Patents by Inventor Christian Lerner
Christian Lerner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230141600Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein: or pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.Type: ApplicationFiled: December 6, 2022Publication date: May 11, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Zhanling CHENG, Christian KRAMER, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Sébastien SCHMITT, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG, Chengang ZHOU
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Publication number: 20230141403Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X, m, n, and R1 to R3 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.Type: ApplicationFiled: December 6, 2022Publication date: May 11, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Zhanling CHENG, Xingchun HAN, Christian KRAMER, Holger KUEHNE, Christian LERNER, Mingming LI, Matthias NETTEKOVEN, Theodor STOLL, Min WANG, Song YANG
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Publication number: 20230133845Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.Type: ApplicationFiled: July 14, 2022Publication date: May 4, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Mathis BRAENDLIN, Sandra Marie Joseph GRALL-ULSEMER, Xingchun HAN, Christian LERNER, Mingming LI, Yongqiang LIU, Sébastien SCHMITT, Jianhua WANG, Yongguang WANG, Min WANG, Song YANG, Chengang ZHOU
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Publication number: 20230127843Abstract: A turbine blade tip, turbine blade and method where improved cooling is made possible by an improved cooling structure with cooling air holes inside a depression in a blade tip and a special arrangement of multiple cooling air holes which are supplied by a single cooling air channel inside a wall.Type: ApplicationFiled: February 8, 2021Publication date: April 27, 2023Applicant: Siemens Energy Global GmbH & Co. KGInventors: Björn Anders, Reiner Anton, Kay Krabiell, Christian Lerner
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Publication number: 20230022724Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.Type: ApplicationFiled: June 16, 2021Publication date: January 26, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Zhanling CHENG, Nawaz KHAN, Christian KRAMER, Christian LERNER, Philippe PFLIEGER, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG
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Publication number: 20230017532Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.Type: ApplicationFiled: June 16, 2021Publication date: January 19, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Zhanling CHENG, Nawaz KHAN, Christian KRAMER, Christian LERNER, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Sebastien SCHMITT, Theodor STOLL, Jianhua WANG, Song YANG
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Publication number: 20230013602Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R14 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.Type: ApplicationFiled: June 16, 2021Publication date: January 19, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Jean-Baptiste BLANC, Nawaz KHAN, Christian KRAMER, Christian LERNER, Philippe PFLIEGER, Theodor STOLL, Song YANG
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Publication number: 20230012368Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.Type: ApplicationFiled: June 16, 2021Publication date: January 12, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Jean-Baptiste BLANC, Zhanling CHENG, Xingchun HAN, Nawaz KHAN, Christian KRAMER, Holger KUEHNE, Christian LERNER, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Sebastien SCHMITT, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG
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Publication number: 20230011869Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.Type: ApplicationFiled: June 16, 2021Publication date: January 12, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Zhanling CHENG, Nawaz KHAN, Christian KRAMER, Christian LERNER, Philippe PFLIEGER, Theodor STOLL, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG
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Publication number: 20220396565Abstract: Provided are novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R4, m, n, and p are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.Type: ApplicationFiled: July 20, 2022Publication date: December 15, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Zhanling CHENG, Xingchun HAN, Christian KRAMER, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Jianhua WANG, Lisha WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
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Patent number: 11390604Abstract: The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1, RA and R3 to R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.Type: GrantFiled: March 6, 2020Date of Patent: July 19, 2022Assignee: Hoffmann-La Roche Inc.Inventors: Jean-Baptiste Blanc, Christian Kramer, Christian Lerner, Matthias Nettekoven, Philippe Pflieger, Bernd Puellmann, Thomas Ryckmans, Sébastien Schmitt, Min Wang, Song Yang, Chengang Zhou
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Publication number: 20200290998Abstract: The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1, RA and R3 to R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.Type: ApplicationFiled: March 6, 2020Publication date: September 17, 2020Applicant: Hoffmann-La Roche Inc.Inventors: Jean-Baptiste Blanc, Christian Kramer, Christian Lerner, Matthias Nettekoven, Philippe Pflieger, Bernd Puellmann, Thomas Ryckmans, Sébastien Schmitt, Min Wang, Song Yang, Chengang Zhou
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Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
Patent number: 9988390Abstract: The present invention relates to compounds having the general formula (Ia) or (Ib), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease, in particular influenza.Type: GrantFiled: October 28, 2016Date of Patent: June 5, 2018Inventors: Hans Hilpert, Lukas Kreis, Christian Lerner, Roland Humm, Thorsten Muser, Bernd Kuhn -
Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
Publication number: 20170267680Abstract: The present invention relates to compounds having the general formula (Ia) or (Ib), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease, in particular influenza.Type: ApplicationFiled: October 28, 2016Publication date: September 21, 2017Inventors: Hans HILPERT, Lukas KREIS, Christian LERNER, Roland HUMM, Thorsten MUSER, Bernd KUHN -
Patent number: 9656971Abstract: The present invention relates to compounds of formula wherein the substituents are described in claim 1 and to the pharmaceutically acceptable salts thereof. These compounds inhibit the enzyme catechol-O-methyltransferase (COMT). The compounds may be used for the treatment of Parkinson's disease, depression, cognitive impairment and motor symptoms, resistant depression, cognitive impairment, mood and negative symptoms of schizophrenia.Type: GrantFiled: June 26, 2015Date of Patent: May 23, 2017Assignee: Hoffmann-La Roche Inc.Inventors: Caterina Bissantz, René Bonnafous, Bernd Buettelmann, Roland Jakob-Roetne, Christian Lerner, Markus Rudolph
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Patent number: 9617271Abstract: The present invention relates to compounds of formula (I) and its use for the treatment of neurological disorders.Type: GrantFiled: May 6, 2015Date of Patent: April 11, 2017Assignee: Hoffmann-La Roche Inc.Inventors: Alexander Flohr, Katrin Groebke Zbinden, Christian Lerner
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Patent number: 9540384Abstract: The invention relates to compounds of formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.Type: GrantFiled: November 26, 2014Date of Patent: January 10, 2017Assignee: Hoffmann-La Roche, Inc.Inventors: Alexander Flohr, Katrin Groebke Zbinden, Matthias Koerner, Christian Lerner
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Patent number: 9394311Abstract: The present invention provides compounds of formula (Ia) and (Ib) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.Type: GrantFiled: November 25, 2014Date of Patent: July 19, 2016Assignee: Hoffmann-La Roche Inc.Inventors: Alexander Flohr, Katrin Groebke Zbinden, Bernd Kuhn, Christian Lerner, Markus Rudolph, Herve Schaffhauser
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Patent number: 9238976Abstract: A turbine guide vane system, in particular for a gas turbine is provided. The turbine guide vane system includes a number of guide vane rows and a guide vane carrier, to enable particularly simple replacement of guide vanes, while maintaining a particularly high degree of efficiency, and thus designed for particularly short repair durations. For this purpose, the guide vane carrier has a number of segments, wherein a segment extends over the entire radial extension of the guide vane carrier and the connection of the remaining segments may be detached, and wherein the turbine guide vane carrier includes at least two sections along the axial extension thereof that are connected to one another and have a different number of segments.Type: GrantFiled: January 5, 2010Date of Patent: January 19, 2016Assignee: SIEMENS AKTIENGESELLSCHAFTInventors: Fathi Ahmad, Giuseppe Gaio, Holger Grote, Christian Lerner, Mirko Milazar, Mathias Stutt, Thomas-Dieter Tenrahm, Bernd Vonnemann
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Publication number: 20160002177Abstract: The present invention relates to compounds of formula wherein the substituents are described in claim 1 and to the pharmaceutically acceptable salts thereof. These compounds inhibit the enzyme catechol-O-methyltransferase (COMT). The compounds may be used for the treatment of Parkinson's disease, depression, cognitive impairment and motor symptoms, resistant depression, cognitive impairment, mood and negative symptoms of schizophrenia.Type: ApplicationFiled: June 26, 2015Publication date: January 7, 2016Applicant: Hoffmann-La Roche Inc.Inventors: Caterina BISSANTZ, René Bonnafous, Bernd Buettelmann, Roland Jakob-Roetne, Christian Lerner, Markus Rudolph