Patents by Inventor Christian Klein

Christian Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT FC-FUSION PROTEIN OF THE FIFTH FIBRONECTIN TYPE III DOMAIN OF DCC
    Publication number: 20130336972
    Abstract: The present invention relates to DCC-fusion proteins, nucleic acid molecules encoding the DCC-fusion proteins, as well as methods for their production and their use in treatment of cancer such as colorectal cancer, NSCLC and metastatic breast cancer. The present invention also relates to methods of treating cancer such as colorectal cancer, NSCLC and metastatic breast cancer by administering DCC-fusion proteins.
    Type: Application
    Filed: August 26, 2011
    Publication date: December 19, 2013
    Inventors: Christian Klein, Erhard Kopetzki, Gerhard Niederfellner, Agnes Bernet, Celine Delloye-Bourgeois, Patrick Mehlen
  • HANDLES INTERACTIONS FOR HUMAN-COMPUTER INTERFACE
    Publication number: 20130311944
    Abstract: A system is disclosed for providing on-screen graphical handles to control interaction between a user and on-screen objects. A handle defines what actions a user may perform on the object, such as for example scrolling through a textual or graphical navigation menu. Affordances are provided to guide the user through the process of interacting with a handle.
    Type: Application
    Filed: July 29, 2013
    Publication date: November 21, 2013
    Applicant: MICROSOFT CORPORATION
    Inventors: Andrew Mattingly, Jeremy Hill, Arjun Daval, Brian Kramp, Ali Vassigh, Christian Klein, Adam Poulos, Alex Kipman, Jeffrey Margolis
  • COMBINATION THERAPY
    Publication number: 20130302274
    Abstract: The present invention is directed to the combination therapy of an afucosylated antibody specifically binding to a tumor-antigen with human IL-15 for the treatment of cancer.
    Type: Application
    Filed: November 21, 2012
    Publication date: November 14, 2013
    Inventors: CHRISTIAN KLEIN, EMILIE LAPREVOTTE, ANNE QUILLET-MARY
  • DETECTION OF A POSTTRANSLATIONALLY MODIFIED POLYPEPTIDE BY A BI-VALENT BINDING AGENT
    Publication number: 20130288266
    Abstract: A bi-valent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bi-valent binding agent, and for use of the disclosed bi-valent binding agent in histological staining procedures.
    Type: Application
    Filed: June 21, 2013
    Publication date: October 31, 2013
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Michael Gerg, Dieter Heindl, Christian Klein, Alfred Mertens, Volker Schmid, Michael Schraeml, Monika Soukupova, Michael Tacke
  • COMBINATION THERAPY OF AN AFUCOSYLATED CD20 ANTIBODY WITH A mTOR INHIBITOR
    Publication number: 20130280243
    Abstract: The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with a mTOR inhibitor for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and a mTOR inhibitor such as Temsirolimus or Everolimus.
    Type: Application
    Filed: October 25, 2012
    Publication date: October 24, 2013
    Inventors: FRANK HERTING, CHRISTIAN KLEIN
  • COMBINATION THERAPY WITH TYPE I AND TYPE II ANTI-CD20 ANTIBODIES
    Publication number: 20130195846
    Abstract: The present invention is directed to a combination therapy involving a type I anti-CD20 antibody and a type II anti-CD20 antibody for the treatment of a patient suffering from cancer, particularly a CD20-expressing cancer. An aspect of the invention is a composition comprising a type I anti-CD20 antibody and a type II anti-CD20 antibody. Another aspect of the invention is a kit comprising a type I anti-CD20 antibody and a type II anti-CD20 antibody. Yet another aspect of the invention is a method for the treatment of a patient suffering from cancer comprising co-administering, to a patient in need of such treatment, a type I anti-CD20 antibody and a type II anti-CD20 antibody.
    Type: Application
    Filed: August 29, 2012
    Publication date: August 1, 2013
    Applicant: Roche Glycart
    Inventors: THOMAS FRIESS, Christian Klein, Pablo Umana
  • Handles interactions for human—computer interface
    Patent number: 8499257
    Abstract: A system is disclosed for providing on-screen graphical handles to control interaction between a user and on-screen objects. A handle defines what actions a user may perform on the object, such as for example scrolling through a textual or graphical navigation menu. Affordances are provided to guide the user through the process of interacting with a handle.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: July 30, 2013
    Assignee: Microsoft Corporation
    Inventors: Andrew Mattingly, Jeremy Hill, Arjun Dayal, Brian Kramp, Ali Vassigh, Christian Klein, Adam Poulos, Alex Kipman, Jeffrey Margolis
  • COMBINATION THERAPY OF AN AFUCOSYLATED CD20 ANTIBODY WITH AN ANTI-VEGF ANTIBODY
    Publication number: 20130183290
    Abstract: The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with an anti-VEGF antibody for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and an anti-VEGF antibody.
    Type: Application
    Filed: August 17, 2011
    Publication date: July 18, 2013
    Inventors: Frank Herting, Christian Klein
  • INPUT COMMANDS
    Publication number: 20130159555
    Abstract: Input command techniques are described. In one or more implementations, a computing device processes one or more inputs that are received from one or more input sources to determine a command that corresponds to the one or more inputs. The command is exposed to one or more controls that are implemented as software that is executed on the computing device and that have subscribed to the command.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 20, 2013
    Applicant: MICROSOFT CORPORATION
    Inventors: Peter D. Rosser, Christian Klein, Anthony R. Young, Arnab Choudhury, Alexander D. Tudor
  • CONTENT SYSTEM WITH SECONDARY TOUCH CONTROLLER
    Publication number: 20130154958
    Abstract: A controller for a content presentation and interaction system which includes a primary content presentation device. The controller includes a tactile control input and a touch screen control input. The tactile control input is responsive to the inputs of a first user and communicatively coupled to the content presentation device. The controller a plurality of tactile input mechanisms and provides a first set of the plurality of control inputs manipulating content. The controller includes a touch screen control input responsive to the inputs of the first user and communicatively coupled to the content presentation device. The second controller is proximate the first controller and provides a second set of the plurality of control inputs. The second set of control inputs includes alternative inputs for at least some of the controls and additional inputs not available using the tactile input mechanisms.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 20, 2013
    Applicant: MICROSOFT CORPORATION
    Inventors: John Clavin, Kenneth A. Lobb, Christopher M. Novak, Kevin Geisner, Christian Klein
  • Gestures and gesture modifiers for manipulating a user-interface
    Patent number: 8457353
    Abstract: Gesture modifiers are provided for modifying and enhancing the control of a user-interface such as that provided by an operating system or application of a general computing system or multimedia console. Symbolic gesture movements are performed by a user in mid-air. A capture device generates depth images and a three-dimensional representation of a capture area including a human target. The human target is tracked using skeletal mapping to capture the mid-air motion of the user. Skeletal mapping data is used to identify movements corresponding to pre-defined gestures using gesture filters. Detection of a viable gesture can trigger one or more user-interface actions or controls. Gesture modifiers are provided to modify the user-interface action triggered by detection of a gesture and/or to aid in the identification of gestures.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: June 4, 2013
    Assignee: Microsoft Corporation
    Inventors: Brendan Reville, Ali Vassigh, Christian Klein, Adam Poulos, Jordan Andersen, Zack Fleischman
  • Adaptive Area Cursor
    Publication number: 20130125066
    Abstract: Described is a technology by which a user's cursor movement is assisted to help select elements of a user interface that may be otherwise difficult to target. An area cursor is provided that may intersect more than one element. If so, a computation result (e.g., a percentage) is computed for each intersected element that is based upon intersection with the cursor and a total size of the element; the largest percentage intersection is selected. The computation (e.g., intersected area divided by total element area) favors smaller elements as they have a smaller area in the denominator. Also described is changing the cursor size to help hit elements and/or based upon one or more criteria. Still further described is determining the total size of an element based upon weighting, in addition to or instead of the element's actual size. Weighting may be based upon one or more criteria.
    Type: Application
    Filed: November 14, 2011
    Publication date: May 16, 2013
    Applicant: MICROSOFT CORPORATION
    Inventors: Christian Klein, Peter D. Rosser
  • Two-Stage Swipe Gesture Recognition
    Publication number: 20130120254
    Abstract: Systems, methods and computer program products for facilitating the recognition of user air swipe gestures are disclosed. Such systems, methods and computer program products provide a two-stage gesture recognition approach that combines desirable aspects of object manipulation gestures and symbolic gestures in order to create an interaction that is both reliable and intuitive for users of a computing system. In a first position-based stage, the user moves the cursor into a swipe activation zone. Second, in a motion-based stage, the user swipes their hand from the activation zone past a swipe gate within a certain amount of time to complete the interaction. GUI feedback is provided following the first stage to let the user know that the swipe interaction is available, and after the second stage to let the user know that the swipe is completed.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 16, 2013
    Applicant: MICROSOFT CORPORATION
    Inventors: Raphael Mun, Christian Klein
  • CHARGER DETECTION WITH PROPRIETARY CHARGER SUPPORT
    Publication number: 20130082644
    Abstract: Method and apparatus, among other things, are provided for detecting a charger type. In an example, a method to classify a potential charger coupled to a port of an electronic device can include detecting the potential charger coupled to a USB-compatible port of the electronic device, applying a pull-down current to first and second data lines of the USB-compatible port to provide a first test voltage on each of the first and second data lines, and executing a primary detection process of a USB Battery Charging 1.2 Compliance Plan if the first test voltage on each of the first and second data lines is not between a first threshold and a second threshold using the pull-down current.
    Type: Application
    Filed: September 26, 2012
    Publication date: April 4, 2013
    Applicant: Fairchild Semiconductor Corporation
    Inventors: Nickole Gagne, Oscar W. Freitas, Christian Klein, Tyler Daigle, Derek Richardson
  • BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
    Publication number: 20130078249
    Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
    Type: Application
    Filed: August 21, 2012
    Publication date: March 28, 2013
    Inventors: Oliver Ast, Peter Bruenker, Tanja Fauti, Anne Freimoser-Grundschober, Christiane Jaeger, Christian Klein, Ekkehard Moessner, Pablo Umana
  • BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
    Publication number: 20130078250
    Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
    Type: Application
    Filed: August 21, 2012
    Publication date: March 28, 2013
    Inventors: Oliver Ast, Tanja Fauti, Christiane Jaeger, Christian Klein, Pablo Umana
  • Antibodies against human angiopoietin 2
    Patent number: 8399626
    Abstract: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: March 19, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Remko Albert Griep, Klaus Kaluza, Anita Kavlie, Christian Klein, Joerg Thomas Regula, Werner Scheuer
  • FC-FREE ANTIBODIES COMPRISING TWO FAB FRAGMENTS AND METHODS OF USE
    Publication number: 20130060011
    Abstract: The present invention relates to bispecific antibodies comprising at least two fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Application
    Filed: August 21, 2012
    Publication date: March 7, 2013
    Inventors: Peter Bruenker, Christiane Jaeger, Christian Klein, Wolfgang Schaefer, Pablo Umana
  • Bispecific antigen binding molecules
    Publication number: 20130058937
    Abstract: The present invention generally relates to novel bispecific antigen binding molecules. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
    Type: Application
    Filed: August 21, 2012
    Publication date: March 7, 2013
    Inventors: Johannes Auer, Peter Bruenker, Tanja Fauti, Christiane Jaeger, Christian Klein, Wolfgang Schaefer, Claudio Sustmann, Pablo Umana
  • BISPECIFIC ANTIBODIES SPECIFIC FOR T-CELL ACTIVATING ANTIGENS AND A TUMOR ANTIGEN AND METHODS OF USE
    Publication number: 20130058936
    Abstract: The present invention relates to bispecific antibodies that specifically bind a T-cell activating antigen and a Tumor Antigen (TA), comprising a first Fab fragment and a second Fab fragment, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody does not comprise a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Application
    Filed: August 21, 2012
    Publication date: March 7, 2013
    Inventors: Peter Bruenker, Tanja Fauti, Christiane Jaeger, Christian Klein, Pablo Umana