Patents by Inventor Chikara Murakata
Chikara Murakata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7910611Abstract: A therapeutic and/or prophylactic agent for restenosis, which comprises a thiadiazoline derivative represented by the general formula (0), or a pharmaceutically acceptable salt thereof: [wherein, n represents an integer of 1 to 3, R0 represents aryl, —NR1CONR2 (wherein R1 represents a hydrogen atom or the like, and R2 represents lower alkyl or the like) or the like, R3 represents lower alkyl, R4 represents a hydrogen atom or the like, and R5 represents aryl or the like].Type: GrantFiled: June 22, 2006Date of Patent: March 22, 2011Assignees: Kyowa Hakko Kirin Co., Ltd., Fujifilm CorporationInventors: Ryuichiro Nakai, Emi Shimoike, Hideaki Kusaka, Chikara Murakata, Yoshinori Yamashita
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Patent number: 7902234Abstract: (wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R6 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents —C(?W)R6 or the like; R3 represents a hydrogen atom, —C(?WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.Type: GrantFiled: June 2, 2010Date of Patent: March 8, 2011Assignees: Kyowa Hakko Kirin Co., Ltd., Fujifilm CorporationInventors: Chikara Murakata, Kazuhiko Kato, Yoshihisa Ohta, Ryuichiro Nakai, Yoshinori Yamashita, Takeshi Takahashi
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Publication number: 20110004000Abstract: A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, —C(?W)R6 (wherein W represents an oxygen atom or a sulfur atom, and R6 represents substituted or unsubstituted lower alkyl and the like) and the like, R3 represents —C(?Z)R19 (wherein Z represents an oxygen atom or a sulfur atom, and R19 represents substituted or unsubstituted lower alkyl and the like) and the like, R4 represents substituted or unsubstituted lower alkyl and the like, and R5 represents substituted or unsubstituted aryl and the like] and the like are provided.Type: ApplicationFiled: September 16, 2010Publication date: January 6, 2011Applicants: KYOWA HAKKO KIRIN CO., LTD., FUJIFILM CORPORATIONInventors: Chikara MURAKATA, Yoshinori YAMASHITA, Ryuichiro NAKAI, Kazuhito AKASAKA, Yoji INO, Kazuhiko KATO, Yushi KITAMURA
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Publication number: 20100240716Abstract: (wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R6 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents —C(?W)R4 or the like; R3 represents a hydrogen atom, —C(=WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.Type: ApplicationFiled: June 2, 2010Publication date: September 23, 2010Applicants: KYOWA HAKKO KIRIN CO., LTD., FUJIFILM CORPORATIONInventors: Chikara MURAKATA, Kazuhiko KATO, Yoshihisa OHTA, Ryuichiro NAKAI, Yoshinori YAMASHITA, Takeshi TAKAHASHI
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Patent number: 7759371Abstract: (wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents —C(?W)R6 or the like; R3 represents a hydrogen atom, —C(?WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.Type: GrantFiled: April 7, 2008Date of Patent: July 20, 2010Assignees: Kyowa Hakko Kinn Co., Ltd., FUJIFILM CorporationInventors: Chikara Murakata, Kazuhiko Kato, Yoshihisa Ohta, Ryuichiro Nakai, Yoshinori Yamashita, Takeshi Takahashi
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Patent number: 7745641Abstract: The present invention provides a nitrogen-containing heterocyclic compound represented by formula (I): {wherein W represents a nitrogen atom or —CH—; X represents —C(?O)— or —CHR4— (wherein R4 represents a hydrogen atom, or the like}; R1 represents a group represented by the following formula: [wherein Q1 represents a nitrogen atom or —CR8— (wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like). Q2 represents —NR15— (wherein R15 represents a hydrogen atom, or the like) and R5 and R6 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like]; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof, and the like.Type: GrantFiled: April 19, 2006Date of Patent: June 29, 2010Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Chikara Murakata, Nobuyoshi Amishiro, Toshiyuki Atsumi, Yoshinori Yamashita, Takeshi Takahashi, Ryuichiro Nakai, Hisashi Tagaya, Hiroko Takahashi, Jun Funahashi, Junichiro Yamamoto, Yuichi Fukuda
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Publication number: 20100029625Abstract: A therapeutic and/or prophylactic agent for restenosis, which comprises a thiadiazoline derivative represented by the general formula (0), or a pharmaceutically acceptable salt thereof: [wherein, n represents an integer of 1 to 3, R0 represents aryl, —NR1CONR2 (wherein R1 represents a hydrogen atom or the like, and R2 represents lower alkyl or the like) or the like, R3 represents lower alkyl, R4 represents a hydrogen atom or the like, and R5 represents aryl or the like].Type: ApplicationFiled: June 22, 2006Publication date: February 4, 2010Applicants: KYOWA HAKKO KIRIN CO., LTD., FUJIFILM CORPORATIONInventors: Ryuichiro Nakai, Emi Shimoike, Hideaki Kusaka, Chikara Murakata, Yoshinori Yamashita
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Publication number: 20090054407Abstract: The present invention provides a nitrogen-containing heterocyclic compound represented by formula (I): {wherein W represents a nitrogen atom or —CH—; X represents —C(?O)— or —CHR4— (wherein R4 represents a hydrogen atom, or the like); R1 represents a group represented by the following formula: [wherein Q1 represents a nitrogen atom or —CR8— (wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like). Q2 represents —NR15— (wherein R15 represents a hydrogen atom, or the like) and R5 and R6 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like]; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof, and the like.Type: ApplicationFiled: April 19, 2006Publication date: February 26, 2009Applicant: Kyowa Hakko Kogyo Co., Ltd.Inventors: Chikara Murakata, Nobuyoshi Amishiro, Toshiyuki Atsumi, Yoshinori Yamashita, Takeshi Takahashi, Ryuichiro Nakai, Hisashi Tagaya, Hiroko Takahashi, Jun Funahashi, Junichiro Yamamoto, Yuichi Fukuda
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Patent number: 7425636Abstract: (wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents —C(?W)R6 or the like; R3 represents a hydrogen atom, —C(?WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.Type: GrantFiled: December 11, 2002Date of Patent: September 16, 2008Assignees: Kyowa Hakko Kogyo Co., Ltd., Fuji Photo Film Co., Ltd.Inventors: Chikara Murakata, Kazuhiko Kato, Yoshihisa Ohta, Ryuichiro Nakai, Yoshinori Yamashita, Takeshi Takahashi
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Publication number: 20080207706Abstract: (wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents —C(?W)R6 or the like; R3 represents a hydrogen atom, —C(?WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.Type: ApplicationFiled: April 7, 2008Publication date: August 28, 2008Applicants: Kyowa Hakko Kogyo Co., Ltd, Fuji Photo Film Co., Ltd.Inventors: Chikara MURAKATA, Kazuhiko Kato, Yoshihisa Ohta, Ryuichiro Nakai, Yoshinori Yamashita, Takeshi Takahashi, Tomohisa Nakano, Yoji Ino
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Publication number: 20080194653Abstract: A therapeutic and/or prophylactic agent for a solid tumor, which comprises a thiadiazoline derivative represented by the general formula (I), or a pharmaceutically acceptable salt thereof: [wherein, n represents an integer of 1 to 3, R1 represents a hydrogen atom, R2 represents lower alkyl, or R1 and R2 are combined together to represent alkylene, R3 represents lower alkyl, R4 represents NHSO2R6 (wherein R6 represents hydroxy or the like) or the like, and R5 represents aryl or the like] and the like are provided.Type: ApplicationFiled: March 22, 2006Publication date: August 14, 2008Applicants: KYOWA HAKKO KOGYO CO., LTD., FUJIFILM CORPORATIONInventors: Chikara Murakata, Kazuhiko Kato, Junichiro Yamamoto, Ryuichiro Nakai, Seiho Okamoto, Yoji Ino, Yushi Kitamura, Toshikazu Saitoh, Takeshi Katsuhira
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Publication number: 20070276017Abstract: A thiadiazoline derivative represented by the general formula (I), or a pharmacologically acceptable salt thereof: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, —COR5 (wherein R5 represents lower alkyl and the like) and the like, R3 represents lower alkyl and the like, R4 represents aryl and the like, A represents —(CH2)n— (wherein n represents an integer of 1 to 6) and the like, and B represents —NR6R7 (wherein R6 and R7 are the same or different and represent a hydrogen atom, lower alkyl and the like) and the like] is provided.Type: ApplicationFiled: June 9, 2004Publication date: November 29, 2007Inventors: Chikara Murakata, Yoji Ino, Kazuhiko Kato, Junichiro Yamamoto, Yushi Kitamura, Ryuichiro Nakai, Tomohisa Nakano, Tetsuya Tsujita
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Publication number: 20070213380Abstract: (wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents —C(?W)R6 or the like; R3 represents a hydrogen atom, —C(?WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.Type: ApplicationFiled: May 11, 2007Publication date: September 13, 2007Applicants: Kyowa Hakko Kogyo Co., Ltd., Fuji Photo Film Co., Ltd.Inventors: Chikara Murakata, Kazuhiko Kato, Yoshihisa Ohta, Ryuichiro Nakai, Yoshinori Yamashita, Takeshi Takahashi, Tomohisa Nakano, Yoji Ino
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Publication number: 20070155804Abstract: A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, —C(?W)R6 (wherein W represents an oxygen atom or a sulfur atom, and R6 represents substituted or unsubstituted lower alkyl and the like) and the like, R3 represents —C(?Z)R19 (wherein Z represents an oxygen atom or a sulfur atom, and R19 represents substituted or unsubstituted lower alkyl and the like) and the like, R4 represents substituted or unsubstituted lower alkyl and the like, and R5 represents substituted or unsubstituted aryl and the like] and the like are provided.Type: ApplicationFiled: April 16, 2004Publication date: July 5, 2007Inventors: Chikara Murakata, Yoshinori Yamashita, Ryuichiro Nakai, Kazuhito Akasaka, Yoji Ino, Kazuhiko Kato, Yushi Kitamura
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Publication number: 20070112044Abstract: An antitumor agent comprising a thiadiazoline derivative represented by the general formula (I), or a pharmacologically acceptable salt thereof as an active ingredient: (wherein Z represents a sulfur atom and the like, R1 represents substituted or unsubstituted lower alkynyl and the like, R2 represents a hydrogen atom and the like, R3 represents substituted or unsubstituted lower alkyl and the like, and R4 represents substituted or unsubstituted aryl and the like), and the like are provided.Type: ApplicationFiled: October 8, 2004Publication date: May 17, 2007Applicants: Kyowa Hakko Kogyo Co., Ltd., Fuji Photo Film Co., Ltd.Inventors: Chikara Murakata, Nobuyoshi Amishiro, Yoji Ino, Junichiro Yamamoto, Toshiyuki Atsumi, Ryuichiro Nakai, Tomohisa Nakano
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Publication number: 20060074113Abstract: (wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents —C(?W)R6 or the like; R3 represents a hydrogen atom, —C(?WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.Type: ApplicationFiled: December 11, 2002Publication date: April 6, 2006Inventors: Chikara Murakata, Kazuhiko Kato, Yoshihisa Ohta, Ryuichiro Nakai, Yoshinori Yamashita, Takeshi Takahashi, Tomohisa Nakano, Yoji Ino
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Publication number: 20060035875Abstract: A therapeutic agent for a hormone-dependent cancer, which comprises (a) a steroid-sulfatase inhibitor and (b) an agent for hormone therapy and/or an agent for chemotherapy, which may be administered together or separately at an interval, is provided. A method for treating a hormone-dependent cancer, which comprises administering (a) a steroid-sulfatase inhibitor and (b) an agent for hormone therapy and/or an agent for chemotherapy together or separately at an interval, is also provided. A steroid-sulfatase inhibitor which is used in combination with an agent for hormone therapy and/or an agent for chemotherapy, and which is administered together therewith or separately therefrom at an interval, is also provided. A kit for treating a hormone-dependent cancer, which comprises a first component comprising (a) a steroid-sulfatase inhibitor and a second component comprising (b) an agent for hormone therapy and/or an agent for chemotherapy, is also provided.Type: ApplicationFiled: October 9, 2003Publication date: February 16, 2006Inventors: Yukimasa Shiotsu, Hiroyuki Ishida, Chikara Murakata, Hideaki Kusaka, Shiro Akinaga
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Patent number: 6953785Abstract: Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I): {wherein R1 and R2 are the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; R3 represents a hydrogen atom etc.; R4 represents a hydrogen atom etc.; R5 represents a hydrogen atom etc.; R6 represents a cyano group, an amino group, COR53 (wherein R53 represents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 24, 2001Date of Patent: October 11, 2005Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Tsutomu Agatsuma, Kozue Muramatsu, Takeshi Takahashi, Shiro Akinaga, Chikara Murakata
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Patent number: 6875865Abstract: Disclosed herein are selected indolocarbazole derivatives which are represented by the general formula: The compounds are useful for enhancing the function and/or survival of a trophic factor responsive cell. They inhibit interleukin-2 production and have immunosuppressive activity.Type: GrantFiled: November 8, 2000Date of Patent: April 5, 2005Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, John P. Mallamo, Masami Hamano, Rieko Tanaka, Chikara Murakata
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Publication number: 20050070591Abstract: There is provided an indole derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of malignant tumor or a brain neurodegenerative disease: (wherein C ring represents a benzene ring or a cyclohexene ring; X and Y are the same or different and each represent —CH2—, —CH(OH)—, —CH(ORx)—, —CH(SRY)— or carbonyl; R1 and R2 are the same or different and each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or substituted or unsubstituted lower alkanoyl or R1 and R2 form a benzene ring together two carbon atoms each being adjacent thereto; and R3, R4 and R5 are the same or different and each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.Type: ApplicationFiled: December 17, 2002Publication date: March 31, 2005Inventors: Fumihiko Kanai, Chikara Murakata, Tetsuya Tsujita, Yoshinori Yamashita, Shiro Akinaga, Tamio Mizukami