Abstract: The present disclosure relates to methods, compositions, and kits for isolating target nucleic acids below a target size from a sample comprising nucleic acid components. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions, at least one solid phase medium, and at least one buffer. Some embodiments provide a kit comprising one or more ATPS compositions, at least one solid phase medium, and at least one buffer. Other embodiments provide methods for diagnosing a disease or condition using the methods described herein.

Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.

Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.

Abstract: A coaxial container for dispensing a tubular product has an inner tube connected to a rotating base allowing the inner tube and the rotating base to rotate relatively. A plurality of elastic latches are arranged in a full circle and disposed on a bottom portion of the inner tube connected to the rotating base, each elastic latch has a harder and thicker first potion and a softer and thinner second potion, and the first potion of the elastic latch is capable of making contact with the inner tube.

Abstract: Therapeutic combinations that comprise at least one antagonist of the Programmed Death 1 receptor (PD-1) and at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway are disclosed herein. Also disclosed is the use of such therapeutic combinations for the treatment of cancers.

Abstract: Therapies comprising administering at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway, and the use of such therapies in the treatment of cell-proliferation disorders such as cancer, are disclosed herein.

Abstract: A coaxial container for dispensing a tubular product has an inner tube connected to a rotating base allowing the inner tube and the rotating base to rotate relatively. A plurality of elastic latches are arranged in a full circle and disposed on a bottom portion of the inner tube connected to the rotating base, each elastic latch has a harder and thicker first potion and a softer and thinner second potion, and the first potion of the elastic latch is capable of making contact with the inner tube.

Abstract: Therapeutic combinations that comprise at least one antagonist of the Programmed Death 1 receptor (PD-1) and at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway are disclosed herein. Also disclosed is the use of such therapeutic combinations for the treatment of cancers.

Abstract: The present invention relates to methods for treating cancer in a patient comprising administering an anti-PD-1 antibody or antigen binding fragment thereof in specific amounts to the patient about every six weeks, in combination with administering an anti-CTLA4 antibody to the patient about every six weeks. In certain embodiments, the PD-1 antagonist is pembrolizumab, or an antigen binding fragment thereof. Also provided are compositions comprising a dosage of an anti-PD-1 antibody, or antigen-binding fragment thereof, and a dosage of an anti-CTLA4 antibody or antigen-binding fragment thereof, and uses thereof for treating cancer.

Abstract: Therapies comprising administering at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway, and the use of such therapies in the treatment of cell-proliferation disorders such as cancer, are disclosed herein.

Abstract: Therapies comprising administering at least one cyclic dinucleotide compound that activates the Stimulator of Interferon Genes (STING) pathway, and the use of such therapies in the treatment of cell-proliferation disorders such as cancer, are disclosed herein.

Abstract: Therapeutic combinations that comprise at least one antagonist of the Programmed Death 1 receptor (PD-1) and at least one cyclic dinucleotide compound that activates the Stimulator of Interferon Genes (STING) pathway are disclosed herein. Also disclosed is the use of such therapeutic combinations for the treatment of cancers.

Abstract: Systems, methods, and software can be used to verify a certificate. In some aspects, a request to connect to a Virtual Private Network (VPN) server is received from an application on a mobile device. A certificate of the VPN server is obtained at the mobile device. A device-level certificate verification for the certificate is performed. Whether an application-level certificate verification is provisioned for the application is determined. In response to determining that the application-level certification verification is provisioned, the application-level certificate verification for the certificate is performed. In response to verifying that the certificate passes the application-level certificate verification, the mobile device is connected to the VPN server.

Abstract: A serialization service module is provided for configuring an asset management system to provide a secure means of generating, assigning to chips (or other electronic objects or devices), and tracking unique serial numbers. To provide this service, a controller connects through a secure, encrypted connection to appliances at a manufacturer's location. Agents can then request serial number values from an appliance by product name. The serial numbers are generated by the appliance, metered, and provided to the agents. The serial numbers are then injected sequentially into each die in a chip manufacturing process using the agent. A log is reported to the controller.

Abstract: Systems, methods, and software can be used to verify a certificate. In some aspects, a request to connect to a Virtual Private Network (VPN) server is received from an application on a mobile device. A certificate of the VPN server is obtained at the mobile device. A device-level certificate verification for the certificate is performed. Whether an application-level certificate verification is provisioned for the application is determined. In response to determining that the application-level certification verification is provisioned, the application-level certificate verification for the certificate is performed. In response to verifying that the certificate passes the application-level certificate verification, the mobile device is connected to the VPN server.

Abstract: Plural modes of operation may be established on a mobile device. Specific modes of operation of the mobile device may be associated with specific spaces in memory. By using a “class” designation within the existing certificate store structure and key store structure, certificates and keys can be assigned to one space among plural spaces. Accordingly, a personal certificate store and a personal key store may exist in a personal space. Similarly, a corporate certificate store and a corporate key store may exist in a corporate space. APIs designed to work within such a system may be arranged to employ a “class” attribute when managing certificates and cryptographic keys.

Abstract: A serialization service module is provided for configuring an asset management system to provide a secure means of generating, assigning to chips (or other electronic objects or devices), and tracking unique serial numbers. To provide this service, a controller connects through a secure, encrypted connection to appliances at a manufacturer's location. Agents can then request serial number values from an appliance by product name. The serial numbers are generated by the appliance, metered, and provided to the agents. The serial numbers are then injected sequentially into each die in a chip manufacturing process using the agent. A log is reported to the controller.

Abstract: A method and a mobile device having a plurality of modes of operation, the method associating each connection interface on the mobile device with one of a plurality of modes; and restricting access to a profile for each connection interface on the mobile device to only a subset of applications based on the mode associated with the profile.

Abstract: Plural modes of operation may be established on a mobile device. Specific modes of operation of the mobile device may be associated with specific spaces in memory. By associating the existing certificate store structure and key store structure with a mode of operation, certificates and keys can be assigned to one space among plural spaces. Furthermore, management (viewing/importation/deletion) of certificates associated with specific modes of operation may be controlled based on the presence or absence of a mobile device administration server and the status (enabled/disabled) of an IT policy.

Abstract: A serialization service module is provided for configuring an asset management system to provide a secure means of generating, assigning to chips (or other electronic objects or devices), and tracking unique serial numbers. To provide this service, a controller is used to define a product model, then to define one or more serialization schemas to be bound to each product model. Each serialization schema contains a range of serial numbers for a particular product. The serial number schemas are sent over a secure, encrypted connection to appliances at the manufacturer's location. Agents can then request serial number values by product name. The serial numbers are generated by the appliance, metered, and provided to the agents. The serial numbers are then injected sequentially into each die in a chip manufacturing process using the agent.