Abstract: Pharmaceutical compositions are produced comprising as the active ingredient a compound of the formula ##STR1## or a pharmaceutically acceptable, nontoxic salt thereof or hydrate thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, halogen, lower alkyl or lower alkoxy, or any two of the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4, taken together with the carbon atoms to which they are joined complete a substituted or unsubstituted carbocyclic ring, and X is a bond or an oxygen atom, is combined with a pharmaceutically acceptable, nontoxic inert diluent or carrier. Those compounds wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all simultaneously hydrogen are novel.When X is a bond, the compounds may be prepared by reacting an appropriately substituted 3-dyanomethylene phthalide with a base and, thereafter, if desired, converting the compound to a salt.

Abstract: Pharmaceutical compositions having anti-allergy activity in which the active anti-allergy agents are certain 3-nitro-.alpha.-pyridones and their pharmaceutically acceptable salts formulated in one or more pharmaceutically acceptable carriers.

Abstract: A pharmaceutical composition is produced which is useful for treating allergic conditions in humans which comprises an anti-allergenic amount of a compound of the formula: ##SPC1##Or a pharmaceutically acceptable salt or ester thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and each is hydrogen, alkyl, alkoxy, aryl, aralkyl or halogen or any two of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 taken together, with the carbon atoms to which they are attached, form a phenyl, cyclohexyl or cyclohexenyl ring, in combination with a pharmaceutically acceptable carrier.

Abstract: Substituted .omega.-nitroacetophenones and their preparation and intermediates therefor are described together with pharmaceutical compositions containing such nitroacetophenones for the prophylaxis and treatment of diseases associated with allergic or immunological reactions such as asthma, hayfever and rhinitis.

Abstract: 3-Carboxyisocoumarins, 2-thiaisocoumarins and related isocarbostyrils are useful anti-allergic agents. Several of these compounds are novel, and a process for their preparation is provided.

Abstract: Pharmaceutical compositions for the treatment of allergies are produced using coumarin derivatives as the active agent. Certain of these compounds and their salts are novel.

Abstract: A class of 4-hydroxy-3-nitroearbostyril derivatives are useful in the inhibition of certain types of antigen antibody reactions.