Patents by Inventor Christian Rey
Christian Rey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20020155137Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature an is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing.Type: ApplicationFiled: April 5, 2002Publication date: October 24, 2002Applicant: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
-
Publication number: 20020136696Abstract: A method for treating a bone defect is provided by identifying a bone site suitable for receiving an implant; and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. A bone defect may be treated by identifying a bone site suitable for receiving an implant; and introducing a hydrated precursor to a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby the hydrated precursor is converted in vivo to a poorly crystalline apatitic calcium phosphate and whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporatic bone, an intervertebral space, an alveolar ridge or a bone fracture.Type: ApplicationFiled: October 16, 1996Publication date: September 26, 2002Inventors: DOSUK D. LEE, CHRISTIAN REY, MARIA AIOLOVA
-
Patent number: 6331312Abstract: A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium phosphate is characterized in that, when placed in an intramuscular or subcutaneous site, resorption of at least 1 g of the material is complete within one year. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable.Type: GrantFiled: March 2, 1998Date of Patent: December 18, 2001Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
-
Patent number: 6287341Abstract: A method for treating a bone defect is provided by identifying a bone site suitable for receiving an implant; and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. A bone defect may be treated by identifying a bone site suitable for receiving an implant; and introducing a hydrated precursor to a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby the hydrated precursor is converted in vivo to a poorly crystalline apatitic calcium phosphate and whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporatic bone, an intervertebral space, an alveolar ridge or a bone fracture.Type: GrantFiled: March 6, 1998Date of Patent: September 11, 2001Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
-
Patent number: 6280789Abstract: Coatings of scarcely crystalline carbonated hydroxyapatite are deposited on metallic or ceramic substrates, by immersing the substrates in a solution containing calcium phosphate and bicarbonate ions, with a molar ratio calcium/phosphate from 0.8 to 2 and a pH from 6.8 to 8.0. Subsequently, the solution is heated to 50-80° C., thus raising the pH and causing a spontaneous deposition of carbonated hydroxyapatite on the substrates. The obtained coatings are highly biocompatible, osteoconductive, bioactive and biodegradable, and can be utilized in structures used for preparing orthopaedic and dental prostheses and implants.Type: GrantFiled: June 28, 1999Date of Patent: August 28, 2001Assignee: Biocoatings S.r.l.Inventors: Christian Rey, Xavier Ranz
-
Patent number: 6277151Abstract: The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vivo and in vitro tissue growth (preferably bone or cartilage), osseous augmentation, and methods of diagnosing disease states by assaying tissue-forming potential of cells isolated from a host. The invention also provides in vitro cell culture systems and cell encapsulation matrices.Type: GrantFiled: February 13, 1998Date of Patent: August 21, 2001Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
-
Patent number: 6214368Abstract: The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provides both bioactivity and structural integrity. This novel amorphous material can be reacted with other calcium phosphates at or below 37° C. to form a bone-like material consisting of poorly crystalline hydroxyapatite.Type: GrantFiled: May 20, 1996Date of Patent: April 10, 2001Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
-
Patent number: 6139578Abstract: The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vivo and in vitro tissue growth (preferably bone or cartilage), osseous augmentation, and methods of diagnosing disease states by assaying tissue-forming potential of cells isolated from a host. The invention also provides in vitro cell culture systems and cell encapsulation matrices.Type: GrantFiled: February 13, 1998Date of Patent: October 31, 2000Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
-
Patent number: 6132463Abstract: The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vivo and in vitro tissue growth (preferably bone or cartilage), osseous augmentation, and methods of diagnosing disease states by assaying tissue-forming potential of cells isolated from a host. The invention also provides in vitro cell culture systems and cell encapsulation matrices.Type: GrantFiled: October 16, 1996Date of Patent: October 17, 2000Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
-
Patent number: 6117456Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature an is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing.Type: GrantFiled: October 16, 1996Date of Patent: September 12, 2000Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
-
Patent number: 6027742Abstract: A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium phosphate is characterized in that, when placed in an intramuscular or subcutaneous site, resorption of at least 1 g of the material is complete within one year. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable.Type: GrantFiled: October 16, 1996Date of Patent: February 22, 2000Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
-
Patent number: 5783217Abstract: A method of preparing a low crystallinity calcium phosphate apatite is described in which a low crystallinity calcium phosphate is precipitated from an aqueous solution comprising calcium and phosphate ions; collected from the solution; and dehydrated in a humidity and at a temperature selected to minimize growth and promote conversion to calcium phosphate apatite. The resultant calcium phosphate apatite is block solid of improved strength, porosity and bioresorbability.Type: GrantFiled: November 7, 1995Date of Patent: July 21, 1998Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Ali Tofighi
-
Patent number: 5691397Abstract: The present invention is a process for first removing and isolating the calcium-phosphate crystals of bone from a substantial amount of the organic matrix and cellular constituents of bone without significant physical, chemical or structural alterations in the crystals. The crystals can then be further treated to remove the remaining amount of organic material associated with the crystals, leaving them essentially free of any of the organic constituents of bone, without significant physical, chemical or structural alterations in the crystals.Type: GrantFiled: October 10, 1996Date of Patent: November 25, 1997Assignee: Children's Medical Center CorporationInventors: Melvin J. Glimcher, Hyun-Man Kim, Christian Rey
-
Patent number: 5683461Abstract: The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provides both bioactivity and structural integrity. This novel amorphous material can be reacted with other calcium phosphates at or below 37.degree. C. to form a bone-like material consisting of poorly crystalline hydroxyapatite.Type: GrantFiled: December 29, 1995Date of Patent: November 4, 1997Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
-
Patent number: 5676976Abstract: The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provides both bioactivity and structural integrity. This novel amorphous material can be reacted with other calcium phosphates at or below 37.degree. C. to form a bone-like material consisting of poorly crystalline hydroxyapatite.Type: GrantFiled: May 19, 1995Date of Patent: October 14, 1997Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
-
Patent number: 5650176Abstract: The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provides both bioactivity and structural integrity. This novel amorphous material can be reacted with other calcium phosphates at or below 37.degree. C. to form a bone-like material consisting of poorly crystalline hydroxyapatite.Type: GrantFiled: December 29, 1995Date of Patent: July 22, 1997Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova
-
Patent number: 5565502Abstract: The present invention is a process for first removing and isolating the calcium-phosphate crystals of bone from a substantial amount of the organic matrix and cellular constituents of bone without significant physical, chemical or structural alterations in the crystals. The crystals can then be further treated to remove the remaining amount of organic material associated with the crystals, leaving them essentially free of any of the organic constituents of bone, without significant physical, chemical or structural alterations in the crystals.Type: GrantFiled: March 24, 1995Date of Patent: October 15, 1996Assignee: Children's Medical Center CorporationInventors: Melvin J. Glimcher, Hyun-Man Kim, Christian Rey
-
Patent number: 5439951Abstract: The present invention is a process for first removing and isolating the calcium-phosphate crystals of bone from a substantial amount of the organic matrix and cellular constituents of bone without significant physical, chemical or structural alterations in the crystals. The crystals can then be further treated to remove the remaining amount of organic material associated with the crystals, leaving them essentially free of any of the organic constituents of bone, without significant physical, chemical or structural alterations in the crystals.Type: GrantFiled: March 24, 1993Date of Patent: August 8, 1995Assignee: Children's Medical Center CorporationInventors: Melvin J. Glimcher, Hyun-Man Kim, Christian Rey
-
Patent number: 5141561Abstract: The invention relates to a biomaterial for bony or dental fillings on the basis of apatite. It provides a biomaterial having antiseptic properties for limiting the proliferation of microorganisms at the site of implantation. The biomaterial according to the invention is based on calcium oxygenated phosphate having an apatitic structure which has oxygenated species with degrees of oxidation greater than or equal to -2. This biomaterial brings together with the antiseptic properties mentioned above an excellent biocompatibility, a very low solutility and good qualities of osteo-induction.Type: GrantFiled: October 9, 1990Date of Patent: August 25, 1992Assignee: Whereas, Agence Conseil 3PInventors: Claude Ledard, Edmond Benque, Jean-Louis Lacout, Christian Rey