Abstract: Provided herein, among other things, is a computer-implemented method for assigning a sequence read to a genomic location, the method including: a) accessing a file containing a sequence read, wherein the sequence read is obtained from a nucleic acid sample that has been enriched by hybridization to a plurality of capture sequences; and b) assigning the sequence read to a genomic location by: i) identifying a capture sequence as being a match with the sequence read if the sequence read contains one or more subsequences of the capture sequence; ii) calculating, using a computer, a score indicating the degree of sequence similarity between each of the matched capture sequences and the sequence read; and iii) assigning the sequence read to the genomic location if the calculated score for a matched capture sequence is above a threshold.

Abstract: Provided herein is a method for identifying a sequence variant in an enriched sample. In certain embodiments, this method may comprise: (a) obtaining: (i) a plurality of sequence reads from a sample that has been enriched for a genomic region and (ii) a reference sequence for the genomic region; (b) assembling the sequence reads to obtain a plurality of discrete sequence assemblies that correspond to potential variants; (c) determining which of the potential variants are true and which are artifacts by examining the sequence reads that make up each of the discrete sequence assemblies; (d) optionally determining whether each of the true potential variants contains a mutation that is known to be associated with the reference sequence; and (e) outputting a report indicating whether the sample comprises a sequence variant.

Abstract: A connection assembly is provided. The connection assembly includes a socket with connection pins, a plug with matching connection pins and a locker for locking the plug relative to the socket while the matching pins are engaged. The lock includes a bolt having a barrel provided with balls movable between a locking position projecting in relation to the barrel and a position retracted inside the barrel, and a rod for retaining the balls in the locking position. The locker also includes a shaft arranged in the plug or the socket for at least partially receiving the bolt and having a groove for receiving the balls in the locked and projecting position. The bolt further includes a spring for returning the rod toward the ball-retaining position, and the rod has a cam surface pushing the balls back into the locked position when the spring urges the rod towards the retaining position.

Abstract: The present invention provides an antenna interface. The antenna interface includes a socket and a plug. The socket includes a body and two coaxial cables, each having a core, a braid coaxial to the core, and an electric insulator between the core and the braid. Each coaxial cable extends between a first end connected to a printed circuit board of the receiver and a second end at which the braid is electrically connected to the body, and at which the core can be accessed through an opening made in the body. The plug includes a body and at least two contactors such that, when the plug and the socket are connected, each contactor is arranged opposite an opening such that the core of a respective cable is electrically connected to the contactor, and the braid of each cable is electrically connected to the body of the plug via the body.

Abstract: A connection assembly is provided. The connection assembly includes a socket with connection pins, a plug with matching connection pins and a locker for locking the plug relative to the socket while the matching pins are engaged. The lock includes a bolt having a barrel provided with balls movable between a locking position projecting in relation to the barrel and a position retracted inside the barrel, and a rod for retaining the balls in the locking position. The locker also includes a shaft arranged in the plug or the socket for at least partially receiving the bolt and having a groove for receiving the balls in the locked and projecting position. The bolt further includes a spring for returning the rod toward the ball-retaining position, and the rod has a cam surface pushing the balls back into the locked position when the spring urges the rod towards the retaining position.

Abstract: The present invention provides an antenna interface. The antenna interface includes a socket and a plug. The socket includes a body and two coaxial cables, each having a core, a braid coaxial to the core, and an electric insulator between the core and the braid. Each coaxial cable extends between a first end connected to a printed circuit board of the receiver and a second end at which the braid is electrically connected to the body, and at which the core can be accessed through an opening made in the body. The plug includes a body and at least two contactors such that, when the plug and the socket are connected, each contactor is arranged opposite an opening such that the core of a respective cable is electrically connected to the contactor, and the braid of each cable is electrically connected to the body of the plug via the body.

Abstract: The present invention relates to methods for treating or controlling schizophrenia in a mammal using compounds having the Formula (I), wherein M1 and M2 are defined in the application.

Abstract: A terrestrial repeater, comprising i) an interface means configured to receive a first data stream originating from a first satellite transmission network, a second data stream originating from a second transmission network, and a third data stream originating from a third terrestrial transmission network, and to transform the received streams into data packets; ii) a first processing means configured to select at least one part of the data packets of at least one of the first, second, and third streams received, and to process each selected stream portion to place the data packets it comprises into a selected broadcast format; and iii) a second processing means configured to combine the selected and processed stream portions to constitute a set of packets to be broadcast, convert the set of packets into at least one radio frequency signal, and amplify the at least one radio frequency signal in order to broadcast wirelessly towards at least one radio communication terminal.

Abstract: The invention relates to an armed stealth surface vessel (1) comprising a hull (2), a deck (5, 6) and superstructures (3). The inventive vessel is equipped with sensors, transmitters, arms and, optionally, handling means. The invention is characterized in that the outer casing (4) of the deadworks comprises walls which are all inclined inwards such that the outer faces thereof are oriented upwards and form an angle that is greater than or equal to 20° with the vertical at least above a line located 5 m above the waterline and, along at least 50% of the length of the vessel, above a line located less than one meter above the waterline. The invention is also characterized in that that the essentially-vertical joint lines between two adjacent walls are inclined inwards and form an angle of more than 20° with the vertical. The invention is further characterized in that the sensors and transmitters, the arms and the handling means are concealed or can be concealed in or under the outer casing of the deadworks.

Abstract: The present invention relates to a novel biosensor. A resonance energy transfter (RET) biosensor comprising a beta(?)-arrestin tagged with a first and a second chromophore, wherein said first chromophore is a fluorophore and said second chromophore is a fluorophore or a bioluminophore is described.

Abstract: A terrestrial repeater (RT), comprising i) interface means (MI) having the function to receive a first data stream originating from a first satellite type transmission network (R1), a second data stream originating from a second transmission network (R2), and a third data stream originating from a third terrestrial type transmission network (R3), and to transform the said received streams into data packets; ii) first processing means (MT1) equipped to select at least one part of the data packets of at least one of the first, second, and third streams received, and to process each selected stream portion so as to place the data packets it comprises into a selected broadcasting format; and iii) second processing means (MT2) having the function to combine the stream portions selected and processed in order to constitute a set of packets to be broadcast, then to convert the said set into at least one radio frequency, and to amplify the said radiofrequency signal with a view to its broadcast via waves towards at l

Abstract: An information exchange system comprising at least one network for the transmission of information, at least one system computer accessing said at least one network, at least one peripheral device for exchanging said information with said at least one system computer, said at least one peripheral device being of sensor or actuator type and having no communication interface with said at least one network, at least one data concentrator associated with at least one associated peripheral device, accessing said at least one network and enabling said associated peripheral device to exchange said information with said at least one system computer, said data concentrator comprising data processing means, network interface means for interfacing said data processing means and said at least one network and device interface means for interfacing said data processing means and said at least one associated peripheral device, said information exchange system further comprising connection means for connecting said at least

Abstract: In some embodiments, a memory control device includes a sensor positioned remotely from a memory device, a register to store an offset value, the offset value corresponding to a difference between a temperature reading of the sensor and an estimated actual temperature of the memory device, and a controller to control an operation of the memory device, wherein the controller is configured to read the offset value from the register and control the operation of the memory device in accordance with the offset value. The controller may be configured to dynamically update the offset value during an operation of the memory device. Other embodiments are disclosed and claimed.

Abstract: Methods, systems and computer readable media for quantifying and removing offset bias signals in a chemical array data set having one or more channels. In one embodiment, for each channel of data in the data set, a first set of features is selected from the data set. Surface intensities are calculated for features in the first selected set of features and surface intensifies of features not in the first selected set are calculated from the calculated surface intensities. A second set of features is selected, the intensity values of which are within a range of correspondingly located surface intensity values defined by upper and lower threshold intensities. Secondary surface intensifies are calculated for features in the second selected set of features and secondary surface intensities for all other locations on the array that were not locations corresponding to the features having secondary surface intensities calculated therefore, are calculated.

Abstract: Using eddy currents to inspect a hole that is possibly not rectilinear and/or of section that is not circular. The inspection device comprises a stick shaped and dimensioned to be capable of being engaged in said hole, at least one arm hinged to a support fastened to one end of the stick, an eddy current sensor being embedded in said arm, and resilient means for urging the arm outwards against the inside surface of the hole.

Abstract: In some embodiments, a memory control device includes a sensor positioned remotely from a memory device, a register to store an offset value, the offset value corresponding to a difference between a temperature reading of the sensor and an estimated actual temperature of the memory device, and a controller to control an operation of the memory device, wherein the controller is configured to read the offset value from the register and control the operation of the memory device in accordance with the offset value. The controller may be configured to dynamically update the offset value during an operation of the memory device. Other embodiments are disclosed and claimed.

Abstract: Using eddy currents to inspect a hole that is possibly not rectilinear and/or of section that is not circular. The inspection device comprises a stick shaped and dimensioned to be capable of being engaged in said hole, at least one arm hinged to a support fastened to one end of the stick, an eddy current sensor being embedded in said arm, and resilient means for urging the arm outwards against the inside surface of the hole.

Abstract: The invention relates to an armed stealth surface vessel (1) comprising a hull (2), a deck (5, 6) and superstructures (3). The inventive vessel is equipped with sensors, transmitters, arms and, optionally, handling means. The invention is characterised in that the outer casing (4) of the deadworks comprises walls which are all inclined inwards such that the outer faces thereof are oriented upwards and form an angle that is greater than or equal to 20° with the vertical at least above a line located 5 m above the waterline and, along at least 50% of the length of the vessel, above a line located less than one metre above the waterline. The invention is also characterised in that that the essentially-vertical joint lines between two adjacent walls are inclined inwards and form an angle of more than 20° with the vertical. The invention is further characterised in that the sensors and transmitters, the arms and the handling means are concealed or can be concealed in or under the outer casing of the deadworks.

Abstract: A method to allow an analyst or other user of molecular-array data to directly tailor pixel-intensity integration of scanned pixel-based representations of features of a molecular array to produce feature signals. The method is embodied in a graphical user interface that allows an analyst or other molecular-array user to input pixel-intensity-weighting functions into a computational system that applies the weighting functions prior to producing integrated feature signals. The GUI provides a user with the ability to select the origin of a feature-centric rectilinear coordinate system, to input a function that specifies the function that is applied to the raw pixel intensities within the region of interest prior to integration of the pixel intensities within the region of interest to produce a feature signal.

Abstract: Methods, systems and computer readable media for quantifying and removing offset bias signals in a chemical array data set having one or more channels. In one embodiment, for each channel of data in the data set, a first set of features is selected from the data set. Surface intensities are calculated for features in the first selected set of features and surface intensifies of features not in the first selected set are calculated from the calculated surface intensities. A second set of features is selected, the intensity values of which are within a range of correspondingly located surface intensity values defined by upper and lower threshold intensities. Secondary surface intensifies are calculated for features in the second selected set of features and secondary surface intensities for all other locations on the array that were not locations corresponding to the features having secondary surface intensities calculated therefore, are calculated.