Patents by Inventor Christian A. Hassig

Christian A. Hassig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease
    Publication number: 20060030543
    Abstract: Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
    Type: Application
    Filed: June 9, 2005
    Publication date: February 9, 2006
    Inventors: James Malecha, Stewart Noble, Christian Hassig, Paul Wash, Brandon Wiley, Charles Lawrence, Timothy Hoffman
  • Class II human histone deacetylases, and uses related thereto
    Publication number: 20050287629
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Application
    Filed: October 13, 2004
    Publication date: December 29, 2005
    Applicant: President and Fellows of Harvard College
    Inventors: Christina Grozinger, Christian .Hassig, Stuart Schreiber
  • Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
    Publication number: 20050026907
    Abstract: Disclosed herein are carbonyl compounds of Formula I, II, or III, and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, autoimmune diseases and cardiovascular conditions, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
    Type: Application
    Filed: June 10, 2004
    Publication date: February 3, 2005
    Applicant: Kalypsys, Inc.
    Inventors: Paul Wash, Brandon Wiley, Christian Hassig, James Malecha, Stewart Noble
  • Histone deacetylases, and uses related thereto
    Patent number: 6777217
    Abstract: The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
    Type: Grant
    Filed: March 26, 1996
    Date of Patent: August 17, 2004
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
  • Class II human histone deacetylases, and uses related thereto
    Publication number: 20030129724
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Application
    Filed: March 5, 2001
    Publication date: July 10, 2003
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber