Abstract: The present invention provides antibodies that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further provides bispecific antibodies that bind to EGFRvIII and another antigen (e.g., CD3) as well as antibody conjugates (e.g., antibody-drug-conjugates). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific) and antibody conjugates. The invention further relates to therapeutic methods for use of these antibodies and antibody conjugates for the treatment of EGFRvIII-mediated pathologies, including cancer such as glioblastoma.

Abstract: The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.

Abstract: The present invention relates a method for detecting a target in a sample, which can acquire a concentration of the target in a sample by detecting the reaction between a complex and a substrate. The complex comprises a first composition, a target, and a second composition, and the second composition comprises a plurality of enzyme to catalyze the reaction of the substrate.

Abstract: The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.

Abstract: The bike's crank speed and crank position are sensed via a micro controller, torque sensor, gyro and accelerator disposed on the bike's crank. External power and control signals can be passed to and from the crank micro controller and the e-bike controller through a throttle connector of the e-bike controller via slip rings around the crank hub with bearings, fixed rings, bushings or springs contacting the respective slip rings. Throttle data can also be provided to the e-bike controller wirelessly via a wireless dongle coupled to the throttle connector of e-bike controller.

Abstract: The bike's crank speed and crank position are sensed via a micro controller, torque sensor, gyro and accelerator disposed on the bike's crank. External power and control signals can be passed to and from the crank micro controller and the e-bike controller through a throttle connector of the e-bike controller via slip rings around the crank hub with and with pogo pin connectors connected to the respective slip rings. Throttle data can also be provided to the e-bike controller wirelessly via a wireless dongle coupled to the throttle connector of e-bike controller.

Abstract: A tray appliance system is usable for obtaining a bite registration and includes a maxillary tray appliance and optionally a mandibular tray appliance. The maxillary tray appliance includes a first contacting portion that extends downwardly from a first base portion. The first contacting portion includes a first contacting surface, a first ridge line, and a first ridge line midpoint. The optional mandibular tray appliance includes a second contacting portion that includes a second contacting surface, a second ridge line, and a second ridge line midpoint. The first contacting portion and second contacting portion contact each other when a patient bites down with the maxillary tray appliance and the mandibular tray appliance situated in the patient's mouth.

Abstract: The present invention provides antibodies that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further provides bispecific antibodies that bind to EGFRvIII and another antigen (e.g., CD3) as well as antibody conjugates (e.g., antibody-drug-conjugates). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific) and antibody conjugates. The invention further relates to therapeutic methods for use of these antibodies and antibody conjugates for the treatment of EGFRvIII-mediated pathologies, including cancer such as glioblastoma.

Abstract: A method of manufacturing a one-piece textile by a jacquard machine includes a preparation step, a jacquard weaving step, a textile separation step, and a textile ironing step. A woven cloth is made of the method and includes a base fabric and multiple textiles connected with the base fabric by at least one sewing area. The woven cloth is a one-piece structure made by a jacquard machine. The textiles are separated by trimming the at least one sewing area from the woven cloth. Each textile is a complete product with a one-piece structure without sewing. The manufacturing method can improve the efficiency of textile production.

Abstract: A tray appliance system is usable for obtaining a bite registration and includes a maxillary tray appliance and optionally a mandibular tray appliance. The maxillary tray appliance includes a first contacting portion that extends downwardly from a first base portion. The first contacting portion includes a first contacting surface, a first ridge line, and a first ridge line midpoint. The optional mandibular tray appliance includes a second contacting portion that includes a second contacting surface, a second ridge line, and a second ridge line midpoint. The first contacting portion and second contacting portion contact each other when a patient bites down with the maxillary tray appliance and the mandibular tray appliance situated in the patient's mouth.

Abstract: A method of making a maxillary tray appliance comprises obtaining a first virtual model of an edentulous maxillary gum of a patient, and obtaining a virtual component, where the virtual component comprises a virtual contacting surface. The method further comprises receiving the first virtual model, aligning the first virtual model or the virtual component in 3D space, generating a virtual tray appliance, and fabricating a maxillary tray appliance using the virtual tray appliance.

Abstract: An apparatus allocation controller includes a control circuit, a bus, and a read-only memory. The control circuit includes multiple switch chipsets. The switch chipsets are electrically connected to multiple servers through multiple connection ports. The bus is electrically connected to multiple peripheral apparatuses. The control circuit sets a unique identifier belonging to the apparatus allocation controller and writes the unique identifier to a read-only memory of each of the switch chipsets. The control circuit determines a resource allocation table according to the unique identifier of the apparatus allocation controller, a plurality of switch chipset serial numbers corresponding to the switch chipsets and a plurality of station numbers. The resource allocation table is configured to recognize resource usage statuses of the servers using the peripheral apparatuses through the apparatus allocation controller. In addition, a resource allocation system and an apparatus recognizing method are also provided.

Abstract: A method for manufacturing a copper composite electrode, including contacting a conductive substrate including copper with a phosphate solution for oxidation to produce a copper phosphate structure on a surface of the conductive substrate, thus acquiring a copper phosphate composite electrode.

Abstract: A paper separation mechanism includes a separation roller assembly, a one-way clutch module, a transmission gear assembly connected with and driving the one-way clutch module, a driving motor for driving the transmission gear assembly, and a locking module. The separation roller assembly includes a separation shaft, a separation roller fastened around the separation shaft, and a pickup roller disposed to the separation roller. The one-way clutch module includes a gear shaft, and a one-way clutch mounted around the gear shaft. The locking module includes a swing arm, a hooking portion fastened to a bottom of the swing arm, a blocking portion fastened under the swing arm, and a spring disposed to the bottom of the swing arm. One side of the swing arm is fastened to the gear shaft, the other side of the swing arm is fastened to the separation shaft.

Abstract: An apparatus allocating controller is provided in the invention. The apparatus allocating controller includes a bus, a communication interface, and a processor. The bus is coupled to a peripheral apparatus, and the peripheral apparatus meets the peripheral component interconnect express. The communication interface is coupled to a server. The apparatus allocating controller and the peripheral apparatus communicate with the server through the communication interface. The processor is coupled to the bus. The processor is configured to allocate the peripheral apparatus to the server, and monitors the connection status of the peripheral apparatus and the bus. When another peripheral apparatus hot plugs in the bus so that a hot-plug event occurs on the bus, the processor determines whether the another peripheral apparatus has a physical function or a virtual function, and the processor reallocates the peripheral apparatus to the server according to the hot-plug event.

Abstract: An apparatus assigning controller is provided. The apparatus assigning controller includes a plurality of peripheral apparatuses, a processor, and a communication interface. The peripheral apparatuses and the communication interface meet the peripheral component interconnect express. The processor is coupled to the peripheral apparatuses by a bus meeting the peripheral component interconnect express. The communication interface is coupled to the processor. A server is coupled to the apparatus assigning controller through the communication interface. When the server is started, the processor receives an apparatus scanning requirement of the server, and provides a predetermined apparatus information to the server, wherein the server reserves a corresponding hardware resource and a corresponding memory space according to the predetermined apparatus information.

Abstract: An apparatus assigning controller is provided. The apparatus assigning controller includes a communication interface and a routing apparatus. The communication interface is configured to respectively connect to a plurality of external servers. The routing apparatus is connected to the communication interface. The routing apparatus is configured to provide a data transfer path between the plurality of servers, so as to connect the routing apparatus to the plurality of servers through the communication interface. The plurality of servers share data with each other via the routing apparatus according to a peripheral component interconnect express (PCI Express) communication protocol. A data sharing method is also provided.

Abstract: A filtering module includes a first inductor and a first capacitor. The first inductor has a first inductance varied by varying the current into the first inductor. The first capacitor is electrically connected to the first inductor. The filtering bandwidth of the filtering module is varied by varying the current into the filtering module.

Abstract: A filtering module includes a first inductor and a first capacitor. The first inductor has a first inductance varied by varying the current into the first inductor. The first capacitor is electrically connected to the first inductor. The filtering bandwidth of the filtering module is varied by varying the current into the filtering module.

Abstract: The present invention provides antibodies that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further provides bispecific antibodies that bind to EGFRvIII and another antigen (e.g., CD3) as well as antibody conjugates (e.g., antibody-drug-conjugates). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific) and antibody conjugates. The invention further relates to therapeutic methods for use of these antibodies and antibody conjugates for the treatment of EGFRvIII-mediated pathologies, including cancer such as glioblastoma.