Abstract: An assembly (10) for potential equalization in potentially explosive areas is described, having an outer housing (20), a gas discharge arrester (22), a short-circuiting device (30) and a fault indicator (42). At least the gas discharge arrester (22) and the short-circuiting device (30) are accommodated in the outer housing (20). The short-circuiting device (30) comprises at least one spring (32) and an actuating element (34), which is preloaded into a short-circuit position by the spring (32). The gas discharge arrester (22) has a base body (24) which is filled with a gas and connected to a first connecting part (16) via a thermally detachable connection (38). The fault indicator (42) is set up to indicate a tripping event of the short-circuiting device (30).

Abstract: The present invention provides an overvoltage protection spark gap assembly and a method for operating an overvoltage protection spark gap assembly. The overvoltage protection spark gap assembly comprises a first overvoltage protection spark gap (1) which has a first main terminal (1a) and a second main terminal (1b); a second overvoltage protection spark gap (1?) which has a third main terminal (1a?) and a fourth main terminal (1b?). The first main terminal (1a) can be connected to a first voltage line (S1) of a supply network via a first terminal contact (A1) and the fourth main terminal (1b?) can be connected to a second voltage line (S2) of the supply network via a second terminal contact (A2). The second main terminal (1b) and the third main terminal (1a?) are electrically connected to one another.

Abstract: The invention relates to a production machine (1) having a control program (4) for visualization of machine components (2) and a method (100) of optimizing process parameters for the production machine having such a control program, as well as a data carrier having such a control program, the control program comprising an interactive user interface embodied as a visualization unit (5) and being adapted to visualize, on the visualization unit, at least one of the machine components in their functions during production in one presentation for each of these machine components and to provide corresponding switch panels (51) for the input of process parameters relating to the respective visualized machine component, the presentation comprising at least one parameter-time diagram (52) with motion curves (53) for components (21) of the respective machine component, wherein at least one of the motion curves being subdivided into different suitably visualized motion sections (53a, 53b, 53c) for each of which the proce

Abstract: Provided herein are FGFR1/KLB targeting agonistic antigen-binding proteins, or fragments thereof, having improved physico-chemical properties. Also provided herein are conjugates comprising an FGFR1/KLB targeting agonistic antigen-binding protein, or a fragment thereof, and at least one GLP-1R agonistic peptide. Further provided are pharmaceutical compositions comprising the antibody (or fragment thereof), or the conjugate provided herein, and the use of the antibody (or fragment thereof), or the use of the conjugate in medicine.

Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: A system for guidance of an operator during concrete compaction using a concrete compaction device includes a planning device for storing planning data. The planning data is used to define locations in a defined region, at which concrete compaction is to be performed using the concrete compaction device, and to define a sequence of the locations in which concrete compaction is to be performed. The system also includes a position determination device for determining the respective current position of the concrete compaction device, and a display device for displaying, at least in each case, the location in the sequence of locations at which concrete compaction is currently to be performed.

Abstract: An apparatus is provided for determining the position of a vibration unit for concrete compaction which can be guided by an operator. The apparatus includes a surface position determination device having a receiving device with the surface position determination device being designed to determine the position of the receiving device in the plane. The apparatus additionally includes an orientation determination device for determining an orientation (A) of a working direction of the operator. The apparatus also includes a correction device for correcting the position of the receiving device with an offset (O) in the direction of the orientation (A) of the working direction and, thus. for determining the position (P2) of the vibration unit in the plane.

Abstract: A lighting apparatus for a motor vehicle, wherein a first structural component of the lighting apparatus is connected to a second structural component of the lighting apparatus, and the connection between the first and second structural components is formed by a twist-on connection. The second structural component comprises at least two coupling elements that fit over, in particular at the perimeter of, the first structural component in the fully assembled state, at least in part, and the first structural component ends up in this engaged position, in particular on the perimeter thereof, through a rotation in relation to the second structural component.

Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: A concrete compaction system includes an unbalance exciter for concrete compaction, a compaction detection device for detecting progress of the compaction in the concrete, and a vibration device for generating a haptic feedback when a prescribed progress of the compaction has been detected by the compaction detection device. An electric motor may drive the unbalance exciter and may be powered by an electric power supply and a converter device for converting an electric current from the electric power supply to a drive current for the electric motor. The compaction detection device may comprise a measurement device for measuring the current drawn from the electric motor. The compaction detection device may also comprise an evaluation device for evaluating the current drawn measured by the measurement device, for determining therefrom the progress of the compaction in the concrete, and for detecting whether a prescribed progress of the compaction has been achieved.

Abstract: A compaction system has a compaction device with an electric motor for generating a compaction movement, an energy device for providing electric energy for the electric motor, a measurement device for measuring the current drawn by the electric motor, and an evaluation device for evaluating the current draw as measured by the measurement device and for determining, from this determination, the compaction progress in the medium being compacted. The evaluation device is arranged at least partly in an external device, spatially separate from the energy device and/or from the compaction device.

Abstract: A concrete compaction device includes a vibrator housing for immersion in flowable concrete, and an unbalance exciter which is driven by an electric motor and which is arranged in the vibrator housing. A current detection device detects the electric current absorbed by the electric motor. Ann evaluation device determines an operating state of the concrete compaction device based on the electric current that is currently detected. The operating state is selected from the group consisting of: positioning of the vibrator housing in the air, immersion of the vibrator housing in the concrete, performance of a compaction process with the vibrator housing immersed in the concrete, and emersion of the vibrator housing from the concrete. The evaluation device is configured to recognize all of these operating states.

Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. Also disclosed herein are nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies, as well as methods of isolating the antibodies.

Abstract: The present invention relates to street sweeper. According to a first aspect of the invention, different mechanisms are disclosed for controlling the movement of the brush-holder arms in a horizontal plane, while also damping side and front impacts. According to a second aspect, a sweeper is disclosed, in which the movement of the brush-holder arms (3) in a vertical plane is imparted by a set of four profile members, arranged in two pairs which each forms a deformable parallelogram, wherein the deformation of the parallelogram is actuated by a jack (25) and the own weight of the sweeping arm. The jack is configured to remain below the upper profile members (11) of the two pairs when the brush-holder arm is raised to its maximum height. According to a third aspect, the suction turbine (103) is arranged in such a way that load losses are reduced during the operation of the sweeper.

Abstract: A method for regulatedly carrying out a chemical reaction in a reactor having reaction tubes which have a number of electrically heatable tube sections, wherein power connections are provided, which are each connected to at least one of the tube sections, wherein at least one connecting element is provided and each of the tube sections is connected to the connecting element. The method comprises conducting a process fluid through the one or more reaction tubes, providing several variable voltages at the several power connections, wherein the several voltages are provided as phases of a multiphase AC voltage so that the at least one connecting element forms a star point, setting the one or more voltages; detecting one or more measured values corresponding to one or more measured variables; changing the several set voltages so that the detected measured values correspond to predetermined values or value ranges of the measured variables.

Abstract: Provided herein are bivalent, bispecific binding proteins that specifically bind to two different HIV-1 Env protein epitopes.

Abstract: Disclosed is a reactor for carrying out a chemical reaction and a corresponding method. The reactor includes a vessel and one or more reaction tubes where a number of tube sections of the reaction tubes run between first second regions in the reactor vessel, and where the tube sections in the first region for the electrical heating of the tube sections can be electrically connected to the phase connections of a polyphase AC power source. Tube sections in the second region are electrically and conductively connected to one another as a whole by means of a single rigid connecting element, or in groups by means of a plurality of rigid connecting elements which are integrally connected to the reaction tubes and are arranged inside the reactor vessel. A corresponding method is also the subject-matter of the present invention.

Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.