Abstract: This application provides an electrode sheet and an electrochemical device. The electrode sheet includes a current collector and a functional coating located on at least one surface of the current collector. The functional coating includes a first coating, a second coating and an active material layer that are sequentially stacked on a surface of the current collector. The first coating includes a conductive agent, a binder and a first functional filler, and the second coating includes a conductive agent, a binder and a second functional filler. A mass ratio of the binder in the first coating to the first coating is a1, a mass ratio of the binder in the second coating to the second coating is a2, and a mass ratio of the binder in the active material layer to the active material layer is a3, and a1>a2>a3.

Abstract: A nanofibrous catalyst for in the electrolyzer and methods of making the catalyst. The catalysts are composed of highly porous transition metal carbonitrides, metal oxides or perovskites derived from the metal-organic frameworks and integrated into a 3D porous nano-network electrode architecture. The catalysts are low-cost, highly active toward OER, with excellent conductivity yet resistant to the oxidation under high potential operable under both acidic and alkaline environments.

Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3E (T-cell surface glycoprotein CD3 epsilon chain), CD3D (T-cell surface glycoprotein CD3 delta chain), and/or CD3G (T-cell surface coprotein CD3 gamma chain), and methods of use thereof.

Abstract: The present disclosure describes techniques for determining performance of a classifier. A first machine learning model and a second machine learning model may be trained by aggregating updates to the first machine learning model and the second machine learning model received from a plurality of client computing devices. A cumulative distribution function (CDF) associated with a distribution of the positive samples in the user data may be estimated using the trained first machine learning model. A probability density function (PDF) associated with a distribution of the negative samples in the user data may be estimated using the trained second machine learning model. An integration-based computation of an area under the receiver operating characteristic curve (AUC) of the classifier may be performed using the PDF and the CDF.

Abstract: Provided are an electrokinetic device and method for in-situ leaching of uranium, belonging to the technical field of in-situ leaching of uranium. The electrokinetic device for in-situ leaching of uranium includes an injection well, a pumping well, a positive electrode, a negative electrode, leaching solution, and a direct current power supply. Uranium ore is provided between the injection well and the pumping well, the negative electrode is arranged in the injection well, and the positive electrode is arranged in the pumping well. The leaching solution is injected from the injection well, flows through the uranium ore, and then is pumped from the pumping well for uranium extraction. The direct current power supply is respectively connected to the positive electrode and the negative electrode, and is configured to apply direct current between the positive electrode and the negative electrode to promote the pooling of uranium-carrying ions towards the pumping well.

Abstract: Disclosed is a polarization fusion orientation method for an occluded environment, which comprises: acquiring a sky polarization image through a polarization camera first, then taking a heading angle output by an E-vector polarization orientation method as a state quantity, taking a heading angle output by a symmetry axis polarization orientation method as an observed quantity, realizing heading angle fusion through a multi-frequency variational Bayesian strong tracking cubature Kalman filter (MF-VBSTCKF), and respectively selecting different methods for a sampling position and a sampling interval period to update an optimal heading angle. The method solves the problem that high-precision and high-robustness heading angle measurement of polarized light cannot be realized in the occluded environment, can improve the precision and robustness of a polarized light orientation method in the occluded environment, and ensures high-frequency output of the heading angle at the same time.

Abstract: Compounds of Formula I, as shown below and defined herein: and pharmaceutically acceptable salts, syntheses, intermediates, formulations, and methods of treating diseases including cancer, inflammation, and autoimmune disease mediated at least in part by Bruton's Tyrosine Kinase (BTK).

Abstract: Provided are genetically modified animal expressing human or chimeric (e.g., humanized) FcRn, and methods of use thereof.

Abstract: A framework for an automated news recommendation system for financial analysis. The system includes the automated ingestion, relevancy, clustering, and ranking of news events for financial analysts in the capital markets. The framework is adaptable to any form of input news data and can seamlessly integrate with other data used for analysis like financial data.

Abstract: Compounds of Formula I, as shown below and defined herein: and pharmaceutically acceptable salts, syntheses, intermediates, formulations, and methods of treating diseases including cancer, inflammation, and autoimmune disease mediated at least in part by Bruton's Tyrosine Kinase (BTK).

Abstract: The present disclosure relates to a linking unit molecule for targeting molecule-drug conjugate, and the corresponding conjugate, the preparation and use thereof, and in particular relates to an antibody-immune agonist conjugate (AIAC) as a novel type of cancer therapy.

Abstract: It relates to the medicinal chemistry field, particularly to a process for separating the isomeric compounds comprising a ring-opened thiosuccinimide group and a chiral moiety.

Abstract: Disclosed is a new drug application of a Pithecellobium Clypearia Benth Extract (EA), and particularly is a method of the EA used for treating multiple diseases caused by drug resistant bacteria infection. Related drug resistant bacteria include a Multi-Drug Resistant (MDR) Acinetobacter Baumannii (MDRAB), an MDR Pseudomonas Aeruginosa (MDRPA), an Extended-Spectrum Beta-Lactamase (ESBL) producing Escherichia Coli (ECO) and an ESBL-producing Klebsiella Pneumonia (KPN).

Abstract: Layered Period Four transition metal oxide materials composed of lithium transition metal oxides and sodium transition metal oxides, in which the transition metal oxide is cobalt, manganese, nickel, or a combination of two or more thereof or provided. Also provided are electrochemical cells incorporating the layered transition metal oxides as electrode materials and methods for extracting dissolved lithium from solution using the electrochemical cells. In the materials a lithium transition metal oxide phase and a sodium transition metal oxide phase exist as separate phases connected by a transition region of intermediate composition and layer spacing to form a stable structure.

Abstract: Described here is an air filter comprising a substrate and a network of polymeric nanofibers deposited on the substrate, wherein the air filter a removal efficiency for PM2.5 of at least 70% when a light transmittance is below 50%. Also described here is an electric air filter comprising a first layer adapted to receive a first electric voltage, wherein the first layer comprises an organic fiber coated with a conductive material. Further described is an air filter for high temperature filtration, comprising a substrate and a network of polymeric nanofibers deposited on the substrate, wherein the air filter has a removal efficiency for PM2.5 of at least 70% at a temperature of a least 70° C.

Abstract: Methods for synthesizing layered lithium transition metal oxides from layered sodium transition metal oxides are provided. Also provided are electrodes for lithium-ion batteries that include the layered lithium transition metal oxides. Similarly, methods for the synthesis of layered sodium transition metal oxides from layered lithium transition metal oxides and electrodes for sodium-ion batteries that include the layered sodium transition metal oxides are provided. The methods couple electrochemical intercalation of alkali ions (Li+ or Na+) with ion-exchange to overcome the kinetic limitation of ion-exchange in the layered alkali transition metal oxides at low vacancy concentrations.

Abstract: A linker molecule for targeting molecule-drug conjugate, has the structure of formula (I): A1p-D1q-Y-Lk-W-A2q-D2p (I). A conjugate has the structure of formula (III): A-((compound of formula (1))-PL t) z (III). The conjugate can be used in the manufacture of a medicament for treating a disease.

Abstract: The present disclosure relates to a linking unit molecule for targeting molecule-drug conjugate, and the corresponding conjugate, the preparation and use thereof, and in particular relates to an antibody-immune agonist conjugate (AIAC) as a novel type of cancer therapy.

Abstract: A computer-implemented method, system and computer program product for automatically drawing infographics. Variables of a dataset are received from a computing device that were selected by the user of the computing device. For those selected variables that are associated with a data model, a procedure to draw infographics for variables assigned or not assigned the role of a target using the data model associated with each of the variables assigned or not assigned the role of target, respectively, is implemented. Alternatively, if the selected variables are not associated with a data model, then such variables are assigned a level of measurement as well as assigned the role of input. Such assignments become the data model which, along with the metadata (e.g., values of the variable) obtained by parsing the original data, are used to implement the procedure to draw infographics for variables not assigned the role of a target.

Abstract: Molybdenum disulfide membranes for ionic and/or molecular filtration applications are provided. The membranes have high separation performance, including high water flux and high molecule and/or ion rejection, and do not need to be stored in a hydrated condition in order to enable their reuse. The membranes are based on stacked MoS2 sheets having small hydrophilic organic functional groups covalently bound thereto.