Patents by Inventor Christian Lerner

Christian Lerner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SULFONYLPIPERAZINYL COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20240417387
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3, A, Q1, Q2, W and X are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 20, 2021
    Publication date: December 19, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Kurt Amrein, Fabian Dey, Xiao Ding, Xinyi Huang, Christian Lerner, Houguang Shi, Xuefei Tan, Jun Wu, Jiamin Zheng, Mingwei Zhou
  • QUATERNARY AMMONIUM CATION SUBSTITUTED COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20240376073
    Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as described herein: Frther provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: January 4, 2024
    Publication date: November 14, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Sandra Marie Joseph GRALL-ULSEMER, Xingchun HAN, Joel Lukas KNECHT, Christian LERNER, Mingming LI, Yongqiang LIU, Patrizio MATTEI, Matthias NETTEKOVEN, Philippe PFLIEGER, Theodor STOLL, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20240368117
    Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: November 10, 2023
    Publication date: November 7, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Mathis BRAENDLIN, Sandra Marie Joseph GRALL-ULSEMER, Xingchun HAN, Christian LERNER, Mingming LI, Yongqiang LIU, Sébastien SCHMITT, Jianhua WANG, Yongguang WANG, Min WANG, Song YANG, Chengang ZHOU
  • Heterocyclic compounds
    Patent number: 11858912
    Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: January 2, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Mathis Braendlin, Sandra Marie Joseph Grall-Ulsemer, Xingchun Han, Christian Lerner, Mingming Li, Yongqiang Liu, Sébastien Schmitt, Jianhua Wang, Yongguang Wang, Min Wang, Song Yang, Chengang Zhou
  • Turbine blade tip, turbine blade and method
    Patent number: 11859510
    Abstract: A turbine blade tip, turbine blade and method where improved cooling is made possible by an improved cooling structure with cooling air holes inside a depression in a blade tip and a special arrangement of multiple cooling air holes which are supplied by a single cooling air channel inside a wall.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: January 2, 2024
    Assignee: Siemens Energy Global GmbH & Co. KG
    Inventors: Björn Anders, Reiner Anton, Kay Krabiell, Christian Lerner
  • HETEROARYL-SUBSTITUTED IMIDAZOLE DERIVATIVES
    Publication number: 20230373978
    Abstract: The invention provides novel heteroaryl-substituted imidazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein A and R1 to R6 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: August 1, 2023
    Publication date: November 23, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian LERNER, Mingming LI, Yongqiang LIU, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • NOVEL IMIDAZOLE-PYRAZOLE DERIVATIVES
    Publication number: 20230295123
    Abstract: The invention provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: February 28, 2023
    Publication date: September 21, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian LERNER, Mingming LI, Yongqiang LIU, Sébastien SCHMITT, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • NOVEL HETEROCYCLIC COMPOUNDS
    Publication number: 20230257354
    Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R9 and p are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: March 6, 2023
    Publication date: August 17, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • IMIDAZOLE-PYRAZOLE DERIVATIVES AS ANTIBACTERIALS
    Publication number: 20230234939
    Abstract: The invention provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein A and R1-R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: February 27, 2023
    Publication date: July 27, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Sandra Marie Joseph GRALL-ULSEMER, Wolfgang GUBA, Christian LERNER, Mingming LI, Yongqiang LIU, Markus RUDOLPH, Sébastien SCHMITT, Lorenz URNER, Yongguang WANG, Min WANG, Jianhua WANG, Song YANG, Chengang ZHOU, Patrizio MATTEI
  • NOVEL IMIDAZOPYRAZNE DERIVATIVES
    Publication number: 20230203047
    Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1 to X4, R1 to R5, R8 to R10, A, and L1 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: November 29, 2022
    Publication date: June 29, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian LERNER, Yongqiang LIU, Song YANG, Chengang ZHOU
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230203043
    Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X and R3 to R9 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: October 28, 2022
    Publication date: June 29, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jean-Baptiste BLANC, Christian LERNER, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Sébastien SCHMITT, Theodor STOLL, Song YANG, Chengang ZHOU
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230141403
    Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X, m, n, and R1 to R3 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: December 6, 2022
    Publication date: May 11, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Xingchun HAN, Christian KRAMER, Holger KUEHNE, Christian LERNER, Mingming LI, Matthias NETTEKOVEN, Theodor STOLL, Min WANG, Song YANG
  • IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230141600
    Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein: or pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: December 6, 2022
    Publication date: May 11, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Christian KRAMER, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Sébastien SCHMITT, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • NOVEL HETEROCYCLIC COMPOUNDS
    Publication number: 20230133845
    Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: July 14, 2022
    Publication date: May 4, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Mathis BRAENDLIN, Sandra Marie Joseph GRALL-ULSEMER, Xingchun HAN, Christian LERNER, Mingming LI, Yongqiang LIU, Sébastien SCHMITT, Jianhua WANG, Yongguang WANG, Min WANG, Song YANG, Chengang ZHOU
  • TURBINE BLADE TIP, TURBINE BLADE AND METHOD
    Publication number: 20230127843
    Abstract: A turbine blade tip, turbine blade and method where improved cooling is made possible by an improved cooling structure with cooling air holes inside a depression in a blade tip and a special arrangement of multiple cooling air holes which are supplied by a single cooling air channel inside a wall.
    Type: Application
    Filed: February 8, 2021
    Publication date: April 27, 2023
    Applicant: Siemens Energy Global GmbH & Co. KG
    Inventors: Björn Anders, Reiner Anton, Kay Krabiell, Christian Lerner
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230022724
    Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 26, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Nawaz KHAN, Christian KRAMER, Christian LERNER, Philippe PFLIEGER, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230013602
    Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R14 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 19, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jean-Baptiste BLANC, Nawaz KHAN, Christian KRAMER, Christian LERNER, Philippe PFLIEGER, Theodor STOLL, Song YANG
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230017532
    Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 19, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Nawaz KHAN, Christian KRAMER, Christian LERNER, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Sebastien SCHMITT, Theodor STOLL, Jianhua WANG, Song YANG
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230011869
    Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 12, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Nawaz KHAN, Christian KRAMER, Christian LERNER, Philippe PFLIEGER, Theodor STOLL, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230012368
    Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 12, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jean-Baptiste BLANC, Zhanling CHENG, Xingchun HAN, Nawaz KHAN, Christian KRAMER, Holger KUEHNE, Christian LERNER, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Sebastien SCHMITT, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG