Abstract: A fermentation process includes contacting a starch hydrolysate with a glucoamylase with agitation. And allowing for settling to form a multi-phase solution. A first phase of the multi-phase solution includes a saccharide component comprising about 30 wt % to about 80 wt % (e.g., 30 wt % to 70 wt %, 30 wt % to 60 wt %) based on a total carbohydrate present. The method further includes draining the first phase to isolate the first phase from a second phase to form a fermentation broth comprising a first portion of the first phase. The method further includes fermenting the fermentation broth until a concentration of glucose in the fermentation broth is 40 g/L or less. The method includes adding a second portion of the first phase to the fermentation broth to maintain a concentration of glucose in a range of from about 1 g/L to about 20 g/L in the fermentation broth.

Abstract: Disclosed herein are compounds of Formula I wherein R1, R2, X, and Y are defined herein. These compounds are type II topoisomerase inhibitors and can be used in methods for treating infections caused by gram-positive pathogens, gram-negative pathogens, and drug-resistant strains thereof.

Abstract: The present invention relates to a method for pneumatically blowing a powdery substitute reducing agent in a dense flow process, by means of a transport gas, into a gasification reactor, or via a tuyere into a blast furnace. The substitute reducing agent is gasified in a gasification reaction. The transport gas comprises a fuel gas, the constituents of which or the oxidation constituents of which are at least partly involved in the gasification reaction.

Abstract: Inter alia, an apparatus including a ramp, the ramp configured to enable variation of a cross section of a ram air passage of the apparatus. The ramp includes a first rigid member, a second rigid member and a flexible member coupled to the first rigid member and the second rigid member. The ramp is movably mounted at two ends. Moreover, a method of varying the cross section of the ram air passage of such an apparatus by moving the ramp of the apparatus is disclosed. Further, an arrangement including such an apparatus and a ram air channel communicating with the ram air passage is disclosed.

Abstract: This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.

Abstract: An aircraft ram air channel assembly having: a first ram air inlet with a deflector protruding from the aircraft outer skin, the deflector guiding an air flow into a first ram air inlet channel; a second ram air inlet having a cross-sectional area flush with the outer skin, the second inlet being coupled to a second ram air inlet channel and arranged proximate to the first inlet upstream of the first inlet; and a flap pivotable about an axis between first and second operating positions. The axis is upstream of the first and second inlets and extends perpendicular to the air flow. The flap in its first position projects into the second inlet channel to control air flow through the second inlet into the second inlet channel, and in its second position projects into the air flow to prevent foreign objects from entering the first and second inlets.

Abstract: An aircraft ram air channel assembly having: a first ram air inlet with a deflector protruding from the aircraft outer skin, the deflector guiding an air flow into a first ram air inlet channel; a second ram air inlet having a cross-sectional area flush with the outer skin, the second inlet being coupled to a second ram air inlet channel and arranged proximate to the first inlet upstream of the first inlet; and a flap pivotable about an axis between first and second operating positions. The axis is upstream of the first and second inlets and extends perpendicular to the air flow. The flap in its first position projects into the second inlet channel to control air flow through the second inlet into the second inlet channel, and in its second position projects into the air flow to prevent foreign objects from entering the first and second inlets.

Abstract: This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens. The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.

Abstract: Disclosed herein are compounds of Formula I wherein R1, R2, X, and Y are defined herein. These compounds are type II topoisomerase inhibitors and can be used in methods for treating infections caused by gram-positive pathogens, gram-negative pathogens, and drug-resistant strains thereof.

Abstract: An aircraft ram air channel assembly having: a first ram air inlet with a deflector protruding from the aircraft outer skin, the deflector guiding an air flow into a first ram air inlet channel; a second ram air inlet having a cross-sectional area flush with the outer skin, the second inlet being coupled to a second ram air inlet channel and arranged proximate to the first inlet upstream of the first inlet; and a flap pivotable about an axis between first and second operating positions. The axis is upstream of the first and second inlets and extends perpendicular to the air flow. The flap in its first position projects into the second inlet channel to control air flow through the second inlet into the second inlet channel, and in its second position projects into the air flow to prevent foreign objects from entering the first and second inlets.

Abstract: The present invention relates to a method for pneumatically blowing a powdery substitute reducing agent in a dense flow process, by means of a transport gas, into a gasification reactor, or via a tuyere into a blast furnace. The substitute reducing agent is gasified in a gasification reaction. The transport gas comprises a fuel gas, the constituents of which or the oxidation constituents of which are at least partly involved in the gasification reaction.

Abstract: This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.

Abstract: Disclosed herein are compounds of Formula I wherein R1, R2, X, and Y are defined herein. These compounds are type II topoisomerase inhibitors and can be used in methods for treating infections caused by gram-positive pathogens, gram-negative pathogens, and drug-resistant strains thereof.

Abstract: This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.

Abstract: This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.

Abstract: Inter alia, an apparatus including a ramp, the ramp configured to enable variation of a cross section of a ram air passage of the apparatus. The ramp includes a first rigid member, a second rigid member and a flexible member coupled to the first rigid member and the second rigid member. The ramp is movably mounted at two ends. Moreover, a method of varying the cross section of the ram air passage of such an apparatus by moving the ramp of the apparatus is disclosed. Further, an arrangement including such an apparatus and a ram air channel communicating with the ram air passage is disclosed.

Abstract: Disclosed herein are compounds of Formula I wherein R1, R2, X, and Y are defined herein. These compounds are type II topoisomerase inhibitors and can be used in methods for treating infections caused by gram-positive pathogens, gram-negative pathogens, and drug-resistant strains thereof.

Abstract: Described are a series of 2-pyridone compounds as a potent and selective new class of type II topoisomerase inhibitors with broad-spectrum antimicrobial activity having the general formula (I); where R1, R2, X, and Y are defined herein Such compounds can be used in methods for treating an infection caused by a gram-positive pathogen, a gram-negative pathogen, or a drug-resistant strains thereof.

Abstract: An aircraft ram air channel assembly having: a first ram air inlet with a deflector protruding from the aircraft outer skin, the deflector guiding an air flow into a first ram air inlet channel; a second ram air inlet having a cross-sectional area flush with the outer skin, the second inlet being coupled to a second ram air inlet channel and arranged proximate to the first inlet upstream of the first inlet; and a flap pivotable about an axis between first and second operating positions. The axis is upstream of the first and second inlets and extends perpendicular to the air flow. The flap in its first position projects into the second inlet channel to control air flow through the second inlet into the second inlet channel, and in its second position projects into the air flow to prevent foreign objects from entering the first and second inlets.

Abstract: This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.