Patents by Inventor Christine D. Nelson
Christine D. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10724985Abstract: A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.Type: GrantFiled: March 6, 2018Date of Patent: July 28, 2020Assignee: Ascensia Diabetes Care Holdings AGInventors: Huan-Ping Wu, Christine D. Nelson
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Patent number: 10261044Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.Type: GrantFiled: August 23, 2016Date of Patent: April 16, 2019Assignee: Ascensia Diabetes Care Holdings AGInventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
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Publication number: 20180196000Abstract: A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.Type: ApplicationFiled: March 6, 2018Publication date: July 12, 2018Inventors: Huan-Ping Wu, Christine D. Nelson
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Patent number: 9939406Abstract: A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.Type: GrantFiled: February 2, 2015Date of Patent: April 10, 2018Assignee: Ascensia Diabetes Care Holdings AGInventors: Huan-Ping Wu, Christine D. Nelson
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Publication number: 20160356738Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.Type: ApplicationFiled: August 23, 2016Publication date: December 8, 2016Inventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
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Patent number: 9459229Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.Type: GrantFiled: December 10, 2015Date of Patent: October 4, 2016Assignee: Ascenia Diabetes Care Holdings AGInventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
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Patent number: 9301717Abstract: A biosensor has an abnormal output detection system that determines whether an output signal from the redox reaction of an analyte has a normal or abnormal shape or configuration. The abnormal output detection system improves the accuracy and precision of the biosensor in determining whether an output signal has a shape or configuration that may not provide an accurate and/or precise analysis of a biological fluid. The biosensor generates an output signal in response to the redox reaction of the analyte. The biosensor normalizes the output signal and compares the normalized output signal with one or more control limits. The biosensor may generate an error signal when the normalized output signal is not within the control limits.Type: GrantFiled: June 28, 2012Date of Patent: April 5, 2016Assignee: Ascensia Diabetes Care Holdings AGInventors: Scott Carpenter, Christine D. Nelson, Huan-Ping Wu
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Publication number: 20160084792Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.Type: ApplicationFiled: December 10, 2015Publication date: March 24, 2016Inventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
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Patent number: 9239312Abstract: The present invention relates to methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL.Type: GrantFiled: April 14, 2014Date of Patent: January 19, 2016Assignee: BAYER HEALTHCARE LLCInventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
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Publication number: 20150144508Abstract: A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.Type: ApplicationFiled: February 2, 2015Publication date: May 28, 2015Inventors: Huan-Ping Wu, Christine D. Nelson
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Patent number: 8973422Abstract: A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.Type: GrantFiled: May 13, 2011Date of Patent: March 10, 2015Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson
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Patent number: 8877035Abstract: A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.Type: GrantFiled: March 28, 2013Date of Patent: November 4, 2014Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson, Greg P. Beer
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Publication number: 20140305808Abstract: The present invention relates to methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL.Type: ApplicationFiled: April 14, 2014Publication date: October 16, 2014Applicant: BAYER HEALTHCARE LLCInventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
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Patent number: 8841133Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.Type: GrantFiled: May 2, 2013Date of Patent: September 23, 2014Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson
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Patent number: 8728299Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.Type: GrantFiled: November 14, 2013Date of Patent: May 20, 2014Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
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Patent number: 8702965Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.Type: GrantFiled: November 22, 2010Date of Patent: April 22, 2014Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
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Publication number: 20140061062Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.Type: ApplicationFiled: November 14, 2013Publication date: March 6, 2014Applicant: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
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Publication number: 20130288282Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.Type: ApplicationFiled: May 2, 2013Publication date: October 31, 2013Applicant: BAYER HEALTHCARE LLCInventors: Huan-Ping Wu, Christine D. Nelson
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Publication number: 20130256156Abstract: A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.Type: ApplicationFiled: March 28, 2013Publication date: October 3, 2013Inventors: Huan-Ping Wu, Christine D. Nelson, Greg P. Beer
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Patent number: 8445290Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.Type: GrantFiled: March 6, 2012Date of Patent: May 21, 2013Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson