Patents by Inventor Christian Guillot
Christian Guillot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11717570Abstract: Lipid formulation particularly for preparing stable gas-filled microvesicles, comprising distearoyl-phosphatidylcholine (DSPC), dipalmitoylphosphatidylethanolamine-PEG5000 (DPPE-PEG5000) and palmitic acid in an advantageous relative molar ratio. The formulation is useful in particular for therapeutic application with ultrasounds.Type: GrantFiled: May 14, 2020Date of Patent: August 8, 2023Assignee: Bracco Suisse SAInventors: Philippe Bussat, Samir Cherkaoui, David Lazarus, Eric Allémann, Michel Schneider, Christian Guillot
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Publication number: 20220211850Abstract: Lipid formulation particularly for preparing stable gas-filled microvesicles, comprising distearoyl-phosphatidylcholine (DSPC), dipalmitoylphosphatidylethanolamine-PEG5000 (DPPE-PEG5000) and palmitic acid in an advantageous relative molar ratio. The formulation is useful in particular for therapeutic application with ultrasounds.Type: ApplicationFiled: May 14, 2020Publication date: July 7, 2022Applicant: Bracco Suisse SAInventors: Philippe Bussat, Samir CHERKAOUI, David LAZARUS, Eric ALLÉMANN, Michel SCHNEIDER, Christian GUILLOT
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Publication number: 20200360289Abstract: Lipid formulation particularly for preparing stable gas-filled microvesicles, comprising distearoyl-phosphatidylcholine (DSPC), dipalmitoylphosphatidylethanolamine-PEG5000 (DPPE-PEG5000) and palmitic acid in an advantageous relative molar ratio. The formulation is useful in particular for therapeutic application with ultrasounds.Type: ApplicationFiled: February 11, 2020Publication date: November 19, 2020Inventors: Michel SCHNEIDER, Eric ALLÉMANN, Philippe Bussat, Christian GUILLOT
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Patent number: 10335502Abstract: A freeze-dried powder composition comprising a phospholipid and a polyethylene glycol, said polyethylene glycol having a percentage of folded polymeric chains of 40% or higher. The composition is suitable for preparing gas-filled microvesicles.Type: GrantFiled: January 29, 2019Date of Patent: July 2, 2019Assignee: Bracco Suisse SAInventors: Anne Lassus, Stéphane Gorgerat, Feng Yan, Christian Guillot, Jean Brochot
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Patent number: 10232061Abstract: A freeze-dried powder composition comprising a phospholipid and a polyethylene glycol, said polyethylene glycol having a percentage of folded polymeric chains of 40% or higher. The composition is suitable for preparing gas-filled microvesicles.Type: GrantFiled: July 6, 2018Date of Patent: March 19, 2019Assignee: Bracco Suisse SAInventors: Anne Lassus, Stéphane Gorgerat, Feng Yan, Christian Guillot, Jean Brochot
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Patent number: 10076580Abstract: The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-linear echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different median sizes. In particular, said preparations preferably have size distributions with respective DV50 values differing from each other by at least 0.5 ?m, more preferably at least 1.0 ?m. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher.Type: GrantFiled: December 28, 2015Date of Patent: September 18, 2018Assignee: BRACCO SUISSE S.A.Inventors: Philippe Bussat, Peter Frinking, Christian Guillot, Michel Schneider
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Patent number: 9446156Abstract: Image enhancing contrast agents for use in diagnostic and/or therapeutic methods, particularly in the form of gas-filled microvesicles, with enhanced stability. The gas-filled microvesicles are stabilized by a layer of amphiphilic material and comprise from 0.15% to 1.0% by moles of a lipid bearing a hydrophilic polymer. The lipid bearing a hydrophilic polymer is preferably a phospholipid linked to polyethyleneglycol.Type: GrantFiled: September 4, 2007Date of Patent: September 20, 2016Assignee: BRACCO SUISSE S.A.Inventors: Stephane Gorgerat, Christian Guillot, Feng Yan
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Publication number: 20160184464Abstract: The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-linear echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different median sizes. In particular, said preparations preferably have size distributions with respective DV50 values differing from each other by at least 0.5 ?m, more preferably at least 1.0 ?m. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher.Type: ApplicationFiled: December 28, 2015Publication date: June 30, 2016Applicant: BRACCO SUISSE S.A.Inventors: Philippe Bussat, Peter Frinking, Christian Guillot, Michel Schneider
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Patent number: 9364569Abstract: Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.Type: GrantFiled: February 3, 2004Date of Patent: June 14, 2016Assignee: Bracco Suisse S.A.Inventors: Michel Schneider, Philippe Bussat, Feng Yan, Christian Guillot
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Patent number: 9248204Abstract: The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-liner echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different mean sizes. In particular, said preparations preferably have size distributions with respective DV50 values differing from each other by at least 0.5 ?m, more preferably at least 1.0 ?m. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher.Type: GrantFiled: August 17, 2005Date of Patent: February 2, 2016Assignee: Bracco Suisse S.A.Inventors: Philippe Bussat, Peter Frinking, Christian Guillot, Michel Schneider
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Patent number: 9107671Abstract: The invention relates to a device capable of stopping the bleeding caused by the withdrawal of an introducer stuck into an introduction area of a patient. The device comprises: a base; a supporting means capable of temporarily attaching the base to the patient; an applicator supported by the base and provided with a transparent pad; and a screw-and-nut adjustment means capable of moving the applicator toward the introduction area so that the applicator moves to a position where the pad exerts pressure on the introduction area. The screw-and-nut system is located completely outside the diameter of the transparent pad. The invention can be used for angiography and angioplasty operations.Type: GrantFiled: July 26, 2010Date of Patent: August 18, 2015Assignee: Perouse MedicalInventor: Romain Christian Guillot
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Patent number: 8528791Abstract: A closure device to be connected to a container, which includes a cap, a moving shutter and a lid, where the moving shutter is housed in a compartment of the cap and presents a platform provided with holes, two elastically deformable tongues and a body with a cylindrical section held in place and guided by a chimney in the lid, where the lid includes a central hole that allows the product to exit. The moving shutter is operated by pressing on the elastic container, which allows a dose of the product to come out, the moving shutter then being returned to its rest position by the tongues.Type: GrantFiled: August 5, 2008Date of Patent: September 10, 2013Assignee: CTL-TH Packaging, S.L. UnipersonalInventors: Javier Fernandez de Mendiola Quintana, Juan Ignacio Valpuesta Landa, Christian Guillot
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Publication number: 20120191127Abstract: The invention relates to a device capable of stopping the bleeding caused by the withdrawal of an injector stuck into an injection area of a patient. The device comprises: a base; a supporting means capable of temporarily attaching the base to the patient; an applicator supported by the base and provided with a transparent pad; and a screw-and-nut adjustment means capable of moving the applicator toward the injection area so that the applicator moves to a position where the pad exerts pressure on the injection area. The screw-and-nut system is located completely outside the diameter of the transparent pad. The invention can be used for angiography and angioplasty operations.Type: ApplicationFiled: July 26, 2010Publication date: July 26, 2012Applicant: PEROUSE MEDICALInventor: Romain Christian Guillot
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Publication number: 20110248048Abstract: Closure device, to be connected to a container (1), which comprises a measuring cap (2), a moving shutter (17) and a lid (24), where the moving shutter (17) is housed in a compartment (3) of the measuring cap (2) and presents a platform (18) provided with holes (19), two elastically deformable tongues (20) and a body with a cylindrical section (21, 22) held in place and guided by a chimney (27) in the lid (24), where the lid (24) comprises a central hole (29) that allows the product to exit. The moving shutter (17) is operated by pressing on the elastic container (1), which allows a dose of the product to come out, the moving shutter then being returned to its rest position by the tongues (20).Type: ApplicationFiled: August 5, 2008Publication date: October 13, 2011Applicant: CTL-TH PACKAGING ,S.L. UNIPERSONALInventors: Javier Fernandez De Mendiola Quintana, Juan Ignacio Valpuesta Landa, Christian Guillot
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Publication number: 20110236320Abstract: Injectable aqueous suspension of microbubbles filled with a biocompatible gas and a method of preparation thereof. At least 10% of the total volume of gas contained in the microbubbles is contained in microbubbles with a diameter of 1.5 ?m or less. The microbubbles can be obtained by preparing an emulsion comprising an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and then reconstituted in an aqueous suspension of gas-filled microbubbles.Type: ApplicationFiled: March 3, 2011Publication date: September 29, 2011Applicant: BRACCO SUISSE S.A.Inventors: Michel Schneider, Philippe Bussat, Feng Yan, Christian Guillot
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Publication number: 20090263330Abstract: Image enhancing contrast agents for use in diagnostic and/or therapeutic methods, particularly in the form of gas-filled microvesicles, with enhanced stability. The gas-filled microvesicles are stabilized by a layer of amphiphilic material and comprise from 0.15% to 1.0% by moles of a lipid bearing a hydrophilic polymer. The lipid bearing a hydrophilic polymer is preferably a phospholipid linked to polyethyleneglycol.Type: ApplicationFiled: September 4, 2007Publication date: October 22, 2009Applicant: BRACCO RESEARCH SAInventors: Stephane Gorgerat, Christian Guillot, Feng Yan
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Publication number: 20080008657Abstract: The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles, which preferably have respective different mean sizes. In particular, said preparations preferably have respective Dv values differing from each other by at least 0.5 ?m, more preferably at least 1.0 ?m. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 ?m, is contained in microvesicles having a diameter of 8 micron or less.Type: ApplicationFiled: August 17, 2005Publication date: January 10, 2008Applicant: Bracco Research S.A.Inventors: Philippe Bussat, Peter Frinking, Christian Guillot, Michel Schneider
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Publication number: 20060051297Abstract: Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.Type: ApplicationFiled: February 3, 2004Publication date: March 9, 2006Inventors: Michel Schneider, Philippe Bussat, Feng Yan, Christian Guillot
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Publication number: 20060034770Abstract: Injectable aqueous suspension of microbubbles filled with a biocompatible gas and a method of preparation thereof. At least 10% of the total volume of gas contained in the microbubbles is contained in microbububbles with a diameter of 1.5 ?m or less. The microbubbles can be obtained by preparing an emulsion comprising an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and then reconstituted in an aqueous suspension of gas-filled microbubbles.Type: ApplicationFiled: August 11, 2005Publication date: February 16, 2006Applicant: Bracco International B.V.Inventors: Michel Schneider, Philippe Bussat, Feng Yan, Christian Guillot
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Patent number: 5980937Abstract: The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.Type: GrantFiled: August 12, 1997Date of Patent: November 9, 1999Assignee: Bracco Research S.A.Inventors: Herve Tournier, Michel Schneider, Christian Guillot