Patents by Inventor Christian Klein

Christian Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Medical devices coated with a fast dissolving biocompatible coating
    Patent number: 8257727
    Abstract: The present invention relates to a medical device comprising a biocompatible medical coating adhered thereto, wherein the coating comprises at least one of a non-crosslinked, water soluble salt of: (i) alginic acid, (ii) hyaluronic acid or (iii) chitosan, wherein the coating is readily dissolvable in at least one mammalian body fluid.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: September 4, 2012
    Assignee: FMC Biopolymer AS
    Inventors: Michael Dornish, Christian Klein Larsen, Therese Andersen
  • Combination therapy of a type II anti-CD20 antibody with a proteasome inhibitor
    Publication number: 20120219549
    Abstract: The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a proteasome inhibitor for the treatment of a patient suffering from cancer, particularly a CD20-expressing cancer. An aspect of the invention is a composition comprising a type II anti-CD20 antibody and a proteasome inhibitor. Another aspect of the invention is a kit comprising a type II anti-CD20 antibody and a proteasome inhibitor. Yet another aspect of the invention is a method for the treatment of a patient suffering from cancer comprising co-administering, to a patient in need of such treatment, a type II anti-CD20 antibody and a proteasome inhibitor.
    Type: Application
    Filed: May 4, 2012
    Publication date: August 30, 2012
    Applicant: Hoffman-La Roche. Inc.
    Inventors: Georg Fertig, Thomas Friess, Christian Klein, Pablo Umana
  • Bivalent, bispecific antibodies
    Patent number: 8242247
    Abstract: The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: August 14, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Christian Klein, Wolfgang Schaefer
  • Bivalent, bispecific antibodies
    Patent number: 8227577
    Abstract: The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: July 24, 2012
    Assignee: Hoffman-La Roche Inc.
    Inventors: Christian Klein, Wolfgang Schaefer
  • Method and Apparatus for the Preparation of Capsules
    Publication number: 20120177727
    Abstract: An apparatus for a continuous encapsulation process is provided. The apparatus is a vibrating tubing used alone, in series, or in combination with an encapsulation apparatus, which is used alone or in series. The vibrating tubing is a flat coil, a standing spiral, or a flume. The encapsulation apparatus includes a winding having coils disposed in an aqueous gelling solution. The winding is rotatable about its longitudinal center axis. The winding has adjacently spaced coils forming a plurality of chambers. Objects to be encapsulated are added to the apparatus such that when the winding is rotated, the chambers transport a volume of objects through the length winding in the aqueous gelling solution in a predetermined time.
    Type: Application
    Filed: March 13, 2012
    Publication date: July 12, 2012
    Applicant: FMC Corporation
    Inventors: Peder Oscar Andersen, Robert Kopesky, Christian Klein Larsen, Olav Gaserod, David Harvey, Sanhuang Tung
  • BIVALENT, BISPECIFIC ANTIBODIES
    Publication number: 20120164726
    Abstract: The present invention relates to a host cell for use in the expression of a novel domain exchanged, bivalent, bispecific antibody.
    Type: Application
    Filed: January 31, 2012
    Publication date: June 28, 2012
    Inventors: CHRISTIAN KLEIN, WOLFGANG SCHAEFER
  • Thiazolyl-dihydro-indazoles
    Patent number: 8207349
    Abstract: The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
    Type: Grant
    Filed: January 11, 2010
    Date of Patent: June 26, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Bodo Betzemeier, Trixi Brandl, Steffen Breitfelder, Ralph Brueckner, Thomas Gerstberger, Michael Gmachl, Matthias Grauert, Frank Hilberg, Christoph Hoenke, Matthias Hoffmann, Maria Impagnatiello, Dirk Kessler, Christian Klein, Bernd Krist, Udo Maier, Darryl McConnell, Charlotte Reither, Stefan Scheuerer, Andreas Schoop, Norbert Schweifer, Oliver Simon, Martin Steegmaier, Steffen Steurer, Irene Waizenegger, Ulrike Weyer-Czernilofsky, Andreas Zoephel
  • PERSISTENT HANDLES FOR INTERFACE GUIDES
    Publication number: 20120157208
    Abstract: A computing system translates a world space position of a hand of a human target to a screen space position of a user interface and locks the hand to a handle of the user interface if world space parameters of the hand overcome a grab threshold of the handle. When the hand is locked to the handle, the computing system translates a world space position of the hand to a screen space handle position that is constrained along one or more interface guides. The hand is unlocked from the handle at a release position of the handle if world space parameters of the hand overcome a release threshold of the handle. The handle is retained at the release position after the hand is unlocked from the handle.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 21, 2012
    Applicant: MICROSOFT CORPORATION
    Inventors: Brendan Reville, Jack Bridges, Andy Mattingly, Jordan Andersen, Christian Klein, Arjun Dayal
  • BISPECIFIC ANTI-EGFR/ANTI-IGF-1R ANTIBODIES
    Publication number: 20120149879
    Abstract: The present invention relates to bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and methods of treatment using the antibodies.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 14, 2012
    Inventors: Ulrich Brinkmann, Rebecca Croasdale, Wilma Dormeyer, Christian Gerdes, Eike Hoffmann, Christian Klein, Klaus-Peter Kuenkele, Wolfgang Schaefer, Jan Olaf Stracke, Pablo Umana
  • Antibodies Against Human Angiopoietin 2
    Publication number: 20120141500
    Abstract: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Application
    Filed: January 26, 2012
    Publication date: June 7, 2012
    Inventors: ULRICH BRINKMANN, REMKO ALBERT GRIEP, KLAUS KALUZA, ANITA KAVLIE, CHRISTIAN KLEIN, JOERG THOMAS REGULA, WERNER SCHEUER
  • Antibodies Against Human Angiopoietin 2
    Publication number: 20120142091
    Abstract: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Application
    Filed: January 26, 2012
    Publication date: June 7, 2012
    Inventors: ULRICH BRINKMANN, REMKO ALBERT GRIEP, KLAUS KALUZA, ANITA KAVLIE, CHRISTIAN KLEIN, JOERG THOMAS REGULA, WERNER SCHEUER
  • COMBINATION THERAPY WITH TYPE I AND TYPE II ANTI-CD20 ANTIBODIES
    Publication number: 20120134990
    Abstract: The present invention is directed to a combination therapy involving a type I anti-CD20 antibody and a type II anti-CD20 antibody for the treatment of a patient suffering from cancer, particularly a CD20-expressing cancer. An aspect of the invention is a composition comprising a type I anti-CD20 antibody and a type II anti-CD20 antibody. Another aspect of the invention is a kit comprising a type I anti-CD20 antibody and a type II anti-CD20 antibody. Yet another aspect of the invention is a method for the treatment of a patient suffering from cancer comprising co-administering, to a patient in need of such treatment, a type I anti-CD20 antibody and a type II anti-CD20 antibody.
    Type: Application
    Filed: February 8, 2012
    Publication date: May 31, 2012
    Applicant: Roche Glycart
    Inventors: Thomas Friess, Christian Klein, Pablo Umaña
  • ANTI-FAP ANTIBODIES AND METHODS OF USE
    Publication number: 20120128591
    Abstract: The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
    Type: Application
    Filed: August 9, 2011
    Publication date: May 24, 2012
    Inventors: Marina Bacac, Anne Freimoser-Grundschober, Ralf Hosse, Christian Klein, Ekkehard Moessner, Valeria G. Nicolini, Pablo Umaña
  • PYRIDO [5, 4-D] PYRIMIDINES AS CELL PROLIFERATION INHIBITORS
    Publication number: 20120094975
    Abstract: The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, X1, X1, X3, L1 and L2 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell pro-liferation, and the use thereof in such a treatment.
    Type: Application
    Filed: September 8, 2009
    Publication date: April 19, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Andreas Mantoulidis, Georg Dahmann, Peter Ettmayer, Christian Klein, Steffen Steurer, Irene Waizenegger, Stephan Karl Zahn
  • SPEECH RECOGNITION USER INTERFACE
    Publication number: 20120089392
    Abstract: Speech recognition techniques are disclosed herein. In one embodiment, a novice mode is available such that when the user is unfamiliar with the speech recognition system, a voice user interface (VUI) may be provided to guide them. The VUI may display one or more speech commands that are presently available. The VUI may also provide feedback to train the user. After the user becomes more familiar with speech recognition, the user may enter speech commands without the aid of the novice mode. In this “experienced mode,” the VUI need not be displayed. Therefore, the user interface is not cluttered.
    Type: Application
    Filed: October 7, 2010
    Publication date: April 12, 2012
    Applicant: MICROSOFT CORPORATION
    Inventors: Vanessa Larco, Ali M. Vassigh, Alan T. Shen, Christian Klein, Thomas M. Soemo
  • Method and apparatus for the preparation of capsules
    Patent number: 8153037
    Abstract: An apparatus for a continuous encapsulation process is provided. The apparatus is a vibrating tubing used alone, in series, or in combination with an encapsulation apparatus, which is used alone or in series. The vibrating tubing is a flat coil, a standing spiral, or a flume. The encapsulation apparatus includes a winding having coils disposed in an aqueous gelling solution. The winding is rotatable about its longitudinal center axis. The winding has adjacently spaced coils forming a plurality of chambers. Objects to be encapsulated are added to the apparatus such that when the winding is rotated, the chambers transport a volume of objects through the length winding in the aqueous gelling solution in a predetermined time.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: April 10, 2012
    Assignee: FMC Corporation
    Inventors: Peder Oscar Andersen, Robert Kopesky, Christian Klein Larsen, Olav Gaserod, David Harvey, Sanhuang Tung
  • Antibodies against human angiopoietin 2
    Patent number: 8133979
    Abstract: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: March 13, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Remko Albert Griep, Klaus Kaluza, Anita Kavlie, Christian Klein, Joerg Thomas Regula, Werner Scheuer
  • Anti-Tenascin-C A2 Antibodies and Methods of Use
    Publication number: 20120039807
    Abstract: The invention provides antibodies against the A2 domain of tenascin-C and methods of using the same.
    Type: Application
    Filed: August 11, 2011
    Publication date: February 16, 2012
    Inventors: Anne Freimoser-Grundschober, Ralf Hosse, Christian Klein, Ekkehard Moessner, Valeria G. Nicolini, Pablo Umana
  • COMPOUND GESTURE-SPEECH COMMANDS
    Publication number: 20110313768
    Abstract: A multimedia entertainment system combines both gestures and voice commands to provide an enhanced control scheme. A user's body position or motion may be recognized as a gesture, and may be used to provide context to recognize user generated sounds, such as speech input. Likewise, speech input may be recognized as a voice command, and may be used to provide context to recognize a body position or motion as a gesture. Weights may be assigned to the inputs to facilitate processing. When a gesture is recognized, a limited set of voice commands associated with the recognized gesture are loaded for use. Further, additional sets of voice commands may be structured in a hierarchical manner such that speaking a voice command from one set of voice commands leads to the system loading a next set of voice commands.
    Type: Application
    Filed: June 18, 2010
    Publication date: December 22, 2011
    Inventors: Christian Klein, Ali M. Vassigh, Jason S. Flaks, Vanessa Larco, Thomas M. Soemo
  • BISPECIFIC ANTIBODIES
    Publication number: 20110293613
    Abstract: The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Application
    Filed: March 24, 2011
    Publication date: December 1, 2011
    Inventors: ULRICH BRINKMANN, REBECCA CROASDALE, HARALD DUERR, CHRISTIAN KLEIN, ERHARD KOPETZKI, WILMA LAU, JOERG THOMAS REGULA, JUERGEN MICHAEL SCHANZER, PABLO UMAÑA, KATHARINA WARTHA