Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract: A turbine guide vane system, in particular for a gas turbine is provided. The turbine guide vane system includes a number of guide vane rows and a guide vane carrier, to enable particularly simple replacement of guide vanes, while maintaining a particularly high degree of efficiency, and thus designed for particularly short repair durations. For this purpose, the guide vane carrier has a number of segments, wherein a segment extends over the entire radial extension of the guide vane carrier and the connection of the remaining segments may be detached, and wherein the turbine guide vane carrier includes at least two sections along the axial extension thereof that are connected to one another and have a different number of segments.

Abstract: A gas turbine including a plurality of rotor blades assembled into rotor blade rows and arranged on a turbine shaft and including a plurality of guide vanes assembled into guide van rows and mounted on a turbine housing by means of a guide van carrier is provided. The guide vane carrier includes a plurality of cooling air holes, and has a particularly high efficiency, while maintaining maximum operating reliability. Therefore, a cooling insert is introduced into a cooling air hole.

Abstract: An axial turbine for a gas turbine including a rotor blade cascade is provided. The rotor blade cascade is formed from rotor blades each including, a front edge, a blade tip, and an annular space wall that surrounds the rotor blade cascade and includes an annular space inner side, enabling the annular space wall to be arranged directly adjacent to the blade tip forming a radial gap between the covering of the blade tip and the annual space inner side. When the turbine is in operation, the area of the blade tip with the highest pressure load is disposed in the region of the front edges, and the rotor blades in the region of their front edges include a radial projection and the annular space wall includes on the annular space inner side, a peripheral radial recess that interacts with the radial projections such that a minimum is established in the direction of the main through-flow of the turbine.

Abstract: A turbine vane or blade including an interior structure is provided. In addition, turbulence elements connected directly upstream of openings disposed at the rear edge of the blade of the turbine vane or blade are also provided. These are disposed in a sequence, each having a flow side against which a coolant flows and which is at least partially arched in a concave manner. Preferably, the turbulence elements are configured in a crescent-shaped manner. This makes it possible to enlarge the openings without resulting in an increased consumption of coolant. A casting core is also provided. The openings required in the casting core for the production of the webs of a turbine vane or blade may now be placed at further distances than before.

Abstract: The invention relates to a turbine blade comprising a vane that runs along a blade axis and a platform region, located at the root of the vane having a platform that extends transversally to the blade axis. The aim of the invention is to configure a delimitation of a flow channel of a gas turbine in the simplest possible manner. Therefore, the platform is configured by an elastic sheet metal part that rests on the vane. Said part leads to a gas turbine comprising a flow conduit that runs along an axis of the gas turbine, said conduit having an annular cross-section for a working medium and a second vane stage that is situated downstream of a first vane stage, which runs along the axis.

Abstract: The present invention relates to compounds of formula I wherein R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract: The present invention relates to compounds of formula I wherein R1a to R1c, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract: There is described a turbine blade of a gas turbine comprising a suction-side blade wall and a pressure-side blade wall that, in the trailing edge area, runs toward the suction-side blade wall. This suction-side blade wall has a trailing edge projection projecting over the end edge of the pressure-side blade wall at least in a partial section of the trailing edge area. A turbine blade of the aforementioned type is designed for a particularly long serviceable life while requiring little cooling air. To this end, the pressure-side surface of the trailing edge projection has a number of trough-shaped recesses that increase the transfer of heat from the trailing edge projection by a local swirling of the cooling air.

Abstract: The invention relates to a turbine blade comprising a vane that runs along a blade axis and a platform region, located at the root of the vane having a platform that extends transversally to the blade axis. The aim of the invention is to configure a delimitation of a flow channel of a gas turbine in the simplest possible manner. Therefore, the platform is configured by an elastic sheet metal part that rests on the vane. Said part leads to a gas turbine comprising a flow conduit that runs along an axis of the gas turbine, said conduit having an annular cross-section for a working medium and a second vane stage that is situated downstream of a first vane stage, which runs along the axis.

Abstract: The invention relates to a turbine blade comprising a vane that runs along a blade axis and a platform region, which is located at the root of the vane having a platform that extends transversally to the blade axis. The aim of the invention is to configure a delimitation of a flow channel of a gas turbine in the simplest possible manner. Therefore, the platform is configured by an elastic sheet metal part that rests on the vane. Said part leads to a gas turbine comprising a flow conduit that runs along an axis of the gas turbine, said conduit having an annular cross-section for a working medium and a second vane stage that is situated downstream of a first vane stage, which runs along the axis.

Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract: The invention relates to a turbine blade comprising a vane that runs along a blade axis and a platform region, which is located at the root of the vane and has a platform that extends transversally to the blade axis. The aim of the invention is to guarantee the improved cooling of a platform region and the transition region from a turbine blade to a platform of a turbine blade, thus ensuring the cooling of the delimitation of a flow channel in a gas turbine. To achieve this, the platform comprises a first platform wall that does not support the vane and a second platform wall that supports said vane. According to the inventive concept, at the root of the vane and over the course of the transition region from the turbine blade to the platform, said first platform wall is aerodynamically curved and the course of the second platform wall has a receding shoulder in relation to the first platform wall, as a continuation of the vane.

Abstract: The invention relates to a turbine blade (63, 65) comprising a vane (67, 69) that runs along a blade axis (73, 75) and a platform region (61), which is located at the root of the vane (67, 69) and has a platform (71) that extends transversally to the blade axis (73, 75). The aim of the invention is to configure a delimitation (87) of a flow channel (5) of a gas turbine (1) in the simplest possible manner. To achieve this, the platform (71) is configured by an elastic sheet metal part (77, 79) that rests on the vane (67, 69). Said part leads to a gas turbine (1) comprising a flow conduit (5) that runs along an axis (3) of the gas turbine (1), said conduit having an annular cross-section for a working medium (M) and a second (9, 13) vane stage (7, 9, 11, 13) that is situated downstream of a first (7, 11) vane stage, which runs along the axis (3).

Abstract: There is described a turbine blade of a gas turbine comprising a suction-side blade wall and a pressure-side blade wall that, in the trailing edge area, runs toward the suction-side blade wall. This suction-side blade wall has a trailing edge projection projecting over the end edge of the pressure-side blade wall at least in a partial section of the trailing edge area. A turbine blade of the aforementioned type is designed for a particularly long serviceable life while requiring little cooling air. To this end, the pressure-side surface of the trailing edge projection has a number of trough-shaped recesses that increase the transfer of heat from the trailing edge projection by a local swirling of the cooling air.

Abstract: The present invention relates to compounds of formula I wherein R1 is as defined in the specification and to esters thereof which are hydrolyzable under physiological conditions and to the pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of COMT and, thus, are useful for the treatment of diseases for which COMT inhibition is beneficial. The invention further relates to the treatment, control, or prevention of diseases such as depression, schizophrenia, Parkinson's disease, and to improve cognition.

Abstract: The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.

Abstract: The present invention relates to compounds of formula I wherein R1 is as defined in the specification and to esters thereof which are hydrolyzable under physiological conditions and to the pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of COMT and, thus, are useful for the treatment of diseases for which COMT inhibition is beneficial. The invention further relates to the treatment, control, or prevention of diseases such as depression, schizophrenia, Parkinson's disease, and to improve cognition.