Abstract: The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

Abstract: The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

Abstract: The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

Abstract: An amplifier system is provided that has a first balun with an input and an output, and a second balun with an input and an output. A first set of amplifiers is coupled in series and to the output of the first balun. A second set of amplifiers is coupled in series and to the output of the second balun. The first and second sets of amplifiers are in series or parallel. A load impedance of the first and second sets of amplifiers does not substantially change at an output of any amplifier that is switched on when another amplifier is switched off.

Abstract: The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

Abstract: A power amplifier assembly has a first power amplifier with a first input conditioning circuit. At least first and second amplifiers are in parallel with each other and having inputs and outputs. An input signal is coupled to the inputs of the first and second amplifiers. A first multi-input power combiner is provided. The outputs of the at least first and second parallel amplifiers are combined by the first multi-input power combiner to add signals of the outputs constructively. A second power amplifier has a first input conditioning circuit. At least first and second amplifiers are in parallel with each other and having inputs and outputs. An input signal is coupled to the inputs of the first and second amplifiers. A second multi-input power combiner is provided. The outputs of the at least first and second parallel amplifiers are combined by the second multi-input power combiner to add signals of the outputs constructively.

Abstract: An amplifier system is provided,with a first balun that has an input and an output. A second balun has an input and an output. An amplifier assembly is provided with at least a first amplifier in parallel to a second amplifier. The first amplifier provides the input to the first balun, and the second amplifier provides the input to the second balun. The outputs of the first and second baluns add constructively and substantially in series.

Abstract: A multi-input power combiner includes a balun with a plurality of layers. A plurality of transmission lines are associated with the plurality of layers. The balun has a largest dimension that is less than half of a ¼ wavelength in a selected material.

Abstract: A power amplifier has an input conditioning circuit. At least first and second amplifiers are in parallel with each other and have inputs and outputs. An input signal is coupled to the inputs of the first and second amplifiers. A multi-input power combiner is provided. The outputs of the first and second parallel amplifiers are combined by the multi-input power combiner to add signals of the outputs constructively.

Abstract: An amplifier system is provided that includes a first balun with an input and an output. A second balun has an input and an output. An amplifier assembly is provided and has at least a first amplifier in parallel to a second amplifier. The first amplifier provides the input to the first balun and the second amplifier provides the input to the second balun. A power combining circuit is provided. The first and second baluns are coupled to a common node of the power combining circuit. A first lumped element circuit is coupled between the output of the first balun and the power combining circuit. A second lumped element circuit is coupled between the output of the second balun and the power combing circuit. The outputs are coupled to the common node.

Abstract: A CMOS device includes a p-type substrate and an isolated PWell region. An isolation region has an NWell region abutting a perimeter of the PWell region. The isolation region includes a DNWell region positioned below the PWell region and an NWell region. The NWell region forms a sidewall of a tub and the DNWell region forms a bottom of the tub. The tub is an n-type region that physically and electrically isolates an enclosed PWell region from the p-type substrate. A NTN region is formed in the p-type substrate and at least partially abuts an outer perimeter of the NWell region. The NTN region is defined as a non-PWell and a non-NWell region. The NTN region enhances electrical isolation of the circuits inside the PWell region from circuits outside of the PWell region. In one embodiment, the high-frequency performance of an NMOSFET inside the isolated PWell is improved because of the reduced sidewall capacitance with the NTN region.

Abstract: A multi-input power combiner includes a balun with a plurality of layers. A plurality of transmission lines are associated with the plurality of layers. The balun has a largest dimension that is less than half of a ¼ wavelength in a selected material.

Abstract: A power amplifier utilizes cascode arrangements to achieve target performance levels for a power amplifier, such as the type used in wireless communication devices. A negative resistance circuit is provided for the cascode arrangement such that high gain, or oscillation, is promoted during operation of the power amplifier. In one embodiment, the negative resistance circuit includes cross-coupling transistors. Various features are provided in order to reduce the susceptibility of the power amplifier to voltage breakdown while maintaining good performance.

Abstract: An amplifier system is provided that includes a first balun with an input and an output. A second balun has an input and an output. An amplifier assembly is provided and has at least a first amplifier in parallel to a second amplifier. The first amplifier provides the input to the first balun and the second amplifier provides the input to the second balun. A power combining circuit is provided. The first and second baluns are coupled to a common node of the power combining circuit. A first lumped element circuit is coupled between the output of the first balun and the power combining circuit. A second lumped element circuit is coupled between the output of the second balun and the power combing circuit. The outputs are coupled to the common node.

Abstract: A power amplifier uses parallel amplification and at least two levels of power combining to manage peak-to-peak voltage swings, so as to reduce the likelihood of voltage breakdown at individual transistors. Each level of power combining provides an upward impedance transformation. For example, both levels of power combining may double the impedance output relative to the impedance input, so that the impedance at the amplifier output is four times the input impedance. For an embodiment in which the second level is a quadrature power combiner, load reflections of the amplifier may be terminated at an isolation port. In addition, energy levels of the load reflections may be monitored.

Abstract: An amplifier system is provided that has a first balun with an input and an output, and a second balun with an input and an output. A first set of amplifiers is coupled in series and to the output of the first balun. A second set of amplifiers is coupled in series and to the output of the second balun. The first and second sets of amplifiers are in series or parallel. A load impedance of the first and second sets of amplifiers does not substantially change at an output of any amplifier that is switched on when another amplifier is switched off.

Abstract: A power amplifier assembly has a first power amplifier with a first input conditioning circuit. At least first and second amplifiers are in parallel with each other and having inputs and outputs. An input signal is coupled to the inputs of the first and second amplifiers. A first multi-input power combiner is provided. The outputs of the at least first and second parallel amplifiers are combined by the first multi-input power combiner to add signals of the outputs constructively. A second power amplifier has a first input conditioning circuit. At least first and second amplifiers are in parallel with each other and having inputs and outputs. An input signal is coupled to the inputs of the first and second amplifiers. A second multi-input power combiner is provided. The outputs of the at least first and second parallel amplifiers are combined by the second multi-input power combiner to add signals of the outputs constructively.

Abstract: A power amplifier has an input conditioning circuit. At least first and second amplifiers are in parallel with each other and have inputs and outputs. An input signal is coupled to the inputs of the first and second amplifiers. A multi-input power combiner is provided. The outputs of the first and second parallel amplifiers are combined by the multi-input power combiner to add signals of the outputs constructively.

Abstract: An amplifier system is provided,with a first balun that has an input and an output. A second balun has an input and an output. An amplifier assembly is provided with at least a first amplifier in parallel to a second amplifier. The first amplifier provides the input to the first balun, and the second amplifier provides the input to the second balun. The outputs of the first and second baluns add constructively and substantially in series.

Abstract: A plurality of devices, such as devices that are utilized for implementing radio frequency applications, can be formed in the same substrate. Each of these devices may be formed over a triple well that includes at least one well capable of being biased. Each of the wells is coupled to a well bias through a resistor. In some embodiments, a plurality of wells operating at a relatively high frequency may be connected to the same bias potential, each through separate resistors. The noise coupling may be reduced through the use of the bias resistors.