Abstract: A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.

Abstract: A method and apparatus for analysis of a specimen in a microscope are provided. A first survey is performed that collects analytical data from a region of interest on the specimen surface using a first set of conditions. A second survey is performed that collects additional analytical data from selected parts of the region of interest on the specimen surface using a second set of conditions, different from the first set of conditions. The analytical data from the first survey is used to select the parts used for data collection in the second survey and to decide the order in which they are used.

Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: Disclosed herein is a process for producing polymers of an N-vinyl carboxamide, including the steps of flowing a reaction mixture containing an aqueous liquid containing at least one polymerization initiator, N-vinyl carboxamide monomer or a monomer mixture containing N-vinyl carboxamide into a reactor system, and polymerizing the monomer or monomer mixture to produce the polymer of a N-vinyl carboxamide. The polymers resulting therefrom may be hydrolyzed to provide polymers containing vinyl amine units. Also disclosed herein is an apparatus suitable for producing the polymers.

Abstract: The present invention relates to a device in the form of a suction nozzle (10) for an urban or industrial aspirator (1), preferably self-propelled, comprising a rigid hose or tube (1000), said rigid hose or tube comprising gripping means (100, 200, 300, 400) that comprise a first gripping element (110, 210, 310, 410) in the form of a handle, a support element (120, 220, 320, 420) serving as a lever, and a second gripping element (130, 230, 330, 430) and optionally a base (101, 201, 301, 401).

Abstract: Method for producing a reinforcement beam for a vehicle, comprising at least one weak zone arranged in such a way that the bending resistance of the beam is less in said weak zone than in the rest of the beam, characterized in that it comprises, in order, a step (A) of extruding a profile part, a step (B) of cutting the profile part so as to obtain at least one profile segment, a step (C) of locally deforming the segment of the profile part in order to create the weak zone or zones.

Abstract: The invention relates to an arrangement for the drive mounting, in particular for a motor vehicle, preferentially a utility vehicle. The arrangement comprises a supporting structure, in particular a cross member structure. The arrangement comprises an, in particular electric, drive unit, which is attached to the supporting structure in a 3-point mounting on an underside and/or from below. Advantageously, the drive unit can thus be fed to the motor vehicle from the rear end. The drive unit can be practically lifted in order to be then attached to the supporting structure on an underside or from below. The 3-point mounting makes possible a quick assembly. In addition, a static redundancy of the mounting through too many bearing points (e.g. four or more) is prevented.

Abstract: A method and apparatus for analysis of a specimen in a microscope are provided. A first survey is performed that collects analytical data from a region of interest on the specimen surface using a first set of conditions. A second survey is performed that collects additional analytical data from selected parts of the region of interest on the specimen surface using a second set of conditions, different from the first set of conditions. The analytical data from the first survey is used to select the parts used for data collection in the second survey and to decide the order in which they are used.

Abstract: The disclosure is based on a sensor device, in particular a hand-held power-tool sensor device, for identifying an uncontrolled occurrence of jamming in the case of a hand-held power tool, having at least one sensor unit, which is provided to sense at least one motion characteristic value of the hand-held power tool, and having a protective unit, which is provided to control the hand-held power tool in dependence on at least one triggering threshold value and the at least one motion characteristic value. It is proposed that the protective unit be provided to set the at least one triggering threshold value in a variable manner and/or to define at least one further triggering threshold value.

Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: A power-tool cooling apparatus for a portable power tool comprises at least one cooling unit configured to generate a cooling fluid flow to cool a drive unit of the portable power tool, and at least one further cooling unit configured to generate a further cooling fluid flow. The at least one further cooling unit is designed to differ from the at least one cooling unit.

Abstract: The present invention relates to a street or industrial vacuum cleaner (1) on a chassis (50) and self-propelled using at least one drive motor comprising a guide element preferably taking the form of a handlebar (70) with at least one handle (740), a hand grip (730) and means or elements (710) for attachment to the chassis (50) of the vacuum cleaner (1), said attachment means or elements (710) making it possible, by the transmission of the movement applied to the hand grip (730), to steer said vacuum cleaner (1), characterized in that the handle (740) comprises a telescopic zone with a sliding part (745) able to move between a first position referred to as an extended position and a second position referred to as a retracted position, preferably with a return spring (780) and at least a switch (770) for detecting the position of the sliding part (745), said switch (770) being able to cause the street vacuum cleaner drive motor to switch off or reverse if the sliding part (745) is in the retracted position.

Abstract: A hand-held power tool, in particular a drilling hammer and/or chisel hammer, that includes at least one housing, at least one handle, and at least one interface device for establishing an electrical and mechanical connection to at least one rechargeable battery pack. The hand-held power tool includes at least one damping unit that is provided for supporting the at least one handle relative to the at least one housing in a vibration-damped manner. The at least one interface device is situated on the at least one handle.

Abstract: A method of monitoring and controlling an access control system (12) comprising a server (18) and an access control device (22) connected to the server (16) for data communication. Data goggles (1) monitor and control the access control system. The data goggles are connected wirelessly to the server (16) and the access control device (22) for data communication and receive data in real time from the server (16) and/or the access control device (22), which enable monitoring of the access control system (12). The data is displayed to the user of the data goggles (1) by a display device (10). The access control system (12) is controlled by commands which are inputted by the data goggles (1) and transmitted to the server (16) and/or the access control device (22). The control commands are input either by voice control, by gesture control, by a touchpad or by eye tracking.

Abstract: A portable machine tool, particularly a hammer drill and/or chisel hammer, has a length, a width, a height and a mass. The portable machine tool has at least one energy storage unit that has a charge carrier capacity and a quick-change tool holder for quick-change tools with a shaft diameter of less than 12 mm. A product formed from the length, the width, the height, the mass and the inverse of the charge carrier capacity is less than 1301 cm3 kg A h?1.

Abstract: A power-tool cooling apparatus for a portable power tool comprises at least one cooling unit configured to generate a cooling fluid flow to cool a drive unit of the portable power tool, and at least one further cooling unit configured to generate a further cooling fluid flow. The at least one further cooling unit is designed to differ from the at least one cooling unit.

Abstract: The invention relates to an appliance which is more particularly applicable in an urban or industrial vacuum cleaner into which the waste is sucked up and then collected in a container. The appliance comprises a flexible tube, the proximal end of which receives the waste and the distal end of which is held by a ring which is pivotable such that the ring can be positioned in one of several pre-defined positions. This variable positioning allows the waste to be deposited in different containers or compartments, according to the characteristics thereof. The appliance can be controlled manually or automatically on the basis of electronic or optical sensors.

Abstract: Some embodiments include a system. The system comprises an input device, an output device, one or more processing modules, and one or more non-transitory memory storage modules storing computer instructions. The computer instructions are configured to run on the processing module(s) and perform the acts of: identifying at least one test web page; and analyzing a first test web page of the at least one test web page. The analyzing the first test web page of the at least one test web page comprises crawling the first test web page to detect a first adverse performance condition of the first test web page, and the first adverse performance condition can impact a first search rank assigned to the first test web page when present. Other embodiments of related systems and methods are also provided.

Abstract: The invention relates to an impact-absorbing structure for a vehicle, the structure of which comprises at least one side rail for supporting a bumper crossbeam, the side rail being a hollow profile member arranged according to the longitudinal axis of the vehicle, the impact-absorbing structure including the bumper crossbeam, at least one absorber placed between the side rail and the bumper crossbeam, the absorber being a hollow profile member intended for deforming in the event of an impact, one end of the profile member being intended to be inserted into the open end of the side rail, the end of the profile member being attached to the side rail via transversely arranged attachment means, and an attachment insert provided with opposing surfaces. Each of the opposing surfaces of the insert is provided with two transverse recesses arranged perpendicular to the opposing surfaces, and offset relative to one another.

Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.