Abstract: A method of forming a composite article includes constructing a preform having a strand layer including an interior portion and a peripheral portion surrounding the interior portion. The strand layer includes a plurality of strand segments traversing the interior portion and defining a first strand segment population density and a second strand segment population density. The preform is inserted into the mold cavity so that the interior portion of the preform is received in a molding region of the mold cavity. The molding region has a first thickness corresponding to the first strand segment population density and a second thickness corresponding to the second strand segment population density. Following the inserting, the mold is closed and the interior portion of the preform is compressed within the molding region. In the closed mold, the peripheral portion of the strand layer may be maintained in a loose state within the relief region.

Abstract: A sole structure for an article of footwear is described. In one example, the sole structure includes first and second foam components and one or more mesh components, e.g., a mesh textile component. The first foam component includes first and second opposing sides, and the second foam component includes first and second opposing sides. The first and second foam components form a stack in the sole structure. The mesh components, e.g., a mesh textile component, are positioned in the stack between and bonded to the second side of the first foam component and the first side of the second foam component. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A method of forming a plate for an article of footwear is disclosed. The method includes applying a first strand portion to a base layer including positioning adjacent segments of the first strand portion to form a first layer on the base layer. The adjacent segments of the first strand portion having a greater density across a width of the plate between a medial side and a lateral side at a midfoot region of the plate than at a forefoot region of the plate and at a heel region of the plate. The method also includes applying at least one of heat and pressure to the first strand portion and to the base layer to conform the first strand portion and the base layer to a predetermined shape.

Abstract: The present invention relates to certain substituted AHR agonist compounds, to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases.

Abstract: An integrated platform system that employ a series of machine learning techniques and prediction and detection units that can process input data and extract and generate meaningful insights and predictions therefrom. The system integrates together multiple different data storage types and applications that generates data of different types, and an associated processing system for processing the different data types, store the data in a common data model to normalize the data, determine the data lineage of the data, and then process the data using different types of techniques. The data can also be processed by a prediction unit for generating meaningful insights and predictions or by an anomaly detection unit for detecting one or more anomalies in the data.

Abstract: The present disclosure relates to certain AHR agonist compounds, their method of making, and to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases, such as psoriasis and atopic dermatitis.

Abstract: A multilateral junction comprising a y-block, lateral legs, and a transition sub for use in downhole well environments. The y-block includes a main bore and lateral bores with main bore and the lateral bores having threaded interfaces. The transition sub also includes lateral bores with threaded interfaces for receiving the lateral legs that also have threaded interfaces. The threaded interfaces of the lateral bore of the y-block has a less number of threads than the threaded interfaces of the lateral bores of the transition sub. The lateral leg includes another threaded interface that couples with the threaded interface of the lateral bore. Another end of each lateral leg includes an interface, e.g. a threaded interface, which couples with an interface of a transition sub. The main bore has an internal diameter that is greater than the internal diameter of the lateral bore.

Abstract: Provided is a sealing/anchoring subassembly, a well system, and method. The sealing/anchoring subassembly, in one aspect, includes a mandrel, as well as a sealing/anchoring element positioned about the mandrel, the sealing/anchoring element configured to move between a radially retracted state and a radially expanded state. The sealing/anchoring subassembly, according to this aspect, also includes a ratch latch body coupled to the sealing/anchoring element, the ratch latch body configured to hold the sealing/anchoring element in the radially expanded state. The ratch latch body, in one aspect, may include a stroke sleeve having a plurality of stroke sleeve teeth disposed thereon, and a base having a plurality of base teeth disposed thereon, the stroke sleeve teeth and the base teeth configured to directly ratchet along one another to hold the sealing/anchoring element in the radially expanded state.

Abstract: A sole structure for an article of footwear is provided. The sole structure includes a first midsole portion, a second midsole portion, and a sheet. The first midsole portion includes a first sidewall. The second midsole portion includes a second sidewall. The sheet is disposed between the first midsole portion and the second midsole portion and extends from the first sidewall and the second sidewall. The sheet extends at least partially over the second sidewall.

Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.

Abstract: A computer implemented method of acquiring and processing autonomous aerial vehicle data comprising obtaining past flight data from an autonomous aerial vehicle; storing the data in a database; conducting netto-variometer calculations to obtain equations to normalize the data; using a filtering technique to normalize the data; storing the equations obtained from the netto-variometer calculations into the database; and using the stored equations and live flight data to generate an optimized sink polar estimate for the UAG, wherein the optimized sink polar estimate is to be used in computing netto-variometer during flight.

Abstract: The invention relates to the field of medicine, specifically to the field of treatment of conditions associated with Staphylococcus infection. The invention relates to a novel endolysin polypeptide specifically targeting a bacterial Staphylococcus cell. The invention further relates to said endolysin polypeptide for medical use, preferably for treating an individual suffering from a condition associated with Staphylococcus infection.

Abstract: Provided is an anchoring/sealing subassembly, a well system, and a method. The anchoring/sealing subassembly, in one aspect, includes an isolation element mandrel, and an isolation element positioned about the isolation element mandrel. The anchoring/sealing subassembly, in one aspect, further includes a shear mandrel coupled to the isolation element mandrel, and a ratch latch body coupled to the isolation element. The anchoring/sealing subassembly, in one aspect; additionally includes a row of radially spaced apart slip ring shear feature openings located in a slip ring, and a row of radially spaced apart shear mandrel shear feature openings located in an isolation element mandrel, the row of slip ring shear feature openings and the row of shear mandrel shear feature openings operable to receive ones of shear features to shearingly couple the slip ring and the isolation element mandrel together.

Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.

Abstract: A sole structure for an article of footwear is provided. The sole structure includes a first midsole portion, a second midsole portion, and a sheet. The first midsole portion includes a first sidewall. The second midsole portion includes a second sidewall. The sheet is disposed between the first midsole portion and the second midsole portion and extends from the first sidewall and the second sidewall. The sheet extends at least partially over the second sidewall.

Abstract: The present invention relates to processes for preparing linkers that are useful in the conjugation of therapeutic molecules (e.g., cytotoxic agents) with targeting moieties (e.g., proteins, peptides, antibodies, nanoparticles, nucleic acids). During said processes lipases like lipase B from Candida antarctica were used for enantioselective resolution of (S,S)-2-benzylthiocyclohexanol or (S,S)-2-benzylthiocycloheptanol in presence of acylating agent which are reduced for deprotection to yield (S,S)-2-mercaptocyclohexanol or (S,S)-2-mercaptocyclopentanol which can then be used for linking therapeutic with targeting moieties.

Abstract: A head-up display, such as found in smart glasses, may include a light source configured to project light for display. A heads-up display may include a polymer aerogel optical waveguide configured to receive the light from the light source, guide the received light to an area in front of an eye of a user, and project the light to the eye of the user. The polymer aerogel optical waveguide can include a core portion made from a glass having a relatively high index of refraction and a cladding portion made from a polymer aerogel having a relatively low index of refraction so that light is guided in the core portion by total internal reflection at an interface between the core portion and the cladding portion.

Abstract: A sole structure for an article of footwear is described. In one example, the sole structure includes first and second foam components and one or more mesh components, e.g., a mesh textile component. The first foam component includes first and second opposing sides, and the second foam component includes first and second opposing sides. The first and second foam components form a stack in the sole structure. The mesh components, e.g., a mesh textile component, are positioned in the stack between and bonded to the second side of the first foam component and the first side of the second foam component. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A technique is described herein for assisting a user in editing a file. The technique involves producing current context information that includes an input message and selected file content. The input message describes a user's editing objective, while the selected file content describes a portion of the file to which the editing objective is to be applied. The technique then requests a pattern-completion engine to generate edit information based on the current context information. The edit information describes one or more changes to the selected file content that satisfy the objective of the user. The pattern-completion engine uses a machine-trained autoregressive text-completion model that is trained on revision history information. The model can be trained in a process that incorporates various tests to ensure that the edit information that is generated works as expected, satisfies various performance metrics, and fulfills the editing objectives of the user.