Abstract: The invention relates to a yeast cell producing isobutanol, characterized in that the cell has an increased metabolic flow of material from pyruvate and acetolactate, 2,3-dihydroxy isovalerate, 2-ketoisovalerate, isobutyraldehyde to isobutanol, in that at least one of the genes coding the enzymes, which are involved in this conversion, is over-expressed, and without any of said genes being heterologous to said yeast cell, and to a method for the production of isobutanol using yeast cells, comprising the provision of the yeast cells according to the invention, and bringing the yeast cell into contact with a fermentable carbon source.

Abstract: Disclosed herein, in certain embodiments, is a method for treating an inflammatory disorder. In some embodiments, the method comprises administering an active agent that inhibits (i) MIF binding to CXCR2 and CXCR4 and/or (ii) MIF-activation of CXCR2 and CXCR4; (iii) the ability of MIF to form a homomultimer; or a combination thereof.

Abstract: In a substrate with a hydrophilic surface and a structure made of a conductive and/or light-emitting organic polymer imprinted on the hydrophilic surface, the hydrophilic surface is formed from a layer arranged on the substrate of an oxide ceramic and/or metallic material.

Abstract: The invention relates to a board connector module including a frame accommodating an array of substantially-parallel signal leads (S) and ground leads (G) extending in a longitudinal direction (L). The said frame includes edges extending substantially parallel to said leads and one or more transverse bars extending between said edges. The transverse bars of the frame may resist deflection or buckling of these leads and consequently allow for higher stack heights in mezzanine circuit board assemblies.

Abstract: Novel mutants of human monocyte chemoattractant protein 1 (MCP-1) with increased glycosaminoglycan (GAG) binding affinity and knocked-out or reduced GPCR activity compared to wild type MCP-1, and their use for therapeutic treatment of inflammatory diseases.

Abstract: Vehicle tires, particularly for commercial vehicles, contain a profiled tread, which is broken down into profiled ribs or block rows by a number of peripheral grooves and is made of a first rubber mixture. A groove base of the peripheral grooves is made of a second rubber mixture, and the modulus of elasticity of the second rubber mixture is less than the modulus of elasticity of the first rubber mixture of the main part of the tread. In particular, the second rubber mixture has a modulus M 100%, which is 5% to 20% less than the modulus M 100% of the first rubber mixture of the main part of the tread. The two rubber mixtures are based on a substantially identical or comparable polymer system.

Abstract: The invention relates to a cable connector with a housing including a base extending along a longitudinal axis of the cable connector. The base includes a cable entry portion for accommodating a ferrule system of a cable and a further portion extending from said cable entry portion along said longitudinal axis. The further portion includes one or more mounting structures. The base also includes a housing part with one or more mounting elements adapted to cooperate with said mounting structures to mount the housing part to the base to complete said housing at said further portion. The mounting structures and mounting elements are structured such that said housing part is forced towards said base when said housing part is moved along said longitudinal axis from a mounting position to a mounted position. Accordingly a tight fitting and easily assembled cable connector is obtained.

Abstract: Micro-electromechanical (MEMS) contact configuration is disclosed, comprising a static contact with at least one contact surface and a movable contact with at least one corresponding contact surface. Particularly flat contact surfaces and correspondingly low contact resistance can be achieved, if at least one contact surface plane is formed by a crystal plane of the wafer. Furthermore a method for manufacturing such a contact configuration is proposed, wherein the contact surfaces are obtained by wet anisotropic etching of a silicon wafer, if need be preceded by appropriate masking to expose the to be edged regions only, if need be followed by coating with an electrically conductive layer, e.g., a metal layer.

Abstract: The invention relates to a shielding cage extending along a longitudinal axis between a front side and a rear side and including a diecast metal section extending from said front side over a first length along said longitudinal axis. The shielding cage contains a sheet metal section extending from said rear side towards said front side over a second length along said longitudinal axis, said first length being substantially shorter than said second length. The shielding cage combines a considerable degree of freedom in shaping and robustness at the diecast front side with a substantial reduction of the temperature induced stresses as the length of the diecast section is substantially shorter than that of the second shield metal section of the cage.

Abstract: The invention relates to a board connector module including a frame accommodating an array of substantially-parallel signal leads (S) and ground leads (G) extending in a longitudinal direction (L). The said frame includes edges extending substantially parallel to said leads and one or more transverse bars extending between said edges. The transverse bars of the frame may resist deflection or buckling of these leads and consequently allow for higher stack heights in mezzanine circuit board assemblies.

Abstract: The invention relates to a cable connector assembly including a cable connector with metallic cover shells and a cable, said cable including a shielding braid in electrical connection with at least one of said metallic cover shells. A portion of said shielding braid is folded back over a support member provided for said cable to clamp said portion of said shielding braid between said support member and at least one of said metallic cover shells in a clamping portion of said cable connector. Accordingly a cable connector assembly is obtained with improved mechanical and electromagnetic shielding characteristics. The support member is not crimped on the cable jacket and may include multiple parts. The invention further relates to a cable connector and a method for assembling a cable to a cable connector.

Abstract: The invention relates to polypeptides of amino acid sequence SEQ ID NO: 1 according to formula (1), the use thereof for producing a medicament, and medicaments for the treatment of diseases related to monocyte recruitment.

Abstract: A V-engine (10) having two banks of cylinders (30) each comprising at least one cylinder (20) and a cylinder head (40) is envisaged, wherein the banks of cylinders (30) each comprise at least one inlet valve (12) and also at least one outlet valve (14) for each cylinder (20), while the at least one inlet valve (12) and the at least one outlet valve (14) are arranged in pairs opposite one another on opposite sides of the cylinder head (10), and each cylinder head (10) and its connections to the other engine components are constructed such that it can be mounted in a first position relative to the respective bank of cylinders (30) and in a position rotated through 180° relative to the first position on the same bank of cylinders (30).

Abstract: The invention relates to a vehicle tire, especially utility vehicle tire, comprising a tread which has a tread cap (9) and a tread base (8), both produced from a rubber mixture, and a multilayer ply structure (3, 4, 5, 6) with at least one undertread strip (7, 7?) covering the ply edges and separating the same from the tread base, said undertread strip being likewise produced from a rubber mixture. The aim of the invention is to reduce temperature and heat build-up in the area of the ply edges. For this purpose, the tread base (8) has a heat conductivity that is by at least 20% higher than that of the tread cap (9) and a heat conductivity that is by at least 10% higher than that of the one or more undertread strips (7, 7?), and the tread base (8) contains at least 25 phr of acetylene black.

Abstract: The invention relates to a cable connector with a housing including a base extending along a longitudinal axis of the cable connector. The base includes a cable entry portion for accommodating a ferrule system of a cable and a further portion extending from said cable entry portion along said longitudinal axis. The further portion includes one or more mounting structures. The base also includes a housing part with one or more mounting elements adapted to cooperate with said mounting structures to mount the housing part to the base to complete said housing at said further portion. The mounting structures and mounting elements are structured such that said housing part is forced towards said base when said housing part is moved along said longitudinal axis from a mounting position to a mounted position. Accordingly a tight fitting and easily assembled cable connector is obtained.

Abstract: Process for creating embossed substrate materials such as metal foils, plastic films, papers and layered materials or laminates in a printing machine, as desired simultaneous to additional printing using ink. For the embossing of the substrate material a gravure roll as printing plate is provided in a printing station along with an impression roll. The printing elements on the printing plate are transferred to the substrate material as an embossed image. To that end, in the printing station, the substrate material is passed between the gravure roll and the impression roll and thereby embossed. The gravure roll acting as printing plate exhibits the e.g. engraved, depressed or and/or raised printing elements. The substrate material exhibits the embossed pattern and if required mono-colored or multi-colored printing. The embossing may reinforce the colored motif and the embossing may also exhibit functional properties e.g. that of an aid to tearing or dot-like print.

Abstract: A V-engine (10) having two banks of cylinders (30) each comprising at least one cylinder (20) and a cylinder head (40) is envisaged, wherein the banks of cylinders (30) each comprise at least one inlet valve (12) and also at least one outlet valve (14) for each cylinder (20), while the at least one inlet valve (12) and the at least one outlet valve (14) are arranged in pairs opposite one another on opposite sides of the cylinder head (10), and each cylinder head (10) and its connections to the other engine components are constructed such that it can be mounted in a first position relative to the respective bank of cylinders (30) and in a position rotated through 180° relative to the first position on the same bank of cylinders (30).

Abstract: A multi-document editor system includes a repository for storing a plurality of documents having code fragments. The system further includes a graphical user interface having an editor window within a display region, the editor window for displaying a rendering of the plurality of documents. A program editor module provides a unified editor control to the editor window for editing the plurality of documents.

Abstract: A sealable connector comprises a first connector portion, a second connector portion adapted to engage the first connector portion, a compliant material disposed between the first and second connector portions, and a fastening mechanism that secures the first connector portion to the second connector portion, such that a force applied upon the compliant material by the respective first and second connector portions can be adjusted. The fastening mechanism allows a single connector to be utilized for a variety of applications and allows the connector to be adequately sealed regardless of the manufacturing tolerances of the compliant material.

Abstract: An engine having an engine block and a cylinder head assembly. The cylinder head assembly includes an air inlet and an air outlet for each cylinder of the engine. The engine is operable with the cylinder head assembly connected to the engine block in either of first or second positions, where the second position is rotated from the first position.