Patents by Inventor Chih-Chuan Chang

Chih-Chuan Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSGLUTAMINASE VARIANTS WITH IMPROVED SPECIFICITY
    Publication number: 20090318349
    Abstract: Variants of transglutaminase from Streptoverticillium ladakanum, which variants have improved selectivity for Gln-141 of human growth hormone are provided.
    Type: Application
    Filed: August 17, 2007
    Publication date: December 24, 2009
    Applicant: Novo Nordisk Health Care AG
    Inventors: Zhixiang Hu, Xin Zhao, Jianhua Wang, Chih-Chuan Chang, Leif Norskov-Lauritsen
  • Use of Nordihydroguaiaretic Acid Derivatives in the Treatment of Drug Resistant Cancer, Viral and Microbial Infection
    Publication number: 20080207532
    Abstract: Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in cells, and for using NDGA derivatives in combination with additional chemotherapeutic agents to treat drug resistant cancer and infections.
    Type: Application
    Filed: October 6, 2005
    Publication date: August 28, 2008
    Applicant: Johns Hopkins University
    Inventors: Ru Chih Huang, Jih Ru Hwu, Ming-Hua Hsu, David E. Mold, Yuan C. Lee, Chih-Chuan Chang
  • Methods and compositions for delivery of catecholic butanes for treatment of obesity
    Publication number: 20060141047
    Abstract: The present invention provides kits, methods and compositions for the treatment of obesity. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment.
    Type: Application
    Filed: November 21, 2005
    Publication date: June 29, 2006
    Inventors: Jonathan Heller, Neil Frazier, Chih-Chuan Chang, Elaine Lin, Ru Huang
  • Methods and compositions for delivery of catecholic butanes for treatment of tumors
    Publication number: 20060141025
    Abstract: The present invention provides kits, methods and compositions for the treatment of tumor and other proliferative diseases such as tumors. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment by a route other than direct injection into the affected tissues or topical application on affected tissues.
    Type: Application
    Filed: November 21, 2005
    Publication date: June 29, 2006
    Inventors: Ru Huang, Richard Park, Chih-Chuan Chang, Yu-Chuan Liang, David Mold, Elaine Lin, Jonathan Heller, Neil Frazer
  • Method for regulation of gene expression in eukaryotic cells using nordihydroguaiaretic acid derivatives
    Patent number: 6777444
    Abstract: Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: August 17, 2004
    Assignee: John Hopkins University
    Inventors: Ru Chih C. Huang, Jonathan D. Heller, Chih-Chuan Chang
  • Method for treatment of tumors using nordihydroguaiaretic acid derivatives
    Publication number: 20040127562
    Abstract: Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 1, 2004
    Applicant: JOHNS HOPKINS UNIVERSITY
    Inventors: Ru Chih C. Huang, Jonathan D. Heller, Chih-Chuan Chang
  • Method for treatment of tumors using nordihydroguaiaretic acid derivatives
    Publication number: 20030171416
    Abstract: Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.
    Type: Application
    Filed: October 15, 2002
    Publication date: September 11, 2003
    Inventors: Ru Chih C. Huang, Jonathan D. Heller, Chih-Chuan Chang
  • Method for treatment of tumors using nordihydroguaiaretic acid derivatives
    Patent number: 6608108
    Abstract: Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: August 19, 2003
    Assignee: Johns Hopkins University
    Inventors: Ru Chih C. Huang, Jonathan D. Heller, Chih-Chuan Chang
  • Microprocessor and main board mounting arrangement
    Patent number: 6421783
    Abstract: A microprocessor and main board mounting arrangement, which includes a computer main board, at least one socket respectively mounted on the computer main board, at least one microprocessor adapter respectively mounted on the at least one socket, said at least one microprocessor adapter each holding a respective microprocessor, for example, a Desktop Celeron CPU, a Mobile Celeron or Mobile Pentium II CPU, for enabling the respective microprocessor to be electrically connected to the computer main board, each microprocessor adapter having a voltage converter for converting output power supply of the computer main board into the necessary working voltage for the microprocessor.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: July 16, 2002
    Assignee: Clevo Co.
    Inventors: Chih-Wen Liu, Chih-Chuan Chang, Yue-Jen Yang, Pao Chang Lin, Chih-Chung Cheng
  • Method for treatment of tumors using nordihydroguaiaretic acid derivatives
    Publication number: 20020065310
    Abstract: Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.
    Type: Application
    Filed: May 9, 2001
    Publication date: May 30, 2002
    Inventors: Ru Chih C. Huang, Jonathan D. Heller, Chih-Chuan Chang