a second electrical connecting port, a third electrical connecting port and a circuit assembly. The second electrical connecting port is disposed in the opening and protrusive beyond or beneath the bearing surface.

Abstract: An insertion needle structure includes a needle sharp and a needle body. The needle body is integrally connected to the needle sharp and has a receiving space for receiving a biosensor. The needle body includes a base wall, two side walls and two slope sections. The side wall has a first inner edge and a first outer edge. The first inner edge is near the receiving space, and the first outer edge faces away from the receiving space. The slope section is connected between the side wall and the needle sharp. The slope section has a second inner edge connected to the first inner edge, and a second outer edge connected to the first outer edge. The first inner edge, the second inner edge, the first outer edge and the second outer edge are curved. A condition of R11>R12 is satisfied.