Abstract: A pump apparatus for an electrohydraulic power steering mechanism for a vehicle includes a hydraulic pump, a working line, a pressure generator, a first control line, a preliminary pressure line, a compensation tank, a shut-off valve having a control inlet, and a second control line. The hydraulic pump is designed to pump a hydraulic oil out of a pump chamber to a pump outlet of the hydraulic pump. The pressure generator has a pressure generation inlet and a pressure generation outlet, and the pressure generator is designed to generate, using an inlet pressure present at the pressure generation inlet, an outlet pressure which can be provided at the pressure generation outlet and is lower than the inlet pressure. As a result, a preliminary pressure can be generated in the pump chamber.

Abstract: An electrohydraulic power steering device for a vehicle includes a hydraulic pump, a drive, a first working line, a second working line, and a heat exchanger. The hydraulic pump is designed, in a first rotation direction, to pump a hydraulic oil to a first pump output of the hydraulic pump and, in a second rotation direction, to pump said oil to a second pump output of the hydraulic pump. The drive is coupled to the hydraulic pump and is designed to drive the hydraulic pump selectively in the first rotation direction or second rotation direction. The first working line is shaped to connect the first pump output fluidically to a first working chamber, the first working chamber being suitable for moving a piston, which is couplable to a steering bar of a steering system, in a first direction. The heat exchanger is designed to transfer heat that is generated during operation of the drive to at least one of the working lines in order to heat the hydraulic oil flowing through the working line.

Abstract: A printhead (1) for printing molten metal for additive manufacturing of a component includes a nozzle component (10) having a nozzle outlet opening (12), a piston (14; 14a) that ejects the molten metal through the nozzle outlet opening (12), an actuator assembly (16; 16a) having an actuator, and a biasing element. By actuating the actuator, the piston (14; 14a) is movable in an actuation direction (y) from an extended position to a retracted position, in which a first piston end (18) that faces the nozzle outlet opening (12) is farther away from the nozzle outlet opening (12) than in the extended position. The biasing element (26; 26a) biases the piston (14; 14a), at least when it is located in the retracted position, back toward the extended position.

Abstract: A steering system for a vehicle, in particular a utility vehicle, has at least one steering transmission, in particular a ball nut hydraulic steering transmission; at least one steering mechanism for steering at least one first vehicle wheel and for steering at least one second vehicle wheel, wherein the steering transmission is coupled to the steering mechanism; at least one hydraulic pump for supplying the steering transmission with hydraulic fluid; and at least one drive motor which is provided independently and/or separately from the traction drive of the vehicle and which is coupled to the hydraulic pump in order to drive same. In the assembled state, the steering transmission, the hydraulic pump, and the drive motor are designed as a unit.

Abstract: Methods and systems for machine learning are disclosed for automated high content screening of drug compounds. Functions in one method include, receiving an assay layout; receiving images of a plurality of wells in one or more plates; training binary AI models based on the positive phenotype controls versus negative control to generate probabilities of an input image being the positive control to which the binary AI models were trained; training an all-control AI model based on all of the positive phenotype controls and the negative control to generate a set of probabilities of an input image being one of the positive phenotype controls or the negative control; and generating one or more visual representations of the set of probabilities to evaluate performance of the trained all-control AI model and the binary AI models.

Abstract: The present disclosure provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A?42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A?42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

Abstract: A method for regulatedly carrying out a chemical reaction in a reactor having reaction tubes which have a number of electrically heatable tube sections, wherein power connections are provided, which are each connected to at least one of the tube sections, wherein at least one connecting element is provided and each of the tube sections is connected to the connecting element. The method comprises conducting a process fluid through the one or more reaction tubes, providing several variable voltages at the several power connections, wherein the several voltages are provided as phases of a multiphase AC voltage so that the at least one connecting element forms a star point, setting the one or more voltages; detecting one or more measured values corresponding to one or more measured variables; changing the several set voltages so that the detected measured values correspond to predetermined values or value ranges of the measured variables.

Abstract: The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A?42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A?42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

Abstract: Disclosed is a reactor for carrying out a chemical reaction and a corresponding method. The reactor includes a vessel and one or more reaction tubes where a number of tube sections of the reaction tubes run between first second regions in the reactor vessel, and where the tube sections in the first region for the electrical heating of the tube sections can be electrically connected to the phase connections of a polyphase AC power source. Tube sections in the second region are electrically and conductively connected to one another as a whole by means of a single rigid connecting element, or in groups by means of a plurality of rigid connecting elements which are integrally connected to the reaction tubes and are arranged inside the reactor vessel. A corresponding method is also the subject-matter of the present invention.

Abstract: Methods, apparatus, and systems for high-resolution image storage and analysis are disclosed. In one disclosed embodiment, a method includes analyzing a high-resolution image; partitioning the high-resolution image into logical blocks; detecting objects in the high-resolution image within the logical blocks, assigning objects that differ or with differing measures to differing layers, and assigning objects that are similar or with similar measures to the same layer; tabulating the detected objects into a table, wherein each row indicates a spatial position of each detected object and at least one measure of each detected object; storing the spatial position and the at least one measure of each detected object into the table; spatially rendering selected objects over the high-resolution image; and displaying the selected objects at a selected resolution within a portion of the high-resolution image on a display device.

Abstract: The invention relates to a production machine with a control program for visualizing stations and/or machine components, highlighting the speed-determining station and/or the speed-determining machine component in order to optimize the process time. The invention also relates to a method of optimizing the process time for a production machine with such a control program and to a data carrier with such a control program.

Abstract: A reactor includes a reactor vessel and one or more reaction tubes A number of tube sections of the one or more reaction tubes in each case run between a first region and a second region in the reactor vessel. For the electrical heating of the tube sections, the tube sections in the first region can be electrically connected to (a) current connection(s) of a current source. In the first region, current feed arrangements are provided; in each case one or in each case one group of the tube sections are electrically connected, and each comprise (a) contact passage(s) that in each case adjoin(s) at least one of the tube sections in the first region. A wall of the contact passages in each case is connected to a current feed element that has a rod-shaped section that runs at a wall passage through a wall of the reactor vessel.

Abstract: The disclosure relates to a hand-held machine tool with a drive unit for driving a tool holder, wherein the drive unit is paired with a planetary gearbox, which is arranged in a gearbox housing and comprises at least one ring gear, and an intermediate shaft, said intermediate shaft being connected to a planet carrier of the planetary gearbox. According to the disclosure, the at least one ring gear is paired with a fixing element which is designed to fix the at least one ring gear in the gearbox housing in the longitudinal direction of the ring gear rotational axis, said fixing element being arranged on the ring gear and/or the intermediate shaft.

Abstract: The invention relates to an HMI system with a mobile operating and monitoring device for operating a production machine for plastics processing. The HMI system is installed on a control unit of the production machine and has a mobile operating and monitoring device.

Abstract: A method is proposed for producing a packaging, having a method step of microperforation of a flexible material as a packaging film, comprising: provision of the flexible material as a packaging film, transport of the flexible material over a transport section, provision of a laser in order to generate a perforation of the flexible material with its beam. For a packaging with improved gas exchange, a laser system with a wavelength in the range of from 150 nm to 1064 nm, preferably from 355 nm to 532 nm, is used for the laser, and the perforation with the laser is carried out during the movement of the flexible material of the packaging film during the transport.

Abstract: Methods and systems for machine learning are disclosed for early detection of morphological changes in cell condition of biological cells. In one disclosed embodiment, the development of vaccines and anti-virals are sped up using machine learning to identify viral plaques earlier than can be detected using human observation alone. In the disclosed embodiment, detecting morphological changes in virus-infected cells can be made before plaques caused by cell death are observable (typical cell death in 2-14 days). Machine learning brings high-content/high-throughput techniques to the study of virology for the development of novel anti-viral compounds. Machine learning can also be used to characterize the effectiveness of novel anti-viral compounds on rapidly mutating viral strains, such as influenza and SARS-CoV-2.

Abstract: The disclosure is based on a hand-held power tool having at least one switch device which comprises at least one switching element at least for activating a power supply of a drive unit, having at least one quick-change tool holder which is provided for holding an insertion tool which is different from an insertion tool with an SDS® shaft having a maximum transverse extent of 10 mm and/or having at least one accumulator interface. It is proposed that the at least one switching device comprises at least one locking unit which is provided for maintaining, at least essentially independently of an effect of an operator activation force, an active operating mode which can be activated by actuating the at least one switching element.

Abstract: The invention relates to a production machine (1) having a control program (4) for visualization of machine components (2) and a method (100) of optimizing process parameters for the production machine having such a control program, as well as a data carrier having such a control program, the control program comprising an interactive user interface embodied as a visualization unit (5) and being adapted to visualize, on the visualization unit, at least one of the machine components in their functions during production in one presentation for each of these machine components and to provide corresponding switch panels (51) for the input of process parameters relating to the respective visualized machine component, the presentation comprising at least one parameter-time diagram (52) with motion curves (53) for components (21) of the respective machine component, wherein at least one of the motion curves being subdivided into different suitably visualized motion sections (53a, 53b, 53c) for each of which the proce

Abstract: The invention relates to a package for outgassing foods and/or maturing foods, in particular roasted coffee and/or coffee beans, comprising a bag for storing the food, which includes a film from which the bag is formed, wherein a valve is provided to enable a discharge of gas from the package bag to the outside in the event of overpressure in the package and to reduce the diffusion-related gas exchange in the case of comparable and/or equal pressure conditions in and/or outside the package bag. It is characterized in that the valve is formed as a microperforation in the film having at least one or two holes of the size of 750 ?m2 to 40 000 ?m2, preferably of 390 ?m2 to 20 000 ?m2, particularly preferably 70 ?m2 to 16 000 ?m2 and/or each having the diameter of 10-70 ?m, preferably 20-60 ?m, particularly preferably 30 ?m.

Abstract: A power-tool cooling apparatus for a portable power tool includes a first fan configured to generate a first cooling fluid flow to cool a drive unit of the portable power tool, and a second fan that generates a further cooling fluid flow to cool an electronics unit of the portable power-tool. A third fan generates a third cooling fluid flow to cool a second electronics unit of the power-tool, and supplies cooling fluid to the first cooling fluid flow.