Patents by Inventor Chikara Murakata
Chikara Murakata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040254241Abstract: The present invention provides an aryl sulfamate derivative represented by Formula (I) 1Type: ApplicationFiled: July 12, 2004Publication date: December 16, 2004Inventors: Yoji Ino, Nobuyoshi Amishiro, Kozue Muramatsu, Yukimasa Shiotsu, Chikara Murakata
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Patent number: 6806266Abstract: The present invention provides an antitumor agent comprising a staurosporin derivative or a pharmaceutically acceptable salt thereof, as an active ingredient, which is represented by the general formula (I): wherein R1 represents hydrogen, hydroxy or lower alkoxy, R2 and R3 are the same or different and represent hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted aryl, a substituted or unsubstituted heterocyclic group, halogen, nitro, formyl, etc., R4 represents hydrogen, etc., R5 represents NR11AR12A (wherein R11A and R12A represent hydrogen, substituted or unsubstituted lower alkyl, etc.), provided that R2 and R3 are not simultaneously hydrogen.Type: GrantFiled: January 11, 2002Date of Patent: October 19, 2004Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumihiko Kanai, Nobuyoshi Amishiro, Yushi Kitamura, Chikara Murakata, Tadakazu Akiyama, Shiro Akinaga, Eiichi Fuse, Takashi Kuwabara, Kenichi Yasoshima
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Publication number: 20040053990Abstract: Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: 1Type: ApplicationFiled: July 30, 2003Publication date: March 18, 2004Applicant: KYOWA HAKKO KOGYO CO., LTDInventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Chikara Murakata, Harumi Ogawa, Tadakazu Akiyama, Shiro Akinaga, Shiro Soga, Yukimasa Shiotsu
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Patent number: 6638923Abstract: Estra-1,3,5(10),16-tetraene derivatives represented by the following formula (I): (wherein R1 is as defined by the present specification.Type: GrantFiled: May 18, 2001Date of Patent: October 28, 2003Assignees: Kyowa Hakko Kogyo Co., Ltd., Duquesne University of the Holy GhostInventors: Yoji Ino, Nobuyoshi Amishiro, Taisuke Nakata, Hiroyuki Ishida, Shiro Akinaga, Chikara Murakata, Pui-Kai Li
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Patent number: 6635662Abstract: Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: wherein R1 and R2 are the same or different, and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl or tert-butyldimethylsilyl; R3 represents Y—R5 {wherein Y represents substituted or unsubstituted alkylene; and R5 represents CONR5R7 (wherein R6 represents hydrogen, hydroxyl, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl, and the like; R7 represents hydroxyl, substituted lower alkyl, and the like), CO2R12 (wherein R12 represents substituted lower alkyl, substituted or unsubstituted higher alkyl, and the like), and the like} and the like; X represents halogen or is combined together with R4 to represent a single bond; and R4 is combined together with X to represent a single bond, or represents hydrogen, alkanoyl, and the like.Type: GrantFiled: February 26, 2001Date of Patent: October 21, 2003Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Chikara Murakata, Harumi Ogawa, Tadakazu Akiyama, Shiro Akinaga, Shiro Soga, Yukimasa Shiotsu
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Patent number: 6436918Abstract: Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of a patient are also disclosed.Type: GrantFiled: November 8, 2001Date of Patent: August 20, 2002Assignees: Duquesne University of the Holy Ghost, Kyowa Hakko Kogyo Co., Ltd.Inventors: Pui-Kai Li, Chikara Murakata, Shiro Akinaga
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Publication number: 20020068726Abstract: Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of a patient are also disclosed.Type: ApplicationFiled: November 8, 2001Publication date: June 6, 2002Inventors: Pui-Kai Li, Chikara Murakata, Shiro Akinaga
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Patent number: 6399595Abstract: Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of a patient are also disclosed.Type: GrantFiled: August 3, 2001Date of Patent: June 4, 2002Assignees: Duquesne University of the Holy Ghost, Kyowa Hakko Kogyo Co., Ltd.Inventors: Pui-Kai Li, Chikara Murakata, Shiro Akinaga
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Publication number: 20020058651Abstract: Estra-1,3,5(10),16-tetraene derivatives represented by the following formula (I): 1Type: ApplicationFiled: May 18, 2001Publication date: May 16, 2002Inventors: Yoji Ino, Nobuyoshi Amishiro, Taisuke Nakata, Hiroyuki Ishida, Shiro Akinaga, Chikara Murakata, Pui-Kai Li
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Patent number: 6376687Abstract: Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of a patient are also disclosed.Type: GrantFiled: January 24, 2000Date of Patent: April 23, 2002Assignees: Duquesne University of the Holy Ghost, Kyowa Hakko Kogyo Co., Ltd.Inventors: Pui-Kai Li, Chikara Murakata, Shiro Akinaga
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Patent number: 6316491Abstract: Radioicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: wherein R1 and R2 are the same or different, and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl or tert-butyldimethylsilyl; R3 represents Y—R5 (wherein Y represents substituted or unsubstituted alkylene; and R5 represents CONR6R7 (wherein R6 represents hydrogen, hydroxyl, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl, and the like; R7 represents hydroxyl, substituted lower alkyl, and the like), CO2R12 (wherein R12 represents substituted lower alkyl, substituted or unsubstituted higher alkyl, and the like), and the like) and the like; X represents halogen or is combined together with R4 to represent a single bond; and R4 is combined together with X to represent a single bond, or represents hydrogen, alkanoyl, and the like.Type: GrantFiled: June 24, 1998Date of Patent: November 13, 2001Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Chikara Murakata, Harumi Ogawa, Tadakazu Akiyama, Shiro Akinaga, Shiro Soga, Yukimasa Shiotsu
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Patent number: 6306849Abstract: Disclosed herein are selected indolocarbazole derivatives which are represented by the general formula: The compounds are useful for enhancing the function and/or survival of a trophic factor responsive cell. They inhibit interleukin-2 production and have immunosuppressive activity.Type: GrantFiled: June 2, 1997Date of Patent: October 23, 2001Assignee: Cephalon, Inc.Inventors: Robert L. Hudkins, John P. Mallamo, Masami Hamano, Reiko Tanaka, Chikara Murakata
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Publication number: 20010027208Abstract: Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: 1Type: ApplicationFiled: February 26, 2001Publication date: October 4, 2001Inventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Chikara Murakata, Harumi Ogawa, Tadakazu Akiyama, Shiro Akinaga, Shiro Soga, Yukimasa Shiotsu
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Patent number: 6288050Abstract: Sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of a patient are also disclosed.Type: GrantFiled: January 25, 1999Date of Patent: September 11, 2001Assignees: Duquesne University of the Holy Ghost, Kyowa Hakko Kogyo Co., Ltd.Inventors: Pui-Kai Li, Chikara Murakata, Shiro Akinaga
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Patent number: 6262043Abstract: Estra-1,3,5(10),16-tetraene derivatives represented by the following formula (I): (wherein R1 represents hydroxy, alkoxy, or NR2R3 (wherein R2 and R3 are the same or different, and each represents hydrogen, straight-chain lower alkyl having 1 to 3 carbon atoms, or branched-chain lower alkyl having 3 to 8 carbon atoms)), or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 13, 2000Date of Patent: July 17, 2001Assignees: Kyowa Hakko Kogyo Co., Ltd., Duquesne University of the Holy GhostInventors: Yoji Ino, Nobuyoshi Amishiro, Taisuke Nakata, Hiroyuki Ishida, Shiro Akinaga, Chikara Murakata, Pui-Kai Li
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Patent number: 6239168Abstract: Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: wherein R1 and R2 are the same or different, and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl or tert-butyldimethylsilyl; R3 represents Y—R5 {wherein Y represents substituted or unsubstituted alkylene; and R5 represents CONR6R7 (wherein R6 represents hydrogen, hydroxyl, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl; R7 represents hydroxyl, substituted lower alkyl), CO2R12 (wherein R12 represents substituted lower alkyl, substituted or unsubstituted higher alkyl, X represents halogen.Type: GrantFiled: February 25, 2000Date of Patent: May 29, 2001Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Chikara Murakata, Harumi Ogawa, Tadakazu Akiyama, Shiro Akinaga, Shiro Soga, Yukimasa Shiotsu
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Patent number: 6080771Abstract: DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents CO(CR.sup.4A R.sup.4B).sub.n1 (O(CH.sub.2).sub.p1).sub.n2 OR.sup.5 {wherein n1 represents an integer of 1 or 2; R.sup.4A and R.sup.4B are the same or different, and each represents hydrogen or lower alkyl; p1 and n2 each represents an integer of 1 to 10; and R.sup.Type: GrantFiled: August 13, 1998Date of Patent: June 27, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yutaka Kanda, Hitoshi Arai, Hiroyuki Yamaguchi, Tadashi Ashizawa, Shun-ichi Ikeda, Chikara Murakata, Tatsuya Tamaoki
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Patent number: 5981558Abstract: DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4, or the like; R.sup.2 represents hydrogen or COR.sup.6 ; R.sup.3 represents --CH.sub.2 OCOR.sup.7, phthalimidomethyl, or the like; and W represents oxygen or NR.sup.8 (wherein R.sup.8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino).Type: GrantFiled: August 13, 1998Date of Patent: November 9, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hitoshi Arai, Yutaka Kanda, Hiroyuki Yamaguchi, Tadashi Ashizawa, Chikara Murakata, Shun-ichi Ikeda, Tatsuya Tamaoki
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Patent number: 5756494Abstract: The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.Type: GrantFiled: June 2, 1995Date of Patent: May 26, 1998Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Michael E. Lewis, James C. Kauer, Nicola Neff, Jill Roberts-Lewis, Chikara Murakata, Hiromitsu Saito, Yuzuru Matsuda, Marcie A. Glicksman, Fumihiko Kanai, Masami Kaneko
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Patent number: 5741808Abstract: The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.Type: GrantFiled: February 14, 1997Date of Patent: April 21, 1998Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Michael E. Lewis, James C. Kauer, Nicola Neff, Jill Roberts-Lewis, Chikara Murakata, Hiromitsu Saito, Yuzuru Matsuda, Marcie A. Glicksman, Fumihiko Kanai, Masami Kaneko