Patents by Inventor Chihaya Imai

Chihaya Imai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXPANSION OF NK CELLS AND THERAPEUTIC USES THEREOF
    Publication number: 20120015434
    Abstract: The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.
    Type: Application
    Filed: September 26, 2011
    Publication date: January 19, 2012
    Applicant: St. Jude Children's Research Hospital
    Inventors: Dario Campana, Chihaya Imai
  • Expansion of NK cells and therapeutic uses thereof
    Patent number: 8026097
    Abstract: The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: September 27, 2011
    Assignee: St. Jude Children's Research Hospital
    Inventors: Dario Campana, Chihaya Imai
  • EXPANSION OF NK CELLS AND THERAPEUTIC USES THEREOF
    Publication number: 20090011498
    Abstract: The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.
    Type: Application
    Filed: September 8, 2008
    Publication date: January 8, 2009
    Applicant: St. Jude Children's Research Hospital
    Inventors: Dario Campana, Chihaya Imai
  • Modified cell line and method for expansion of NK cell
    Patent number: 7435596
    Abstract: The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: October 14, 2008
    Assignee: St. Jude Children's Research Hospital, Inc.
    Inventors: Dario Campana, Chihaya Imai
  • Expansion of NK cells and therapeutic uses thereof
    Publication number: 20060093605
    Abstract: The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.
    Type: Application
    Filed: March 8, 2005
    Publication date: May 4, 2006
    Inventors: Dario Campana, Chihaya Imai
  • Chimeric receptors with 4-1BB stimulatory signaling domain
    Publication number: 20050113564
    Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use. Also included is a method for obtaining an enriched population of NK cells from a mixed population of NK cells and T cells.
    Type: Application
    Filed: November 4, 2004
    Publication date: May 26, 2005
    Inventors: Dario Campana, Chihaya Imai