Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

Abstract: Message routing techniques include use of at least one controller module configured to maintain a graph. The graph defines communication relations between a plurality of message communication modules. Each communication relation defines a particular message type for a particular pair of modules. The plurality of message communication modules includes a first module configured to receive a message wherein the received message has a message type and is associated with least one pre-condition. Upon verification of an acceptance condition of the at least one pre-condition the received message is accepted if the acceptance condition is fulfilled. Upon verification of a generating condition of the at least one pre-condition, the first module generates a generated message directed to at least a second module or an external data consumer in accordance with the graph if the generating condition is fulfilled.

Abstract: A method includes: generating an indicator of present operating conditions of an engine; determining a first amount of noise based on vibration measured during a first plurality of combustion events of a cylinder; storing the first amount of noise and a first value of the indicator in a mapping based on a first engine speed and a first engine load; determining the first value of the indicator from the mapping based on a second engine speed and a second engine load; generating a trigger signal when the first value is different than a second value of the indicator; and, when the trigger signal is generated: determining a second amount of noise based on vibration measured during a second plurality of combustion events of the cylinder; and replacing the first amount of noise and the first value in the mapping with the second amount of noise and the second value.

Abstract: In order to further improve a method for producing a carrier body for a friction lining of a disk brake, in such a way that the rigid connection between a friction-lining carrier plate of the carrier body and a first damper mass of the carrier body is more robust, a force directed perpendicularly towards the first pin-shaped project is exerted, according to the invention, by means of pressing until the first pin-shaped projection is compressed to such an extent that the first pin-shaped projection forms, within the first hole, a form closure with an inner wall of the first hole in some regions.

Abstract: The invention relates to a unit (1) for determining the dominant light source type in electromagnetic radiation (2) incident on the unit (1) and generated from a plurality of light sources of different types. The unit comprises at least one first photodiode (10) designed to detect electromagnetic radiation in the visible spectral range and to generate a first output signal (11). The unit comprises at least one second photodiode (20) designed to detect electromagnetic radiation in the infrared spectral range and to generate a second output signal (21). The unit comprises at least one calculation unit (30) designed to derive a quotient result (23) and a frequency result (13) from the first (11) and second (21) output signals. The frequency result (13) provides information about the presence or absence of signal components in a predetermined frequency range contained in the electromagnetic radiation.

Abstract: A through silicon via is described that has conductivity at high frequencies. In one example, the via includes a channel through at least a portion of a silicon die. A first conductive layer has a first electrical conductivity. A second conductive layer covers the outer surface of the first conductive layer and has a second electrical conductivity higher than the first electrical conductivity.

Abstract: The invention is a simulation cabinet with two side walls, a bottom wall, a top wall, an exterior wall, and an interior chamber, with a rear wall being arranged in the interior chamber at a distance from the exterior wall, and at least one ventilator arranged between the rear wall and the exterior wall, with the rear wall showing air openings for suctioning air from the interior chamber via the ventilator, with the rear wall showing at least one opening and at least a first flow restrictor each being arranged between the rear wall and the exterior wall such that the air suctioned by the ventilator through the air openings of the rear wall, after flowing through the flow restrictor, can be guided through the opening into the interior.

Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

Abstract: A polarized relay comprising an electromagnet, a two-pole or three-pole permanent magnet, an armature, and switches, which are mounted in and on a shelf-like support component. The support component accommodates magnetic flux pieces and the permanent magnet in an upper cavity, and the permanent magnet is magnetized while the electromagnet is still outside the support component. Subsequently, the electromagnet is inserted into lower cavity of the support component and the rest of the components of the relay are mounted.

Abstract: Method, system, and computer program product embodiments of controlling filling levels of a plurality of storage pools are provided. A plurality of files is selected from each storage pool of the plurality of storage pools. Each file is then copied to a server and a list is updated. The list comprises an entry for each file of the plurality of files. Each entry comprises a status information. The status information indicates that the corresponding file has been copied to the server. Each entry further comprises an identifier indicating the storage pool on which the corresponding file is stored. If it is detected that the filling level of a storage pool reaches a predefined first threshold value, then a first set of files is determined by use of the list. Each file of the first set of files is replaced by a stub file. The status information is updated.

Abstract: A method of dicing a plurality of integrated devices included in a semiconductor substrate using laser energy comprises the steps of directing a first laser beam onto a cutting line along the substrate to ablate a portion of the substrate located along the cutting line to be diced, the portion of the substrate that is ablated forming a recast material adjacent to the cutting line of the substrate that has been diced. A second laser beam is directed onto another portion of the substrate adjacent to the cutting line to conduct heat processing of the recast material formed adjacent to the cutting line.

Abstract: An electromechanical relay is provided, comprising a magnetic system and a pivotable armature. A diagnostic switch is arranged on one side of the relay, and the set of contacts of the diagnostic switch is driven by the adjacent leg of the armature. A load switch is arranged on the bottom side of the relay and is driven by the second leg of the armature via an insulating coupling member.

Abstract: Operating a data processing and storage apparatus to perform continuous backup monitoring for a collection of stored file system objects. In response to changes respective to a number of the file system objects, a set of Data Management Application Program Interface (DMAPI) events is created. For each of the events, accessory file system object information relative to a file system object subject to the change is determined. The events are grouped into an event group and a unique group identifier and an overall group size count are assigned to each of the events included in the event group. The events are sent together with the respective accessory file system object information, the respective group identifier and the respective group size to a number of backup clients registered as applications. The backup clients are to process the events together with the respective accessory file system object information, the respective group identifier and the respective group size into a number of backup requests.

Abstract: The present invention relates to the use of substantially linear polypropyleneimine as a hardener for epoxy resins, and also to a corresponding curable composition, to the curing thereof, and to the cured epoxy resin obtainable therefrom.

Abstract: A method of dicing a plurality of integrated devices included in a semiconductor substrate using laser energy comprises the steps of directing a first laser beam onto a cutting line along the substrate to ablate a portion of the substrate located along the cutting line to be diced, the portion of the substrate that is ablated forming a recast material adjacent to the cutting line of the substrate that has been diced. A second laser beam is directed onto another portion of the substrate adjacent to the cutting line to conduct heat processing of the recast material formed adjacent to the cutting line.

Abstract: An electromotive drive for furniture, includes a power supply device, a manual control, and a control device. The power supply device has an disconnecting unit that can be controlled by means of a control line, the electrical control signal of said control line being able to be modified by a switching contact of the manual control such that, when the manual control has not been actuated, the power supply device can be switched into the “disconnection” operating state, said disconnecting unit being connected to a signal feedback arrangement of a control circuit of the power supply device and being integrated in a path of said signal feedback arrangement, or said disconnecting unit being set in, or placed on, an input path or an output path of the control device.

Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

Abstract: The present disclosure provides a hierarchical storage management system for storing data. A first controller receives a request to migrate a data item to a first storage tier. The data item is associated with at least an initial object ID. The first controller, in response to the request, generates a new object ID and identifies a first record in a data structure, wherein the initial object ID is identical to an object ID of the first record and to a parent object ID of the first record. The first controller replaces the object ID of the first record with the new object ID, creates in the data structure a new record that is associated with the data item, sets an object ID of the new record and a parent object ID of the new record to the initial object ID, and stores the data item to the first storage tier.

Abstract: An apparatus comprises a first integrated circuit (IC) die that includes a top layer, a bottom surface, a sidewall surface extending from a top surface of the top layer to the bottom surface, and at least one multi-surface contact pad, a second IC die including a top layer, a bottom surface, a sidewall surface extending from a top surface of the top layer to the bottom surface, and at least one multi-surface contact pad, wherein the second IC die is arranged adjacent to the first IC die, and includes an electrically conductive bond in contact with at least one of the top surface or the side surface of the multi-surface contact pad of the first IC die and the top surface of the multi-surface contact pad of the second IC die.

Abstract: The invention relates to a drive device for multiaxial transport of workpieces through successive machining stations of a machine tool, in particular of a multistage forming press, wherein the drive device comprises two gripper rails, wherein the two gripper rails are transversely displaceable independently of each other by a first transverse drive assigned to the first gripper rail and a second transverse drive assigned to the second gripper rail for the execution of a closing movement. The gripper rails are here vertically displaceable independently of each other for the execution of a lifting movement, and/or the gripper rails are longitudinally displaceable independently of each other for the execution of a transport movement.