Abstract: A syringe device for ejecting a dose of a medicament, the syringe device comprising: a dose limiting mechanism arranged to interact with a dose ejecting mechanism to prevent ejection of a dose exceeding a set dose, and a safety mechanism, which is arranged such with respect to the dose ejecting mechanism that, if the dose limiting mechanism fails, the safety mechanism prevents ejection of a dose exceeding the set dose.

Abstract: A display device for a motor vehicle is provided. The display device includes at least one display with a display surface for displaying content via a plurality of pixels. The display device comprises a light-guiding lens with at least one entry surface and an exit surface. During operation of the display device the light emitted from the display surface enters the light-guiding lens through the at least one entry surface and is emitted by an exit surface, such that the content is shown on the exit surface. In one embodiment, the exit surface features a different shape. In another embodiment, the exit surface is a different size than the at least one display surface. In another embodiment, the display device comprises several displays with display surfaces at distances to each other, and the light-guiding lens features merely one exit surface or several exit surfaces directly adjoining each other.

Abstract: An inhaler vaporizer cartridge includes a housing body with a flow channel, a liquid storage tank, and a vaporizer unit. The vaporizer unit has a wick member and heating member and is liquid-permeable such that liquid is conveyed from the tank through the vaporizer unit to the flow channel. The housing body has a cavity forming the tank and a wick member receiving chamber, and housing is divided by an intermediate wall and a flow channel section. An access opening from the receiving chamber to the flow channel is formed in the intermediate wall and covered by the heating member. Granular grains in the receiving chamber form the wick member and bear against the heating member. The grains form microchannels and are retained by a cover element. An access opening, covered with a liquid-permeable grid structure, establishes a liquid connection from the tank to receiving chamber in the intermediate wall.

Abstract: The invention relates to a control drive, in particular a spindle drive for adjusting a swivelable vehicle flap, comprising a housing (2), a spindle rod (3) that is rotatably mounted in the housing (2), a first coupling element (5) for driving a rotational movement of the spindle rod (3), and a torque-limiting device (6) arranged between the first coupling element (5) and the spindle rod (3) for limiting the torque transmitted from the first coupling element (5) to the spindle rod (3), comprising an adapter sleeve (8) arranged at a first end (3a) of the spindle rod (3) in a rotationally fixed manner, and a first tolerance element (13) arranged between the spindle rod (3) and the first coupling element (5). According to the invention, a control drive is provided, which is designed such that it is compact and can be economically produced, in such a way that the first tolerance element (13) is rotationally fixed to one of the first coupling element (5) and the adapter sleeve (8).

Abstract: A plug connector housing for a plug connector, having a main body and a latching installation. The latching installation has a first connection portion integrally connecting the latching mechanism to the main body. A void extends along a longitudinal axis on the main body and is at least in portions formed between the latching installation and the main body. The plug connector housing furthermore has first and second protective elements which extend in each case integrally from the main body. The latching installation is disposed between the protective elements, wherein each of the protective elements in at least one covered region covers the void in a transverse direction. Each of the protective elements moreover configures at least one access region in which the void is accessible along the transverse direction. Each of the covered regions faces a respective access region of the respective other protective element along the transverse direction.

Abstract: The invention relates to a method for pooling and analyzing datasets from data providers. The method includes, at the level of each data provider, for each dataset, a first encryption of each variable of the dataset with a first encryption key common to all data providers, and a second encryption of at least each variable of the dataset with a second encryption key specific to the each data provider and shared with an intermediary. The method also includes, at the level of the intermediary, for each encrypted dataset, decryption of the variables with the second encryption key, and a third encryption of each confidential variable with a third encryption key. The method also includes transmission of the datasets encrypted with the third encryption key to an analysis environment for analysis. It also relates to a computer program and a system for implementing such a method.

Abstract: The present invention relates to a method for the cleaning and/or anti-corrosion pretreatment of a plurality of components in series, in which the components of the series are at least partially composed of zinc-coated (ZM) steel. After a cleaning stage and before further cleaning and/or anti-corrosion pretreatment, the components pass through a treatment stage for improving the wettability of the zinc-coated (ZM) steel surfaces in which at least the surfaces of the zinc-coated (ZM) steel of the components are brought into contact with an aqueous medium which contains at least one builder which is a salt of a Lewis acid-base pair in which the Lewis acid is selected from Li+, Na+, K+, Ca2+, Mg2+ or Al3+, and the Lewis base is selected from anions of a polyprotic Brønsted acid.

Abstract: The present invention relates to a device, system and method for segmentation of images. The device comprises an input (20) configured to obtain image data including a first image slice of a plurality of image slices of a 3D image data set, first segmentation of the first image slice in which at least one object is segmented, and a second image slice of the plurality of image slices of the 3D image data set. A processing unit (21, 21a) is configured to compute a second segmentation of the second image slice based on the obtained image data by applying a trained algorithm or computing system that has been trained on a plurality of segmentations of a plurality of objects in a plurality of image slices onto the obtained image data to propagate the segmentation of the at least one object in the first segmentation from the first image slice to the second image slice and to compute a third segmentation of a third image slice arranged, within the 3D image data set, in between the first and second image slices.

Abstract: The present invention relates to an in-line method of radio sterilization of wound dressings using electrons. A packaged wound dressing is provided by means of a production apparatus and conveyed to a sterilization module by means of a conveying device. The packaged wound dressing is sterilized by means of a sterilization module coupled in-line to the production apparatus. The sterilization module comprises an electron beam source, which generates electrons having an energy of between 150 keV and 350 keV. The energy dose to which the packaged wound dressings are exposed is at least 15 kGy and no more than 30 kGy. The conveying device moves the packaged wound dressings at a speed of at least 10 m/min and no more than 200 m/min.

Abstract: A vaporizer cartridge for an inhaler has a hollow body with a continuous flow channel and liquid storage tank. The tank has an access opening to the channel and a vaporizer unit extending over the entire access opening. The vaporizer unit has a wick member and a heating member. The vaporizer unit is liquid-permeable such that liquid is conveyed at least initially in a capillary manner from the storage tank through the vaporizer unit in the direction of the flow channel. The wick member is formed from a plurality of granular grains which, as a result of their fill and/or formation, form microchannels which establish a fluid connection between the storage tank and the flow channel, continuously from an entry side to an exit side of the wick member. An additional securing means is provided which is holds the granular wick member in position. A corresponding inhaler is also provided.

Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

Abstract: A valve unit comprises an operating piston for closing and opening a connection between a process pressure input line and a process pressure output line, at least one control line and at least one control chamber for controlling the operating piston. The operating piston has a closing ring which in the closed state of the connection sealingly abuts a valve seat of the valve housing (or the valve housing has a closing ring which in the closed state of the connection sealingly abuts against a valve seat of the operating piston). The valve seat consists of a softer and more elastic material than a circumferential sealing edge abutting said valve seat. An annular sealing element is present which comprises the valve seat. The sealing element has the shape of a truncated cone with an outwardly widening base.

Abstract: An apparatus for generating an enhanced signal from an input signal, wherein the enhanced signal has spectral values for an enhancement spectral region, the spectral values for the enhancement spectral regions not being contained in the input signal, includes a mapper for mapping a source spectral region of the input signal to a target region in the enhancement spectral region, the source spectral region including a noise-filling region; and a noise filler configured for generating first noise values for the noise-filling region in the source spectral region of the input signal and for generating second noise values for a noise region in the target region, wherein the second noise values are decorrelated from the first noise values or for generating second noise values for a noise region in the target region, wherein the second noise values are decorrelated from first noise values in the source region.

Abstract: The present invention relates to a thermal insulation board (IB) comprising at least two insulating layers (A) bonded together. At least one of the at least two insulating layers (A) comprises at least one aerogel composite material, wherein the aerogel composite material comprises at least one silica aerogel (a1), at least one polymer foam (a2) and at least one flame retardant (a3). The present invention also relates to a thermal insulation system (IS) comprising the thermal insulation board (IB). Further, it relates to a process for the production of the thermal insulation board (IB) and to the use of the thermal insulation board (IB) and of the thermal insulation system (IS) for the thermal insulation of buildings, parts and/or elements of buildings.

Abstract: Aspects of this invention, inter alia, relate to novel systems for targeting, editing or manipulating DNA in a cell, using novel synthetic RNA-guided nucleases (sRGNs). The sRGNs are derived from wildtype or parental small type II CRISPR Cas9 endonucleases.

Abstract: The present disclosure generally relates to an on-board electrical subsystem which has an overall electrical supply circuit having at least a first actuator, a load, a first voltage source, a second voltage source, and at least one switching device. A total power requirement of the first actuator is determined. If the total power requirement exceeds a first power threshold value, then a first supply subcircuit and a second supply subcircuit are formed. The first supply subcircuit comprises the first actuator and the first voltage source to provide a high voltage amplitude to the first actuator. The first supply subcircuit and the second supply subcircuit are electrically separated from one another. The second supply subcircuit supplies a standard voltage amplitude to the load. The separation of the first voltage source from the second voltage source and the load avoids corresponding power losses.

Abstract: A honeycomb body for the aftertreatment of exhaust gases from an internal combustion engine formed from a plurality of metal foils which are stacked on one another to form a layer stack and are wound around at least one center of rotation. The layer stack is formed alternatingly from smooth and at least partially structured metal foils, the metal foils have a foil width and a foil length. The width of the foils runs along the main throughflow direction of the honeycomb body from a gas inlet side to a gas outlet side, and the foil length runs transversely to this direction, wherein at least some metal foils have at least some slots which divide the respective metal foil into a plurality of segments.

Abstract: A method is provided for producing a hologram for a retroreflector. A retroreflector is provided containing numerous facets, each of which reflects light. A photosensitive recording material is applied to the retroreflector. A laser beam is generated, and numerous facets of the retroreflector are successively lit with the laser beam through the recording material, such that the laser beam is reflected by each of the facets and then passes back though the recording material. The laser beam that moves through the recording material toward the facet is a reference beam, and the laser beam reflected back by the facet forms an object beam, such that a segment of the hologram is generated in a part of the photosensitive recording material in front of each of the facets by superimposing the laser beam moving toward the facet with the reflected laser beam.

Abstract: The present invention relates to wheat plants having an increased yield. More specifically, the invention relates to wheat plants in which expression of ENHANCER OF DA1 (EOD1) is functionally reduced. Provided are wheat plants comprising mutant EOD1 alleles as well as methods and means to produced wheat plants with an increased yield.

Abstract: A lighting device for a motor vehicle, wherein the lighting device has a circuit board with a multiplicity of light-emitting diodes arranged thereon, a transparent optical layer, and a reflector element, wherein the reflector element is arranged between the circuit board and the optical layer, wherein the reflector element has multiple segments into which the reflector element is subdivided, wherein a segment is associated with each light-emitting diode so that light emitted by the light-emitting diodes can be reflected by the reflector element and can pass through the optical layer. Two light-emitting diodes are arranged in a segment. In addition, a lighting system and a motor vehicle are provided.