Patents by Inventor Christian Rey
Christian Rey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10376612Abstract: A material, especially a glassy material of pyrophosphate type, corresponding to the general formula (I): {[(M2+)1?x(R+)2x]2[(P2O74?)1?y(PO43?)4y/3]} n(H2O) in which x and y are positive rational numbers each between 0 and 0.8, and n is such that the weight percentage of water in the material is greater than 0 and less than or equal to 95. M2+ represents a bivalent ion of a metal chosen from calcium, magnesium, strontium, copper, zinc, cobalt, manganese and nickel, or any mixture of such bivalent ions. R+ represents a monovalent ion of a metal selected from potassium, lithium, sodium, and silver, or any mixture of such monovalent ions. This material in particular can be used in manufacturing of bone replacements or prosthesis coatings.Type: GrantFiled: September 29, 2015Date of Patent: August 13, 2019Assignees: INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER TOULOUSE IIIInventors: Jérémy Soulie, Christèle Combes, Christian Rey, Pierre Gras
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Publication number: 20170304493Abstract: A material, especially a glassy material of pyrophosphate type, corresponding to the general formula (I): {[(M2+)1?x(R+)2x]2[(P2O74?)1?y(PO43?)4y/3]} n(H2O) in which x and y are positive rational numbers each between 0 and 0.8, and n is such that the weight percentage of water in the material is greater than 0 and less than or equal to 95. M2+ represents a bivalent ion of a metal chosen from calcium, magnesium, strontium, copper, zinc, cobalt, manganese and nickel, or any mixture of such bivalent ions. R+ represents a monovalent ion of a metal selected from potassium, lithium, sodium, and silver, or any mixture of such monovalent ions. This material in particular can be used in manufacturing of bone replacements or prosthesis coatings.Type: ApplicationFiled: September 29, 2015Publication date: October 26, 2017Inventors: JÉRÉMY SOULIE, CHRISTÈLE COMBES, CHRISTIAN REY, PIERRE GRAS
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Patent number: 8216630Abstract: The present invention relates to a porous biomaterials surface activation method by coating with a layer of apatitic nanocrystals in order to increase their surface reactivity. The method according to the invention is characterized by the following steps: a) preparing a nanocrystalline apatitic calcium phosphate analogous to bone mineral by mixing a calcium salt solution with a phosphate salt solution in a Ca/P ratio ranging between 1.3 and 2 at a temperature ranging between 0 and 60 ° C., b) slurrying the mixture obtained in step a) in an aqueous solution so as to obtain a fluid, homogeneous paste containing 80 to 98% of water, c) bringing a porous biomaterial into contact with the suspension obtained in step b), d) drying the porous biomaterial at a temperature below 100 ° C.Type: GrantFiled: June 18, 2009Date of Patent: July 10, 2012Assignees: Institut National Polytechnique de Toulouse, TEKNIMEDInventors: Hélène Autefage, Sophie Cazalbou, Christèle Combes, Christian Rey
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Publication number: 20100323094Abstract: The present invention relates to a porous biomaterials surface activation method by coating with a layer of apatitic nanocrystals in order to increase their surface reactivity. The method according to the invention is characterized by the following steps: a) preparing a nanocrystalline apatitic calcium phosphate analogous to bone mineral by mixing a calcium salt solution with a phosphate salt solution in a Ca/P ratio ranging between 1.3 and 2 at a temperature ranging between 0 and 60° C., b) slurrying the mixture obtained in step a) in an aqueous solution so as to obtain a fluid, homogeneous paste containing 80 to 98% of water, c) bringing a porous biomaterial into contact with the suspension obtained in step b), d) drying the porous biomaterial at a temperature below 100° C.Type: ApplicationFiled: June 18, 2009Publication date: December 23, 2010Applicants: TEKNIMED, Institut National Polytechnique de Toulouse, Universite Paul SabatierInventors: Héléne AUTEFAGE, Sophie CAZALBOU, Christéle COMBES, Christian REY
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Patent number: 7686239Abstract: A low crystallinity calcium phosphate powder is prepared by mechanically grinding a calcium phosphate solid under grinding forces local heating sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate solid to less than about 100 nm. The method is useful for making any calcium phosphate material by solid-solid mixing and high energy grinding.Type: GrantFiled: October 26, 2004Date of Patent: March 30, 2010Assignee: Etex CorportationInventors: Aliassghar N. Tofighi, Christian Rey
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Patent number: 7645969Abstract: A method, device, and projectile having a device for guiding or piloting projectiles or missiles (self-propelled or non-self-propelled), to deflect, in a direction Y, a hypervelocity projectile operating in a gas, such as a shell, a bullet, or a missile, having a nose, generally in the shape of a cone, with a more or less pointed tip, by generating a first high-voltage discharge able to produce a plasma over a first limited sector of the projectile surface and in direction Y, maintaining the plasma, and generating another low-voltage discharge able to supply the plasma with energy over a second limited sector of the projectile surface and in direction Y, the first and the second sectors being different and may overlap.Type: GrantFiled: September 22, 2006Date of Patent: January 12, 2010Assignee: Institut Franco-Allemand de Recherches de Saint-LouisInventors: Patrick Gnemmi, Christian Rey
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Patent number: 7517539Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite.Type: GrantFiled: October 16, 1997Date of Patent: April 14, 2009Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
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Patent number: 7318841Abstract: A low crystallinity calcium phosphate powder is prepared by mechanically grinding a calcium phosphate solid under grinding forces local heating sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate solid to less than about 100 nm. The method is useful for making any calcium phosphate material by solid-solid mixing and high energy grinding.Type: GrantFiled: August 16, 2002Date of Patent: January 15, 2008Assignee: Etex CorporationInventors: Aliassghar Tofighi, Christian Rey
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Publication number: 20070200028Abstract: A method, device, and projectile having a device for guiding or piloting projectiles or missiles (self-propelled or non-self-propelled), to deflect, in a direction Y, a hypervelocity projectile operating in a gas, such as a shell, a bullet, or a missile, having a nose, generally in the shape of a cone, with a more or less pointed tip, by generating a first high-voltage discharge able to produce a plasma over a first limited sector of the projectile surface and in direction Y, maintaining the plasma, and generating another low-voltage discharge able to supply the plasma with energy over a second limited sector of the projectile surface and in direction Y, the first and the second sectors being different and may overlap.Type: ApplicationFiled: September 22, 2006Publication date: August 30, 2007Applicant: INSTITUT FRANCO-ALLEMAND DE RECHERCHES DE SAINT-LOUISInventors: Patrick Gnemmi, Christian Rey
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Patent number: 7166946Abstract: The present invention relates to an electrical machine, comprising: a supporting structure; a stator cantilevered-out from the structure; and a rotor mounted to rotate on the structure about an axis of rotation in such a manner as to be capable of being driven by the stator, the supporting structure comprising a hollow central shaft substantially coaxial about the axis of rotation of the rotor, an electric cable for powering the stator traveling along the inside of the shaft, and the rotor having a drive surface for transmitting torque to at least one element that is to be driven, the drive surface being situated at least in part around the shaft.Type: GrantFiled: June 22, 2004Date of Patent: January 23, 2007Assignee: Moteurs Leroy-SomerInventors: Pascal Gauthier, Christophe Gilles, Pascal Beynaud, Christian Rey
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Patent number: 7150879Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature an is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing.Type: GrantFiled: May 11, 2000Date of Patent: December 19, 2006Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
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Patent number: 6972130Abstract: The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful for a variety of in vivo and in vitro applications, including drug delivery (for example, to bony sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites) tissue growth (preferably bone or cartilage) osseous augmentation, and methods of diagnosing disease states by assaying tissue forming potential of cells isolated from a host. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention further provides in vitro cell culture systems and cell encapsulation materials. The invention is useful for both medical and veterinary applications.Type: GrantFiled: October 16, 1997Date of Patent: December 6, 2005Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
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Patent number: 6953594Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite.Type: GrantFiled: November 23, 2001Date of Patent: October 11, 2005Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
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Publication number: 20050147551Abstract: A low crystallinity calcium phosphate powder is prepared by mechanically grinding a calcium phosphate solid under grinding forces local heating sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate solid to less than about 100 nm. The method is useful for making any calcium phosphate material by solid-solid mixing and high energy grinding.Type: ApplicationFiled: October 26, 2004Publication date: July 7, 2005Inventors: Aliassghar Tofighi, Christian Rey
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Publication number: 20050029883Abstract: The present invention relates to an electrical machine, comprising: a supporting structure; a stator cantilevered-out from the structure; and a rotor mounted to rotate on the structure about an axis of rotation in such a manner as to be capable of being driven by the stator, the supporting structure comprising a hollow central shaft substantially coaxial about the axis of rotation of the rotor, an electric cable for powering the stator traveling along the inside of the shaft, and the rotor having a drive surface for transmitting torque to at least one element that is to be driven, the drive surface being situated at least in part around the shaft.Type: ApplicationFiled: June 22, 2004Publication date: February 10, 2005Applicant: MOTEURS LEROY-SOMERInventors: Pascal Gauthier, Christophe Gilles, Pascal Beynaud, Christian Rey
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Publication number: 20030120351Abstract: A low crystallinity calcium phosphate powder is prepared by mechanically grinding a calcium phosphate solid under grinding forces local heating sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate solid to less than about 100 nm. The method is useful for making any calcium phosphate material by solid-solid mixing and high energy grinding.Type: ApplicationFiled: August 16, 2002Publication date: June 26, 2003Applicant: Etex CorporationInventors: Aliassghar Tofighi, Christian Rey
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Patent number: 6544290Abstract: The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vivo and in vitro tissue growth (preferably bone or cartilage), osseous augmentation, and methods of diagnosing disease states by assaying tissue-forming potential of cells isolated from a host. The invention also provides in vitro cell culture systems and cell encapsulation matrices.Type: GrantFiled: February 13, 1998Date of Patent: April 8, 2003Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
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Patent number: 6541037Abstract: The present invention provides delivery vehicles comprising a synthetic, poorly crystalline apatite (PCA) calcium phosphate and a biologically active agent. The PCA calcium phosphate offers many advantages over known delivery materials and is particularly useful for delivery of agents to bone sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention is useful for both medical and veterinary applications.Type: GrantFiled: October 16, 1996Date of Patent: April 1, 2003Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
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Publication number: 20030049329Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite.Type: ApplicationFiled: November 23, 2001Publication date: March 13, 2003Inventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
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Publication number: 20020155167Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature an is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing.Type: ApplicationFiled: April 5, 2002Publication date: October 24, 2002Applicant: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi