Abstract: Minimally-invasive spinal inventions are often performed using fluoroscopic imaging methods, which can give a real-time impression of the location of a surgical instrument, at the expense of a small field of view. When operating on a spinal column, a small field of view can be a problem, because a medical professional is left with no reference vertebra in the fluoroscopy image, from which to identify a vertebra, which is the subject of the intervention. Identifying contiguous vertebrae is difficult because such contiguous vertebrae are similar in shape. However, characteristic features, which differentiate one vertebra from other vertebra, and which are visible in the fluoroscopic view, may be used to provide a reference.

Abstract: The invention relates to an imaging system (10) for imaging an elongated region of interest of an object, an imaging method for imaging an elongated region of interest of an object, a computer program element for controlling such system for performing such method and a computer readable medium having stored such computer program element. The imaging system (10) comprises an acquisition unit (11) and a processing unit (13). The acquisition unit (11) is a C-arm acquisition unit and configured to acquire first image data of the object to be imaged with a first imaging parameter. The acquisition unit (11) is further configured to acquire second, different image data of an object to be imaged with a second imaging parameter. The second geometric imaging parameter is defined based on object specific data for the volume data to be aligned with the elongated region of interest of the object to be imaged. The processing unit (13) is configured to combine the first and second image data into volume data.

Abstract: A customizable modular lamp is made up of an outer lens customized by known per se techniques, which covers a housing provided with at least one recess in which is mounted a customizable module consisting of a retro-reflective lens under which there is an inner customized lens personalized by known per se techniques, under which there is a printed circuit board with LEDs that is held in a holder fastened to a cover provided with at least one element for ventilation. During the daylight, personalization is visible on the outer customized lens. In the darkness and—depending on the recipient's request—when activating the lights for changing direction, position or braking, customization becomes evident by lighting inside the lamp, on the surface of the inner customized lens.

Abstract: The present invention is related to a conjugate comprising a structure of general formula (1) [TM1]-[AD1]-[LM]-[AD2]-[TM2] (1), wherein TM1 is a first targeting moiety, wherein the first targeting moiety is capable of binding to a first target, AD1 is a first adapter moiety or is absent, LM is a linker moiety or is absent, AD2 is a second adapter moiety or is absent, and TM2 is a second targeting moiety, wherein the second targeting moiety is capable of binding to a second target; wherein the first targeting moiety and/or the second targeting moiety is a compound of formula (2): wherein R1 is selected from the group consisting of hydrogen, methyl and cyclopropylmethyl; AA-COOH is an amino acid selected from the group consisting of 2-amino-2 adamantane carboxylic acid, cyclohexylglycine and 9-amino-bicyclo[3.3.

Abstract: The present invention is related to a compound of formula (I) wherein R1 is selected from the group consisting of hydrogen, methyl and cyclopropylmethyl; AA-COOH is an amino acid selected from the group consisting of 2-amino-2-adamantane carboxylic acid, cyclohexylglycine and 9-amino-bicyclo[3.3.1]nonane-9-carboxylic acid; R2 is selected from the group consisting of (C1-C6)alkyl, (C3-C8)cycloalkyl, (C3-C5)cycloalkylmethyl, halogen, nitro and trifluoromethyl; ALK is (C2-C5)alkylidene; R3, R4 and R5 are each and independently selected from the group consisting of hydrogen and (C1-C4)alkyl under the proviso that one of R3, R4 and R5 is of the formula (II) wherein ALK? is (C2-C5)alkylidene; R6 is selected from the group consisting of hydrogen and (C1-C4)alkyl; and R7 is selected from the group consisting of H and an Effector moiety; or a pharmacologically acceptable salt, solvate or hydrate thereof.