Patents by Inventor Christian Sirrenberg

Christian Sirrenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIAZOLE DERIVATIVES II
    Publication number: 20100022540
    Abstract: Novel triazole derivatives of the formula (I) in which R1—R6 and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
    Type: Application
    Filed: April 20, 2007
    Publication date: January 28, 2010
    Inventors: Hans-Michael Eggenweiler, Michael Wolf, Hans-Peter Buchstaller, Christian Sirrenberg
  • 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS
    Publication number: 20090325974
    Abstract: Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
    Type: Application
    Filed: April 20, 2007
    Publication date: December 31, 2009
    Inventors: Hans-Michael Eggenweiler, Michael Wolf, Hans-Peter Buchstaller, Christian Sirrenberg
  • METHYLENE UREA DERIVATIVES
    Publication number: 20090298885
    Abstract: The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: June 19, 2009
    Publication date: December 3, 2009
    Applicant: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Oliver Schadt, Christiane Amendt, Frank Zenke, Christian Sirrenberg, Matthias Grell, Dirk Finsinger
  • Semicarbazide derivatives as kinase inhibitors
    Publication number: 20090253688
    Abstract: The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: February 14, 2005
    Publication date: October 8, 2009
    Applicant: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Dirk Finsinger, Frank Stieber, Matthias Wiesner, Christiane Amendt, Christian Sirrenberg, Frank Zenke, Matthias Grell
  • Pyrrole derivatives
    Patent number: 7598274
    Abstract: Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: October 6, 2009
    Assignee: Merck Patent GmbH
    Inventors: Dirk Finsinger, Hans-Peter Buchstaller, Lars Burgdorf, Matthias Wiesner, Christiane Amendt, Matthias Grell, Christian Sirrenberg, Frank Zenke
  • Methylene urea derivatives
    Patent number: 7589112
    Abstract: The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: September 15, 2009
    Assignee: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Oliver Schadt, Christiane Amendt, Frank Zenke, Christian Sirrenberg, Matthias Grell, Dirk Finsinger
  • INDAZOLE DERIVATIVES FOR THE TREATMENT OF HSP90-INDUCED DISEASES
    Publication number: 20090197882
    Abstract: Novel indazole derivatives of the formula (I), in which R1-R3 have the meanings indicated in Claim (1), are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
    Type: Application
    Filed: June 18, 2007
    Publication date: August 6, 2009
    Inventors: Hans Peter Buchstaller, Hans-Michael Eggenweiler, Michael Wolf, Christian Sirrenberg
  • GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS
    Publication number: 20090163556
    Abstract: The present invention relates to glycinamide derivatives of formula I, A-D-B??(I), wherein A, D, and B are as herein defined, as well as the use of the compounds of formula I as inhibitors of raf-kinase, the use of the compounds of formula I for the manufacture of a pharmaceutical composition, and a method of treatment comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: November 18, 2008
    Publication date: June 25, 2009
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Oliver Schadt, Christiane Amendt, Frank Zenke, Christian Sirrenberg, Matthias Grell
  • Oxindoles as Kinase Inhibitors
    Publication number: 20090131506
    Abstract: The present invention relates to oxindoles of the formula I, their use as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases and their use for the manufacture of a pharmaceutical composition.
    Type: Application
    Filed: May 11, 2006
    Publication date: May 21, 2009
    Inventors: Lars Thore Burgdorf, David Bruge, Hartmut Greiner, Maria Kordowicz, Christian Sirrenberg, Frank Zenke
  • Glycinamide derivatives as raf-kinase inhibitors
    Patent number: 7476683
    Abstract: The present invention relates to glycinamide derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: January 13, 2009
    Assignee: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Oliver Schadt, Christiane Amendt, Frank Zenke, Christian Sirrenberg, Matthias Grell
  • 2-OXADIAZOLECHROMONE DERIVATIVES
    Publication number: 20080182879
    Abstract: Novel compounds of the formula I in which R, X and n are as defined herein, are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.
    Type: Application
    Filed: April 1, 2008
    Publication date: July 31, 2008
    Inventors: Teresa MUJICA-FERNAUD, Herwig Buchholz, Christophe Carola, Wilfried Rautenberg, Christian Sirrenberg
  • CHROMENONE DERIVATIVES
    Publication number: 20080146589
    Abstract: Novel compounds of the formula I in which R1, R2, R3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.
    Type: Application
    Filed: January 23, 2008
    Publication date: June 19, 2008
    Inventors: Teresa MUJICA-FERNAUD, Herwig Buchholz, Wilfried Rautenberg, Christian Sirrenberg
  • Chromenone derivatives
    Patent number: 7378421
    Abstract: Novel compounds of the formula I in which R1, R2, R3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: May 27, 2008
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Teresa Mujica-Fernaud, Herwig Buchholz, Wilfried Rautenberg, Christian Sirrenberg
  • 2-oxadiazolechromone derivatives
    Patent number: 7354945
    Abstract: Novel compounds of the formula I in which R, X and n are as defined herein, are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: April 8, 2008
    Assignee: Merck Patent GmbH
    Inventors: Teresa Mujica-Fernaud, Herwig Buchholz, Christophe Carola, Wilfried Rautenberg, Christian Sirrenberg
  • 2-Benzoylchromone derivatives
    Patent number: 7307100
    Abstract: Novel compounds of the formula I in which R, X, n and m are as defined herein are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: December 11, 2007
    Assignee: Merck Patent GmbH
    Inventors: Teresa Mujica-Fernaud, Herwig Buchholz, Christophe Carola, Wilfried Rautenberg, Christian Sirrenberg
  • Malonamide Derivatives
    Publication number: 20070213374
    Abstract: The present invention relates to malonamide derivatives of formula A-D-B-1, as inhibitors of raf-kinase and the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition.
    Type: Application
    Filed: June 18, 2004
    Publication date: September 13, 2007
    Applicant: Merck Patent GmbH
    Inventors: David Bruge, Hans-Peter Buchstaller, Matthias Wiesner, Dirk Finsinger, Manfred Baumgarth, Christian Sirrenberg, Frank Zenke, Christian Amendt, Matthias Grell
  • Isoquinoline derivatives
    Publication number: 20070191423
    Abstract: The present invention relates to isoquinoline derivatives of formula (I), the use of the compounds of formula (I), as inhibitors of one or more kinases, the use of the compounds of formula (I), for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: February 1, 2005
    Publication date: August 16, 2007
    Applicant: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Lars Burgdorf, Dirk Finsinger, Christiana Amendt, Matthias Grell, Christian Sirrenberg, Frank Zenke
  • Benzimidazolyl derivatives
    Publication number: 20070191444
    Abstract: The present invention relates to benzimidazolyl derivatives of formula (I), with the definition of R8, p, Ar1, E, D, R9, q and R10 according to claim 1, the use of the compounds of formula (I) as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: February 14, 2005
    Publication date: August 16, 2007
    Inventors: Hans-Peter Buchstaller, Lars Burgdorf, Frank Stieber, Christiane Amendt, Matthias Grell, Christian Sirrenberg, Frank Zenke
  • Use of thiadiazoleurea derivatives
    Publication number: 20070191353
    Abstract: Use of compounds of the formula (I), in which Ar1, Ar2 and Z have the meanings indicated in Patent Claim 1, for the prophylaxis and/or treatment of diseases in which the inhibition, regulation and/or modulation of signal transduction by kinases, in particular RAF kinases, plays a role.
    Type: Application
    Filed: January 31, 2005
    Publication date: August 16, 2007
    Inventors: Lars Burgdorf, Frank Stieber, Hans-Peter Buchstaller, Soheila Anzali, Christiane Amendt, Hartmut Greiner, Matthias Grell, Christian Sirrenberg, Frank Zenke
  • Pyrrole derivatives
    Publication number: 20070149594
    Abstract: Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours
    Type: Application
    Filed: October 26, 2004
    Publication date: June 28, 2007
    Inventors: Dirk Finsinger, Hans-Peter Buchstaller, Lars Burgdorf, Matthias Wiesner, Christiane Amendt, Matthias Grell, Christian Sirrenberg, Frank Zenke