Abstract: The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.

Abstract: An electrical deposition apparatus includes a brush plating head. The brush plating head includes a plurality of channels, and there are openings at the same surface of the brush plating head. Each of the channels extends from within the brush plating head to each of the openings.

Abstract: A funnel assembly used for adding motor oil to cars or motorcycles is revealed. The funnel assembly includes a main body, a first sleeve, an extension tube, a second sleeve and a cover. The main body is connected to the first sleeve and the first sleeve is assembled with the extension tube. The extension tube is connected to the second sleeve and the second sleeve is assembled with the cover. The first sleeve and the extension tube can be assembled with each other toward different directions and so do the second sleeve and the cover. Thereby the funnel assembly can be applied to and mounted into oil fill holes at different positions of various cars.

Abstract: A spring probe includes a needle, a spring sleeve sleeved onto and fixed to the needle and having non-spring sections and at least one spring section, and an outer sleeve sleeved onto the spring sleeve and covering the at least one spring section. A part of the outer sleeve is connected with the spring sleeve. A probe device includes the spring probe, and a probe seat having dies piled on one another, including upper and lower dies. The spring probe is inserted through the dies in a way that a bottom end of the spring sleeve is abutted on the lower die.

Abstract: An assembly tool for assembly and replacement of bolts on a wheel hub is revealed. The tool includes a first tool set and a second tool set. The first tool set has a base and a fastener. The base is a circular body with a receiving part. A pad is disposed on the receiving part and a bearing is arranged under the pad. The fastener includes a hexagonal head, an enlarged part, a cylindrical part and an axial hole arranged with a thread. The second tool set has a first arm and a second arm pivotally connected to each other. A wheel bolt is pressed into the wheel hub by the first tool set while the wheel hub is positioned by the first and second arms of the second tool set fastened with the wheel bolts of the wheel hub for convenient assembly of the wheel bolts.

Abstract: The present invention relates to a funnel apparatus for filling of liquids, which comprises a funnel, a sealing means, a locking means, and a soft tube. The funnel apparatus has a fluid receiving member and a tubular member provided for carrying fluid. The latter has a passageway that has a top end portion installed with a handle, and a bottom end portion equipped with a stopper provided for blocking movement of the tubular member. The plunger rod has recessed portions patterned in a longitudinal orientation across its surface. The locking means has an assembly bore and a rim connected with a series of spokes; the assembly bore is fixedly disposed at an end of the receiving member so the plunger rod stretches over the assembly bore and can move axially thereby. The soft tube is inserted into the recessed portions on the plunger rod for providing an air exchange functionality.

Abstract: An atomizing apparatus for development of biological trace evidence comprises a container which has an opening and a housing space communicating with the opening, a trace evidence developing solution held in the housing space to develop a biological trace evidence and an atomizer located in the opening. The atomizer includes a piezoelectric vibration element in contact with the trace evidence developing solution. The piezoelectric vibration element can shake the trace evidence developing solution via high frequency vibration to form a plurality of small liquid particles to be discharged outside the container. The small liquid particles of the trace evidence developing solution pass through the opening and spray directly on the biological trace evidence to generate an oxidized reduction reaction therewith to produce colored substance to reveal the biological trace evidence in a visible fashion.

Abstract: A funnel assembly used for adding motor oil to cars or motorcycles is revealed. The funnel assembly includes a main body, a first sleeve, an extension tube, a second sleeve and a cover. The main body is connected to the first sleeve and the first sleeve is assembled with the extension tube. The extension tube is connected to the second sleeve and the second sleeve is assembled with the cover. The first sleeve and the extension tube can be assembled with each other toward different directions and so do the second sleeve and the cover. Thereby the funnel assembly can be applied to and mounted into oil fill holes at different positions of various cars.

Abstract: An assembly tool for assembly and replacement of bolts on a wheel hub is revealed. The tool includes a first tool set and a second tool set. The first tool set has a base and a fastener. The base is a circular body with a receiving part. A pad is disposed on the receiving part and a bearing is arranged under the pad. The fastener includes a hexagonal head, an enlarged part, a cylindrical part and an axial hole arranged with a thread. The second tool set has a first arm and a second arm pivotally connected to each other. A wheel bolt is pressed into the wheel hub by the first tool set while the wheel hub is positioned by the first and second arms of the second tool set fastened with the wheel bolts of the wheel hub for convenient assembly of the wheel bolts.

Abstract: A transmission device for an automatic document feeder includes a driving gear set driven by a driving motor, a first swing arm equipped with a first driving roller set, a second swing arm equipped with a second driving roller set, and a one-way gear set driven by the driving gear set to keep transmitting rollers rotating in the same direction. The first swing arm is driven by the driving gear set and swingable between a first position and a second position to mesh the first driving roller set with a pickup device or an output device. The second swing arm is driven by the driving gear set and swingable between a third position and a fourth position to mesh the second driving roller set with the pickup device or the output device. When the first swing arm swings toward the first position, the second arm swings toward the fourth position, and when the first swing arm swings toward the second position, the second swing arm swings to the third position.

Abstract: A layer-type complex structure includes a base layer, a decoration layer fixed to the top surface of the base layer, a cured resin layer attached to the top surface of the decoration layer and a portion of the base layer that is not covered by the decoration layer, and a decoration structure formed on the top surface of the cured resin layer. The decoration layer provides patterns and/or colors displayed on the surface of the complex structure. The decoration structure is a smooth surface or a stereoscopic surface.

Abstract: The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof.

Abstract: A battery core and a method of manufacturing the same are disclosed herein. The battery core includes a first electrode plate and a second electrode plate. The first electrode plate includes a substrate and a first active material. A first portion of the first active material is formed on a first area of the substrate, and a second portion of the first active material is formed on a second area of the substrate. The second electrode plate includes first and second substrates disconnected from each other, and a second active material. The first and second substrates are positioned corresponding to the first and second first areas respectively. A first portion of the second active material is formed on the first substrate, and a second portion of the second active material is formed on the second substrate.

Abstract: An electrochemical affinity sensing chip integrated with fluidic stirring suitable for sensing objects is provided. The electrochemical affinity sensing chip integrated with fluidic stirring includes a substrate and a plurality of electrochemical-sensing electrode groups. The electrochemical-sensing electrode groups are disposed on the substrate and for electrochemically sensing the object. Each electrode group comprises a disk electrode, a first ring electrode, and a second ring electrode. The disk electrode is disk-shaped, and the electrode surface is immobilized with a probe. The first ring electrode is curved and surrounds the disk electrode. The second ring electrode is curved and surrounds the first ring electrode. The first ring electrode and the second ring electrode produce an alternating current electrohydrodynamic (ACEHD) stirring to promote the hybridization efficiency between the objects and the probes immobilized on the surface of disk electrode.

Abstract: A striking tool for pounding or hammering is revealed. The striking tool includes a handle, a neck and a head. The neck is extended from one end of the handle and the head is formed by extension of one end of the neck. The neck has resilience. The head consists of a first head threaded with a first striking element and a second head threaded with a second striking element. The design of the structure minimizes bounce of the handle.

Abstract: The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof.

Abstract: An automatic document feeder includes a paper transmitting path for guiding documents, a driving motor for providing driving torque, a pickup device disposed at the upstream of the paper transmitting path, an output device disposed at the downstream of the paper transmitting path and transmitting rollers disposed along the paper transmitting path for transmitting the documents, a first driving gear disposed between the pickup device and the output device, a transmitting gear swing arm equipped with a transmitting gear set and axially hinged with the first driving gear to swing according to the driving torque between a first position meshing the transmitting gear set with the pickup device and a second position idling the transmitting gear set, an actuator connected with the output device and a braking device disposed on the output device for locking the transmitting gear swing arm according to the position of the output device.