Abstract: Molecular anti-counterfeiting taggants are made from a plurality of synthetic polynucleotides that collectively encode a bit sequence using the sequences and hybridization states of the polynucleotides. The polynucleotide taggant is placed on an item as a molecular identifier of authenticity. The bit sequence encoded by the polynucleotide taggant is read out using a substrate which has bound polynucleotides complexes that hybridize with the synthetic polynucleotides in the polynucleotide taggant. A detectable signal is present where hybridization occurs. To prevent a bad actor from reverse engineering and creating a copy of the polynucleotide taggant using the results of hybridization to the substrate, multiple versions of the substrate are created. Each version hybridizes to different subsets of the synthetic polynucleotides in the polynucleotide taggant. A detectable pattern on the substrate that is present when exposed to the polynucleotide taggant is used for validating authenticity of the item.

Abstract: Virtual auditory display devices are described. An example virtual auditory display device comprises a first and a second ear-worn device, each of which include an acoustic package, an ear interface having multiple cavities, and an electronics package. The acoustic package may be positioned at least partially within the ear interface cavities and includes a housing, a connector including a set of annular electrical contacts, and one or more speakers positioned within the housing that are configured to emit sound based on signals received by the set of annular electrical contacts. The electronics package is removably coupleable to the acoustic package and includes a set of electrical connectors configured to connect with the set of annular electrical contacts and electronics configured to receive audio signals, generate the signals based on the audio signals, and provide the signals to the set of annular electrical contacts via the set of electrical connectors.

Abstract: In an embodiment, a method of manufacturing (100) is described. The method comprises providing (102) a first layer defining a first inner surface (203a) and a first outer surface (203b), a second layer defining a second inner surface (205a) and a second outer surface (205b), and an electrical component (206) positioned on the first inner surface or the second inner surface. The method further comprises attaching (104) the first and second layers together to create a device (200) comprising the first and second layers, wherein the first outer surface and the second outer surface define an external surface of the device. The device further comprises a sealed portion (208) defined by liquid-tight attachment between the first and second inner surfaces. In use of the device, the sealed portion prevents liquid ingress into the device between the first and second layers towards the electrical component.

Abstract: A system is provided that employs a machine learning (ML) decision tree to provide a treatment analysis for an arrhythmia. The ML decision tree includes decision nodes (non-leaf nodes) and treatment analysis nodes (leaf nodes). Each decision node corresponds to a feature derived from electronic health records and has branches corresponding to feature values. A treatment analysis node corresponds to a treatment analysis based on feature values of a path from the root node to that treatment analysis node. To provide a treatment analysis for a candidate, the system identifies a path from the root node to a treatment analysis node based on a candidate feature vector derived from an electronic health record of the candidate and outputs the treatment analysis of the treatment analysis node of the identified path.

Abstract: A multi-cluster computing system which includes a query result caching system is presented. The multi-cluster computing system may include a data processing service and client devices communicatively coupled over a network. The data processing service may include a control layer and a data layer. The control layer may be configured to receive and process requests from the client devices and manage resources in the data layer. The data layer may be configured to include instances of clusters of computing resources for executing jobs. The data layer may include a data storage system, which further includes a remote query result cache Store. The query result cache store may include a cloud storage query result cache which stores data associated with results of previously executed requests. As such, when a cluster encounters a previously executed request, the cluster may efficiently retrieve the cached result of the request from the in-memory query result cache or the cloud storage query result cache.

Abstract: A multi-cluster computing system which includes a query result caching system is presented. The multi-cluster computing system may include a data processing service and client devices communicatively coupled over a network. The data processing service may include a control layer and a data layer. The control layer may be configured to receive and process requests from the client devices and manage resources in the data layer. The data layer may be configured to include instances of clusters of computing resources for executing jobs. The data layer may include a data storage system, which further includes a remote query result cache Store. The query result cache store may include a cloud storage query result cache which stores data associated with results of previously executed requests. As such, when a cluster encounters a previously executed request, the cluster may efficiently retrieve the cached result of the request from the in-memory query result cache or the cloud storage query result cache.

Abstract: The present invention relates to the field of production of novel biosurfactants. More specifically, the present invention relates to the efficient generation of short chained on-glycosides with less than 10%, preferably less than 1%, ?-1 glycosides using a fungal strain such as the yeast Starmerella bombicola having a dysfunctional CYP52M1 cytochrome P450 monooxygenase and a dysfunctional FAO1 fatty alcohol oxidase to produce high amounts of so-called unsaturated (symmetrical) ?,?-bola glycosides free from contaminating ?,?-1 bola glycosides, and subjecting said unsaturated (symmetrical) ?,?-bola glycosides to conditions inducing the breaking of the present double bond(s) such as for example through ozonolysis performed in water. More specifically, the present invention discloses the generation of (acetylated) C9:0 ?-sophoroside aldehydes, C9:0 ?-glucoside aldehydes, C9:0 ?-glucolipids, C9:0 ?-sophorolipids, C9:0 ?-sophoroside alcohols and C9:0 ?-glucoside alcohols and their further derivatives.

Abstract: In an embodiment, a method of manufacturing (100) is described. The method comprises providing (102) a first layer defining a first inner surface (203a) and a first outer surface (203b), a second layer defining a second inner surface (205a) and a second outer surface (205b), and an electrical component (206) positioned on the first inner surface or the second inner surface. The method further comprises attaching (104) the first and second layers together to create a device (200) comprising the first and second layers, wherein the first outer surface and the second outer surface define an external surface of the device. The device further comprises a sealed portion (208) defined by liquid-tight attachment between the first and second inner surfaces. In use of the device, the sealed portion prevents liquid ingress into the device between the first and second layers towards the electrical component.

Abstract: The present disclosure relates to a process for the manufacturing of a 3-5 halopropionylhalide, wherein the process comprises the steps of: a) providing a flow reactor comprising a reaction chamber; b) providing reactants comprising: i. acrylic acid; ii. a reaction co-agent selected from the group consisting of N,N-0 disubstituted amides; and iii. a halogenating agent; and c) incorporating the reactants into the reaction chamber of the flow reactor, thereby forming a reaction product stream comprising a 3-halopropionyl-halide; wherein the molar ratio of acrylic acid to the halogenating agent is 1 to at least 5 0.8; wherein the temperature of the reaction chamber of the flow reactor is greater than 60° C.; and wherein the residence time of the reaction product stream comprising the 3-halopropionylhalide in the reaction chamber of the flow reactor is greater than 10 minutes.

Abstract: A process for making a brominating agent includes the step of continuously feeding a bromide source and an oxidizing agent into a continuous flow reactor.

Abstract: The present disclosure relates to a process for the manufacturing of a 3-5 halopropionylhalide, wherein the process comprises the steps of: a) providing a flow reactor comprising a reaction chamber; b) providing reactants comprising: i. acrylic acid; ii. a reaction co-agent selected from the group consisting of N,N-0 disubstituted amides; and iii. a halogenating agent; and c) incorporating the reactants into the reaction chamber of the flow reactor, thereby forming a reaction product stream comprising a 3-halopropionyl-halide; wherein the molar ratio of acrylic acid to the halogenating agent is 1 to at least 5 0.8; wherein the temperature of the reaction chamber of the flow reactor is greater than 60° C.; and wherein the residence time of the reaction product stream comprising the 3-halopropionylhalide in the reaction chamber of the flow reactor is greater than 10 minutes.

Abstract: The present disclosure relates to a process for the manufacturing of an acid halide, wherein the process comprises the steps of: a) providing a flow reactor comprising a reaction chamber; b) providing reactants comprising: i. a carboxylic acid; ii. a reaction co-agent selected from the group consisting of N,N-disubstituted amides; and iii. a phosphoryl halide; c) incorporating the reactants into the reaction chamber of the flow reactor, wherein the molar ratio of the carboxylic acid to the phosphoryl halide is 1 to at least 0.8, and the molar ratio of the carboxylic acid to the co-agent is 1 to at least 0.5; and d) producing a reaction product stream comprising the acid halide. In another aspect, the present disclosure is directed to the use of a phosphoryl halide for the manufacturing of an acid halide in a flow reactor.

Abstract: The present invention relates to compounds which can be used to control plant development. Indeed, the present invention discloses a new class of pyrabactin analogues which have a physiological effect on—for example—seed germination, and/or stomatal closure, and/or have developmental effects on root and shoot development and organogenesis. Hence, the latter compounds can be used to control plant development such as—for example—increasing the tolerance of plants to drought stress or to control physiological phenomena such as pre-harvest sprouting, tolerance to pathogens etc.

Abstract: The disclosure relates to efficient methods of controlling biological conversions while simultaneously removing and converting some of the generated products. More specifically, and, for example, the disclosure discloses electrochemical processes to remove and capture potentially toxic ammonium during anaerobic digestions and to remove and capture carboxylic acids during bioethanol production. The disclosure can, thus, be used to enhance bioproduction processes via controlling pH and/or reduction/oxidation, in combination with in situ product recovery.

Abstract: This invention relates generally to new findings to improve a method of thermal energy storage or heat pump, i.e. increase the thermal energy from an external heat source, using a reversible condensation reaction with an inorganic oxoacid compound. It accordingly provides components to be used in said improved process as well as the use thereof in the aforementioned method, including the use in the manufacture of products of the condensation products or in the manufacture of the hydrolysis products.

Abstract: The present invention relates to compounds which can be used to control plant development. Indeed, the present invention discloses a new class of pyrabactin analogues which have a physiological effect on—for example—seed germination, and/or stomatal closure, and/or have developmental effects on root and shoot development and organogenesis. Hence, the latter compounds can be used to control plant development such as—for example—increasing the tolerance of plants to drought stress or to control physiological phenomena such as pre-harvest sprouting, tolerance to pathogens etc.

Abstract: The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.

Abstract: A method is provided for storing thermal energy or increasing the thermal energy of a heat pump using reversible chemical reactions in which inorganic oxoacid compounds and/or their salts are hydrolysed and condensed or polymerized in order to release and capture heat. The method allows thermal energy to be stored at ambient circumstances in a transportable medium and allows converting a continuous heat generation process into a discontinuous and even dislocated consumption.

Abstract: This invention relates generally to new findings to improve a method of thermal energy storage or heat pump, i.e. increase the thermal energy from an external heat source, using a reversible condensation reaction with an inorganic oxoacid compound. It accordingly provides components to be used in said improved process as well as the use thereof in the aforementioned method, including the use in the manufacture of products of the condensation products or in the manufacture of the hydrolysis products.

Abstract: The disclosure relates to efficient methods of controlling biological conversions while simultaneously removing and converting some of the generated products. More specifically, and, for example, the disclosure discloses electrochemical processes to remove and capture potentially toxic ammonium during anaerobic digestions and to remove and capture carboxylic acids during bioethanol production. The disclosure can, thus, be used to enhance bioproduction processes via controlling pH and/or reduction/oxidation, in combination with in situ product recovery.